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The map label for this gene is wecC [H]

Identifier: 212223649

GI number: 212223649

Start: 460318

End: 461607

Strand: Reverse

Name: wecC [H]

Synonym: TON_0502

Alternate gene names: 212223649

Gene position: 461607-460318 (Counterclockwise)

Preceding gene: 212223651

Following gene: 212223648

Centisome position: 24.98

GC content: 50.0

Gene sequence:

>1290_bases
ATGCTAGAAAAGATGATAGAGGAAAGAACAGCGGAGATAGCGGTCATAGGCCTCGGATATATCGGCCTCCCAACGGCCAT
AATGTTTGCCAACGCGGGTTTTAGGGTTATAGGCTACGAGATACGGGAGAAGGTCGTTGAGAAGATAAACTCCGGAAAGG
CACACATAATCGAGCCGGAGATAGATGAACTCCTTAGAAAAGCCATTGAAAGCGGCAACCTGAAAGCGACCTCAAATCCA
GAAGAGATAAGAGAAAAGGACGTTTACATAATCTGCGTCCAGACTCCCCTGAAGGAAGATAAAACGCCCAATCTAAGCTA
TCTCGAGAGTGCCGTGGAGACCGTTGCAAAGGCTATGAAAAAAGGCTCGCTCATTATCATAGAGAGCACGGTCCCGCCGC
TTACCACAGTGAAGATGGCGGAGTTGATTGAAGCGATCACTGGACTCAAACCCGGGGAGGACTTCTACATGGTTCACGCC
CCAGAGAGGGTCATGCCGGGGAGGATATTTAAAGAGCTCATTTACAATTCAAGAATCTTTGGCGGAATAACTCCCGAGAG
CGCCGAACTCGCCGAGAAGCTTTACCGTTCCTTTGTTAAGGGACAAACCTTCAAGACCAACTCCACCGTCAGCGAGGTAG
TCAAGCTCATGGAGAACACCTTCCGCGACGTAAACATCGCTTTGGCCAACGAATTCGCTTTCTTGGCCCATCAGTATGGA
ATAAACGTTTTTGAGGCGATAGAGCTGGCCAACACCCACCCGAGGGTTAAAATCCATGTTCCAGGAATAGGCGTCGGCGG
ACACTGCCTGCCGAAAGATCCTCACCTTCTCGTCTGGCCTGCGAAGGAAGACTTCGGCTTGATAAAGCTGGCAAGAGAGA
TAAACGACAGCATGCCGCTCTTCACGAAGGATCTGCTCTTTGAGGCTCTCAGGACGATAAATCTGCCGCCCGAAGAGGCA
GTTGTAGTTATCCTTGGTCTGGCCTACAAGGGAAACAGTGATGACACCAGGAATTCACCGGCCTTTGCCTTTATGGACGC
CATAAATGAGGAGGTTAAAGAGGTTAGAACTTACGATCCCTTCGTAAAAGGGACTCATGAGAGCATAGAAGATGCTGTTA
AAGGCGCAGATGCAATAGTCATAGCAACCGACCATACGGCCTTCAAATCCCTCGACTGGGAGGAGCTCGGAAAGCTGATG
AGAAACAGAATCCTCATCGACGGCAGGCACATCGTAGAAGATCCGCCCAAGGGGTTCATCTTCAAAGGCCTTGGGAGGGG
AGAGTATTGA

Upstream 100 bases:

>100_bases
AATTCTCCCAGAGTCACTCACATCGCAGAAATCAGTTCAGAAATCGTTTTTTGGGAAAGGCTTTTATTGAGAGACATCTC
CACTGGGATAGGTGAGAGGC

Downstream 100 bases:

>100_bases
AACCGGCCTTCGTATTCGGAACGAGGCCGGAGATAATAAAGCTTGCTCCTGTTATCAGAGCCTTCGAGGAGAGGGGCGTT
GAGCCCCTTTTAATCCATAC

Product: UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: UDP-ManNAc 6-dehydrogenase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLEKMIEERTAEIAVIGLGYIGLPTAIMFANAGFRVIGYEIREKVVEKINSGKAHIIEPEIDELLRKAIESGNLKATSNP
EEIREKDVYIICVQTPLKEDKTPNLSYLESAVETVAKAMKKGSLIIIESTVPPLTTVKMAELIEAITGLKPGEDFYMVHA
PERVMPGRIFKELIYNSRIFGGITPESAELAEKLYRSFVKGQTFKTNSTVSEVVKLMENTFRDVNIALANEFAFLAHQYG
INVFEAIELANTHPRVKIHVPGIGVGGHCLPKDPHLLVWPAKEDFGLIKLAREINDSMPLFTKDLLFEALRTINLPPEEA
VVVILGLAYKGNSDDTRNSPAFAFMDAINEEVKEVRTYDPFVKGTHESIEDAVKGADAIVIATDHTAFKSLDWEELGKLM
RNRILIDGRHIVEDPPKGFIFKGLGRGEY

Sequences:

>Translated_429_residues
MLEKMIEERTAEIAVIGLGYIGLPTAIMFANAGFRVIGYEIREKVVEKINSGKAHIIEPEIDELLRKAIESGNLKATSNP
EEIREKDVYIICVQTPLKEDKTPNLSYLESAVETVAKAMKKGSLIIIESTVPPLTTVKMAELIEAITGLKPGEDFYMVHA
PERVMPGRIFKELIYNSRIFGGITPESAELAEKLYRSFVKGQTFKTNSTVSEVVKLMENTFRDVNIALANEFAFLAHQYG
INVFEAIELANTHPRVKIHVPGIGVGGHCLPKDPHLLVWPAKEDFGLIKLAREINDSMPLFTKDLLFEALRTINLPPEEA
VVVILGLAYKGNSDDTRNSPAFAFMDAINEEVKEVRTYDPFVKGTHESIEDAVKGADAIVIATDHTAFKSLDWEELGKLM
RNRILIDGRHIVEDPPKGFIFKGLGRGEY
>Mature_429_residues
MLEKMIEERTAEIAVIGLGYIGLPTAIMFANAGFRVIGYEIREKVVEKINSGKAHIIEPEIDELLRKAIESGNLKATSNP
EEIREKDVYIICVQTPLKEDKTPNLSYLESAVETVAKAMKKGSLIIIESTVPPLTTVKMAELIEAITGLKPGEDFYMVHA
PERVMPGRIFKELIYNSRIFGGITPESAELAEKLYRSFVKGQTFKTNSTVSEVVKLMENTFRDVNIALANEFAFLAHQYG
INVFEAIELANTHPRVKIHVPGIGVGGHCLPKDPHLLVWPAKEDFGLIKLAREINDSMPLFTKDLLFEALRTINLPPEEA
VVVILGLAYKGNSDDTRNSPAFAFMDAINEEVKEVRTYDPFVKGTHESIEDAVKGADAIVIATDHTAFKSLDWEELGKLM
RNRILIDGRHIVEDPPKGFIFKGLGRGEY

Specific function: Catalyzes the four-electron oxidation of UDP-N-acetyl-D- mannosamine (UDP-ManNAc), reducing NAD(+) and releasing UDP-N- acetylmannosaminuronic acid (UDP-ManNAcA) [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=450, Percent_Identity=26, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI296040438, Length=354, Percent_Identity=25.4237288135593, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI48994968, Length=425, Percent_Identity=38.8235294117647, Blast_Score=295, Evalue=4e-81,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=28.7292817679558, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17560350, Length=456, Percent_Identity=26.9736842105263, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI17136908, Length=452, Percent_Identity=26.7699115044248, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 47793; Mature: 47793

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKMIEERTAEIAVIGLGYIGLPTAIMFANAGFRVIGYEIREKVVEKINSGKAHIIEPE
CHHHHHHHHCCEEEEEEECHHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCEEEECCH
IDELLRKAIESGNLKATSNPEEIREKDVYIICVQTPLKEDKTPNLSYLESAVETVAKAMK
HHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
KGSLIIIESTVPPLTTVKMAELIEAITGLKPGEDFYMVHAPERVMPGRIFKELIYNSRIF
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEE
GGITPESAELAEKLYRSFVKGQTFKTNSTVSEVVKLMENTFRDVNIALANEFAFLAHQYG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHC
INVFEAIELANTHPRVKIHVPGIGVGGHCLPKDPHLLVWPAKEDFGLIKLAREINDSMPL
CCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCH
FTKDLLFEALRTINLPPEEAVVVILGLAYKGNSDDTRNSPAFAFMDAINEEVKEVRTYDP
HHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
FVKGTHESIEDAVKGADAIVIATDHTAFKSLDWEELGKLMRNRILIDGRHIVEDPPKGFI
HHCCCHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHCCEEECCCHHCCCCCCCCE
FKGLGRGEY
EECCCCCCC
>Mature Secondary Structure
MLEKMIEERTAEIAVIGLGYIGLPTAIMFANAGFRVIGYEIREKVVEKINSGKAHIIEPE
CHHHHHHHHCCEEEEEEECHHHHHHHHHHHCCCCEEECHHHHHHHHHHHCCCCEEEECCH
IDELLRKAIESGNLKATSNPEEIREKDVYIICVQTPLKEDKTPNLSYLESAVETVAKAMK
HHHHHHHHHHCCCCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
KGSLIIIESTVPPLTTVKMAELIEAITGLKPGEDFYMVHAPERVMPGRIFKELIYNSRIF
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEE
GGITPESAELAEKLYRSFVKGQTFKTNSTVSEVVKLMENTFRDVNIALANEFAFLAHQYG
CCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHC
INVFEAIELANTHPRVKIHVPGIGVGGHCLPKDPHLLVWPAKEDFGLIKLAREINDSMPL
CCHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCCH
FTKDLLFEALRTINLPPEEAVVVILGLAYKGNSDDTRNSPAFAFMDAINEEVKEVRTYDP
HHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
FVKGTHESIEDAVKGADAIVIATDHTAFKSLDWEELGKLMRNRILIDGRHIVEDPPKGFI
HHCCCHHHHHHHHCCCCEEEEEECCHHHHCCCHHHHHHHHHCCEEECCCHHCCCCCCCCE
FKGLGRGEY
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA