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The map label for this gene is hutH [H]

Identifier: 213159148

GI number: 213159148

Start: 3982607

End: 3984145

Strand: Reverse

Name: hutH [H]

Synonym: AB57_3859

Alternate gene names: 213159148

Gene position: 3984145-3982607 (Counterclockwise)

Preceding gene: 213159149

Following gene: 213159147

Centisome position: 98.36

GC content: 43.66

Gene sequence:

>1539_bases
ATGGAATTACTGATCCAACCGGGAAAACTGACCTTAGCCGATTTACGTCAAGCTTACCTCAACCCAATTAAAGTTAAACT
AGATGAAAGTGCTTCATCTGCAATTAATGCAAGCGTGGCTTGTGTAGAGCAAATTGTAAATGAAGGACGTACAGCTTACG
GTATTAATACAGGTTTTGGCTTACTTGCCTCAACTAAAATTGCGCCTGAAGATTTAGAAAAATTACAGCGTTCATTAGTT
CTTTCGCATGCGGCAGGTGTAGGCGAAGCACTTGATGATGCAATGGTTCGTTTAATTATTCTATTGAAAGCAAATAGCTT
GGCACGTGGTTTCTCTGGTATTCGTCGTAAAGTCATTGATGCTTTGTTGGCCTTAATTAATGCTGAAGTTTACCCACACA
TTCCACTTAAAGGTTCAGTAGGAGCTTCTGGCGACTTGGCACCACTTGCACACATGTCTTTAGTTTTACTTGGTGAAAGT
AAGGCACGTTATAAAGGTGAATGGTTACCAGCAGTTGAAGCTTTAAAAATTGCAGGTTTAGAACCAATTTCTTTAGCGGC
TAAAGAAGGTTTGGCACTTTTAAATGGTACACAGGTTTCAACAGCTTACGCTTTACGCGGCTTATTCGAAGCAGAAGATT
TATTTGCTGCCGCGACAGTTTGTGGTGGCTTAAGTGTTGAAGCAATGCTTGGTTCACGTGCACCTTTCGATGCGCGTATT
CACGAAGTACGCGGCCAACGTGGTCAAATTGATGTGGCTGCGGCTTATCGCGATTTATTGACTGATTCGAGTGAAATCTC
TCGTTCACATGAAGAATGTGGCAAAGTTCAAGACCCATATTCTTTACGTTGCCAACCACAGGTGATGGGTGCATGTTTAA
CTCAAATCCGTCAGGCTGCTGAAGTATTAGAAATTGAAGCAAATGCTGTATCTGATAACCCGCTTGTGTTTGCTGAACAA
GGTGACGTGATTTCTGGTGGTAACTTCCATGCAGAACCCGTTGCAATGGCGGCTGATAATCTAGCTTTGGCAATTGCAGA
AATTGGTTCACTGTCTGAACGTCGTATTTCAATGATGATGGACCGTCATATGTCACAGCTTCCACCGTTCTTGGTGGCAA
ATGGTGGTGTTAACTCGGGCTTTATGATTGCTCAGGTAACCGCTGCTGCTCTTGCAAGTGACAACAAGGCGCTTGCACAT
CCAGCAAGTGTGGATAGCCTACCGACTTCAGCCAACCAAGAAGACCATGTATCGATGGCTCCAAATGCTGGTAAACGTCT
TTGGTATATGGCTGATAACGTCCGCGGCATTTTAGCTGTTGAATGGTTAGGCGCTTGTCAGGGTCTAGACTTCCGTGAAG
GTTTAAAAAGCTCGCCTAAACTTGAACAAGCTCGTAAAATCTTGCGCGACCAAGTTCCTTACTACAGTGAAGACCGTTTC
TTTGCTCCTGATATCGAACAGGCTAGTGAATTGCTTGCGAGTGGTTGCCTAAACGAGTTACTCATTCCAAAACTACTCCC
TAGTTTATCTGAAGTGTGA

Upstream 100 bases:

>100_bases
GATCACCCAATAAAAATACATGGAAGAACTGGCGGTGCTTTTTGCAATTGTGAAAAGCACCGTCTCAGCAGAATATAGTG
CAAAAAATTAGGAAGCCAAC

Downstream 100 bases:

>100_bases
TTGATAAAACGGTCACATGGAGTGGCCGAATCCAACTAAATTTCCTCAAGGATTGGAGATTATAATGTCACAAAACTCCA
CACTACAGCGGGGCTTAAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEQIVNEGRTAYGINTGFGLLASTKIAPEDLEKLQRSLV
LSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVIDALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGES
KARYKGEWLPAVEALKIAGLEPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARI
HEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAEQ
GDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMMDRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAH
PASVDSLPTSANQEDHVSMAPNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRF
FAPDIEQASELLASGCLNELLIPKLLPSLSEV

Sequences:

>Translated_512_residues
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEQIVNEGRTAYGINTGFGLLASTKIAPEDLEKLQRSLV
LSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVIDALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGES
KARYKGEWLPAVEALKIAGLEPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARI
HEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAEQ
GDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMMDRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAH
PASVDSLPTSANQEDHVSMAPNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRF
FAPDIEQASELLASGCLNELLIPKLLPSLSEV
>Mature_512_residues
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEQIVNEGRTAYGINTGFGLLASTKIAPEDLEKLQRSLV
LSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVIDALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGES
KARYKGEWLPAVEALKIAGLEPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARI
HEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAEQ
GDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMMDRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAH
PASVDSLPTSANQEDHVSMAPNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRF
FAPDIEQASELLASGCLNELLIPKLLPSLSEV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=501, Percent_Identity=43.7125748502994, Blast_Score=406, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=507, Percent_Identity=41.6173570019724, Blast_Score=371, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54611; Mature: 54611

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00488 PAL_HISTIDASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEQIVNEGRTAYGINTGFG
CCEEECCCCEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
LLASTKIAPEDLEKLQRSLVLSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVID
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGESKARYKGEWLPAVEALKIAGL
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHCCC
EPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARI
CHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHH
HEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAA
HHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVLEIEANAVSDNPLVFAEQGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMM
HHHHHCCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHHH
DRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMA
HHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEC
PNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRF
CCCCCEEEEEECCCCEEHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC
FAPDIEQASELLASGCLNELLIPKLLPSLSEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MELLIQPGKLTLADLRQAYLNPIKVKLDESASSAINASVACVEQIVNEGRTAYGINTGFG
CCEEECCCCEEHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCH
LLASTKIAPEDLEKLQRSLVLSHAAGVGEALDDAMVRLIILLKANSLARGFSGIRRKVID
HHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
ALLALINAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGESKARYKGEWLPAVEALKIAGL
HHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCCCCCCHHHHHHHCCC
EPISLAAKEGLALLNGTQVSTAYALRGLFEAEDLFAAATVCGGLSVEAMLGSRAPFDARI
CHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHH
HEVRGQRGQIDVAAAYRDLLTDSSEISRSHEECGKVQDPYSLRCQPQVMGACLTQIRQAA
HHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVLEIEANAVSDNPLVFAEQGDVISGGNFHAEPVAMAADNLALAIAEIGSLSERRISMMM
HHHHHCCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHHH
DRHMSQLPPFLVANGGVNSGFMIAQVTAAALASDNKALAHPASVDSLPTSANQEDHVSMA
HHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEC
PNAGKRLWYMADNVRGILAVEWLGACQGLDFREGLKSSPKLEQARKILRDQVPYYSEDRF
CCCCCEEEEEECCCCEEHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCCCCCCC
FAPDIEQASELLASGCLNELLIPKLLPSLSEV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA