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The map label for this gene is hisQ [H]

Identifier: 213158700

GI number: 213158700

Start: 2745888

End: 2746577

Strand: Reverse

Name: hisQ [H]

Synonym: AB57_2658

Alternate gene names: 213158700

Gene position: 2746577-2745888 (Counterclockwise)

Preceding gene: 213158701

Following gene: 213158699

Centisome position: 67.81

GC content: 42.32

Gene sequence:

>690_bases
ATGTCTTTTTCTGGCTATGGGCCACTCCTTCTTAGCGGAACATGGATGACCATACAGCTTGCGCTGTTATCACTCTTGCT
TTCTGTCATTATTGGCTTAATTGGTGCGAGTTCAAAACTCTCTAATATTAAAGCCTTACGTTATGTTGCAACCGCCTATA
CCACGCTCATCCGTAGTGTGCCTGACTTAGTGATTATGCTGCTGTTATTTTATAGCTTGCAGTTGGGCTTAAACCAAATT
ACTGAAGCACTGCAAATGGATCAAATTGATATCAACCCATTTGTGGCTGGTGTGATTACTTTAGCGTTCATTTATGGTGC
ATATTTTACCGAGACCTTTCGTGGTGCATTTCAATCGGTTCCAAGGGGACAAATTGAAGCAGCAATGGCCTATGGGATGA
CGCCTTGGCAGGTTTTTCACCGTGTATTATTCCCTCAAATGATGCGTTTTGCATTGCCCGGCATTGGTAACAACTGGCAA
GTTTTGATTAAGGCGACCGCATTGGTTTCTATTATTGGCCTGACTGATATTGTAAAAATTACGCAAGATGCAGGTAGAAG
TACCATGCAACTGTTCTTTTTCAGCATCGTCGCTGCTGCCATTTATTTGGCAATTACCACAGTGTCGAACCTGATTTTAA
TATGGCTTGAACGTCATTATTCTGCTGGTGTGAGGAAGGGACAATTATGA

Upstream 100 bases:

>100_bases
ATTTACTAATGATGTGAAAAATGTCGGCTGAGTGCCGACATTTTTAAATCTATTCTCATCTCATCAATATTAGATATTGT
TTTTAAGGAGAAGATGAGTC

Downstream 100 bases:

>100_bases
TTGAAATCCTTCAACAATATTGGCAGGCATACCTTTGGACCGATGGCCTACAAATGACCGGTGTGGCGATGACTGCTTGG
TTATTGGTGCTATCGATTGG

Product: histidine transport system permease protein HisQ

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MSFSGYGPLLLSGTWMTIQLALLSLLLSVIIGLIGASSKLSNIKALRYVATAYTTLIRSVPDLVIMLLLFYSLQLGLNQI
TEALQMDQIDINPFVAGVITLAFIYGAYFTETFRGAFQSVPRGQIEAAMAYGMTPWQVFHRVLFPQMMRFALPGIGNNWQ
VLIKATALVSIIGLTDIVKITQDAGRSTMQLFFFSIVAAAIYLAITTVSNLILIWLERHYSAGVRKGQL

Sequences:

>Translated_229_residues
MSFSGYGPLLLSGTWMTIQLALLSLLLSVIIGLIGASSKLSNIKALRYVATAYTTLIRSVPDLVIMLLLFYSLQLGLNQI
TEALQMDQIDINPFVAGVITLAFIYGAYFTETFRGAFQSVPRGQIEAAMAYGMTPWQVFHRVLFPQMMRFALPGIGNNWQ
VLIKATALVSIIGLTDIVKITQDAGRSTMQLFFFSIVAAAIYLAITTVSNLILIWLERHYSAGVRKGQL
>Mature_228_residues
SFSGYGPLLLSGTWMTIQLALLSLLLSVIIGLIGASSKLSNIKALRYVATAYTTLIRSVPDLVIMLLLFYSLQLGLNQIT
EALQMDQIDINPFVAGVITLAFIYGAYFTETFRGAFQSVPRGQIEAAMAYGMTPWQVFHRVLFPQMMRFALPGIGNNWQV
LIKATALVSIIGLTDIVKITQDAGRSTMQLFFFSIVAAAIYLAITTVSNLILIWLERHYSAGVRKGQL

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=225, Percent_Identity=60.4444444444444, Blast_Score=283, Evalue=9e-78,
Organism=Escherichia coli, GI1787087, Length=217, Percent_Identity=35.4838709677419, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1788226, Length=222, Percent_Identity=30.6306306306306, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787030, Length=212, Percent_Identity=30.6603773584906, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788645, Length=198, Percent_Identity=30.8080808080808, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1786873, Length=212, Percent_Identity=28.7735849056604, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI87082239, Length=199, Percent_Identity=26.1306532663317, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786874, Length=173, Percent_Identity=29.4797687861272, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787086, Length=225, Percent_Identity=25.7777777777778, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 25250; Mature: 25119

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSGYGPLLLSGTWMTIQLALLSLLLSVIIGLIGASSKLSNIKALRYVATAYTTLIRSV
CCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
PDLVIMLLLFYSLQLGLNQITEALQMDQIDINPFVAGVITLAFIYGAYFTETFRGAFQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGQIEAAMAYGMTPWQVFHRVLFPQMMRFALPGIGNNWQVLIKATALVSIIGLTDIVKI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQDAGRSTMQLFFFSIVAAAIYLAITTVSNLILIWLERHYSAGVRKGQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SFSGYGPLLLSGTWMTIQLALLSLLLSVIIGLIGASSKLSNIKALRYVATAYTTLIRSV
CCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
PDLVIMLLLFYSLQLGLNQITEALQMDQIDINPFVAGVITLAFIYGAYFTETFRGAFQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PRGQIEAAMAYGMTPWQVFHRVLFPQMMRFALPGIGNNWQVLIKATALVSIIGLTDIVKI
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TQDAGRSTMQLFFFSIVAAAIYLAITTVSNLILIWLERHYSAGVRKGQL
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]