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The map label for this gene is ubiB [C]

Identifier: 213158526

GI number: 213158526

Start: 2571215

End: 2572513

Strand: Reverse

Name: ubiB [C]

Synonym: AB57_2477

Alternate gene names: 213158526

Gene position: 2572513-2571215 (Counterclockwise)

Preceding gene: 213158527

Following gene: 213158525

Centisome position: 63.51

GC content: 39.88

Gene sequence:

>1299_bases
ATGAAAAAAAATATTTTATTTGATGGATTGCGCTCAGTTGCCCGCATCGGTGAAACCGCAGTAGTTGCGGCTAAAGCCGG
TATTAAGTATGCAACTGATAAGCCAAGTAATGCCAAACTCATGCGTGAGACTTTTGAGTCGCTTGGCTCAACATATATTA
AGCTTGGTCAGTTTATCGCGAGTACCCCATCGCTATTCCCACGTGAGTATGTAGAAGAATTCCAAGGCTGTTTAGACCAG
ACCCCAACTTTACCTTTTAGCTATATTCAAGGTGTACTTGCGTCTGAGTTTGAAGGGCGTGATTTAAGCCAGATTTTTAG
TTATATCGATGAAACACCACTAGCTTCTGCCTCAATTGCTCAGGTTCATGCGGCTAAACTAACTACTGGTGAAGATGTCG
TTATTAAAGTACAAAAACCGGGTGTTGAAACCATTTTGTACACTGACCTAAATGTGGTGCATTGGGCTGCTAAATTGCTT
GAACGTGCGGTACCTAAAATTAAATTTGCCGCTCTTTCTGACATTGTTGATGAAATTAAAACCCGTATGGTGCGTGAAGT
CGATTTCATTGAAGAAGCACAAAATTTAGATGACTTTGTGGAATATTTAAATATTTCCCAAAACCAAGCTGCTACTGCAC
CTAAAGTTTATCATCAGTTTTCTACGCGCCGTGTTTTGACCATGCAGCGTTTATATGGGGTCCCTTTGACAGACTTTAGC
GTGGTTAAACAATATGCTAAAGATCCATCGCAAGTACTCATTACTGCCATGAACACATGGTTTGGTAGCTTAATGTTATG
TAAGAGCTTCCATGCGGACTTACATGCTGGGAACCTAATGTTGCTTGAAGATGGACGTATTGGTTTTATTGATTTCGGTA
TTGTAGGGCAGTTAAAGCCGGAAGTTTGGACAGCATGTATTGCATTTATGGATGCTTTACAAAAGACAGATTATCAGGCA
ATGGCTGAAAACATGCTCAAAATGGGTATGACCCATAATAAAATTGACGTTCAGGTTTTAGCACAAGATCTAGAGCGTTT
ATTTAATGGTGTGTTAATGGCTGATCCACAGCAGATTTTGGCTTCTAATCCAGCCGATTTAAATGACATCATGATGGATA
TGGTGGCTGTTGGTGAGCGTCATGGTATTAAATTCCCTCGAGATTTTGCCTTATTATTTAAGCAAATGCTTTATTTCGAT
CGTTTTATGCGCGTACTCGCACCTTATACTGATATTTATGCAGACCAACGTTTGAAAATGGTTCAAAATATGGAACCTGC
TTCGTTGTTAAAGCACTAA

Upstream 100 bases:

>100_bases
TTTGATAAAGACATAAATTGTCCACTTTGTCAGGCAAGCTAATCAGCAAATAAACCAAAATTTGCTACACTTGATTTGAA
TATTCTGGTTTTAAAGAAAT

Downstream 100 bases:

>100_bases
GGTCAGTTTAAATTTATGGATGCCATTATTATTGAAGGCTTGAAGGTTGAGACAGTGATTGGCTGTTTCAACTGGGAAAG
ACAAATCATTCAACCTTTAA

Product: ABC-1 domain protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKKNILFDGLRSVARIGETAVVAAKAGIKYATDKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGCLDQ
TPTLPFSYIQGVLASEFEGRDLSQIFSYIDETPLASASIAQVHAAKLTTGEDVVIKVQKPGVETILYTDLNVVHWAAKLL
ERAVPKIKFAALSDIVDEIKTRMVREVDFIEEAQNLDDFVEYLNISQNQAATAPKVYHQFSTRRVLTMQRLYGVPLTDFS
VVKQYAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLKPEVWTACIAFMDALQKTDYQA
MAENMLKMGMTHNKIDVQVLAQDLERLFNGVLMADPQQILASNPADLNDIMMDMVAVGERHGIKFPRDFALLFKQMLYFD
RFMRVLAPYTDIYADQRLKMVQNMEPASLLKH

Sequences:

