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The map label for this gene is guaB [H]

Identifier: 213691487

GI number: 213691487

Start: 659678

End: 661231

Strand: Direct

Name: guaB [H]

Synonym: Blon_0584

Alternate gene names: 213691487

Gene position: 659678-661231 (Clockwise)

Preceding gene: 213691486

Following gene: 213691488

Centisome position: 23.29

GC content: 64.03

Gene sequence:

>1554_bases
ATGGCTACAAACCTTGATGAATTGAACGCCCAGTCGGCGTATGCTCCCCTTCCCCCGATTTTCGCCAAGCTCGGCCTTGC
CTATGATGATGTGTTGCTGCTGCCGAACGAGACGGATGTCATTCCTTCCGAAGTGGACACCAGCACTCATCTGACCCGCG
AGATCGTGATGAAGGCCCCGGTCCTCTCCGCTGCCATGGATACTGTGACCGAGTCCGAGATGGCCATCGCCATGGCCCGT
AACGGCGGCATCGGCGTGCTGCACCGCAACCTGTCCATCGACGACCAGGCCGCTCAGGTCGACGTGGTCAAGCGTTCCGA
GTCCGGTATGATCACCGACCCGCTGACCGTCAGCCCCGAGGTCACGCTGGCCGATCTCGACAAGCTGTGCGGCAAGTTCC
ACATCTCCGGTCTGCCGGTTGTGGACAAGGACAACAAGCTCGTCGGCATCATCACCAACCGTGACATGCGCTTCATCGCC
TCCGATGATTACGACACCCTGAAGGTCAAGGATGTCATGACCAAGGAGAACCTGGTCACTGGTCCGTCCAACATCTCCAA
GGATGACGCCCACCGTCTGCTCGCCCAGCACAAGGTCGAGAAGCTGCCGCTGGTCGATGACGAAGGCCGCCTGACCGGTC
TGATCACCGTCAAGGACTTCGTCAAGACCGAGCAGTACCCGGACGCCACCAAGGATGAGCAGGGCCGTCTGCGCGTGGCC
GCCGGTGTCGGCTTCCTCGGCGACGCCTGGCAGCGTGCCTCCGCTCTGATGGAGGCCGGCGTGGACGTGCTCGTGGTCGA
CACCGCCAACGGTGAGGCCCGTCTGGCGCTCGACATGATTTCCCGCCTGAAGCACGACTCCGCCTTCGATGGCGTGCAGA
TCATCGGCGGCAACGTGGGCACCCGTTCCGGCGCCCAGGCCATGATTGAGGCTGGCGCGGACGCCGTCAAGGTCGGTATC
GGCCCCGGCTCCATCTGCACCACCCGTATCGTTGCCGGTGTCGGTGTCCCGCAGCTCACCGCCGTGTACGAGGCCGCTCA
GGCCTGCCGTGCTGCGGGCATCCCCTGCATCGCCGACGGTGGCATCCACTATTCCGGTGACATCGCCAAGGCCCTCGTGG
CTGGCGCCTCCTCCGTGATGCTCGGCGGCGCGCTCGCCGGCTGTGAGGAAGCCCCGGGCGAGAAGGTGCTCCTGCACGGC
AAGCAGTACAAGCTGTACCGTGGCATGGGCTCCCTCGGTGCCATGGCCCCGCGCGGCAAGAAGTCCTACTCCAAGGACCG
CTACTTCCAGGCCGACGTGACCTCCAGCGACAAGGTCGTGCCGGAAGGCGTGGAAGGCGAAGTGCCGTATCGCGGCCCGC
TGAACGCCGTGCTCTACCAGATGCTCGGTGGCCTGCACCAGTCCATGTTCTACATCGGCGCCCACAACATCGCCGAGATG
CCGGAGCGTGGCAAGTTCATCCGCATCACCGATGCCGGTCTGCGCGAATCGCACCCGCACGATATCGTGATGACCGCCGA
AGCCCCGAACTACTCCGGCTTCCACAACAACTGA

Upstream 100 bases:

>100_bases
CGGGACTCGCAGGTGGGTGAGGTGCAGGACCCGGCAGCGGATAAGTGAGCGCTCACAAGCGTGTGTCGTGAAGGTCAGCG
CATTTTCATATAGTGTTTAC

Downstream 100 bases:

>100_bases
TCGGTTGATGCCCGCTAGCTTGCGCTAGTTAGGGGTTGATTCCTTGTGAAAAGGGTCTGCTTATGCAGGCCCTTTTCGCG
TATGTGGCTCGAGATAGCTT

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MATNLDELNAQSAYAPLPPIFAKLGLAYDDVLLLPNETDVIPSEVDTSTHLTREIVMKAPVLSAAMDTVTESEMAIAMAR
NGGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVSPEVTLADLDKLCGKFHISGLPVVDKDNKLVGIITNRDMRFIA
SDDYDTLKVKDVMTKENLVTGPSNISKDDAHRLLAQHKVEKLPLVDDEGRLTGLITVKDFVKTEQYPDATKDEQGRLRVA
AGVGFLGDAWQRASALMEAGVDVLVVDTANGEARLALDMISRLKHDSAFDGVQIIGGNVGTRSGAQAMIEAGADAVKVGI
GPGSICTTRIVAGVGVPQLTAVYEAAQACRAAGIPCIADGGIHYSGDIAKALVAGASSVMLGGALAGCEEAPGEKVLLHG
KQYKLYRGMGSLGAMAPRGKKSYSKDRYFQADVTSSDKVVPEGVEGEVPYRGPLNAVLYQMLGGLHQSMFYIGAHNIAEM
PERGKFIRITDAGLRESHPHDIVMTAEAPNYSGFHNN

Sequences:

>Translated_517_residues
MATNLDELNAQSAYAPLPPIFAKLGLAYDDVLLLPNETDVIPSEVDTSTHLTREIVMKAPVLSAAMDTVTESEMAIAMAR
NGGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVSPEVTLADLDKLCGKFHISGLPVVDKDNKLVGIITNRDMRFIA
SDDYDTLKVKDVMTKENLVTGPSNISKDDAHRLLAQHKVEKLPLVDDEGRLTGLITVKDFVKTEQYPDATKDEQGRLRVA
AGVGFLGDAWQRASALMEAGVDVLVVDTANGEARLALDMISRLKHDSAFDGVQIIGGNVGTRSGAQAMIEAGADAVKVGI
GPGSICTTRIVAGVGVPQLTAVYEAAQACRAAGIPCIADGGIHYSGDIAKALVAGASSVMLGGALAGCEEAPGEKVLLHG
KQYKLYRGMGSLGAMAPRGKKSYSKDRYFQADVTSSDKVVPEGVEGEVPYRGPLNAVLYQMLGGLHQSMFYIGAHNIAEM
PERGKFIRITDAGLRESHPHDIVMTAEAPNYSGFHNN
>Mature_516_residues
ATNLDELNAQSAYAPLPPIFAKLGLAYDDVLLLPNETDVIPSEVDTSTHLTREIVMKAPVLSAAMDTVTESEMAIAMARN
GGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVSPEVTLADLDKLCGKFHISGLPVVDKDNKLVGIITNRDMRFIAS
DDYDTLKVKDVMTKENLVTGPSNISKDDAHRLLAQHKVEKLPLVDDEGRLTGLITVKDFVKTEQYPDATKDEQGRLRVAA
GVGFLGDAWQRASALMEAGVDVLVVDTANGEARLALDMISRLKHDSAFDGVQIIGGNVGTRSGAQAMIEAGADAVKVGIG
PGSICTTRIVAGVGVPQLTAVYEAAQACRAAGIPCIADGGIHYSGDIAKALVAGASSVMLGGALAGCEEAPGEKVLLHGK
QYKLYRGMGSLGAMAPRGKKSYSKDRYFQADVTSSDKVVPEGVEGEVPYRGPLNAVLYQMLGGLHQSMFYIGAHNIAEMP
ERGKFIRITDAGLRESHPHDIVMTAEAPNYSGFHNN

