Click here to switch to the map view.

The map label for this gene is galM [H]

Identifier: 209551375

GI number: 209551375

Start: 3935245

End: 3936267

Strand: Reverse

Name: galM [H]

Synonym: Rleg2_3804

Alternate gene names: 209551375

Gene position: 3936267-3935245 (Counterclockwise)

Preceding gene: 209551376

Following gene: 209551374

Centisome position: 86.74

GC content: 61.97

Gene sequence:

>1023_bases
ATGTCGGATAAGTTAGAACGGGAAGTTTTCGGGCAGACCAAGGCGGGCGAGACCGTTTATCGCGTCGTCATCAGGGGCGG
CGGGCTGACGGCCAAGATCATTAGCTGGGGCGCGGTCATCCAGGATCTGCGCCTGGAAGGGCATGACGCGCCGCTGCAGC
TCGGCTTTGAGGATTTTGACAGCTACCCGCTCTATTCGGCTTATTTCGGCGCGACGCCCGGCCGCTGTGCCAACCGTGTC
GGCGGCGGCGCCTTTACGCTCGACGGCAAGGACCACCAGCTCGAGCTGAACGAAAACGGCGTGACGCATCTGCATGGCGG
CAGCGACAATATCGCCAAACGCAACTGGACGGTCGTCGAGCACGATGTCGACCGCGTGGTGCTGAAGATCGTCGATCCCG
ATGGCCGTGCCGGCTATCCCGGCAATTGCACCATCCAGGCAACCTTCTGGGTGCACGGCAACGGCGAACTGTCGGTGACC
TACGAATCCACAAGCGACCAGCCGACGCTCGCCAATGTCTGCCAGCATGCCTATTTCAATCTCGATGGCCGCGAGGACGC
GCTCGGCCACGACATCATGATCGCTGCCGACCACTATCTGCCGACCGACGAGAAACAGGTGCCGACCGGCGAGATCCGTT
CCGTCGCCGGCACGGAATTCGATTTCCGCGAGATGGCGCCGATGAAGCGTTTCGCCGGCAGCGAACAGATGCTGTACGAC
CATAATTTCTGCCTGTCCGGCGAACGTACCGCCAAGCGTAGCGTTGCGCTCGCCCGAAGCCTCTATTCCGGTGTGTCGCT
TGAGGTGCGCAGCACCGAGCCGGGTGTGCAGTTCTATGCCGGTTTCAAGCTGAATACCGGTGCTCCCGGCCTCGGCGGGC
GCAAATACGGCCCCTTCGCCGGCTTCTGCCTGGAGACGCAGGTCTGGCCGGATGCCATCAATCACCAGGGTTTCCCGAAT
GCGGTGCTGCGCCCCGGCGAAGTGCTGCGTCAGGAAACGGATTATATCTTCACCAAGAGCTGA

Upstream 100 bases:

>100_bases
TCTGTGAGGGGCATCCCTTTCTGATCTCGGCCGGTTGCGGTTTGGAACAAATGCGGGCAGGTTCCGGTCGGAATGCTAGA
TATCAAACGGACGGTCGATC

Downstream 100 bases:

>100_bases
GCGTCTTTTTCGAGACGCGGGCCGGGACGTACGGCTGTCAAATTTTATCGCTATGAAAACCTCTCCGGCCCGCCGGGGAG
GTTTTTTCTTGCTTGTCCAT

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSDKLEREVFGQTKAGETVYRVVIRGGGLTAKIISWGAVIQDLRLEGHDAPLQLGFEDFDSYPLYSAYFGATPGRCANRV
GGGAFTLDGKDHQLELNENGVTHLHGGSDNIAKRNWTVVEHDVDRVVLKIVDPDGRAGYPGNCTIQATFWVHGNGELSVT
YESTSDQPTLANVCQHAYFNLDGREDALGHDIMIAADHYLPTDEKQVPTGEIRSVAGTEFDFREMAPMKRFAGSEQMLYD
HNFCLSGERTAKRSVALARSLYSGVSLEVRSTEPGVQFYAGFKLNTGAPGLGGRKYGPFAGFCLETQVWPDAINHQGFPN
AVLRPGEVLRQETDYIFTKS

Sequences:

>Translated_340_residues
MSDKLEREVFGQTKAGETVYRVVIRGGGLTAKIISWGAVIQDLRLEGHDAPLQLGFEDFDSYPLYSAYFGATPGRCANRV
GGGAFTLDGKDHQLELNENGVTHLHGGSDNIAKRNWTVVEHDVDRVVLKIVDPDGRAGYPGNCTIQATFWVHGNGELSVT
YESTSDQPTLANVCQHAYFNLDGREDALGHDIMIAADHYLPTDEKQVPTGEIRSVAGTEFDFREMAPMKRFAGSEQMLYD
HNFCLSGERTAKRSVALARSLYSGVSLEVRSTEPGVQFYAGFKLNTGAPGLGGRKYGPFAGFCLETQVWPDAINHQGFPN
AVLRPGEVLRQETDYIFTKS
>Mature_339_residues
SDKLEREVFGQTKAGETVYRVVIRGGGLTAKIISWGAVIQDLRLEGHDAPLQLGFEDFDSYPLYSAYFGATPGRCANRVG
GGAFTLDGKDHQLELNENGVTHLHGGSDNIAKRNWTVVEHDVDRVVLKIVDPDGRAGYPGNCTIQATFWVHGNGELSVTY
ESTSDQPTLANVCQHAYFNLDGREDALGHDIMIAADHYLPTDEKQVPTGEIRSVAGTEFDFREMAPMKRFAGSEQMLYDH
NFCLSGERTAKRSVALARSLYSGVSLEVRSTEPGVQFYAGFKLNTGAPGLGGRKYGPFAGFCLETQVWPDAINHQGFPNA
VLRPGEVLRQETDYIFTKS

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=343, Percent_Identity=39.3586005830904, Blast_Score=218, Evalue=7e-57,
Organism=Escherichia coli, GI1786971, Length=331, Percent_Identity=34.1389728096677, Blast_Score=187, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17557428, Length=318, Percent_Identity=31.7610062893082, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI115533334, Length=318, Percent_Identity=31.7610062893082, Blast_Score=156, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319493, Length=341, Percent_Identity=29.3255131964809, Blast_Score=103, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322004, Length=345, Percent_Identity=29.2753623188406, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324399, Length=349, Percent_Identity=25.7879656160458, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24659048, Length=343, Percent_Identity=37.3177842565598, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24668278, Length=357, Percent_Identity=35.5742296918768, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24583720, Length=359, Percent_Identity=33.983286908078, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24668282, Length=328, Percent_Identity=31.4024390243902, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24641876, Length=361, Percent_Identity=29.6398891966759, Blast_Score=131, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37346; Mature: 37215

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDKLEREVFGQTKAGETVYRVVIRGGGLTAKIISWGAVIQDLRLEGHDAPLQLGFEDFD
CCCHHHHHHHCCCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHCCCCCCCEEECHHHCC
SYPLYSAYFGATPGRCANRVGGGAFTLDGKDHQLELNENGVTHLHGGSDNIAKRNWTVVE
CCCCCHHHHCCCCCHHHHHCCCCEEEECCCCCEEEECCCCEEEEECCCCCCCCCCCEEEE
HDVDRVVLKIVDPDGRAGYPGNCTIQATFWVHGNGELSVTYESTSDQPTLANVCQHAYFN
ECCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCC
LDGREDALGHDIMIAADHYLPTDEKQVPTGEIRSVAGTEFDFREMAPMKRFAGSEQMLYD
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
HNFCLSGERTAKRSVALARSLYSGVSLEVRSTEPGVQFYAGFKLNTGAPGLGGRKYGPFA
CCEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
GFCLETQVWPDAINHQGFPNAVLRPGEVLRQETDYIFTKS
CEEEECCCCCHHHCCCCCCHHHCCCHHHHHHCCCEEEECC
>Mature Secondary Structure 
SDKLEREVFGQTKAGETVYRVVIRGGGLTAKIISWGAVIQDLRLEGHDAPLQLGFEDFD
CCHHHHHHHCCCCCCCEEEEEEEECCCCEEEEHHHHHHHHHHHCCCCCCCEEECHHHCC
SYPLYSAYFGATPGRCANRVGGGAFTLDGKDHQLELNENGVTHLHGGSDNIAKRNWTVVE
CCCCCHHHHCCCCCHHHHHCCCCEEEECCCCCEEEECCCCEEEEECCCCCCCCCCCEEEE
HDVDRVVLKIVDPDGRAGYPGNCTIQATFWVHGNGELSVTYESTSDQPTLANVCQHAYFN
ECCCEEEEEEECCCCCCCCCCCEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHCC
LDGREDALGHDIMIAADHYLPTDEKQVPTGEIRSVAGTEFDFREMAPMKRFAGSEQMLYD
CCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEE
HNFCLSGERTAKRSVALARSLYSGVSLEVRSTEPGVQFYAGFKLNTGAPGLGGRKYGPFA
CCEEECCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCCCC
GFCLETQVWPDAINHQGFPNAVLRPGEVLRQETDYIFTKS
CEEEECCCCCHHHCCCCCCHHHCCCHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7966338; 8905232; 9278503 [H]