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The map label for this gene is acsA [H]

Identifier: 213158529

GI number: 213158529

Start: 2574140

End: 2575783

Strand: Reverse

Name: acsA [H]

Synonym: AB57_2480

Alternate gene names: 213158529

Gene position: 2575783-2574140 (Counterclockwise)

Preceding gene: 213158530

Following gene: 213158527

Centisome position: 63.59

GC content: 40.15

Gene sequence:

>1644_bases
ATGAAAACTTTGGCAGAAGCTTATCAGCAATTTGATCTTACAAGGCTCATCGAAGAGCAACTTGTTGGGCATCCCCAAGC
AATAAATGCTTATGTTGAGTGCTGTGAGCGTTATGTAGGAAAAAATAAAACAGCGCTTATCTGGGAAGGAAAAAACGGGC
AGGCAGAGCACTATACGTTCGAACAACTTGCTGAACTTTCTGGAAAACTTGCTAACTTCTTTAAAGCACAAGGAATTCAA
GCTGGAGATTGTATTGCAGGACTTCTACCAAGAACGCCTGAGTTATTAATTACAATTTTGGCAGCATGGCGTATAGGCGC
TATTTATCAGCCTTTATTTACTGCCTTTGAAGCAAAATCGATTGATCACCGAATTACGACTGCTCAAACTAAATTGATTG
TGACCAATGATGAACAGCGCCCTAAACTGAATACCTTGAATGTTCCGGTTATTGTAACTGTTCATCAAACAGGTCTTTTA
TCTGAGCATGACTTTGATTTTTGGCAATCTTTACAACGATATTCTGAGCAATGTGAGCCAGTAAATCGTAGCTTTGATGA
TGACTTTTTAATGATGTTTACCTCAGGCACAACTGGACTTGCAAAGTCTGTACCTGTTCCACTAAAAGCAATTTTAGCAT
TTAAAGGTTATATGACCCATGCCGTTGATTTGCGTGAAGAGGATATGTTCTGGAATCTGGCAGATCCGGGCTGGGCATAT
GGATTGTATTATGGCATTACCGGGCCTTTAAGCTTGGGTCATGGCATTATTATGGATGAGCGTTCATTTAATGTAGATCA
GGCAATAGAATTAATTAAAAAATATAAAGTAAGTAATTTAACAGGATCGCCTACAGCATTTCGCATGTTCTTTGGATTTA
AGGAAAAATTTGACCCTTCAATTAAACAACATTTACGCGTAGTGAGTAGTGCAGGTGAGCCATTAACTCCTGAGGTTGTG
AATTGGTTTAAGCAGGATTTAGAGGTCAATATTTTTGATCAATATGGCCAAACTGAGCTAGGCATGGTAATTGCGAACCA
CCATGCGCTTGAGCATCCATTAAAAGTAGGTTCAGCTGGTTTTGCAATTCCTGGGCATCGTTTTGCGGTGTTAGACCAAA
ATTATCAAGAATTGCCAACTGGTGGTGTTGGTATTTTGGCGATGGACTCGGAGCAATCGCCATTAATGTGGTTTAAAGGT
TATGGTGGCAATAATCGCAAAGCCTTTGTTGGTAAGTATTATTTAACAGGTGACACGGTCACTTTAAATGAACATGGGGG
CATTGATTTTGTGGGGCGTGCTGACGATGTCATTACAACTTCGGGTTATCGAGTTGGACCATTTGATGTTGAAAGTACTT
TATTAGAGTGTGAGGCCGTATTGGAGTCAGCAGTAATTGGTAAGCCAGATCCGGAACGAACCGAAATAGTCAAAGCTTTT
GTGGTACTTAAGCCTGCTTATCAAGCGTGTGAAACATTAAAAGATAAGTTACAGCAATATGTTCGTAACCGTTTATCTCG
TCATGCTTATCCAAAAGAGATTGAGTTTGTGGACAGTCTACCGAAAACCACGAGCGGAAAAATTCAAAGAGGACTGTTGA
AGCAGCAAGAAATTGCAAAAATGCAGCAAGCCTACGCAAGCTAA

Upstream 100 bases:

>100_bases
GAAGAAATATTCTTCAAGCTTTAGCTAAAACAATAACAGTCAGGACAGATTTTGTAGCCTTACACAAAATCAATCATCAA
ACGGAATGAAGGTGAGCATC

Downstream 100 bases:

