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The map label for this gene is wecA [H]

Identifier: 213691486

GI number: 213691486

Start: 658342

End: 659625

Strand: Direct

Name: wecA [H]

Synonym: Blon_0583

Alternate gene names: 213691486

Gene position: 658342-659625 (Clockwise)

Preceding gene: 213691485

Following gene: 213691487

Centisome position: 23.24

GC content: 58.57

Gene sequence:

>1284_bases
ATGAGAATCTACTTACTGATTGCCGCCATCGCCGGTGGCGTCACCTGGCTGGTGACTCCGCTGATTCGCCACGTCGCCAT
CGAAATCGGTGCGGTTGGCGAGGTGCGTGCCCGAGACGTGCACACCATTCCCACGCCGCGCATGGGCGGCCTTGGCATGC
TTATCGGTTTTGCCGTGGCTACCGTGTTCGCCAGTCGGCTGCCTTTTCTCTCGGGATTGTTCAACGGCAATCATCAGATG
TGGGTGATTCTTGCCGGCGGCATCATGATCAGTCTGCTAGGCATGGCCGATGACCTGTGGGATCTCGATTGGATGCTGAA
ACTTGCCGGTCAGCTGCTGATTTCCGTATTCGTGGCCTGGGGCGGATTGCAGATCATCTCACTGCCTTTGGGCGATTCGC
TGATTACCGCCTCGCCGAGTCTGTCCATGGCGATCACCGCATTCCTGATCGTCGCCTCGATCAACGCGGTCAATTTCGTT
GATGGCCTCGATGGTCTGGCGGCCGGTATCGTGGCGATTGGTGGCATAGCGTTCGCCGCCTATTCGTATATCATCGCCCG
GTCTTCCCCGAGTTATGCTTCGTTGGCCACGCTGATCGACGTGATGATGGTGGGTATCTGCGTGGGCTTCCTGCTGCATA
ATTGGCATCCCGCCAAACTGTTCATGGGCGATTCCGGTTCGATGCTGCTTGGCTATCTCATCACCTGCGCTTCGATTGTG
ATGACCGGACGTCTTGACCCGGCCTCGATTCATGCCAGCATCTATCTGCCGGTGTTCATACCAATTCTGCTGCCGGTTCT
GGTGTTATTCCTGCCTGTGCTCGACATGTGTCTGGCGATTGTGCGGCGTTTGGCCAAAGGCCAGTCGCCCATGCATCCGG
ACCGTATGCACCTGCACCATCGCATGCTGAAGATCGGGCATTCGGTGCGTGGCGCCGTGCTGATCCTGTGGGGATGGGCC
GCGCTGATCGCATTCGGTTCGCTGACGATTCTGTTCTTCGAAGCGCAGCATGTGGCCGTGGGCATGGCCATCGCCGTGGT
GGTGCTCACCATAGCCACGATGTACCCCTATCTGCGGCATCGTATTCCCGAGATCCAAGCCGAGAACCTGACGCTCGAAT
CCGCGCGAAAGAACGCGCAGTATTCAGTCTCTAAATCGCAGTCTGCAGTAGGGGGGAGCCGGGATTCGATTGGCTCTCAG
GCAGCGGATTCGATGACTGATTCGCCTGCGGATTCGCGGGACTCGCAGGTGGGTGAGGTGCAGGACCCGGCAGCGGATAA
GTGA

Upstream 100 bases:

>100_bases
ATCCGTATGCGCGCGACGGCATCGAGATCCTGCGTGAAGGCGTCATCGCCCAAAACGTGATTCGCAAGGCCCTCCACCTC
AACGGCGGGGGACTTGGCGC

Downstream 100 bases:

>100_bases
GCGCTCACAAGCGTGTGTCGTGAAGGTCAGCGCATTTTCATATAGTGTTTACATGGCTACAAACCTTGATGAATTGAACG
CCCAGTCGGCGTATGCTCCC

Product: glycosyl transferase, family 4

Products: UMP; Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

Alternate protein names: UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase; Undecaprenyl-Phosphate GlcNAc-1-phosphate transferase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRIYLLIAAIAGGVTWLVTPLIRHVAIEIGAVGEVRARDVHTIPTPRMGGLGMLIGFAVATVFASRLPFLSGLFNGNHQM
WVILAGGIMISLLGMADDLWDLDWMLKLAGQLLISVFVAWGGLQIISLPLGDSLITASPSLSMAITAFLIVASINAVNFV
DGLDGLAAGIVAIGGIAFAAYSYIIARSSPSYASLATLIDVMMVGICVGFLLHNWHPAKLFMGDSGSMLLGYLITCASIV
MTGRLDPASIHASIYLPVFIPILLPVLVLFLPVLDMCLAIVRRLAKGQSPMHPDRMHLHHRMLKIGHSVRGAVLILWGWA
ALIAFGSLTILFFEAQHVAVGMAIAVVVLTIATMYPYLRHRIPEIQAENLTLESARKNAQYSVSKSQSAVGGSRDSIGSQ
AADSMTDSPADSRDSQVGEVQDPAADK

Sequences:

>Translated_427_residues
MRIYLLIAAIAGGVTWLVTPLIRHVAIEIGAVGEVRARDVHTIPTPRMGGLGMLIGFAVATVFASRLPFLSGLFNGNHQM
WVILAGGIMISLLGMADDLWDLDWMLKLAGQLLISVFVAWGGLQIISLPLGDSLITASPSLSMAITAFLIVASINAVNFV
DGLDGLAAGIVAIGGIAFAAYSYIIARSSPSYASLATLIDVMMVGICVGFLLHNWHPAKLFMGDSGSMLLGYLITCASIV
MTGRLDPASIHASIYLPVFIPILLPVLVLFLPVLDMCLAIVRRLAKGQSPMHPDRMHLHHRMLKIGHSVRGAVLILWGWA
ALIAFGSLTILFFEAQHVAVGMAIAVVVLTIATMYPYLRHRIPEIQAENLTLESARKNAQYSVSKSQSAVGGSRDSIGSQ
AADSMTDSPADSRDSQVGEVQDPAADK
>Mature_427_residues
MRIYLLIAAIAGGVTWLVTPLIRHVAIEIGAVGEVRARDVHTIPTPRMGGLGMLIGFAVATVFASRLPFLSGLFNGNHQM
WVILAGGIMISLLGMADDLWDLDWMLKLAGQLLISVFVAWGGLQIISLPLGDSLITASPSLSMAITAFLIVASINAVNFV
DGLDGLAAGIVAIGGIAFAAYSYIIARSSPSYASLATLIDVMMVGICVGFLLHNWHPAKLFMGDSGSMLLGYLITCASIV
MTGRLDPASIHASIYLPVFIPILLPVLVLFLPVLDMCLAIVRRLAKGQSPMHPDRMHLHHRMLKIGHSVRGAVLILWGWA
ALIAFGSLTILFFEAQHVAVGMAIAVVVLTIATMYPYLRHRIPEIQAENLTLESARKNAQYSVSKSQSAVGGSRDSIGSQ
AADSMTDSPADSRDSQVGEVQDPAADK

Specific function: Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55), the lipid intermediate involved in the synthesis of various bacter

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. WecA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790218, Length=303, Percent_Identity=26.4026402640264, Blast_Score=86, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000715 [H]

Pfam domain/function: PF00953 Glycos_transf_4 [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 45559; Mature: 45559

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIYLLIAAIAGGVTWLVTPLIRHVAIEIGAVGEVRARDVHTIPTPRMGGLGMLIGFAVA
CEEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
TVFASRLPFLSGLFNGNHQMWVILAGGIMISLLGMADDLWDLDWMLKLAGQLLISVFVAW
HHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLQIISLPLGDSLITASPSLSMAITAFLIVASINAVNFVDGLDGLAAGIVAIGGIAFAA
CCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YSYIIARSSPSYASLATLIDVMMVGICVGFLLHNWHPAKLFMGDSGSMLLGYLITCASIV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
MTGRLDPASIHASIYLPVFIPILLPVLVLFLPVLDMCLAIVRRLAKGQSPMHPDRMHLHH
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
RMLKIGHSVRGAVLILWGWAALIAFGSLTILFFEAQHVAVGMAIAVVVLTIATMYPYLRH
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RIPEIQAENLTLESARKNAQYSVSKSQSAVGGSRDSIGSQAADSMTDSPADSRDSQVGEV
CCCCCCCCCCCHHHHHCCCCEECCCCHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCC
QDPAADK
CCCCCCC
>Mature Secondary Structure
MRIYLLIAAIAGGVTWLVTPLIRHVAIEIGAVGEVRARDVHTIPTPRMGGLGMLIGFAVA
CEEEEEEHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
TVFASRLPFLSGLFNGNHQMWVILAGGIMISLLGMADDLWDLDWMLKLAGQLLISVFVAW
HHHHHHHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GGLQIISLPLGDSLITASPSLSMAITAFLIVASINAVNFVDGLDGLAAGIVAIGGIAFAA
CCCEEEEECCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YSYIIARSSPSYASLATLIDVMMVGICVGFLLHNWHPAKLFMGDSGSMLLGYLITCASIV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHH
MTGRLDPASIHASIYLPVFIPILLPVLVLFLPVLDMCLAIVRRLAKGQSPMHPDRMHLHH
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
RMLKIGHSVRGAVLILWGWAALIAFGSLTILFFEAQHVAVGMAIAVVVLTIATMYPYLRH
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
RIPEIQAENLTLESARKNAQYSVSKSQSAVGGSRDSIGSQAADSMTDSPADSRDSQVGEV
CCCCCCCCCCCHHHHHCCCCEECCCCHHHCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCC
QDPAADK
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-Acetyl-D-Glucosamine; Undecaprenyl Phosphate [C]

Specific reaction: UDP-N-Acetyl-D-Glucosamine + Undecaprenyl Phosphate = UMP + Undecaprenyl N-Acetyl-Alpha-D-Glucosaminyl Pyrophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]