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The map label for this gene is moeB [H]

Identifier: 213158527

GI number: 213158527

Start: 2572572

End: 2573348

Strand: Reverse

Name: moeB [H]

Synonym: AB57_2478

Alternate gene names: 213158527

Gene position: 2573348-2572572 (Counterclockwise)

Preceding gene: 213158529

Following gene: 213158526

Centisome position: 63.53

GC content: 39.25

Gene sequence:

>777_bases
GTGACCGAGCTTCAAGATATCGATTTTGTAGAGTTAAGTGATGAAGAAATGCATCTCTATAGCCGTCAGATTTTACTTGA
TGGATGGGATATTGAAGCTCAGGAAAAACTTAAACTCGCCAATGTGCTGATTGTCGGTGCTGGCGGAATAGGCTGTAGTA
GCGCGGAACTACTTGCACGAGCAGGAGTTGGGAAAATTACCCTCATTGATGCAGATACCATTGAGATAAGTAATTTACAA
CGTCAAATCGCATTTGGTCATGAAGATATTGGACGTTATAAAGCTGAAGTTTTAGCTAAACGGTTACAGAAAATTAACCC
TTATATCTGTGTTGAATACTTTAACGAACGTTTAGACGAACATAACATTGATAAACTAGTTGAACATCAAGACGTCGTTT
TAGATGGTTGTGATAACTTTACAACGCGTTATTTAGTGAATGCAGCTTGTAAAAAGCATCAGGTCGCATTAATTAGTGCT
TCTGCAATTGGCTTTCAGGCGCAAATGTTTATGGTCGAAGGTGATTCAGCTTGTTATGAATGTTTGTTCCCGAAAGAACA
ACATGCCAATGAAGGGCTGCGATGTGCGGAATCTGGTGTGCTTGCGACTACACCTGTAATGATTGCGTCATTACAAGCAC
ATCACACTTTATTGTATTTAGGACTAAACAGAACGCCGCTAAAACAAAAACTGTTACTTTGGGATGGGTTAAATATGACG
CAACGCATTGTTAGTTTTGATAAAGACATAAATTGTCCACTTTGTCAGGCAAGCTAA

Upstream 100 bases:

>100_bases
AGGGGATTAACTGAATAAAAAAGTTGTTTCCATTTTATAGCTTTCCTAATGACGAACTTAGTCATAAAATCACTTGGCTT
CTAAGTAAAAGGATTAACGT

Downstream 100 bases:

>100_bases
TCAGCAAATAAACCAAAATTTGCTACACTTGATTTGAATATTCTGGTTTTAAAGAAATATGAAAAAAAATATTTTATTTG
ATGGATTGCGCTCAGTTGCC

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTELQDIDFVELSDEEMHLYSRQILLDGWDIEAQEKLKLANVLIVGAGGIGCSSAELLARAGVGKITLIDADTIEISNLQ
RQIAFGHEDIGRYKAEVLAKRLQKINPYICVEYFNERLDEHNIDKLVEHQDVVLDGCDNFTTRYLVNAACKKHQVALISA
SAIGFQAQMFMVEGDSACYECLFPKEQHANEGLRCAESGVLATTPVMIASLQAHHTLLYLGLNRTPLKQKLLLWDGLNMT
QRIVSFDKDINCPLCQAS

Sequences:

>Translated_258_residues
MTELQDIDFVELSDEEMHLYSRQILLDGWDIEAQEKLKLANVLIVGAGGIGCSSAELLARAGVGKITLIDADTIEISNLQ
RQIAFGHEDIGRYKAEVLAKRLQKINPYICVEYFNERLDEHNIDKLVEHQDVVLDGCDNFTTRYLVNAACKKHQVALISA
SAIGFQAQMFMVEGDSACYECLFPKEQHANEGLRCAESGVLATTPVMIASLQAHHTLLYLGLNRTPLKQKLLLWDGLNMT
QRIVSFDKDINCPLCQAS
>Mature_257_residues
TELQDIDFVELSDEEMHLYSRQILLDGWDIEAQEKLKLANVLIVGAGGIGCSSAELLARAGVGKITLIDADTIEISNLQR
QIAFGHEDIGRYKAEVLAKRLQKINPYICVEYFNERLDEHNIDKLVEHQDVVLDGCDNFTTRYLVNAACKKHQVALISAS
AIGFQAQMFMVEGDSACYECLFPKEQHANEGLRCAESGVLATTPVMIASLQAHHTLLYLGLNRTPLKQKLLLWDGLNMTQ
RIVSFDKDINCPLCQAS

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=230, Percent_Identity=40.4347826086956, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI4885649, Length=157, Percent_Identity=33.1210191082803, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI38045948, Length=149, Percent_Identity=37.5838926174497, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI38045944, Length=167, Percent_Identity=33.5329341317365, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI38045942, Length=167, Percent_Identity=33.5329341317365, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI23510338, Length=162, Percent_Identity=30.8641975308642, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI23510340, Length=162, Percent_Identity=30.8641975308642, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI225543285, Length=159, Percent_Identity=28.9308176100629, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI13376212, Length=226, Percent_Identity=31.4159292035398, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI4885585, Length=159, Percent_Identity=28.9308176100629, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI225543288, Length=159, Percent_Identity=28.9308176100629, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI38327032, Length=210, Percent_Identity=31.4285714285714, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=37.7510040160643, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI87082356, Length=249, Percent_Identity=38.1526104417671, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789177, Length=128, Percent_Identity=33.59375, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540406, Length=247, Percent_Identity=37.246963562753, Blast_Score=167, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI193203301, Length=153, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71984476, Length=172, Percent_Identity=29.0697674418605, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI86565433, Length=162, Percent_Identity=30.8641975308642, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=162, Percent_Identity=30.8641975308642, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508819, Length=187, Percent_Identity=29.9465240641711, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=234, Percent_Identity=32.9059829059829, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6320598, Length=152, Percent_Identity=30.9210526315789, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6325438, Length=166, Percent_Identity=27.710843373494, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6322639, Length=175, Percent_Identity=28, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6321965, Length=168, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24582879, Length=251, Percent_Identity=34.2629482071713, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24660640, Length=161, Percent_Identity=34.1614906832298, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24641311, Length=226, Percent_Identity=30.9734513274336, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129973, Length=162, Percent_Identity=31.4814814814815, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 28798; Mature: 28667

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELQDIDFVELSDEEMHLYSRQILLDGWDIEAQEKLKLANVLIVGAGGIGCSSAELLAR
CCCCCCCCEEEECCCHHHHHHHEEEEECCCCCHHHHEEEEEEEEEECCCCCCCHHHHHHH
AGVGKITLIDADTIEISNLQRQIAFGHEDIGRYKAEVLAKRLQKINPYICVEYFNERLDE
CCCCEEEEEECCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCC
HNIDKLVEHQDVVLDGCDNFTTRYLVNAACKKHQVALISASAIGFQAQMFMVEGDSACYE
CCHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEECCCHHHH
CLFPKEQHANEGLRCAESGVLATTPVMIASLQAHHTLLYLGLNRTPLKQKLLLWDGLNMT
HCCCCHHCCCCCCCHHCCCCEEECHHHHHHHHHCEEEEEEECCCCCHHHHEEEECCCCHH
QRIVSFDKDINCPLCQAS
HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TELQDIDFVELSDEEMHLYSRQILLDGWDIEAQEKLKLANVLIVGAGGIGCSSAELLAR
CCCCCCCEEEECCCHHHHHHHEEEEECCCCCHHHHEEEEEEEEEECCCCCCCHHHHHHH
AGVGKITLIDADTIEISNLQRQIAFGHEDIGRYKAEVLAKRLQKINPYICVEYFNERLDE
CCCCEEEEEECCCEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHCCC
HNIDKLVEHQDVVLDGCDNFTTRYLVNAACKKHQVALISASAIGFQAQMFMVEGDSACYE
CCHHHHHHHCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEEEECCCHHHH
CLFPKEQHANEGLRCAESGVLATTPVMIASLQAHHTLLYLGLNRTPLKQKLLLWDGLNMT
HCCCCHHCCCCCCCHHCCCCEEECHHHHHHHHHCEEEEEEECCCCCHHHHEEEECCCCHH
QRIVSFDKDINCPLCQAS
HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]