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI34328928, Length=478, Percent_Identity=41.2133891213389, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI34328930, Length=478, Percent_Identity=41.2133891213389, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI217035146, Length=478, Percent_Identity=41.2133891213389, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI156616279, Length=478, Percent_Identity=41.2133891213389, Blast_Score=331, Evalue=1e-90,
Organism=Homo sapiens, GI66933016, Length=461, Percent_Identity=40.5639913232104, Blast_Score=329, Evalue=5e-90,
Organism=Homo sapiens, GI217035152, Length=454, Percent_Identity=41.6299559471366, Blast_Score=323, Evalue=4e-88,
Organism=Homo sapiens, GI217035148, Length=478, Percent_Identity=40.5857740585774, Blast_Score=321, Evalue=9e-88,
Organism=Homo sapiens, GI217035150, Length=478, Percent_Identity=38.9121338912134, Blast_Score=299, Evalue=4e-81,
Organism=Homo sapiens, GI50541954, Length=273, Percent_Identity=35.8974358974359, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI50541952, Length=273, Percent_Identity=35.8974358974359, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI50541948, Length=273, Percent_Identity=35.8974358974359, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI50541956, Length=274, Percent_Identity=35.7664233576642, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI156104880, Length=266, Percent_Identity=35.3383458646617, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1788855, Length=492, Percent_Identity=51.4227642276423, Blast_Score=439, Evalue=1e-124,
Organism=Escherichia coli, GI1786293, Length=231, Percent_Identity=38.0952380952381, Blast_Score=145, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=37.7593360995851, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=434, Percent_Identity=39.63133640553, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17560440, Length=264, Percent_Identity=35.9848484848485, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6322012, Length=470, Percent_Identity=40.2127659574468, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=40.7327586206897, Blast_Score=326, Evalue=6e-90,
Organism=Saccharomyces cerevisiae, GI6323464, Length=464, Percent_Identity=41.5948275862069, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6319352, Length=347, Percent_Identity=40.0576368876081, Blast_Score=249, Evalue=8e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=41.8803418803419, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641071, Length=487, Percent_Identity=39.0143737166324, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24641073, Length=487, Percent_Identity=39.0143737166324, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI28571163, Length=446, Percent_Identity=38.7892376681614, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54978; Mature: 54847

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNLDELNAQSAYAPLPPIFAKLGLAYDDVLLLPNETDVIPSEVDTSTHLTREIVMKAP
CCCCCHHCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCH
VLSAAMDTVTESEMAIAMARNGGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVSPE
HHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCHHEEEEEEECCCCCEECCEECCCC
VTLADLDKLCGKFHISGLPVVDKDNKLVGIITNRDMRFIASDDYDTLKVKDVMTKENLVT
CCHHHHHHHHHHEECCCCCEECCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHCCEEC
GPSNISKDDAHRLLAQHKVEKLPLVDDEGRLTGLITVKDFVKTEQYPDATKDEQGRLRVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCEEEE
AGVGFLGDAWQRASALMEAGVDVLVVDTANGEARLALDMISRLKHDSAFDGVQIIGGNVG
ECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCEEEECCCCC
TRSGAQAMIEAGADAVKVGIGPGSICTTRIVAGVGVPQLTAVYEAAQACRAAGIPCIADG
CCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECC
GIHYSGDIAKALVAGASSVMLGGALAGCEEAPGEKVLLHGKQYKLYRGMGSLGAMAPRGK
CEEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCEEEEHHCCCCCCCCCCCCC
KSYSKDRYFQADVTSSDKVVPEGVEGEVPYRGPLNAVLYQMLGGLHQSMFYIGAHNIAEM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHCC
PERGKFIRITDAGLRESHPHDIVMTAEAPNYSGFHNN
CCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure 
ATNLDELNAQSAYAPLPPIFAKLGLAYDDVLLLPNETDVIPSEVDTSTHLTREIVMKAP
CCCCHHCCCCCCCCCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHCH
VLSAAMDTVTESEMAIAMARNGGIGVLHRNLSIDDQAAQVDVVKRSESGMITDPLTVSPE
HHHHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCCHHEEEEEEECCCCCEECCEECCCC
VTLADLDKLCGKFHISGLPVVDKDNKLVGIITNRDMRFIASDDYDTLKVKDVMTKENLVT
CCHHHHHHHHHHEECCCCCEECCCCCEEEEEECCCEEEEECCCCCEEEEHHHHHHCCEEC
GPSNISKDDAHRLLAQHKVEKLPLVDDEGRLTGLITVKDFVKTEQYPDATKDEQGRLRVA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCCCCCEEEE
AGVGFLGDAWQRASALMEAGVDVLVVDTANGEARLALDMISRLKHDSAFDGVQIIGGNVG
ECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHHHHHCCCCCCCCEEEECCCCC
TRSGAQAMIEAGADAVKVGIGPGSICTTRIVAGVGVPQLTAVYEAAQACRAAGIPCIADG
CCCHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEECC
GIHYSGDIAKALVAGASSVMLGGALAGCEEAPGEKVLLHGKQYKLYRGMGSLGAMAPRGK
CEEECCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCEEEEHHCCCCCCCCCCCCC
KSYSKDRYFQADVTSSDKVVPEGVEGEVPYRGPLNAVLYQMLGGLHQSMFYIGAHNIAEM
CCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCHHCC
PERGKFIRITDAGLRESHPHDIVMTAEAPNYSGFHNN
CCCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]