>100_bases
TTGAACAAAGGGAAATATTTAGAATTTCCCTTTATTCTTTATATTAAAGATCGGCTTTCACTTCCTCACCAATTAAATAA
AATGTGCCACCAGCAATATA

Product: acyl-CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MKTLAEAYQQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEHYTFEQLAELSGKLANFFKAQGIQ
AGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKSIDHRITTAQTKLIVTNDEQRPKLNTLNVPVIVTVHQTGLL
SEHDFDFWQSLQRYSEQCEPVNRSFDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAY
GLYYGITGPLSLGHGIIMDERSFNVDQAIELIKKYKVSNLTGSPTAFRMFFGFKEKFDPSIKQHLRVVSSAGEPLTPEVV
NWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAGFAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKG
YGGNNRKAFVGKYYLTGDTVTLNEHGGIDFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAF
VVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAKMQQAYAS

Sequences:

>Translated_547_residues
MKTLAEAYQQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEHYTFEQLAELSGKLANFFKAQGIQ
AGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKSIDHRITTAQTKLIVTNDEQRPKLNTLNVPVIVTVHQTGLL
SEHDFDFWQSLQRYSEQCEPVNRSFDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAY
GLYYGITGPLSLGHGIIMDERSFNVDQAIELIKKYKVSNLTGSPTAFRMFFGFKEKFDPSIKQHLRVVSSAGEPLTPEVV
NWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAGFAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKG
YGGNNRKAFVGKYYLTGDTVTLNEHGGIDFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAF
VVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAKMQQAYAS
>Mature_547_residues
MKTLAEAYQQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEHYTFEQLAELSGKLANFFKAQGIQ
AGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKSIDHRITTAQTKLIVTNDEQRPKLNTLNVPVIVTVHQTGLL
SEHDFDFWQSLQRYSEQCEPVNRSFDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAY
GLYYGITGPLSLGHGIIMDERSFNVDQAIELIKKYKVSNLTGSPTAFRMFFGFKEKFDPSIKQHLRVVSSAGEPLTPEVV
NWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAGFAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKG
YGGNNRKAFVGKYYLTGDTVTLNEHGGIDFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAF
VVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAKMQQAYAS

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI122937307, Length=535, Percent_Identity=33.2710280373832, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI42544132, Length=536, Percent_Identity=30.9701492537313, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=34.3023255813954, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI115511026, Length=513, Percent_Identity=30.9941520467836, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI58082049, Length=515, Percent_Identity=31.2621359223301, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI157311624, Length=515, Percent_Identity=30.873786407767, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI157311622, Length=515, Percent_Identity=30.873786407767, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI28416953, Length=556, Percent_Identity=29.136690647482, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI8923896, Length=559, Percent_Identity=29.1592128801431, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI253970489, Length=572, Percent_Identity=29.1958041958042, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI13375727, Length=555, Percent_Identity=27.5675675675676, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI42544134, Length=360, Percent_Identity=26.1111111111111, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI195947378, Length=417, Percent_Identity=25.1798561151079, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI40807357, Length=533, Percent_Identity=22.8893058161351, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI156151445, Length=527, Percent_Identity=24.6679316888046, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI45580730, Length=359, Percent_Identity=28.133704735376, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790505, Length=552, Percent_Identity=27.536231884058, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI145693145, Length=513, Percent_Identity=25.9259259259259, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1786529, Length=547, Percent_Identity=27.7879341864717, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788107, Length=553, Percent_Identity=23.1464737793852, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786801, Length=436, Percent_Identity=23.394495412844, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1786810, Length=526, Percent_Identity=21.6730038022814, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1789201, Length=464, Percent_Identity=24.5689655172414, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=563, Percent_Identity=27.708703374778, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71982997, Length=563, Percent_Identity=27.708703374778, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32563687, Length=487, Percent_Identity=25.6673511293634, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17557194, Length=534, Percent_Identity=24.1573033707865, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=533, Percent_Identity=26.078799249531, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=462, Percent_Identity=22.7272727272727, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17560308, Length=379, Percent_Identity=24.5382585751979, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=495, Percent_Identity=25.8585858585859, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71994694, Length=520, Percent_Identity=20.3846153846154, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=520, Percent_Identity=20.3846153846154, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=362, Percent_Identity=22.0994475138122, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=538, Percent_Identity=24.1635687732342, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17559526, Length=543, Percent_Identity=24.1252302025783, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=291, Percent_Identity=26.1168384879725, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=392, Percent_Identity=24.7448979591837, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319264, Length=559, Percent_Identity=31.484794275492, Blast_Score=216, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6323182, Length=575, Percent_Identity=29.5652173913043, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319699, Length=354, Percent_Identity=24.0112994350282, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667955, Length=551, Percent_Identity=29.4010889292196, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI62472339, Length=532, Percent_Identity=29.6992481203008, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI24667959, Length=502, Percent_Identity=29.4820717131474, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21355225, Length=565, Percent_Identity=24.2477876106195, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18859661, Length=526, Percent_Identity=25.2851711026616, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24581924, Length=511, Percent_Identity=22.3091976516634, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355181, Length=506, Percent_Identity=25.098814229249, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24648260, Length=497, Percent_Identity=23.5412474849095, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19922652, Length=511, Percent_Identity=24.0704500978474, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656500, Length=495, Percent_Identity=24.040404040404, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24653035, Length=485, Percent_Identity=21.0309278350515, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356947, Length=489, Percent_Identity=21.0633946830266, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24648255, Length=484, Percent_Identity=23.3471074380165, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24648253, Length=483, Percent_Identity=22.360248447205, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281365686, Length=488, Percent_Identity=21.7213114754098, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 61289; Mature: 61289

