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The map label for this gene is atoC [H]

Identifier: 209550871

GI number: 209550871

Start: 3382401

End: 3383945

Strand: Reverse

Name: atoC [H]

Synonym: Rleg2_3295

Alternate gene names: 209550871

Gene position: 3383945-3382401 (Counterclockwise)

Preceding gene: 209550883

Following gene: 209550870

Centisome position: 74.57

GC content: 62.52

Gene sequence:

>1545_bases
ATGACCGGTTACAATGAGCTCAAGGGAGCAGGGCAAATTCTCGTGGTCGAGGACGACCCCGTGCAGCGCCGCCTGCTCAA
GAACGCAATCGAGCGTCACGGCCATGTCGTGCACCAGGCGGAAAACGGCCGCATCGGCTTGGAAATGGTCAAACGCGACA
GCGGCCTTTTCAACGTCATCGTGCTCGACCTGATGATGCCGGAGATGACCGGCCTCGAATTCCTCGACGCGCTTCATGAA
TTCGGCACGCAGATCCCCGTCATCGTGCAGACGGGCCAGGGCGGCATCGAGACCGTGGTGCAGGCAATGCGCGCCGGCGC
CTTCGATTTTGTCGTCAAGCCGGTTTCGCCGGAACGGATCGCCACCTCGATCTCGAATGCGATGAAGCTCGACCAGCGCG
AGGTGAAGGCGCGGGCCGGACGCCGGTCGCGCTCCGGCTCGGTCGGCTTCGATGACATCGTCTCGGCAAGCCCGGCGATG
CTCCGCGTCATCGACCTCGCCCAGCGGGCGGCTCAGTCCAACATTCCGGTCGTGCTCGAAGGCGAATCCGGCGTCGGCAA
GGAACTGGTGGCGCGCGCCATCCAATCCGGCGGCGACCGCTCGAACAAGCCCTTCGTCACGGTCAATTGCGGGGCGATCC
CGCACAATCTCGTCGAGAGCATTCTGTTCGGCCACGAGAAGGGCGCCTTTACCGGCGCGACCGAGCGCCATATCGGCAAA
TTCATGGAAGCCGACGGCGGCACCATCTTCCTAGACGAGATCGGCGACCTGCCGCTCGAGGTGCAGGTGAAGCTGTTGCG
CGCCGTGCAGCAGGGCGAGATCGAGACCGTCGGTGCACGGACCGCACACAAGGTCAATGTCCGGCTGATCTCGGCGACCA
ACAAGGATCTGATCGAGGAGGTCAAGAACGGCCATTTCCGCGAGGATCTCTACTATCGCCTCAACGTTTTCCCGATCACC
ATCCCGGCGCTGCGCAAGCGCAAGGAAGATATTCCGCATCTGGTGCGCGTCTTTGCCGAACGCTTCTCCAGCGAGCAGAA
GAACGGCCGCCGCATGACGGTCAACGCAGGCGCGCTGGCGCTGCTGACCGCCTATGACTGGCCGGGCAACATCCGCCAGC
TCGAAAATGCGATCTTCCGCGCAGTCGTTCTGGCCGAAGGGCCGGAGCTGACGGAAGGGGACTTCCCGCAGATCGCCGCC
CAGCTTCCGGAATACGAGGTCGTCGATCACCTGGCGCTGGTTGCCGACAATACCGGCCTCGATCCCGACGACAGCTATGG
CGAGGAGTTCAGGGCGTCGATCTCGGGAGAGGTGCACCACCGTCTGTCCGAAGTCTCCGAAAACGCGATCGCCAGCGTCA
ATCCGGCCGGCGACGTGCGCAGGCTTGCCGATGTCGAGGAGGAGCTCATCCGATTCGCGCTCAAATTCTATCGTGGGCAG
ATGAGTCAAGTGGCGCGCAAACTTGGCATCGGCCGGTCCACACTTTATCGCAAGCTCAAAGATTACGGCATAGACCCCGA
TAATCCCCAGAAAGATGCGGCTTAA

Upstream 100 bases:

>100_bases
GACCCGTTCCAATCGTTAAAATGCAATTATTTCTCAAAACAGGATGTTCAAGCCTTTCTGTCAGAGTGCGCTTCATGGTT
TCGCATGAAGTGAGGCGACA

Downstream 100 bases:

>100_bases
GCGCTTTTTATTAAGACTAAGGCAACCACGATTTGTTACTGATCATAAACCACTTGTTAGTGGCTCGTTCACTATGTAAA
GAAAAGGTTGATCATGTGTG

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTGYNELKGAGQILVVEDDPVQRRLLKNAIERHGHVVHQAENGRIGLEMVKRDSGLFNVIVLDLMMPEMTGLEFLDALHE
FGTQIPVIVQTGQGGIETVVQAMRAGAFDFVVKPVSPERIATSISNAMKLDQREVKARAGRRSRSGSVGFDDIVSASPAM
LRVIDLAQRAAQSNIPVVLEGESGVGKELVARAIQSGGDRSNKPFVTVNCGAIPHNLVESILFGHEKGAFTGATERHIGK
FMEADGGTIFLDEIGDLPLEVQVKLLRAVQQGEIETVGARTAHKVNVRLISATNKDLIEEVKNGHFREDLYYRLNVFPIT
IPALRKRKEDIPHLVRVFAERFSSEQKNGRRMTVNAGALALLTAYDWPGNIRQLENAIFRAVVLAEGPELTEGDFPQIAA
QLPEYEVVDHLALVADNTGLDPDDSYGEEFRASISGEVHHRLSEVSENAIASVNPAGDVRRLADVEEELIRFALKFYRGQ
MSQVARKLGIGRSTLYRKLKDYGIDPDNPQKDAA

Sequences:

>Translated_514_residues
MTGYNELKGAGQILVVEDDPVQRRLLKNAIERHGHVVHQAENGRIGLEMVKRDSGLFNVIVLDLMMPEMTGLEFLDALHE
FGTQIPVIVQTGQGGIETVVQAMRAGAFDFVVKPVSPERIATSISNAMKLDQREVKARAGRRSRSGSVGFDDIVSASPAM
LRVIDLAQRAAQSNIPVVLEGESGVGKELVARAIQSGGDRSNKPFVTVNCGAIPHNLVESILFGHEKGAFTGATERHIGK
FMEADGGTIFLDEIGDLPLEVQVKLLRAVQQGEIETVGARTAHKVNVRLISATNKDLIEEVKNGHFREDLYYRLNVFPIT
IPALRKRKEDIPHLVRVFAERFSSEQKNGRRMTVNAGALALLTAYDWPGNIRQLENAIFRAVVLAEGPELTEGDFPQIAA
QLPEYEVVDHLALVADNTGLDPDDSYGEEFRASISGEVHHRLSEVSENAIASVNPAGDVRRLADVEEELIRFALKFYRGQ
MSQVARKLGIGRSTLYRKLKDYGIDPDNPQKDAA
>Mature_513_residues
TGYNELKGAGQILVVEDDPVQRRLLKNAIERHGHVVHQAENGRIGLEMVKRDSGLFNVIVLDLMMPEMTGLEFLDALHEF
GTQIPVIVQTGQGGIETVVQAMRAGAFDFVVKPVSPERIATSISNAMKLDQREVKARAGRRSRSGSVGFDDIVSASPAML
RVIDLAQRAAQSNIPVVLEGESGVGKELVARAIQSGGDRSNKPFVTVNCGAIPHNLVESILFGHEKGAFTGATERHIGKF
MEADGGTIFLDEIGDLPLEVQVKLLRAVQQGEIETVGARTAHKVNVRLISATNKDLIEEVKNGHFREDLYYRLNVFPITI
PALRKRKEDIPHLVRVFAERFSSEQKNGRRMTVNAGALALLTAYDWPGNIRQLENAIFRAVVLAEGPELTEGDFPQIAAQ
LPEYEVVDHLALVADNTGLDPDDSYGEEFRASISGEVHHRLSEVSENAIASVNPAGDVRRLADVEEELIRFALKFYRGQM
SQVARKLGIGRSTLYRKLKDYGIDPDNPQKDAA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=500, Percent_Identity=38.2, Blast_Score=332, Evalue=5e-92,
Organism=Escherichia coli, GI1790437, Length=488, Percent_Identity=38.7295081967213, Blast_Score=321, Evalue=9e-89,
Organism=Escherichia coli, GI1790299, Length=501, Percent_Identity=37.5249500998004, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788905, Length=387, Percent_Identity=39.7932816537468, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI87082117, Length=250, Percent_Identity=50.4, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789087, Length=397, Percent_Identity=38.5390428211587, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI87082152, Length=264, Percent_Identity=45.0757575757576, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1789233, Length=362, Percent_Identity=40.0552486187845, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1787583, Length=258, Percent_Identity=42.2480620155039, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=43.1034482758621, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1786524, Length=269, Percent_Identity=40.5204460966543, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI87081858, Length=352, Percent_Identity=31.25, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789828, Length=343, Percent_Identity=32.0699708454811, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 56521; Mature: 56390

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGYNELKGAGQILVVEDDPVQRRLLKNAIERHGHVVHQAENGRIGLEMVKRDSGLFNVI
CCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHCCCCHHHHH
VLDLMMPEMTGLEFLDALHEFGTQIPVIVQTGQGGIETVVQAMRAGAFDFVVKPVSPERI
HHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHHH
ATSISNAMKLDQREVKARAGRRSRSGSVGFDDIVSASPAMLRVIDLAQRAAQSNIPVVLE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEE
GESGVGKELVARAIQSGGDRSNKPFVTVNCGAIPHNLVESILFGHEKGAFTGATERHIGK
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
FMEADGGTIFLDEIGDLPLEVQVKLLRAVQQGEIETVGARTAHKVNVRLISATNKDLIEE
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCHHHHHH
VKNGHFREDLYYRLNVFPITIPALRKRKEDIPHLVRVFAERFSSEQKNGRRMTVNAGALA
HHCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEECCEEE
LLTAYDWPGNIRQLENAIFRAVVLAEGPELTEGDFPQIAAQLPEYEVVDHLALVADNTGL
EEEEECCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCC
DPDDSYGEEFRASISGEVHHRLSEVSENAIASVNPAGDVRRLADVEEELIRFALKFYRGQ
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MSQVARKLGIGRSTLYRKLKDYGIDPDNPQKDAA
HHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TGYNELKGAGQILVVEDDPVQRRLLKNAIERHGHVVHQAENGRIGLEMVKRDSGLFNVI
CCCHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHCCCCHHHHH
VLDLMMPEMTGLEFLDALHEFGTQIPVIVQTGQGGIETVVQAMRAGAFDFVVKPVSPERI
HHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCCHHHH
ATSISNAMKLDQREVKARAGRRSRSGSVGFDDIVSASPAMLRVIDLAQRAAQSNIPVVLE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEE
GESGVGKELVARAIQSGGDRSNKPFVTVNCGAIPHNLVESILFGHEKGAFTGATERHIGK
CCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHH
FMEADGGTIFLDEIGDLPLEVQVKLLRAVQQGEIETVGARTAHKVNVRLISATNKDLIEE
HHHCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCEEEEEEEEEECCCHHHHHH
VKNGHFREDLYYRLNVFPITIPALRKRKEDIPHLVRVFAERFSSEQKNGRRMTVNAGALA
HHCCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCEEEEECCEEE
LLTAYDWPGNIRQLENAIFRAVVLAEGPELTEGDFPQIAAQLPEYEVVDHLALVADNTGL
EEEEECCCCHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCCC
DPDDSYGEEFRASISGEVHHRLSEVSENAIASVNPAGDVRRLADVEEELIRFALKFYRGQ
CCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
MSQVARKLGIGRSTLYRKLKDYGIDPDNPQKDAA
HHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]