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The map label for this gene is mug [H]

Identifier: 213691040

GI number: 213691040

Start: 141067

End: 141705

Strand: Reverse

Name: mug [H]

Synonym: Blon_0119

Alternate gene names: 213691040

Gene position: 141705-141067 (Counterclockwise)

Preceding gene: 213691053

Following gene: 213691022

Centisome position: 5.0

GC content: 67.29

Gene sequence:

>639_bases
ATGGAACCCGTGAGCGATATTCGACATTCTCCGCTGGAAGGCCGGCGGCCGAAGCGCACCGAGCTCGCCGGTTTCGTCGA
CGGCACGGTCGACGACATCCGCTGCCCGCACCCCAAACTGCTTATCGTGGGCATCAACCCCGGGTTATGGACGGCCGCGG
TCAACGCACCCTTCGCCTATCCCGGCAACCGATTCTGGCCGTCGCTTTTCGCCTCGGGGCTCACGCCGTGGCAGGTGGAC
GCCAGTTACGGCCTACGCCTTCACGATGAGCGCATGATGATCGACCGCGGCATCGGGCTTACCAATCTCGTCAATCGCGC
CACCGCGAAAGCGAGTGAGCTGAACACCGCCGAGCTGCGTCATGGCGCCGATCGGCTGCGGGAGCTGTGCGCGAGGGTCC
ATCCCCGGGCCATTGCGATACTGGGCATTACGGCGTACCGACAGGCGTTCGCCGATAAGTCCGCCGCGCTGGGGCTGCAG
GACCTCACCGCGGAAGAGACCGACCGGTTCGGAGGCGCGCAGCTGTGGGTGATTCCCCAGCCCAGCGGGTTGAACGCGCA
CGCCACCATGCCGGTGCTGGTCGACTGGTGGCGCAGGGTCGCCGACGCGGCCGGTCTGGATCTCGCCGCCGCGCGCTAG

Upstream 100 bases:

>100_bases
TCGGGGAGGCCTCGGCGGCGAATGTGCGCAAGATCACCTTGCCCGCGAGGCGCGGAGCTCACCGAATGGCGGTATGCCGT
CGGAACGGGGCGCGACTACC

Downstream 100 bases:

>100_bases
TATCCTACGCCGTTGATTCGTTTGTTAATTCTGGCTCCCCTCAGAGAGGGGAGCCAGACATTGTTAACGAATTAAAGCTA
GGCGATAGCCTTTCGACTGT

Product: Uracil-DNA glycosylase superfamily

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MEPVSDIRHSPLEGRRPKRTELAGFVDGTVDDIRCPHPKLLIVGINPGLWTAAVNAPFAYPGNRFWPSLFASGLTPWQVD
ASYGLRLHDERMMIDRGIGLTNLVNRATAKASELNTAELRHGADRLRELCARVHPRAIAILGITAYRQAFADKSAALGLQ
DLTAEETDRFGGAQLWVIPQPSGLNAHATMPVLVDWWRRVADAAGLDLAAAR

Sequences:

>Translated_212_residues
MEPVSDIRHSPLEGRRPKRTELAGFVDGTVDDIRCPHPKLLIVGINPGLWTAAVNAPFAYPGNRFWPSLFASGLTPWQVD
ASYGLRLHDERMMIDRGIGLTNLVNRATAKASELNTAELRHGADRLRELCARVHPRAIAILGITAYRQAFADKSAALGLQ
DLTAEETDRFGGAQLWVIPQPSGLNAHATMPVLVDWWRRVADAAGLDLAAAR
>Mature_212_residues
MEPVSDIRHSPLEGRRPKRTELAGFVDGTVDDIRCPHPKLLIVGINPGLWTAAVNAPFAYPGNRFWPSLFASGLTPWQVD
ASYGLRLHDERMMIDRGIGLTNLVNRATAKASELNTAELRHGADRLRELCARVHPRAIAILGITAYRQAFADKSAALGLQ
DLTAEETDRFGGAQLWVIPQPSGLNAHATMPVLVDWWRRVADAAGLDLAAAR

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=140, Percent_Identity=30.7142857142857, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1789449, Length=174, Percent_Identity=37.3563218390805, Blast_Score=118, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356805, Length=155, Percent_Identity=33.5483870967742, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 23219; Mature: 23219

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPVSDIRHSPLEGRRPKRTELAGFVDGTVDDIRCPHPKLLIVGINPGLWTAAVNAPFAY
CCCHHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCCCC
PGNRFWPSLFASGLTPWQVDASYGLRLHDERMMIDRGIGLTNLVNRATAKASELNTAELR
CCCCCCHHHHHCCCCCEEECCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
HGADRLRELCARVHPRAIAILGITAYRQAFADKSAALGLQDLTAEETDRFGGAQLWVIPQ
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHCHHHHHCCCCEEEEEEEC
PSGLNAHATMPVLVDWWRRVADAAGLDLAAAR
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEPVSDIRHSPLEGRRPKRTELAGFVDGTVDDIRCPHPKLLIVGINPGLWTAAVNAPFAY
CCCHHHHHCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCEEEECCCCCCC
PGNRFWPSLFASGLTPWQVDASYGLRLHDERMMIDRGIGLTNLVNRATAKASELNTAELR
CCCCCCHHHHHCCCCCEEECCCCCCEECCCHHHHHCCCCHHHHHHHHHHHHHHCCHHHHH
HGADRLRELCARVHPRAIAILGITAYRQAFADKSAALGLQDLTAEETDRFGGAQLWVIPQ
HHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHCHHHHHCCCCEEEEEEEC
PSGLNAHATMPVLVDWWRRVADAAGLDLAAAR
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA