Click here to switch to the map view.

The map label for this gene is purM [H]

Identifier: 213692819

GI number: 213692819

Start: 2140315

End: 2141352

Strand: Direct

Name: purM [H]

Synonym: Blon_1959

Alternate gene names: 213692819

Gene position: 2140315-2141352 (Clockwise)

Preceding gene: 213692818

Following gene: 213692820

Centisome position: 75.56

GC content: 63.1

Gene sequence:

>1038_bases
ATGCCAAAAGCATATGAGAACGCCGGCGTGAGCGTCGAAGCCGGGTACGAAGTCGTCAAGCGTATCAAGTCGCACGTGGC
CCGCACGAACCGCCCTGGCGTAGTTGGCGGTATCGGCGGTTTCGGCGGTCTGTTCGACCTGGCCTCCCTGGGATACAAGG
AGCCGGTTCTCATCTCCGGCACCGACGGCGTGGGCACCAAGCTCATGGTCGCCAAGCTGGCCAACAAGCACAACACCATC
GGCATCGACTGCGTGGCCATGTGCGTCAACGACATCGCCGCCCAGGGAGCCGAGCCGTTGTTCTTCCTTGACTACATCGC
CTGCGGCAAGAACGACCCGGCACTGCTTGAGCAGGTCGTGGCCGGTGTGGCCGACGGCTGTGTACAGGCCGGTTCCGCGC
TGGTCGGCGGCGAAACCGCCGAAATGCCGGGCATGTACGACGAGGACGAGTACGATCTCGCCGGATTCTCGATCGGCGTT
GCCGAAAAGTCCGCCATCGTGGACGGTTCCACCATCGTTGAAGGCGACGTGCTCATCGGCCTGCCCTCCACCGGCGTACA
CTCCAACGGCTTCTCCCTGGTGCGCAAGGCCCTGTTCGAGCAGGCTGGCTACACCGTGGACACCAAGCTCGACGAGCTGG
GCGGCGAAAAGCTCGGCGACGTGTTGCTCACCCCCACCAAGATCTACGTCAAGGCCCTCTCCCCGCTGTTCAAGGCGGGC
GTGGTCAAGGGCGTGGCCCACATCACCGGCGGTGGCTTCATCGAGAACATCCCGCGCATGATCCCGGACGGCCTGGCCGC
CGAGATCGAGCTCGGCACCTGGCCTGTGCTCCCGATTTTCGACGTGCTGGAGAAGGCTGGCAACATCGATCACAAGGAGA
TGTACAACATCTTCAACATGGGCATCGGCATGGTGCTGGCCATCGACCCCGCTCGCAAGGACGAGGCGCTGAAGCTGCTC
GCCGATAACAACGAGCCCGCCTATGTGCTCGGCCAGATCACTGCCGACACCACCGGCACGCAAATCGTACTGAAGTAA

Upstream 100 bases:

>100_bases
AACAATTCTTTGAACCAGAGGCGCTTGCCTCCCCTCAGTCGGCTTTGCCGACAGCCCCCCCCTCCAGAGGGGAGCCAAAA
TAAGTAGAAAGGCCAACCAA

Downstream 100 bases:

>100_bases
CTCGCTTTCCGCAGGAAAGGAACAACATGGGTCAGAAAGTATTGGTTATCGGCTCCGGTGCGCGTGAGCACACCATTGCC
TACACGCTGCTCAAAGCGCC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MPKAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVGGIGGFGGLFDLASLGYKEPVLISGTDGVGTKLMVAKLANKHNTI
GIDCVAMCVNDIAAQGAEPLFFLDYIACGKNDPALLEQVVAGVADGCVQAGSALVGGETAEMPGMYDEDEYDLAGFSIGV
AEKSAIVDGSTIVEGDVLIGLPSTGVHSNGFSLVRKALFEQAGYTVDTKLDELGGEKLGDVLLTPTKIYVKALSPLFKAG
VVKGVAHITGGGFIENIPRMIPDGLAAEIELGTWPVLPIFDVLEKAGNIDHKEMYNIFNMGIGMVLAIDPARKDEALKLL
ADNNEPAYVLGQITADTTGTQIVLK

Sequences:

>Translated_345_residues
MPKAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVGGIGGFGGLFDLASLGYKEPVLISGTDGVGTKLMVAKLANKHNTI
GIDCVAMCVNDIAAQGAEPLFFLDYIACGKNDPALLEQVVAGVADGCVQAGSALVGGETAEMPGMYDEDEYDLAGFSIGV
AEKSAIVDGSTIVEGDVLIGLPSTGVHSNGFSLVRKALFEQAGYTVDTKLDELGGEKLGDVLLTPTKIYVKALSPLFKAG
VVKGVAHITGGGFIENIPRMIPDGLAAEIELGTWPVLPIFDVLEKAGNIDHKEMYNIFNMGIGMVLAIDPARKDEALKLL
ADNNEPAYVLGQITADTTGTQIVLK
>Mature_344_residues
PKAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVGGIGGFGGLFDLASLGYKEPVLISGTDGVGTKLMVAKLANKHNTIG
IDCVAMCVNDIAAQGAEPLFFLDYIACGKNDPALLEQVVAGVADGCVQAGSALVGGETAEMPGMYDEDEYDLAGFSIGVA
EKSAIVDGSTIVEGDVLIGLPSTGVHSNGFSLVRKALFEQAGYTVDTKLDELGGEKLGDVLLTPTKIYVKALSPLFKAGV
VKGVAHITGGGFIENIPRMIPDGLAAEIELGTWPVLPIFDVLEKAGNIDHKEMYNIFNMGIGMVLAIDPARKDEALKLLA
DNNEPAYVLGQITADTTGTQIVLK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=48.9614243323442, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=48.9614243323442, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=48.9614243323442, Blast_Score=337, Evalue=8e-93,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=52.6315789473684, Blast_Score=351, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=41.6184971098266, Blast_Score=251, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6321203, Length=323, Percent_Identity=48.9164086687306, Blast_Score=299, Evalue=5e-82,
Organism=Drosophila melanogaster, GI24582400, Length=299, Percent_Identity=45.4849498327759, Blast_Score=243, Evalue=1e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36084; Mature: 35953

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVGGIGGFGGLFDLASLGYKEPVLISG
CCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEC
TDGVGTKLMVAKLANKHNTIGIDCVAMCVNDIAAQGAEPLFFLDYIACGKNDPALLEQVV
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHH
AGVADGCVQAGSALVGGETAEMPGMYDEDEYDLAGFSIGVAEKSAIVDGSTIVEGDVLIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCEEEECCEEEE
LPSTGVHSNGFSLVRKALFEQAGYTVDTKLDELGGEKLGDVLLTPTKIYVKALSPLFKAG
CCCCCCCCCCHHHHHHHHHHHCCCEEECHHHHHCCHHHCCEEECCHHHHHHHHHHHHHHH
VVKGVAHITGGGFIENIPRMIPDGLAAEIELGTWPVLPIFDVLEKAGNIDHKEMYNIFNM
HHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHC
GIGMVLAIDPARKDEALKLLADNNEPAYVLGQITADTTGTQIVLK
CCCEEEEECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEC
>Mature Secondary Structure 
PKAYENAGVSVEAGYEVVKRIKSHVARTNRPGVVGGIGGFGGLFDLASLGYKEPVLISG
CCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCEEEEC
TDGVGTKLMVAKLANKHNTIGIDCVAMCVNDIAAQGAEPLFFLDYIACGKNDPALLEQVV
CCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHH
AGVADGCVQAGSALVGGETAEMPGMYDEDEYDLAGFSIGVAEKSAIVDGSTIVEGDVLIG
HHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEEECCCCCEEECCCEEEECCEEEE
LPSTGVHSNGFSLVRKALFEQAGYTVDTKLDELGGEKLGDVLLTPTKIYVKALSPLFKAG
CCCCCCCCCCHHHHHHHHHHHCCCEEECHHHHHCCHHHCCEEECCHHHHHHHHHHHHHHH
VVKGVAHITGGGFIENIPRMIPDGLAAEIELGTWPVLPIFDVLEKAGNIDHKEMYNIFNM
HHHHHHHHCCCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHC
GIGMVLAIDPARKDEALKLLADNNEPAYVLGQITADTTGTQIVLK
CCCEEEEECCCCCCCCEEEEECCCCCEEEEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA