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The map label for this gene is hutC [H]

Identifier: 213159151

GI number: 213159151

Start: 3986735

End: 3987487

Strand: Reverse

Name: hutC [H]

Synonym: AB57_3862

Alternate gene names: 213159151

Gene position: 3987487-3986735 (Counterclockwise)

Preceding gene: 213159153

Following gene: 213159150

Centisome position: 98.44

GC content: 40.9

Gene sequence:

>753_bases
ATGCCCAGAACATCAAAACAAGAACATACTGAGCTTTCGATTGAAGCTGATAGTCCAGTTCCTTTATATCAGCGCGTAAA
ACAGCTGATTTCACAAAAGATTTATGAAGGCTCTTGGGCTGTAAATAAAAAAATTCCTTCGGAAAGTGAACTCGTTAATC
AACTCGGCTGTAGCCGTATGACGGTAAACCGTGCGCTACGCGAGTTAACAACAGAAGGCTTACTTGTTCGAATTCAGGGT
GTTGGTTCTTTCGTTGCTGAAGGGCAAGGCCGAACTGCACTTTTCCAAATTAACAATATTGCCGATGAGATTATTGCACG
AAACCATAAGCACCATGCTGAAGTTTTAGTCTTAGAACAAATTTATGCAAATGCAGAGCAAAGCGTGTTAATGCAGACTC
GCGAAGGGCAAAAATTATTTCACTCGATTATTGTGCATTATGAAAATGATGTACCTGTTCAGGTCGAAGATCGTTTAGTT
GATGCAGCACTGATTCCAGATTATTTAGAACAAGATTTTAAAACCATTACCCCAAATGCTTACCTCATGGCAAAAGCACC
CGTGACAGAAGGTGAACACATTGTTGAGGCCGTTTTAGCATCACCTCAAGAGTGTAAGTGGTTAAAGATTACTAAAGCTG
AACCGTGTTTACTCATCCGGCGTCGCACATGGTCAAACAAACAACTCATTTCAAGTGCACGATTGATTTATCCGGGCAGT
CGCTATTATCTCGAAGGGAAATTTAATCCATGA

Upstream 100 bases:

>100_bases
AATATATTTAATTCATAAATTAACATGTTGTATGTGGTTGTATATACATAGCATGTCAACTAAAATACCTTTTTGCCTGC
TGCCTTTTTGAGTATTTGTT

Downstream 100 bases:

>100_bases
TTGAATTGATCAGGGCCGATCAATATACAAAAATGCTTTGGAAAAATGGTGCAGGCTTTACTTTAGAAATTGCTCGAAGC
CAAGGTGAAGCCGACTTTGA

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MPRTSKQEHTELSIEADSPVPLYQRVKQLISQKIYEGSWAVNKKIPSESELVNQLGCSRMTVNRALRELTTEGLLVRIQG
VGSFVAEGQGRTALFQINNIADEIIARNHKHHAEVLVLEQIYANAEQSVLMQTREGQKLFHSIIVHYENDVPVQVEDRLV
DAALIPDYLEQDFKTITPNAYLMAKAPVTEGEHIVEAVLASPQECKWLKITKAEPCLLIRRRTWSNKQLISSARLIYPGS
RYYLEGKFNP

Sequences:

>Translated_250_residues
MPRTSKQEHTELSIEADSPVPLYQRVKQLISQKIYEGSWAVNKKIPSESELVNQLGCSRMTVNRALRELTTEGLLVRIQG
VGSFVAEGQGRTALFQINNIADEIIARNHKHHAEVLVLEQIYANAEQSVLMQTREGQKLFHSIIVHYENDVPVQVEDRLV
DAALIPDYLEQDFKTITPNAYLMAKAPVTEGEHIVEAVLASPQECKWLKITKAEPCLLIRRRTWSNKQLISSARLIYPGS
RYYLEGKFNP
>Mature_249_residues
PRTSKQEHTELSIEADSPVPLYQRVKQLISQKIYEGSWAVNKKIPSESELVNQLGCSRMTVNRALRELTTEGLLVRIQGV
GSFVAEGQGRTALFQINNIADEIIARNHKHHAEVLVLEQIYANAEQSVLMQTREGQKLFHSIIVHYENDVPVQVEDRLVD
AALIPDYLEQDFKTITPNAYLMAKAPVTEGEHIVEAVLASPQECKWLKITKAEPCLLIRRRTWSNKQLISSARLIYPGSR
YYLEGKFNP

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786950, Length=202, Percent_Identity=26.7326732673267, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI87082252, Length=202, Percent_Identity=24.2574257425743, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 28406; Mature: 28275

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTSKQEHTELSIEADSPVPLYQRVKQLISQKIYEGSWAVNKKIPSESELVNQLGCSRM
CCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCHH
TVNRALRELTTEGLLVRIQGVGSFVAEGQGRTALFQINNIADEIIARNHKHHAEVLVLEQ
HHHHHHHHHCCCCEEEEEECCCHHHHCCCCCEEEEEEHHHHHHHHHCCCCCHHHHEEHHH
IYANAEQSVLMQTREGQKLFHSIIVHYENDVPVQVEDRLVDAALIPDYLEQDFKTITPNA
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHCHHHHHHHHEECCCCE
YLMAKAPVTEGEHIVEAVLASPQECKWLKITKAEPCLLIRRRTWSNKQLISSARLIYPGS
EEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHCCEEEECCC
RYYLEGKFNP
EEEEECCCCC
>Mature Secondary Structure 
PRTSKQEHTELSIEADSPVPLYQRVKQLISQKIYEGSWAVNKKIPSESELVNQLGCSRM
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCHH
TVNRALRELTTEGLLVRIQGVGSFVAEGQGRTALFQINNIADEIIARNHKHHAEVLVLEQ
HHHHHHHHHCCCCEEEEEECCCHHHHCCCCCEEEEEEHHHHHHHHHCCCCCHHHHEEHHH
IYANAEQSVLMQTREGQKLFHSIIVHYENDVPVQVEDRLVDAALIPDYLEQDFKTITPNA
HHCCCHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHCHHHHHHHHEECCCCE
YLMAKAPVTEGEHIVEAVLASPQECKWLKITKAEPCLLIRRRTWSNKQLISSARLIYPGS
EEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHCCEEEECCC
RYYLEGKFNP
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203753 [H]