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The map label for this gene is adeR [H]

Identifier: 213157394

GI number: 213157394

Start: 2163698

End: 2164441

Strand: Direct

Name: adeR [H]

Synonym: AB57_2083

Alternate gene names: 213157394

Gene position: 2163698-2164441 (Clockwise)

Preceding gene: 213157390

Following gene: 213157395

Centisome position: 53.42

GC content: 36.83

Gene sequence:

>744_bases
ATGTTTGATCATTCTTTTTCTTTTGATTGCCAAGATAAAGTTATTCTTGTGGTAGAAGATGACTACGATATTGGCGACAT
TATTGAAAATTATTTAAAACGTGAAGGCATGAGTGTTATTCGGGCCATGAATGGAAAGCAAGCGATTGAATTGCACGCTA
GCCAACCCATCGATTTAATCTTACTTGATATTAAATTACCCGAATTAAACGGTTGGGAAGTATTAAATAAAATACGCCAA
AAAGCTCAGACTCCCGTGATCATGTTGACGGCGCTAGATCAAGATATTGATAAAGTTATGGCATTACGCATAGGTGCAGA
TGACTTTGTGGTGAAGCCTTTTAACCCAAATGAAGTCGTCGCTAGAGTTCAGGCAGTCCTAAGACGTACTCAGTTTGCAA
ACAAAGCAACTAATAAAAATAAACTCTATAAAAATATTGAAATTGATACCGACACTCATAGCGTTTATATACACTCTGAG
AATAAGAAGATCTTGCTTAATCTGACGCTGACTGAATATAAAATTATTTCATTCATGATTGATCAGCCTCATAAAGTTTT
TACGCGCGGAGAGCTTATGAATCACTGCATGAATGATAGCGATGCACTAGAGCGAACCGTAGATAGCCATGTGAGTAAGC
TGAGAAAAAAACTAGAAGAACAAGGCATATTTCAAATGTTAATTAATGTGCGTGGCGTGGGATATAGACTAGATAATCCC
CTAGCTGTAAAAGATGATGCCTAA

Upstream 100 bases:

>100_bases
GAGTGTGTAGGGATAATCACTAAAGTGTGGAGTAAGTGTGGAGAAATACGGATAATTTAGCGTATGATGAGTTGAAGCAC
TTTCTATAGCCAGATTTTCT

Downstream 100 bases:

>100_bases
ATAATATTAAAAAATAGCTAGGGAATATTTTATGAAAAGTAAGTTAGGAATTAGTAAGCAACTTTTTATTGCCTTAACTA
TTGTGAATTTAAGCGTTACG

Product: AdeR

Products: NA

Alternate protein names: Staphylococcal respiratory response protein A [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MFDHSFSFDCQDKVILVVEDDYDIGDIIENYLKREGMSVIRAMNGKQAIELHASQPIDLILLDIKLPELNGWEVLNKIRQ
KAQTPVIMLTALDQDIDKVMALRIGADDFVVKPFNPNEVVARVQAVLRRTQFANKATNKNKLYKNIEIDTDTHSVYIHSE
NKKILLNLTLTEYKIISFMIDQPHKVFTRGELMNHCMNDSDALERTVDSHVSKLRKKLEEQGIFQMLINVRGVGYRLDNP
LAVKDDA

Sequences:

>Translated_247_residues
MFDHSFSFDCQDKVILVVEDDYDIGDIIENYLKREGMSVIRAMNGKQAIELHASQPIDLILLDIKLPELNGWEVLNKIRQ
KAQTPVIMLTALDQDIDKVMALRIGADDFVVKPFNPNEVVARVQAVLRRTQFANKATNKNKLYKNIEIDTDTHSVYIHSE
NKKILLNLTLTEYKIISFMIDQPHKVFTRGELMNHCMNDSDALERTVDSHVSKLRKKLEEQGIFQMLINVRGVGYRLDNP
LAVKDDA
>Mature_247_residues
MFDHSFSFDCQDKVILVVEDDYDIGDIIENYLKREGMSVIRAMNGKQAIELHASQPIDLILLDIKLPELNGWEVLNKIRQ
KAQTPVIMLTALDQDIDKVMALRIGADDFVVKPFNPNEVVARVQAVLRRTQFANKATNKNKLYKNIEIDTDTHSVYIHSE
NKKILLNLTLTEYKIISFMIDQPHKVFTRGELMNHCMNDSDALERTVDSHVSKLRKKLEEQGIFQMLINVRGVGYRLDNP
LAVKDDA

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. SrrA binds to the agr, spa and tst promoters and represses their transcript

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.9557522123894, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=36.0869565217391, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=31.140350877193, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1790860, Length=230, Percent_Identity=31.7391304347826, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.2105263157895, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=30.9734513274336, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=30.8035714285714, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=27.3504273504274, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=32.1739130434783, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=29.8701298701299, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=30.3571428571429, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=31.3304721030043, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788550, Length=115, Percent_Identity=35.6521739130435, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787487, Length=141, Percent_Identity=29.7872340425532, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=130, Percent_Identity=33.8461538461538, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=33.0508474576271, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28354; Mature: 28354

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDHSFSFDCQDKVILVVEDDYDIGDIIENYLKREGMSVIRAMNGKQAIELHASQPIDLI
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEE
LLDIKLPELNGWEVLNKIRQKAQTPVIMLTALDQDIDKVMALRIGADDFVVKPFNPNEVV
EEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHEECCCCEEEECCCHHHHH
ARVQAVLRRTQFANKATNKNKLYKNIEIDTDTHSVYIHSENKKILLNLTLTEYKIISFMI
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCEEEEEEEEHHHEEEHHHH
DQPHKVFTRGELMNHCMNDSDALERTVDSHVSKLRKKLEEQGIFQMLINVRGVGYRLDNP
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
LAVKDDA
EEECCCC
>Mature Secondary Structure
MFDHSFSFDCQDKVILVVEDDYDIGDIIENYLKREGMSVIRAMNGKQAIELHASQPIDLI
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEE
LLDIKLPELNGWEVLNKIRQKAQTPVIMLTALDQDIDKVMALRIGADDFVVKPFNPNEVV
EEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHEECCCCEEEECCCHHHHH
ARVQAVLRRTQFANKATNKNKLYKNIEIDTDTHSVYIHSENKKILLNLTLTEYKIISFMI
HHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEEECCCCEEEEEEEEHHHEEEHHHH
DQPHKVFTRGELMNHCMNDSDALERTVDSHVSKLRKKLEEQGIFQMLINVRGVGYRLDNP
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
LAVKDDA
EEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA