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The map label for this gene is hutU

Identifier: 213159149

GI number: 213159149

Start: 3984233

End: 3985909

Strand: Reverse

Name: hutU

Synonym: AB57_3860

Alternate gene names: 213159149

Gene position: 3985909-3984233 (Counterclockwise)

Preceding gene: 213159150

Following gene: 213159148

Centisome position: 98.41

GC content: 44.72

Gene sequence:

>1677_bases
GTGACAACAATGACAACAAAATTTCGTGATGTAGAAATTCGTGCGCCACGCGGCACTGAATTGACGGCTAAAAGTTGGTT
AACTGAAGCTCCATTACGTATGTTGATGAATAACCTTGATCCGGACGTTGCAGAAAACCCGAAAGAGTTGGTTGTATACG
GTGGTATTGGCCGTGCAGCACGAAACTGGGAATGTTTCGACAAAATTGTAGATACTTTAAAAAATCTTGAAACTGATGAA
ACTTTATTGGTTCAATCAGGTAAGCCAGTAGGTGTATTTAAAACTCATAAAGATGCACCTCGCGTTTTAATTGCAAACTC
AAACCTTGTACCGCACTGGGCAAACTGGGAACACTTCAACGAGTTAGATGCAAAAGCTTTGGCGATGTACGGTCAAATGA
CAGCGGGTTCGTGGATCTACATTGGTAGCCAAGGTATTGTACAAGGTACTTATGAAACTTTCGTTGAGGCAGGTCGCCAA
CATTACAATGGTGATTTAAAAGGTCGTTGGGTTCTTACTGCCGGTTTAGGTGGTATGGGTGGCGCTCAGCCTTTAGCTGC
AACACTTGCAGGTGCGTGTTCTTTAAACATTGAATGCCAACAAGCAAGTATCGATTTCCGTTTACGTACCCGTTATGTAG
ATGAACAAGCAACTGATTTAGACGACGCTTTAGCGCGTATTGATCGTTATACAAAAGAAGGTAAAGCAATTTCAATCGCA
CTTCATGGTAATGCTGCTGAAATTTTACCTGAGCTTGTACGCCGTGGTGTACGTCCAGACATGGTAACTGACCAAACAAG
TGCACATGATCCACTTAATGGCTACTTACCAGTAGGCTGGACTTGGGATGAATACCGTGAACGCGCGAAAAAAGAACCGG
AAGCTGTTGTAAAAGCTGCAAAACAGTCGATGGCAAAACACGTACAAGCCATGCTTGATTTCCAAAAAATGGGTGTTCCA
ACATTTGACTATGGCAATAACATCCGTCAAATGGCGAAAGAAGAAGGCGTAGCAAACGCTTTTGATTTCCCGGGCTTCGT
ACCTGCCTACATCCGTCCATTGTTCTGCCGTGGTATTGGTCCATTCCGTTGGGCAGCGCTTTCTGGTGACCCTGAAGATA
TTTATAAAACAGATGCCAAAGTTAAGGAGTTAATTCCTGATGATGAGCATTTACATCACTGGTTAGACATGGCTCGTGAA
CGTATTAGCTTCCAAGGCTTACCAGCGCGTATTTGCTGGGTAGGTTTAGGCTTACGTGCAAAACTTGGTTTGGCATTTAA
CGAAATGGTTCGTAGCGGTGAATTATCTGCACCGATCGTGATTGGTCGTGACCACTTAGACTCAGGTTCGGTTGCAAGTC
CTAACCGTGAAACTGAAGCAATGCAAGACGGATCAGATGCAGTATCAGACTGGCCTTTATTAAATGCCTTGTTAAATACA
GCAGGCGGCGCAACTTGGGTGTCTCTACATCATGGTGGCGGTGTAGGTATGGGCTTCTCTCAACACTCAGGCGTTGTGAT
TGTGTGTGACGGTACAGATGAAGCTGCTGCACGTATTGCTCGCGTACTAACCAATGACCCTGCAACAGGTGTTATGCGTC
ATGCCGATGCAGGTTATGAAATTGCGATTAACTGTGCCAAAGAGCAAGGCCTACACTTGCCAATGATCACCCAATAA

Upstream 100 bases:

>100_bases
TGTGTAGTATATGGATGTATATACAAGTTAATACATTACTATACAAATGCAGAAATAAGTGATGTTCTGCTGATGTAAGC
TCAAAGGAAGGAGTCCGCCT

Downstream 100 bases:

>100_bases
AAATACATGGAAGAACTGGCGGTGCTTTTTGCAATTGTGAAAAGCACCGTCTCAGCAGAATATAGTGCAAAAAATTAGGA
AGCCAACATGGAATTACTGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 558; Mature: 557

Protein sequence:

>558_residues
MTTMTTKFRDVEIRAPRGTELTAKSWLTEAPLRMLMNNLDPDVAENPKELVVYGGIGRAARNWECFDKIVDTLKNLETDE
TLLVQSGKPVGVFKTHKDAPRVLIANSNLVPHWANWEHFNELDAKALAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQ
HYNGDLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIDRYTKEGKAISIA
LHGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWDEYRERAKKEPEAVVKAAKQSMAKHVQAMLDFQKMGVP
TFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDEHLHHWLDMARE
RISFQGLPARICWVGLGLRAKLGLAFNEMVRSGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNT
AGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLTNDPATGVMRHADAGYEIAINCAKEQGLHLPMITQ

Sequences:

>Translated_558_residues
MTTMTTKFRDVEIRAPRGTELTAKSWLTEAPLRMLMNNLDPDVAENPKELVVYGGIGRAARNWECFDKIVDTLKNLETDE
TLLVQSGKPVGVFKTHKDAPRVLIANSNLVPHWANWEHFNELDAKALAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQ
HYNGDLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIDRYTKEGKAISIA
LHGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWDEYRERAKKEPEAVVKAAKQSMAKHVQAMLDFQKMGVP
TFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDEHLHHWLDMARE
RISFQGLPARICWVGLGLRAKLGLAFNEMVRSGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNT
AGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLTNDPATGVMRHADAGYEIAINCAKEQGLHLPMITQ
>Mature_557_residues
TTMTTKFRDVEIRAPRGTELTAKSWLTEAPLRMLMNNLDPDVAENPKELVVYGGIGRAARNWECFDKIVDTLKNLETDET
LLVQSGKPVGVFKTHKDAPRVLIANSNLVPHWANWEHFNELDAKALAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQH
YNGDLKGRWVLTAGLGGMGGAQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIDRYTKEGKAISIAL
HGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWDEYRERAKKEPEAVVKAAKQSMAKHVQAMLDFQKMGVPT
FDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIGPFRWAALSGDPEDIYKTDAKVKELIPDDEHLHHWLDMARER
ISFQGLPARICWVGLGLRAKLGLAFNEMVRSGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNTA
GGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLTNDPATGVMRHADAGYEIAINCAKEQGLHLPMITQ

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=572, Percent_Identity=33.9160839160839, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI260306182, Length=219, Percent_Identity=38.8127853881278, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71997891, Length=567, Percent_Identity=34.2151675485009, Blast_Score=315, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_ACIB3 (B7GUU5)

Other databases:

- EMBL:   CP001172
- RefSeq:   YP_002324017.1
- ProteinModelPortal:   B7GUU5
- SMR:   B7GUU5
- GeneID:   7058744
- GenomeReviews:   CP001172_GR
- KEGG:   abb:ABBFA_000076
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 61233; Mature: 61102

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 412-412

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTMTTKFRDVEIRAPRGTELTAKSWLTEAPLRMLMNNLDPDVAENPKELVVYGGIGRAA
CCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
RNWECFDKIVDTLKNLETDETLLVQSGKPVGVFKTHKDAPRVLIANSNLVPHWANWEHFN
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHH
ELDAKALAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGDLKGRWVLTAGLGGMG
HHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
GAQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIDRYTKEGKAISIA
CCHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHCCCCEEEEE
LHGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWDEYRERAKKEPEAVVKAA
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCHHHHHHHH
KQSMAKHVQAMLDFQKMGVPTFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
PFRWAALSGDPEDIYKTDAKVKELIPDDEHLHHWLDMARERISFQGLPARICWVGLGLRA
CCEEEECCCCHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
KLGLAFNEMVRSGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNT
HHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
AGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLTNDPATGVMRHADAGYE
CCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCE
IAINCAKEQGLHLPMITQ
EEEEEHHHCCCCCCCCCC
>Mature Secondary Structure 
TTMTTKFRDVEIRAPRGTELTAKSWLTEAPLRMLMNNLDPDVAENPKELVVYGGIGRAA
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC
RNWECFDKIVDTLKNLETDETLLVQSGKPVGVFKTHKDAPRVLIANSNLVPHWANWEHFN
CCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCCCCCCHHHH
ELDAKALAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGDLKGRWVLTAGLGGMG
HHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
GAQPLAATLAGACSLNIECQQASIDFRLRTRYVDEQATDLDDALARIDRYTKEGKAISIA
CCHHHHHHHHHHEEEEEEEECCCCCEEEEEEECCCHHCCHHHHHHHHHHHHCCCCEEEEE
LHGNAAEILPELVRRGVRPDMVTDQTSAHDPLNGYLPVGWTWDEYRERAKKEPEAVVKAA
ECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHCCCHHHHHHHH
KQSMAKHVQAMLDFQKMGVPTFDYGNNIRQMAKEEGVANAFDFPGFVPAYIRPLFCRGIG
HHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCC
PFRWAALSGDPEDIYKTDAKVKELIPDDEHLHHWLDMARERISFQGLPARICWVGLGLRA
CCEEEECCCCHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHH
KLGLAFNEMVRSGELSAPIVIGRDHLDSGSVASPNRETEAMQDGSDAVSDWPLLNALLNT
HHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHC
AGGATWVSLHHGGGVGMGFSQHSGVVIVCDGTDEAAARIARVLTNDPATGVMRHADAGYE
CCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCE
IAINCAKEQGLHLPMITQ
EEEEEHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA