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The map label for this gene is glxR [H]

Identifier: 209550670

GI number: 209550670

Start: 3158655

End: 3159566

Strand: Reverse

Name: glxR [H]

Synonym: Rleg2_3094

Alternate gene names: 209550670

Gene position: 3159566-3158655 (Counterclockwise)

Preceding gene: 209550671

Following gene: 209550669

Centisome position: 69.63

GC content: 64.91

Gene sequence:

>912_bases
ATGACAGGTTCGAGCAGAGGTCATGATGGCAGGCGGATCGCCTTCCTCGGCACCGGGCTGATGGGGGCACCGATGGCTCG
CCGGCTGCTTGGCGCGGGTTTTGCCGTCAGCGTCTGGAATCGTGATCGCAGCAAAGCCGAGGCGCTGGCGCAAGACGGCG
CGATCTGTGCCGAAACACCCGCGGATGCCGTTTCGGGCGCCGACGTCGTCATCACCATGCTGACCAATGCCGAGGCGGTG
AAGGACGTGCTGTTCGACCGCGGAGCGGCCGATGCGATGACATCGGGGGCCACCGTGATCGATATGAGTTCGATCGCCCC
GCATTTTGCCCGCGACCATGCTGCCAGGCTTGCCGAACGCGGCATCGCTCATGTCGATGCGCCGGTTTCCGGCGGCGTCG
TCGGAGCTGATGCCGGTACGCTCGCCATCATGGCGGGCGGCGAAGAGGATGTGATCGACGCGCTTGCAGATGTCTTTGCG
CCGATGGGGCGCGTGACCCGCGTCGGCCCAAGCGGGGCGGGCCAGCTTGCCAAGCTTGCCAACCAGCAGATCGTCGCGGT
GACGATCGGCGCCGTCGCCGAAGCGATGATGCTGATTTCAGCCGGCGGCGGCTCGCCGGCAGCCTTCCGCGACGCCATTC
GCGGCGGCTTTGCCGAGAGCCGGATCCTTGACCTCCACGGCAAACGCATGGTCGAGCGGCAGTTTACCCCAGGCGGTTCG
TCCAGCAACCAGCTGAAGGATCTGAACGCCGCCATGGAGACCGCCAACGCCCTGTCGCTGACGCTGCCCCTGACTGCGAC
GGTACACGCCGAATTCACCGAATTCGTTGCAAACGGCAATGGTGAAAAGGATCATAGCGGCCTGCTCCTGCATCTCGAAG
AGAAGAATGCCCTGCCCGGAGGCAAAAGGTGA

Upstream 100 bases:

>100_bases
CGGTTCTCGCCCGTATCGTTTTCAGGCCGATGCGTCATCAAAACGGTTGCAACGATGGGTGAGGGGGTTATCAAAGACGA
ACAACAGTTGGGAGGACTGA

Downstream 100 bases:

>100_bases
CCGACAGCCATCTTCCGAAGCGGCGCCTGCGGTCGCAGGATTGGTTCGACAATCCCGACCATATCGACATGGCAGCGCTC
TATCTCGAGCGTTTCATGAA

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTGSSRGHDGRRIAFLGTGLMGAPMARRLLGAGFAVSVWNRDRSKAEALAQDGAICAETPADAVSGADVVITMLTNAEAV
KDVLFDRGAADAMTSGATVIDMSSIAPHFARDHAARLAERGIAHVDAPVSGGVVGADAGTLAIMAGGEEDVIDALADVFA
PMGRVTRVGPSGAGQLAKLANQQIVAVTIGAVAEAMMLISAGGGSPAAFRDAIRGGFAESRILDLHGKRMVERQFTPGGS
SSNQLKDLNAAMETANALSLTLPLTATVHAEFTEFVANGNGEKDHSGLLLHLEEKNALPGGKR

Sequences:

>Translated_303_residues
MTGSSRGHDGRRIAFLGTGLMGAPMARRLLGAGFAVSVWNRDRSKAEALAQDGAICAETPADAVSGADVVITMLTNAEAV
KDVLFDRGAADAMTSGATVIDMSSIAPHFARDHAARLAERGIAHVDAPVSGGVVGADAGTLAIMAGGEEDVIDALADVFA
PMGRVTRVGPSGAGQLAKLANQQIVAVTIGAVAEAMMLISAGGGSPAAFRDAIRGGFAESRILDLHGKRMVERQFTPGGS
SSNQLKDLNAAMETANALSLTLPLTATVHAEFTEFVANGNGEKDHSGLLLHLEEKNALPGGKR
>Mature_302_residues
TGSSRGHDGRRIAFLGTGLMGAPMARRLLGAGFAVSVWNRDRSKAEALAQDGAICAETPADAVSGADVVITMLTNAEAVK
DVLFDRGAADAMTSGATVIDMSSIAPHFARDHAARLAERGIAHVDAPVSGGVVGADAGTLAIMAGGEEDVIDALADVFAP
MGRVTRVGPSGAGQLAKLANQQIVAVTIGAVAEAMMLISAGGGSPAAFRDAIRGGFAESRILDLHGKRMVERQFTPGGSS
SNQLKDLNAAMETANALSLTLPLTATVHAEFTEFVANGNGEKDHSGLLLHLEEKNALPGGKR

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=28.5245901639344, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI40556376, Length=281, Percent_Identity=27.4021352313167, Blast_Score=108, Evalue=5e-24,
Organism=Escherichia coli, GI1786719, Length=284, Percent_Identity=42.2535211267606, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI145693186, Length=285, Percent_Identity=39.2982456140351, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1790315, Length=288, Percent_Identity=30.2083333333333, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789092, Length=297, Percent_Identity=31.6498316498317, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17557316, Length=192, Percent_Identity=32.2916666666667, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24655230, Length=284, Percent_Identity=32.3943661971831, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19922568, Length=284, Percent_Identity=32.3943661971831, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI28574115, Length=280, Percent_Identity=26.7857142857143, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 30992; Mature: 30860

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSSRGHDGRRIAFLGTGLMGAPMARRLLGAGFAVSVWNRDRSKAEALAQDGAICAETP
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEECCCC
ADAVSGADVVITMLTNAEAVKDVLFDRGAADAMTSGATVIDMSSIAPHFARDHAARLAER
HHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCEEEEHHHHCHHHHHHHHHHHHHC
GIAHVDAPVSGGVVGADAGTLAIMAGGEEDVIDALADVFAPMGRVTRVGPSGAGQLAKLA
CCCEECCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHC
NQQIVAVTIGAVAEAMMLISAGGGSPAAFRDAIRGGFAESRILDLHGKRMVERQFTPGGS
CCCEEEEEHHHHHHHHHHEECCCCCHHHHHHHHHCCCCHHHEEHHHHHHHHHHCCCCCCC
SSNQLKDLNAAMETANALSLTLPLTATVHAEFTEFVANGNGEKDHSGLLLHLEEKNALPG
CCHHHHHHHHHHHHCCEEEEEECEEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
GKR
CCC
>Mature Secondary Structure 
TGSSRGHDGRRIAFLGTGLMGAPMARRLLGAGFAVSVWNRDRSKAEALAQDGAICAETP
CCCCCCCCCCEEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCEECCCC
ADAVSGADVVITMLTNAEAVKDVLFDRGAADAMTSGATVIDMSSIAPHFARDHAARLAER
HHHCCCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCEEEEHHHHCHHHHHHHHHHHHHC
GIAHVDAPVSGGVVGADAGTLAIMAGGEEDVIDALADVFAPMGRVTRVGPSGAGQLAKLA
CCCEECCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHC
NQQIVAVTIGAVAEAMMLISAGGGSPAAFRDAIRGGFAESRILDLHGKRMVERQFTPGGS
CCCEEEEEHHHHHHHHHHEECCCCCHHHHHHHHHCCCCHHHEEHHHHHHHHHHCCCCCCC
SSNQLKDLNAAMETANALSLTLPLTATVHAEFTEFVANGNGEKDHSGLLLHLEEKNALPG
CCHHHHHHHHHHHHCCEEEEEECEEEEHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
GKR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]