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The map label for this gene is wecB [H]

Identifier: 212223648

GI number: 212223648

Start: 459188

End: 460321

Strand: Reverse

Name: wecB [H]

Synonym: TON_0501

Alternate gene names: 212223648

Gene position: 460321-459188 (Counterclockwise)

Preceding gene: 212223649

Following gene: 212223646

Centisome position: 24.91

GC content: 51.85

Gene sequence:

>1134_bases
TTGAAACCGGCCTTCGTATTCGGAACGAGGCCGGAGATAATAAAGCTTGCTCCTGTTATCAGAGCCTTCGAGGAGAGGGG
CGTTGAGCCCCTTTTAATCCATACCGGCCAGCACTATGACTACGAGATGAGCAGTGTATTCCTCGAGGAGCTAGAGCTCA
GGAGGATAGACTACCACCTTGAAGTTGGTTCTGGAACACAGGCCGAACAGACGGGAACGGCAATGATTAAGATTGAAAAG
GTCCTGATGGAAGAAAAGCCCGACGTCACGCTCGTTCAGGGCGATACGAACACCGTCCTTGCCGGCGCACTGGCAAGCGT
CAAGCTGAAAATCCCCGTTGCCCATGTTGAAGCTGGCTTAAGGAGCTTCGACAGAACGATGCCGGAGGAGATAAACAGGA
TTTTAGCGGATCACGCAAGTGAGGTTCTCTTTGCCCCGACGGAAGAGGCAAGAAAAAACCTCGAACGCGAGGGCATAACT
GAGAACGTTTACGTCGTGGGCAATACCGTTGTTGACGCAGTCCTCCAGAACGCAGAGATAGCCGAGAGGAAAAGCGACGT
CCTCGAAAGGTTCGGCCTCAAACCCAAGGAGTACATACTCCTCACCGCCCACAGAGCTGAGAACACGGACAGCAAGGAGA
ATCTCAGAAGGCTCTTGGAAATCCTTGAGGAGTTGCCGGTTAAGGTTGTCTATCCCATGCATCCCAGAACGAGGAAGAAG
CTCGAGAGTTTTGGCCTCTGGGAACGTGTTGAGGCGATAGAGAACCTTATCGTCACGAAGCCGCTTGGATATCTCGACTT
CCTAAAGCTCCAGAGGAACGCGAAAATAGTCATGACGGACTCGGGAGGTGTTCAGGAGGAGAGCATAATCCTCAACGTAC
CGTGCCTGACCCTCCGCTACAACACTGAGAGGCCAGAGACCGTGAAAGCCGGCGGCAACGTCCTCGTTGGTCTCGAAAAG
GAGAGAACCCTGAGCCACGTCGAAAGACTTCTGAGCGATGAGGAATTCTACAAGAAGATGGCTAGTGCTCCAAATCCCTT
CGGCGATGGAAAATCGGGACAGAGAATAGCTGAAATTCTGCTTGAGCTTTACGAAAAAGGAGAGCTGAATGTGAGGAGTT
CACGATTTATATAA

Upstream 100 bases:

>100_bases
TCGGAAAGCTGATGAGAAACAGAATCCTCATCGACGGCAGGCACATCGTAGAAGATCCGCCCAAGGGGTTCATCTTCAAA
GGCCTTGGGAGGGGAGAGTA

Downstream 100 bases:

>100_bases
AGTTTTGAACCAGTCTTCAACGTCATTCATCATTTTTCCGCTTCAACAGTTTTTGACGTCCGTAGGATAAAAGGAACCAT
CGGCCAAAACAACAACGTAA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: NA

Alternate protein names: UDP-GlcNAc-2-epimerase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKPAFVFGTRPEIIKLAPVIRAFEERGVEPLLIHTGQHYDYEMSSVFLEELELRRIDYHLEVGSGTQAEQTGTAMIKIEK
VLMEEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEARKNLEREGIT
ENVYVVGNTVVDAVLQNAEIAERKSDVLERFGLKPKEYILLTAHRAENTDSKENLRRLLEILEELPVKVVYPMHPRTRKK
LESFGLWERVEAIENLIVTKPLGYLDFLKLQRNAKIVMTDSGGVQEESIILNVPCLTLRYNTERPETVKAGGNVLVGLEK
ERTLSHVERLLSDEEFYKKMASAPNPFGDGKSGQRIAEILLELYEKGELNVRSSRFI

Sequences:

>Translated_377_residues
MKPAFVFGTRPEIIKLAPVIRAFEERGVEPLLIHTGQHYDYEMSSVFLEELELRRIDYHLEVGSGTQAEQTGTAMIKIEK
VLMEEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEARKNLEREGIT
ENVYVVGNTVVDAVLQNAEIAERKSDVLERFGLKPKEYILLTAHRAENTDSKENLRRLLEILEELPVKVVYPMHPRTRKK
LESFGLWERVEAIENLIVTKPLGYLDFLKLQRNAKIVMTDSGGVQEESIILNVPCLTLRYNTERPETVKAGGNVLVGLEK
ERTLSHVERLLSDEEFYKKMASAPNPFGDGKSGQRIAEILLELYEKGELNVRSSRFI
>Mature_377_residues
MKPAFVFGTRPEIIKLAPVIRAFEERGVEPLLIHTGQHYDYEMSSVFLEELELRRIDYHLEVGSGTQAEQTGTAMIKIEK
VLMEEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGLRSFDRTMPEEINRILADHASEVLFAPTEEARKNLEREGIT
ENVYVVGNTVVDAVLQNAEIAERKSDVLERFGLKPKEYILLTAHRAENTDSKENLRRLLEILEELPVKVVYPMHPRTRKK
LESFGLWERVEAIENLIVTKPLGYLDFLKLQRNAKIVMTDSGGVQEESIILNVPCLTLRYNTERPETVKAGGNVLVGLEK
ERTLSHVERLLSDEEFYKKMASAPNPFGDGKSGQRIAEILLELYEKGELNVRSSRFI

Specific function: Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-N-acetylglucosamine 2-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI48994967, Length=377, Percent_Identity=38.7267904509284, Blast_Score=201, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: =5.1.3.14 [H]

Molecular weight: Translated: 42617; Mature: 42617

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAFVFGTRPEIIKLAPVIRAFEERGVEPLLIHTGQHYDYEMSSVFLEELELRRIDYHL
CCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEE
EVGSGTQAEQTGTAMIKIEKVLMEEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGL
EECCCCCCHHCCHHHEEEHHHHHCCCCCEEEEECCCCHHHHHHHEEEEEEEEHHHHHHHH
RSFDRTMPEEINRILADHASEVLFAPTEEARKNLEREGITENVYVVGNTVVDAVLQNAEI
HHHHHCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHH
AERKSDVLERFGLKPKEYILLTAHRAENTDSKENLRRLLEILEELPVKVVYPMHPRTRKK
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHH
LESFGLWERVEAIENLIVTKPLGYLDFLKLQRNAKIVMTDSGGVQEESIILNVPCLTLRY
HHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEEE
NTERPETVKAGGNVLVGLEKERTLSHVERLLSDEEFYKKMASAPNPFGDGKSGQRIAEIL
CCCCCCEEECCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LELYEKGELNVRSSRFI
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKPAFVFGTRPEIIKLAPVIRAFEERGVEPLLIHTGQHYDYEMSSVFLEELELRRIDYHL
CCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHEEEEE
EVGSGTQAEQTGTAMIKIEKVLMEEKPDVTLVQGDTNTVLAGALASVKLKIPVAHVEAGL
EECCCCCCHHCCHHHEEEHHHHHCCCCCEEEEECCCCHHHHHHHEEEEEEEEHHHHHHHH
RSFDRTMPEEINRILADHASEVLFAPTEEARKNLEREGITENVYVVGNTVVDAVLQNAEI
HHHHHCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHH
AERKSDVLERFGLKPKEYILLTAHRAENTDSKENLRRLLEILEELPVKVVYPMHPRTRKK
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHH
LESFGLWERVEAIENLIVTKPLGYLDFLKLQRNAKIVMTDSGGVQEESIILNVPCLTLRY
HHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCEEEEECCEEEEEE
NTERPETVKAGGNVLVGLEKERTLSHVERLLSDEEFYKKMASAPNPFGDGKSGQRIAEIL
CCCCCCEEECCCCEEEEECHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCCCHHHHHHHH
LELYEKGELNVRSSRFI
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]