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The map label for this gene is ilvD [H]

Identifier: 209550669

GI number: 209550669

Start: 3156874

End: 3158658

Strand: Reverse

Name: ilvD [H]

Synonym: Rleg2_3093

Alternate gene names: 209550669

Gene position: 3158658-3156874 (Counterclockwise)

Preceding gene: 209550670

Following gene: 209550668

Centisome position: 69.61

GC content: 64.82

Gene sequence:

>1785_bases
GTGACCGACAGCCATCTTCCGAAGCGGCGCCTGCGGTCGCAGGATTGGTTCGACAATCCCGACCATATCGACATGGCAGC
GCTCTATCTCGAGCGTTTCATGAATTACGGCATCACGCCGGAAGAGCTGCGCTCCGGCAAGCCCATCATCGGGATTGCCC
AGAGCGGCAGCGATCTTACGCCTTGCAACAGGGTGCATGTCGAGCTTGCCAAGCGCGTGCGCGACGGCATTCGCGATGCC
GGCGGCATTCCGATCGAATTTCCGACACATCCGATCTTCGAGAACTGCAAGCGCCCAACGGCGGCACTCGACCGCAATCT
TGCCTATCTCGGCCTCGTTGAAATCCTCTATGGCTATCCGCTCGACGGCGTCGTGCTGACGACCGGCTGCGACAAGACCA
CGCCGTCGGCGATCATGGCGGCGTCGACGGTCGATATTCCGGCGATCGTGCTCTCCGGCGGCCCGATGCTCGACGGCTGG
CATGAGGGAGAGCTGGCGGGTTCCGGCACGGTGATCTGGCGGATGCGGCGGAAATATGCGGCAGGCGAGATCGACCGCGA
GGAATTCCTGCAGGCAGCGCTCGACTCAGCGCCCTCCGTCGGCCACTGCAATACGATGGGCACGGCCTCGACGATGAATG
CGCTCGCCGAGGCGCTCGGTCTGTCGCTGACCGGATGCGGCGCCATTCCAGCTCCCTACCGCGAACGCGGGCAGATGGCC
TATCGCACCGGGCGGCGTGCCGTCGAGATCGTCTTCGAGGACCTGAAGCCGTCGGATATCCTGACGCGCGCGGCCTTCCT
CAATGCCATCCGCACCAATTCGGCGATCGGCGGTTCGACCAACGCGCAGCCGCATCTGGCGGCGATGGCCAAACACGCCG
GCGTCGAGATTCATCCCGACGACTGGCAGGTGCACGGCTTCGATATCCCGCTGCTCGCCAACGTCCAGCCGGCCGGCGCC
TATCTCGGCGAGCGTTATCATCGCGCCGGCGGCACGCCGGCGATCATGTGGGAATTGCTGCAGGCTGGAAAGCTGGATGG
CGACTGTCATACGGTGACGGGCAGGAGGATGGCCGAGAACCTGCAGGGCAAGGAAGCCAGCGACCGCGAGGTCATTCGGC
CGTTCGGCGAGCCGCTGAAGGAGCGGGCCGGATTTCTCGTTCTCAAGGGCAATCTCTTCGATTTCGCCATCATGAAGATG
AGCGTAGTCTCGGAGGATTTTCGCCGGCGCTACCTTCAGGAGCCCGGGCGGGAGGGCGTCTTCGAAGGCAAGGCGGTCGT
CTTCGACGGGTCGGAAGATTATCACAAGCGCATCAACGATCCCGACCTCGGCATCGACGAGAATACCATTCTGGTCATCC
GCGGCGCCGGGCCGCTCGGCTGGCCGGGTTCGGCAGAGGTTGTCAACATGCAGCCGCCCGACCATCTTCTGAAGCGCGGC
ATCAGCAGCCTGCCGACGATCGGTGACGGCCGCCAGTCGGGCACGGCCGACAGCCCGTCGATCCTCAACGCCTCGCCGGA
GAGCGCGGCCGGCGGCGGCCTCGCCTGGCTTCGCAGCGGCGATATCATCCGCATCAACTTCAACCATGGGCGTTGCGACA
TGCTGGTCGACGAGACCGAGATCGAACGGCGCAAGGGCGACGGTATTCCGCCGGTGCCGCCGGATGCGACGCCTTGGCAG
CAGATCTACCGCCGCTCGGTCACGCAACTGTCGGACGGCGCGGTTCTGGAAGGAGCGGCGGAATTCCGCCGGATTGCCAA
AAACCCGCCGCGCCACAACCACTGA

Upstream 100 bases:

>100_bases
CCGAATTCACCGAATTCGTTGCAAACGGCAATGGTGAAAAGGATCATAGCGGCCTGCTCCTGCATCTCGAAGAGAAGAAT
GCCCTGCCCGGAGGCAAAAG

Downstream 100 bases:

>100_bases
TCTCAGCTGTGTTTTGGACTGCAAGTCCTTTGATCCAAAAGGGGAAAGTCGTAACGGACAGTTCACCTAGTGACTAGTTC
GATCATCGGAACAAGGCTTC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MTDSHLPKRRLRSQDWFDNPDHIDMAALYLERFMNYGITPEELRSGKPIIGIAQSGSDLTPCNRVHVELAKRVRDGIRDA
GGIPIEFPTHPIFENCKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPSAIMAASTVDIPAIVLSGGPMLDGW
HEGELAGSGTVIWRMRRKYAAGEIDREEFLQAALDSAPSVGHCNTMGTASTMNALAEALGLSLTGCGAIPAPYRERGQMA
YRTGRRAVEIVFEDLKPSDILTRAAFLNAIRTNSAIGGSTNAQPHLAAMAKHAGVEIHPDDWQVHGFDIPLLANVQPAGA
YLGERYHRAGGTPAIMWELLQAGKLDGDCHTVTGRRMAENLQGKEASDREVIRPFGEPLKERAGFLVLKGNLFDFAIMKM
SVVSEDFRRRYLQEPGREGVFEGKAVVFDGSEDYHKRINDPDLGIDENTILVIRGAGPLGWPGSAEVVNMQPPDHLLKRG
ISSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRSGDIIRINFNHGRCDMLVDETEIERRKGDGIPPVPPDATPWQ
QIYRRSVTQLSDGAVLEGAAEFRRIAKNPPRHNH

Sequences:

>Translated_594_residues
MTDSHLPKRRLRSQDWFDNPDHIDMAALYLERFMNYGITPEELRSGKPIIGIAQSGSDLTPCNRVHVELAKRVRDGIRDA
GGIPIEFPTHPIFENCKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPSAIMAASTVDIPAIVLSGGPMLDGW
HEGELAGSGTVIWRMRRKYAAGEIDREEFLQAALDSAPSVGHCNTMGTASTMNALAEALGLSLTGCGAIPAPYRERGQMA
YRTGRRAVEIVFEDLKPSDILTRAAFLNAIRTNSAIGGSTNAQPHLAAMAKHAGVEIHPDDWQVHGFDIPLLANVQPAGA
YLGERYHRAGGTPAIMWELLQAGKLDGDCHTVTGRRMAENLQGKEASDREVIRPFGEPLKERAGFLVLKGNLFDFAIMKM
SVVSEDFRRRYLQEPGREGVFEGKAVVFDGSEDYHKRINDPDLGIDENTILVIRGAGPLGWPGSAEVVNMQPPDHLLKRG
ISSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRSGDIIRINFNHGRCDMLVDETEIERRKGDGIPPVPPDATPWQ
QIYRRSVTQLSDGAVLEGAAEFRRIAKNPPRHNH
>Mature_593_residues
TDSHLPKRRLRSQDWFDNPDHIDMAALYLERFMNYGITPEELRSGKPIIGIAQSGSDLTPCNRVHVELAKRVRDGIRDAG
GIPIEFPTHPIFENCKRPTAALDRNLAYLGLVEILYGYPLDGVVLTTGCDKTTPSAIMAASTVDIPAIVLSGGPMLDGWH
EGELAGSGTVIWRMRRKYAAGEIDREEFLQAALDSAPSVGHCNTMGTASTMNALAEALGLSLTGCGAIPAPYRERGQMAY
RTGRRAVEIVFEDLKPSDILTRAAFLNAIRTNSAIGGSTNAQPHLAAMAKHAGVEIHPDDWQVHGFDIPLLANVQPAGAY
LGERYHRAGGTPAIMWELLQAGKLDGDCHTVTGRRMAENLQGKEASDREVIRPFGEPLKERAGFLVLKGNLFDFAIMKMS
VVSEDFRRRYLQEPGREGVFEGKAVVFDGSEDYHKRINDPDLGIDENTILVIRGAGPLGWPGSAEVVNMQPPDHLLKRGI
SSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRSGDIIRINFNHGRCDMLVDETEIERRKGDGIPPVPPDATPWQQ
IYRRSVTQLSDGAVLEGAAEFRRIAKNPPRHNH

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=444, Percent_Identity=31.5315315315315, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI48994964, Length=559, Percent_Identity=28.8014311270125, Blast_Score=175, Evalue=8e-45,
Organism=Escherichia coli, GI2367371, Length=473, Percent_Identity=28.1183932346723, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786464, Length=477, Percent_Identity=28.9308176100629, Blast_Score=118, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6322476, Length=556, Percent_Identity=28.4172661870504, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 64749; Mature: 64618

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSHLPKRRLRSQDWFDNPDHIDMAALYLERFMNYGITPEELRSGKPIIGIAQSGSDLT
CCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRVHVELAKRVRDGIRDAGGIPIEFPTHPIFENCKRPTAALDRNLAYLGLVEILYGYP
CHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPSAIMAASTVDIPAIVLSGGPMLDGWHEGELAGSGTVIWRMRRKYA
CCCEEEECCCCCCCCHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHH
AGEIDREEFLQAALDSAPSVGHCNTMGTASTMNALAEALGLSLTGCGAIPAPYRERGQMA
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHHCCHH
YRTGRRAVEIVFEDLKPSDILTRAAFLNAIRTNSAIGGSTNAQPHLAAMAKHAGVEIHPD
HHHCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEECCC
DWQVHGFDIPLLANVQPAGAYLGERYHRAGGTPAIMWELLQAGKLDGDCHTVTGRRMAEN
CCEEECCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHH
LQGKEASDREVIRPFGEPLKERAGFLVLKGNLFDFAIMKMSVVSEDFRRRYLQEPGREGV
CCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEGKAVVFDGSEDYHKRINDPDLGIDENTILVIRGAGPLGWPGSAEVVNMQPPDHLLKRG
CCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHH
ISSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRSGDIIRINFNHGRCDMLVDETE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCEEEEECHHH
IERRKGDGIPPVPPDATPWQQIYRRSVTQLSDGAVLEGAAEFRRIAKNPPRHNH
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDSHLPKRRLRSQDWFDNPDHIDMAALYLERFMNYGITPEELRSGKPIIGIAQSGSDLT
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCC
PCNRVHVELAKRVRDGIRDAGGIPIEFPTHPIFENCKRPTAALDRNLAYLGLVEILYGYP
CHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCHHHHHCCHHHHHHHHHHHCCC
LDGVVLTTGCDKTTPSAIMAASTVDIPAIVLSGGPMLDGWHEGELAGSGTVIWRMRRKYA
CCCEEEECCCCCCCCHHHHEECCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEHHHHHHH
AGEIDREEFLQAALDSAPSVGHCNTMGTASTMNALAEALGLSLTGCGAIPAPYRERGQMA
CCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCEEECCCCCCCCHHHHCCHH
YRTGRRAVEIVFEDLKPSDILTRAAFLNAIRTNSAIGGSTNAQPHLAAMAKHAGVEIHPD
HHHCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEECCC
DWQVHGFDIPLLANVQPAGAYLGERYHRAGGTPAIMWELLQAGKLDGDCHTVTGRRMAEN
CCEEECCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEECCHHHHHHH
LQGKEASDREVIRPFGEPLKERAGFLVLKGNLFDFAIMKMSVVSEDFRRRYLQEPGREGV
CCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
FEGKAVVFDGSEDYHKRINDPDLGIDENTILVIRGAGPLGWPGSAEVVNMQPPDHLLKRG
CCCCEEEECCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHH
ISSLPTIGDGRQSGTADSPSILNASPESAAGGGLAWLRSGDIIRINFNHGRCDMLVDETE
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCEEEEECHHH
IERRKGDGIPPVPPDATPWQQIYRRSVTQLSDGAVLEGAAEFRRIAKNPPRHNH
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]