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The map label for this gene is hisM [H]

Identifier: 213158699

GI number: 213158699

Start: 2745178

End: 2745891

Strand: Reverse

Name: hisM [H]

Synonym: AB57_2657

Alternate gene names: 213158699

Gene position: 2745891-2745178 (Counterclockwise)

Preceding gene: 213158700

Following gene: 213158694

Centisome position: 67.79

GC content: 41.6

Gene sequence:

>714_bases
ATGATTGAAATCCTTCAACAATATTGGCAGGCATACCTTTGGACCGATGGCCTACAAATGACCGGTGTGGCGATGACTGC
TTGGTTATTGGTGCTATCGATTGGTATTGGGTTTGTGCTTGCTGTGCCTTTGTCACTTGCGCGAGTATCAGAAAATATCT
GGTTGCATGGTCCAGTTTGGTTGTTTACCTATGTTTTTCGTGGCACACCACTGTATATCCAACTACTGATTATTTACTCG
GGTATTTACAGCTTTGATTATATCCACGAGCATCAGACACTCGATGCATTCTTTCGAGAGGGCATAAATTGCACCATTTT
GGCATTCGCGCTCAATACTAGTGCATATACGACTGAAATCTTCGCTGGAGCAATTCGTTCTATTCCACATGGTGAGATTG
AAGCTGCCCAAGCTTTTGGTATGTCAAAATGGAAACTCTACACACGTATTATCATTCCATCGATGTTACGCCGTGCTTTG
CCGTTTTACGGCAATGAAGTCATTTTAATGTTGCATGCCACAACCATTGCATTTACAGCAACAGTTCCCGACATTTTAAA
AATTGCGCGTGATGTGAATGCGGCAACCTATGACACTTTCAGTGCTTTTGGAATTGCTGCAGTGTTATATGCAGTGTTGG
CATTTATTTTGATTTGGATATTTCGTAAGTTGGAAAAACGTTGGTTGGCATTTTTAAAGCCATCGAATCATTAG

Upstream 100 bases:

>100_bases
TCGTCGCTGCTGCCATTTATTTGGCAATTACCACAGTGTCGAACCTGATTTTAATATGGCTTGAACGTCATTATTCTGCT
GGTGTGAGGAAGGGACAATT

Downstream 100 bases:

>100_bases
GAGACATAAATGGAACAGGTTGCAAAACTAGTGATTCGCGATTTACATAAGACATTCGGCGATCATGAGGTACTTAAAGG
AATATCACTTGATGCAAATG

Product: histidine transport system permease protein HisM

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 237

Protein sequence:

>237_residues
MIEILQQYWQAYLWTDGLQMTGVAMTAWLLVLSIGIGFVLAVPLSLARVSENIWLHGPVWLFTYVFRGTPLYIQLLIIYS
GIYSFDYIHEHQTLDAFFREGINCTILAFALNTSAYTTEIFAGAIRSIPHGEIEAAQAFGMSKWKLYTRIIIPSMLRRAL
PFYGNEVILMLHATTIAFTATVPDILKIARDVNAATYDTFSAFGIAAVLYAVLAFILIWIFRKLEKRWLAFLKPSNH

Sequences:

>Translated_237_residues
MIEILQQYWQAYLWTDGLQMTGVAMTAWLLVLSIGIGFVLAVPLSLARVSENIWLHGPVWLFTYVFRGTPLYIQLLIIYS
GIYSFDYIHEHQTLDAFFREGINCTILAFALNTSAYTTEIFAGAIRSIPHGEIEAAQAFGMSKWKLYTRIIIPSMLRRAL
PFYGNEVILMLHATTIAFTATVPDILKIARDVNAATYDTFSAFGIAAVLYAVLAFILIWIFRKLEKRWLAFLKPSNH
>Mature_237_residues
MIEILQQYWQAYLWTDGLQMTGVAMTAWLLVLSIGIGFVLAVPLSLARVSENIWLHGPVWLFTYVFRGTPLYIQLLIIYS
GIYSFDYIHEHQTLDAFFREGINCTILAFALNTSAYTTEIFAGAIRSIPHGEIEAAQAFGMSKWKLYTRIIIPSMLRRAL
PFYGNEVILMLHATTIAFTATVPDILKIARDVNAATYDTFSAFGIAAVLYAVLAFILIWIFRKLEKRWLAFLKPSNH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=236, Percent_Identity=64.4067796610169, Blast_Score=325, Evalue=2e-90,
Organism=Escherichia coli, GI1787086, Length=212, Percent_Identity=33.9622641509434, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787030, Length=224, Percent_Identity=29.4642857142857, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788226, Length=198, Percent_Identity=35.3535353535354, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788646, Length=223, Percent_Identity=28.2511210762332, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1787087, Length=177, Percent_Identity=25.9887005649718, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI87082239, Length=222, Percent_Identity=25.6756756756757, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26940; Mature: 26940

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQQYWQAYLWTDGLQMTGVAMTAWLLVLSIGIGFVLAVPLSLARVSENIWLHGPVW
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHH
LFTYVFRGTPLYIQLLIIYSGIYSFDYIHEHQTLDAFFREGINCTILAFALNTSAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
FAGAIRSIPHGEIEAAQAFGMSKWKLYTRIIIPSMLRRALPFYGNEVILMLHATTIAFTA
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNAATYDTFSAFGIAAVLYAVLAFILIWIFRKLEKRWLAFLKPSNH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIEILQQYWQAYLWTDGLQMTGVAMTAWLLVLSIGIGFVLAVPLSLARVSENIWLHGPVW
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHH
LFTYVFRGTPLYIQLLIIYSGIYSFDYIHEHQTLDAFFREGINCTILAFALNTSAYTTEI
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
FAGAIRSIPHGEIEAAQAFGMSKWKLYTRIIIPSMLRRALPFYGNEVILMLHATTIAFTA
HHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHH
TVPDILKIARDVNAATYDTFSAFGIAAVLYAVLAFILIWIFRKLEKRWLAFLKPSNH
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]