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLAEAYQQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEHYTF
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
EQLAELSGKLANFFKAQGIQAGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDHRITTAQTKLIVTNDEQRPKLNTLNVPVIVTVHQTGLLSEHDFDFWQSLQRYSEQCEP
CCCEEEEEEEEEEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
VNRSFDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAY
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEE
GLYYGITGPLSLGHGIIMDERSFNVDQAIELIKKYKVSNLTGSPTAFRMFFGFKEKFDPS
EEEECCCCCHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHCCHH
IKQHLRVVSSAGEPLTPEVVNWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAG
HHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECCCCCCCHHEEEECCHHHHCCHHCCCCC
FAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKGYGGNNRKAFVGKYYLTGDTV
CCCCCCEEEEECCCHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEEEEECCEE
TLNEHGGIDFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAF
EECCCCCEEEECCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHH
MQQAYAS
HHHHHCC
>Mature Secondary Structure
MKTLAEAYQQFDLTRLIEEQLVGHPQAINAYVECCERYVGKNKTALIWEGKNGQAEHYTF
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHH
EQLAELSGKLANFFKAQGIQAGDCIAGLLPRTPELLITILAAWRIGAIYQPLFTAFEAKS
HHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
IDHRITTAQTKLIVTNDEQRPKLNTLNVPVIVTVHQTGLLSEHDFDFWQSLQRYSEQCEP
CCCEEEEEEEEEEEECCCCCCCCEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCC
VNRSFDDDFLMMFTSGTTGLAKSVPVPLKAILAFKGYMTHAVDLREEDMFWNLADPGWAY
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEE
GLYYGITGPLSLGHGIIMDERSFNVDQAIELIKKYKVSNLTGSPTAFRMFFGFKEKFDPS
EEEECCCCCHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHCCHH
IKQHLRVVSSAGEPLTPEVVNWFKQDLEVNIFDQYGQTELGMVIANHHALEHPLKVGSAG
HHHHHHHHHCCCCCCCHHHHHHHHHCCEEEEECCCCCCCHHEEEECCHHHHCCHHCCCCC
FAIPGHRFAVLDQNYQELPTGGVGILAMDSEQSPLMWFKGYGGNNRKAFVGKYYLTGDTV
CCCCCCEEEEECCCHHHCCCCCEEEEEECCCCCCEEEEECCCCCCCEEEEEEEEEECCEE
TLNEHGGIDFVGRADDVITTSGYRVGPFDVESTLLECEAVLESAVIGKPDPERTEIVKAF
EECCCCCEEEECCCCCEEECCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
VVLKPAYQACETLKDKLQQYVRNRLSRHAYPKEIEFVDSLPKTTSGKIQRGLLKQQEIAK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHH
MQQAYAS
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]