>Translated_432_residues
MKKNILFDGLRSVARIGETAVVAAKAGIKYATDKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGCLDQ
TPTLPFSYIQGVLASEFEGRDLSQIFSYIDETPLASASIAQVHAAKLTTGEDVVIKVQKPGVETILYTDLNVVHWAAKLL
ERAVPKIKFAALSDIVDEIKTRMVREVDFIEEAQNLDDFVEYLNISQNQAATAPKVYHQFSTRRVLTMQRLYGVPLTDFS
VVKQYAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLKPEVWTACIAFMDALQKTDYQA
MAENMLKMGMTHNKIDVQVLAQDLERLFNGVLMADPQQILASNPADLNDIMMDMVAVGERHGIKFPRDFALLFKQMLYFD
RFMRVLAPYTDIYADQRLKMVQNMEPASLLKH
>Mature_432_residues
MKKNILFDGLRSVARIGETAVVAAKAGIKYATDKPSNAKLMRETFESLGSTYIKLGQFIASTPSLFPREYVEEFQGCLDQ
TPTLPFSYIQGVLASEFEGRDLSQIFSYIDETPLASASIAQVHAAKLTTGEDVVIKVQKPGVETILYTDLNVVHWAAKLL
ERAVPKIKFAALSDIVDEIKTRMVREVDFIEEAQNLDDFVEYLNISQNQAATAPKVYHQFSTRRVLTMQRLYGVPLTDFS
VVKQYAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLKPEVWTACIAFMDALQKTDYQA
MAENMLKMGMTHNKIDVQVLAQDLERLFNGVLMADPQQILASNPADLNDIMMDMVAVGERHGIKFPRDFALLFKQMLYFD
RFMRVLAPYTDIYADQRLKMVQNMEPASLLKH

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=310, Percent_Identity=26.1290322580645, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI41393593, Length=256, Percent_Identity=26.953125, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI217035081, Length=259, Percent_Identity=25.8687258687259, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI27363457, Length=211, Percent_Identity=27.0142180094787, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI32261307, Length=169, Percent_Identity=28.9940828402367, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI2367309, Length=378, Percent_Identity=24.0740740740741, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17559152, Length=346, Percent_Identity=28.6127167630058, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=203, Percent_Identity=29.5566502463054, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325148, Length=442, Percent_Identity=22.8506787330317, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323282, Length=244, Percent_Identity=27.4590163934426, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321319, Length=217, Percent_Identity=29.4930875576037, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI22024280, Length=286, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24662575, Length=298, Percent_Identity=24.496644295302, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859849, Length=275, Percent_Identity=24.3636363636364, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 48672; Mature: 48672

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNILFDGLRSVARIGETAVVAAKAGIKYATDKPSNAKLMRETFESLGSTYIKLGQFIA
CCCCHHHHHHHHHHHHCCHHEEHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
STPSLFPREYVEEFQGCLDQTPTLPFSYIQGVLASEFEGRDLSQIFSYIDETPLASASIA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHH
QVHAAKLTTGEDVVIKVQKPGVETILYTDLNVVHWAAKLLERAVPKIKFAALSDIVDEIK
HHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TRMVREVDFIEEAQNLDDFVEYLNISQNQAATAPKVYHQFSTRRVLTMQRLYGVPLTDFS
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VVKQYAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLKP
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCH
EVWTACIAFMDALQKTDYQAMAENMLKMGMTHNKIDVQVLAQDLERLFNGVLMADPQQIL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
ASNPADLNDIMMDMVAVGERHGIKFPRDFALLFKQMLYFDRFMRVLAPYTDIYADQRLKM
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQNMEPASLLKH
HHCCCHHHHHCC
>Mature Secondary Structure
MKKNILFDGLRSVARIGETAVVAAKAGIKYATDKPSNAKLMRETFESLGSTYIKLGQFIA
CCCCHHHHHHHHHHHHCCHHEEHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
STPSLFPREYVEEFQGCLDQTPTLPFSYIQGVLASEFEGRDLSQIFSYIDETPLASASIA
CCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHH
QVHAAKLTTGEDVVIKVQKPGVETILYTDLNVVHWAAKLLERAVPKIKFAALSDIVDEIK
HHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
TRMVREVDFIEEAQNLDDFVEYLNISQNQAATAPKVYHQFSTRRVLTMQRLYGVPLTDFS
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHH
VVKQYAKDPSQVLITAMNTWFGSLMLCKSFHADLHAGNLMLLEDGRIGFIDFGIVGQLKP
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCEEEEECCCCCCCCH
EVWTACIAFMDALQKTDYQAMAENMLKMGMTHNKIDVQVLAQDLERLFNGVLMADPQQIL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHH
ASNPADLNDIMMDMVAVGERHGIKFPRDFALLFKQMLYFDRFMRVLAPYTDIYADQRLKM
CCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VQNMEPASLLKH
HHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]