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The map label for this gene is gyaR

Identifier: 212224094

GI number: 212224094

Start: 870555

End: 871559

Strand: Reverse

Name: gyaR

Synonym: TON_0945

Alternate gene names: 212224094

Gene position: 871559-870555 (Counterclockwise)

Preceding gene: 212224097

Following gene: 212224092

Centisome position: 47.17

GC content: 54.83

Gene sequence:

>1005_bases
ATGAAGCCAAAGGTCCTCATCACAAGGAAAATTCCTGAGAACGGAATAAAGATGTTGAGGGAGCACTTTGAGGTCGAGGT
CTGGGAGGACGAGCACGAGATTTCGAGGGAAGTCCTGCTCGAGAAGGTAAGGGACGTCGATGCTCTCGTTACCATGCTGA
GCGAGAGGATTGACGCCGAGGTCTTCGATGCCGCCCCAAGGCTCAAAATCGTTGCCAACTACGCGGTTGGTTATGACAAC
ATAGACATCGAGGAGGCAACTAAGATGGGAGTCTACATCACCAACACGCCCGACGTTCTTACCAATGCCACTGCAGACAT
GGCCTGGGTTCTCCTCCTAGCGACAGCACGGCGGCTCATTGAGGCAGACAAATTCGTCCGCTCCGGCGAGTGGAAGAAGC
GCGGTGTTGCCTGGCACCCGCTGATGTTCCTCGGTTACGACGTCTACGGCAGGACCATAGGAATAGTTGGCTTCGGCAGA
ATCGGTCAGGCGATAGCGAGGCGCGCTAAGGGCTTCGGGATGAGGATACTTTACAACTCCCGCACGAGGAAGCCAGAAGT
TGAGAAGGAGCTCGGCGCTGAGTTCATGCCATTGGACGAGCTCTTAAAGGAGAGCGATTTCGTTGTCCTGGTCGTTCCAC
TGACCAAGGAGACCTACCACATGATAAACGAGGAGCGTCTGAAGCTGATGAAACCGACCGCGATACTCGTCAACATAGCG
AGGGGAAAGGTCGTCGATACGGAGGCGCTCGTTAAGGCTCTCAGGGAGGGCTGGATCGCCGGAGCTGGGCTGGACGTCTT
TGAGGAGGAGCCATATTACCACGAGGAGCTTTTCAGCCTGGATAACGTCGTTCTCGCACCCCATATCGGTAGCGCCACTT
ACGGCGCGAGGGAAGGGATGGCAGAGCTCGTGGCGAGGAATTTAATAGCCTTCAAGAACGGCGAAGTTCCGCCGACGCTG
GTCAATAGAGAAGTTTTAAACGTCAGGAAGCCAGGATTTGAATAA

Upstream 100 bases:

>100_bases
CCGGCCAAAAACTTCACGTCCTTCATAGCCATCACCCGATAAGGATATTAGCATTGAGACTTATGTCTAAAGGCATATTT
AACGTTTCCAGGTGGTGGAG

Downstream 100 bases:

>100_bases
ACTTGAGAGGGAATCCCGGCGATGATGACCCCACCCTTGGCTGACCCATGATGAGCTGGACCCGTGCCTGAGCCTAGAGC
ATTGCCTTGAAGCGCTTCGC

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEVFDAAPRLKIVANYAVGYDN
IDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGR
IGQAIARRAKGFGMRILYNSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIA
RGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTL
VNREVLNVRKPGFE

Sequences:

>Translated_334_residues
MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEVFDAAPRLKIVANYAVGYDN
IDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGR
IGQAIARRAKGFGMRILYNSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIA
RGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTL
VNREVLNVRKPGFE
>Mature_334_residues
MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAEVFDAAPRLKIVANYAVGYDN
IDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLIEADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGR
IGQAIARRAKGFGMRILYNSRTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIA
RGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGMAELVARNLIAFKNGEVPPTL
VNREVLNVRKPGFE

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily

Homologues:

Organism=Homo sapiens, GI6912396, Length=328, Percent_Identity=42.3780487804878, Blast_Score=241, Evalue=6e-64,
Organism=Homo sapiens, GI23308577, Length=324, Percent_Identity=31.4814814814815, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI4557497, Length=299, Percent_Identity=35.1170568561873, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI61743967, Length=299, Percent_Identity=35.1170568561873, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI145580578, Length=309, Percent_Identity=33.0097087378641, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI4557499, Length=309, Percent_Identity=33.0097087378641, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI145580575, Length=309, Percent_Identity=33.0097087378641, Blast_Score=144, Evalue=1e-34,
Organism=Escherichia coli, GI87082289, Length=328, Percent_Identity=41.4634146341463, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1789279, Length=329, Percent_Identity=29.7872340425532, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=30.3370786516854, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788660, Length=247, Percent_Identity=27.5303643724696, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081824, Length=187, Percent_Identity=32.0855614973262, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=327, Percent_Identity=31.8042813455657, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25147481, Length=312, Percent_Identity=26.9230769230769, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=328, Percent_Identity=37.5, Blast_Score=192, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6320925, Length=327, Percent_Identity=30.2752293577982, Blast_Score=156, Evalue=4e-39,
Organism=Saccharomyces cerevisiae, GI6322116, Length=327, Percent_Identity=29.0519877675841, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321253, Length=284, Percent_Identity=30.6338028169014, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324964, Length=244, Percent_Identity=27.4590163934426, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=151, Percent_Identity=37.0860927152318, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324980, Length=163, Percent_Identity=28.8343558282209, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28571528, Length=316, Percent_Identity=43.3544303797468, Blast_Score=231, Evalue=5e-61,
Organism=Drosophila melanogaster, GI45551003, Length=317, Percent_Identity=41.9558359621451, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI45552429, Length=317, Percent_Identity=41.9558359621451, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24585514, Length=317, Percent_Identity=41.9558359621451, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574282, Length=317, Percent_Identity=41.9558359621451, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574284, Length=317, Percent_Identity=41.9558359621451, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI28574286, Length=320, Percent_Identity=40, Blast_Score=214, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24585516, Length=310, Percent_Identity=34.8387096774194, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19921140, Length=333, Percent_Identity=31.5315315315315, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646446, Length=311, Percent_Identity=33.4405144694534, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646448, Length=311, Percent_Identity=33.4405144694534, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646452, Length=311, Percent_Identity=33.4405144694534, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646450, Length=311, Percent_Identity=33.4405144694534, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI62472511, Length=311, Percent_Identity=33.4405144694534, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GYAR_THEON (B6YWH0)

Other databases:

- EMBL:   CP000855
- RefSeq:   YP_002307330.1
- ProteinModelPortal:   B6YWH0
- GeneID:   7017248
- GenomeReviews:   CP000855_GR
- KEGG:   ton:TON_0945
- HOGENOM:   HBG731446
- OMA:   KPRVFIT
- ProtClustDB:   PRK13243
- GO:   GO:0005737
- HAMAP:   MF_00776
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.26

Molecular weight: Translated: 37780; Mature: 37780

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 241-241 ACT_SITE 270-270 ACT_SITE 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAE
CCCCEEEEECCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VFDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLI
HHCCCCCEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHH
EADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNS
HHHHHHHCCCCHHCCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCEEEEECC
RTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIA
CCCCCCHHHHHCCCCCCHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEC
RGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGM
CCCEECHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHCCCCEEEECCCCCCCCCHHHHH
AELVARNLIAFKNGEVPPTLVNREVLNVRKPGFE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKPKVLITRKIPENGIKMLREHFEVEVWEDEHEISREVLLEKVRDVDALVTMLSERIDAE
CCCCEEEEECCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
VFDAAPRLKIVANYAVGYDNIDIEEATKMGVYITNTPDVLTNATADMAWVLLLATARRLI
HHCCCCCEEEEEEEEECCCCCCHHHHHHCCEEEECCCHHHHCCHHHHHHHHHHHHHHHHH
EADKFVRSGEWKKRGVAWHPLMFLGYDVYGRTIGIVGFGRIGQAIARRAKGFGMRILYNS
HHHHHHHCCCCHHCCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHHCCCCEEEEECC
RTRKPEVEKELGAEFMPLDELLKESDFVVLVVPLTKETYHMINEERLKLMKPTAILVNIA
CCCCCCHHHHHCCCCCCHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCEEEEEEC
RGKVVDTEALVKALREGWIAGAGLDVFEEEPYYHEELFSLDNVVLAPHIGSATYGAREGM
CCCEECHHHHHHHHHHCCCCCCCCCHHCCCCCHHHHHHCCCCEEEECCCCCCCCCHHHHH
AELVARNLIAFKNGEVPPTLVNREVLNVRKPGFE
HHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA