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The map label for this gene is tdh [H]

Identifier: 212223543

GI number: 212223543

Start: 369632

End: 370684

Strand: Reverse

Name: tdh [H]

Synonym: TON_0397

Alternate gene names: 212223543

Gene position: 370684-369632 (Counterclockwise)

Preceding gene: 212223548

Following gene: 212223542

Centisome position: 20.06

GC content: 53.18

Gene sequence:

>1053_bases
ATGGCCGAAAAGATGCCGGCGATCGTTAAGACGAAGCCCGCCTACGGTGCGGAGCTCGTTGAAGTTGATATCCCCAAGCC
CGGTCCTGGAGAGGTTCTCATCAAGGTTCTTGCCACCAGTATCTGTGGAACTGACCTGCACATCTATGAATGGAACGAAT
GGGCGCAGAGCAGGATCAAACCGCCCCAGATAATGGGTCACGAAGTCGCCGGAGAGGTCATCGAGGTTGGTCCCGGCGTT
GATACAATCAATGTTGGTGATTACATTTCAGCTGAGACTCACATAGTCTGTGGAAAATGTTACGCCTGCAAGCACAATCG
CTACCACGTCTGCCAGAACACAAAGATATTCGGCGTTGACATGGACGGTGTCTTTGCCGAATACGCTATAGTTCCCGCCC
AGAACGCTTGGAAGAATCCGAAAGACATGCCTCCCGAGTATGCAACCCTCCAAGAGCCCCTTGGAAACGCCGTTGATACA
GTTCTTGCTGGTCCAATAGCTGGAAGGAGCACGCTTATCACAGGCGCAGGTCCGCTCGGTCTCCTAGGTATAGCCGTTGC
TAAGGCCAGTGGCGCTTATCCTGTCATCGTCAGCGAGCCAAGCGAGTTTAGACGCGAGCTAGCAAAGAAAGTTGGTGCTG
ACTACGTTGTCAACCCCTTCGAAGAGGATCCAGTTAAGTTCGTTATGGACATAACTGATGGAGCCGGTGTTGAAGTCTTT
CTCGAGTTCAGCGGCGCTCCTAAGGCCTTCGAACAGGGCCTCCAGGCGGTAACACCGGGAGGAAGGGTCTCGTTGCTCGG
CCTCTTCCCGAGAGAGGTCACCTTTGACATCAACAACCTCGTAATCTTCAAGGCCCTTGAAGTACACGGAATAACCGGAA
GGCACCTCTGGGAGACCTGGTACACCGTTTCGAGCCTTATTCAGAGCGGCAAGCTCAACCTCGATCCAATAATAACCCAC
AAGTACAAGGGCTTCGACAAGTTTGAGGAAGCCTTTGAGCTCATGCGCGCCGGCAAGACTGGAAAGGTCGTCTTCTTCCC
CCACAAGAAGTGA

Upstream 100 bases:

>100_bases
TCCATCAGGAAAACTATTGTTTACATCATTGAACCTTCACAAAAGGTTTATATCGCCCCGCCATTTAGATAAGCATGTAA
ACATTAAGGAGATGGTTGCT

Downstream 100 bases:

>100_bases
GTTTTCCTTATTTTTCTTTCACCGCAATTCTTAAGTAACTCTTCTCAAACTCAACCCAAGGAGGTGGCCCTATGGAGCTT
AGCTATCAAGAGAAGCTGAC

Product: L-threonine 3-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MAEKMPAIVKTKPAYGAELVEVDIPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVIEVGPGV
DTINVGDYISAETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAEYAIVPAQNAWKNPKDMPPEYATLQEPLGNAVDT
VLAGPIAGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRELAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVF
LEFSGAPKAFEQGLQAVTPGGRVSLLGLFPREVTFDINNLVIFKALEVHGITGRHLWETWYTVSSLIQSGKLNLDPIITH
KYKGFDKFEEAFELMRAGKTGKVVFFPHKK

Sequences:

>Translated_350_residues
MAEKMPAIVKTKPAYGAELVEVDIPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVIEVGPGV
DTINVGDYISAETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAEYAIVPAQNAWKNPKDMPPEYATLQEPLGNAVDT
VLAGPIAGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRELAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVF
LEFSGAPKAFEQGLQAVTPGGRVSLLGLFPREVTFDINNLVIFKALEVHGITGRHLWETWYTVSSLIQSGKLNLDPIITH
KYKGFDKFEEAFELMRAGKTGKVVFFPHKK
>Mature_349_residues
AEKMPAIVKTKPAYGAELVEVDIPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIKPPQIMGHEVAGEVIEVGPGVD
TINVGDYISAETHIVCGKCYACKHNRYHVCQNTKIFGVDMDGVFAEYAIVPAQNAWKNPKDMPPEYATLQEPLGNAVDTV
LAGPIAGRSTLITGAGPLGLLGIAVAKASGAYPVIVSEPSEFRRELAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVFL
EFSGAPKAFEQGLQAVTPGGRVSLLGLFPREVTFDINNLVIFKALEVHGITGRHLWETWYTVSSLIQSGKLNLDPIITHK
YKGFDKFEEAFELMRAGKTGKVVFFPHKK

Specific function: Threonine catabolism; first step. [C]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=30.4878048780488, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI156523966, Length=375, Percent_Identity=26.9333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI4501939, Length=368, Percent_Identity=27.445652173913, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI4501929, Length=358, Percent_Identity=27.3743016759777, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI71565152, Length=364, Percent_Identity=25.8241758241758, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI34577061, Length=357, Percent_Identity=27.4509803921569, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=357, Percent_Identity=27.4509803921569, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI71743840, Length=354, Percent_Identity=26.8361581920904, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262073058, Length=354, Percent_Identity=26.8361581920904, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71565154, Length=377, Percent_Identity=27.0557029177719, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=42.8152492668622, Blast_Score=296, Evalue=9e-82,
Organism=Escherichia coli, GI1787863, Length=337, Percent_Identity=32.3442136498516, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1788075, Length=360, Percent_Identity=28.3333333333333, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI226510992, Length=321, Percent_Identity=30.8411214953271, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788073, Length=321, Percent_Identity=27.4143302180685, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788407, Length=333, Percent_Identity=28.8288288288288, Blast_Score=128, Evalue=7e-31,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=27.0967741935484, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786825, Length=396, Percent_Identity=27.7777777777778, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082125, Length=351, Percent_Identity=27.6353276353276, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081918, Length=258, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=26.5957446808511, Blast_Score=83, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17562876, Length=338, Percent_Identity=33.1360946745562, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17562878, Length=332, Percent_Identity=30.1204819277108, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562584, Length=281, Percent_Identity=28.4697508896797, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=296, Percent_Identity=28.0405405405405, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=287, Percent_Identity=28.9198606271777, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=363, Percent_Identity=25.068870523416, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=367, Percent_Identity=25.0681198910082, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323099, Length=334, Percent_Identity=32.3353293413174, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322619, Length=331, Percent_Identity=29.3051359516616, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319955, Length=331, Percent_Identity=29.0030211480363, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319257, Length=270, Percent_Identity=32.2222222222222, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319258, Length=358, Percent_Identity=29.0502793296089, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=275, Percent_Identity=31.2727272727273, Blast_Score=88, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=258, Percent_Identity=31.0077519379845, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=26.1455525606469, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=288, Percent_Identity=30.2083333333333, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=253, Percent_Identity=29.2490118577075, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=263, Percent_Identity=27.7566539923954, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6319949, Length=228, Percent_Identity=30.2631578947368, Blast_Score=62, Evalue=1e-10,
Organism=Drosophila melanogaster, GI17737897, Length=331, Percent_Identity=28.3987915407855, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI17137530, Length=333, Percent_Identity=27.6276276276276, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI17737895, Length=360, Percent_Identity=27.2222222222222, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221457811, Length=331, Percent_Identity=23.5649546827795, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45550770, Length=189, Percent_Identity=28.042328042328, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551930, Length=189, Percent_Identity=28.042328042328, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR004627
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.103 [H]

Molecular weight: Translated: 38110; Mature: 37979

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKMPAIVKTKPAYGAELVEVDIPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIK
CCCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCC
PPQIMGHEVAGEVIEVGPGVDTINVGDYISAETHIVCGKCYACKHNRYHVCQNTKIFGVD
CHHHHCHHHCCCEEEECCCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEC
MDGVFAEYAIVPAQNAWKNPKDMPPEYATLQEPLGNAVDTVLAGPIAGRSTLITGAGPLG
CCCCEEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHH
LLGIAVAKASGAYPVIVSEPSEFRRELAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVF
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCCEEEE
LEFSGAPKAFEQGLQAVTPGGRVSLLGLFPREVTFDINNLVIFKALEVHGITGRHLWETW
EEECCCCHHHHHCHHHCCCCCCEEEEEECCCEEEEECCCEEEEEEEEECCCCCHHHHHHH
YTVSSLIQSGKLNLDPIITHKYKGFDKFEEAFELMRAGKTGKVVFFPHKK
HHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCC
>Mature Secondary Structure 
AEKMPAIVKTKPAYGAELVEVDIPKPGPGEVLIKVLATSICGTDLHIYEWNEWAQSRIK
CCCCCCCEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCC
PPQIMGHEVAGEVIEVGPGVDTINVGDYISAETHIVCGKCYACKHNRYHVCQNTKIFGVD
CHHHHCHHHCCCEEEECCCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEECCCEEEEEC
MDGVFAEYAIVPAQNAWKNPKDMPPEYATLQEPLGNAVDTVLAGPIAGRSTLITGAGPLG
CCCCEEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHH
LLGIAVAKASGAYPVIVSEPSEFRRELAKKVGADYVVNPFEEDPVKFVMDITDGAGVEVF
HHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEEECCCCCEEEE
LEFSGAPKAFEQGLQAVTPGGRVSLLGLFPREVTFDINNLVIFKALEVHGITGRHLWETW
EEECCCCHHHHHCHHHCCCCCCEEEEEECCCEEEEECCCEEEEEEEEECCCCCHHHHHHH
YTVSSLIQSGKLNLDPIITHKYKGFDKFEEAFELMRAGKTGKVVFFPHKK
HHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA