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The map label for this gene is hemE [H]

Identifier: 209551505

GI number: 209551505

Start: 4084838

End: 4085860

Strand: Reverse

Name: hemE [H]

Synonym: Rleg2_3934

Alternate gene names: 209551505

Gene position: 4085860-4084838 (Counterclockwise)

Preceding gene: 209551511

Following gene: 209551504

Centisome position: 90.04

GC content: 62.37

Gene sequence:

>1023_bases
ATGAGGGTTCTCGAAGGTGAAAGCCTCTCCCCTCCTCCTCTCTGGCTGATGAGACAGGCGGGACGTTATCTCCCGGAATA
TCGGCAGACACGGGCAAAGGCCGGGAGCTTCCTCGATCTCTGTTATACGCCCGATCATGCCGTCGAAGTGACATTGCAGC
CGATCCGCCGTTATGGCTTTGACGCCGCCATTCTGTTTTCCGATATCCTGGTTATTCCCGATGCAATGAAGCGGAATGTC
CGGTTCACCGAGGGCCATGGCCCGGAGATGGATCCGATCGATGAAGCCGGGATCGGGCGATTGAACGGCGAAGAGGTCGT
CGATTATCTCAGACCGGTTCTGGAAACGGTGCGGCGGCTGCGCCAGGAGTTGCCTGATGAGACGACGCTGCTCGGCTTCT
GCGGGGCGCCCTGGACGGTTGCGACCTATATGATCGCCGGTCACGGCACGCCGGATCAGGCCCCTGCCCGTCTCTTCGCC
TACAAACATCCCCGCGCTTTCGAACAGCTGCTGATGCTGCTTGCGGATGTGTCGGCCGATTATCTCGTCGCCCAGATCGA
TGCCGGCGCCGATGCCGTGCAGATCTTCGATTCCTGGGCTGGCGTTCTCGGCGAGAGGGAGTTCGAGGCGTTCGCGATCC
GGCCGGTTGCGCGAATGATCGCTTCGGTCAAATCGCGGCGGCCGCAGGCGCGCATCATCGCCTTCGCCAAGGGCGCCGGT
TACCAGCTGAAGAACTATCGTCAGAAGACGGGCGCCGATGCGATCGGCCTCGACTGGTCGGTGCCTTTGGCCTTTGCCGC
CGAACTTCAGAAGGACGGACCGGTGCAGGGCAATCTCGATCCGATGCGCGTCGTTGCGGGCGGGCGGGCGCTCGAAGAGG
GTATTGACGATATTCTGCAGCATCTCGGCCAAGGACCGCTGATCTTCAATCTCGGCCACGGCATCACGCCGCAGGCCGAC
CCCGAGCATGTGCGCCTGCTGGTCGATCGCGTGCGGGGTGGCCAGATGCGAGGCGGGAAGTGA

Upstream 100 bases:

>100_bases
TAATCCTTGATAGACACCGACTCTAAGAAATAGAAACCTTTTAAAATATCTTTGATTTTTTATAGGGAAGAAGCGCTTGA
GCGACACGCGCCGAAAGATC

Downstream 100 bases:

>100_bases
CGATGGAAAGGCAGACCGATCGCCGGACCGGCGCCTATGCCCGCCGGCGCGCGCATTTTGCGCTGGTTTTCTTCGCGCTG
ATGGCGGTCGGGCTTTTCGC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:

>340_residues
MRVLEGESLSPPPLWLMRQAGRYLPEYRQTRAKAGSFLDLCYTPDHAVEVTLQPIRRYGFDAAILFSDILVIPDAMKRNV
RFTEGHGPEMDPIDEAGIGRLNGEEVVDYLRPVLETVRRLRQELPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFA
YKHPRAFEQLLMLLADVSADYLVAQIDAGADAVQIFDSWAGVLGEREFEAFAIRPVARMIASVKSRRPQARIIAFAKGAG
YQLKNYRQKTGADAIGLDWSVPLAFAAELQKDGPVQGNLDPMRVVAGGRALEEGIDDILQHLGQGPLIFNLGHGITPQAD
PEHVRLLVDRVRGGQMRGGK

Sequences:

>Translated_340_residues
MRVLEGESLSPPPLWLMRQAGRYLPEYRQTRAKAGSFLDLCYTPDHAVEVTLQPIRRYGFDAAILFSDILVIPDAMKRNV
RFTEGHGPEMDPIDEAGIGRLNGEEVVDYLRPVLETVRRLRQELPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFA
YKHPRAFEQLLMLLADVSADYLVAQIDAGADAVQIFDSWAGVLGEREFEAFAIRPVARMIASVKSRRPQARIIAFAKGAG
YQLKNYRQKTGADAIGLDWSVPLAFAAELQKDGPVQGNLDPMRVVAGGRALEEGIDDILQHLGQGPLIFNLGHGITPQAD
PEHVRLLVDRVRGGQMRGGK
>Mature_340_residues
MRVLEGESLSPPPLWLMRQAGRYLPEYRQTRAKAGSFLDLCYTPDHAVEVTLQPIRRYGFDAAILFSDILVIPDAMKRNV
RFTEGHGPEMDPIDEAGIGRLNGEEVVDYLRPVLETVRRLRQELPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFA
YKHPRAFEQLLMLLADVSADYLVAQIDAGADAVQIFDSWAGVLGEREFEAFAIRPVARMIASVKSRRPQARIIAFAKGAG
YQLKNYRQKTGADAIGLDWSVPLAFAAELQKDGPVQGNLDPMRVVAGGRALEEGIDDILQHLGQGPLIFNLGHGITPQAD
PEHVRLLVDRVRGGQMRGGK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=341, Percent_Identity=41.6422287390029, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI2367337, Length=338, Percent_Identity=41.7159763313609, Blast_Score=241, Evalue=7e-65,
Organism=Saccharomyces cerevisiae, GI6320252, Length=347, Percent_Identity=34.8703170028818, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI221330099, Length=340, Percent_Identity=37.6470588235294, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI19921920, Length=340, Percent_Identity=37.6470588235294, Blast_Score=209, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 37522; Mature: 37522

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLEGESLSPPPLWLMRQAGRYLPEYRQTRAKAGSFLDLCYTPDHAVEVTLQPIRRYGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHCCC
DAAILFSDILVIPDAMKRNVRFTEGHGPEMDPIDEAGIGRLNGEEVVDYLRPVLETVRRL
CHHHHHHHHHHCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RQELPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYKHPRAFEQLLMLLADVSAD
HHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCC
YLVAQIDAGADAVQIFDSWAGVLGEREFEAFAIRPVARMIASVKSRRPQARIIAFAKGAG
EEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
YQLKNYRQKTGADAIGLDWSVPLAFAAELQKDGPVQGNLDPMRVVAGGRALEEGIDDILQ
CHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHHHHHHHHH
HLGQGPLIFNLGHGITPQADPEHVRLLVDRVRGGQMRGGK
HCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRVLEGESLSPPPLWLMRQAGRYLPEYRQTRAKAGSFLDLCYTPDHAVEVTLQPIRRYGF
CCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCEEEEEHHHHHCCC
DAAILFSDILVIPDAMKRNVRFTEGHGPEMDPIDEAGIGRLNGEEVVDYLRPVLETVRRL
CHHHHHHHHHHCCHHHHCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
RQELPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYKHPRAFEQLLMLLADVSAD
HHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCC
YLVAQIDAGADAVQIFDSWAGVLGEREFEAFAIRPVARMIASVKSRRPQARIIAFAKGAG
EEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
YQLKNYRQKTGADAIGLDWSVPLAFAAELQKDGPVQGNLDPMRVVAGGRALEEGIDDILQ
CHHHHHHHHHCCCEECCCCCCHHHHHHHHHCCCCCCCCCCHHHEECCCHHHHHHHHHHHH
HLGQGPLIFNLGHGITPQADPEHVRLLVDRVRGGQMRGGK
HCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA