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The map label for this gene is aqpZ2 [H]

Identifier: 209550170

GI number: 209550170

Start: 2629573

End: 2630259

Strand: Reverse

Name: aqpZ2 [H]

Synonym: Rleg2_2590

Alternate gene names: 209550170

Gene position: 2630259-2629573 (Counterclockwise)

Preceding gene: 209550172

Following gene: 209550169

Centisome position: 57.96

GC content: 63.76

Gene sequence:

>687_bases
ATGCAAAAGAGTCTTGTTGCGGAGTTTCTCGGCACGTTCTGGCTTGTCTTTGGTGGATGCGGCAGCGCCGTCCTTGCCGC
GGCCTATCCCGAATTGGGCATCGGTTTTGTCGGCGTGGCCTTTGCATTCGGCCTCACCGTGCTCACCATGGCCTATGCCG
TGGGCGGTATTTCGGGCGGTCACTTCAACCCGGCCGTCTCCCTCGGCCTGACGGTCGCCGGGCGCTTTCCTGCCGCACGC
CTGCTTCCCTATATCGGCGTCCAGCTTGTCGGCGCCGTCGCCGCGGCCGCGCTGCTTTATCTCATTGCCAGCGGCAAGGC
GGGTTTCGAACTCGGCGGCTTTGCCGCCAACGGCTATGGCGATCATTCCCCGGGCGGCTATTCGCTGCTTTCGGCACTGC
TGATCGAAGTGCTGCTGACCATGTTCTTCCTGATCATCATCCTCGGATCGACCAGCAGCCGAGTGCCGGCGGGCTTTGCG
CCGCTTGCGATCGGTCTCGGGCTGACGCTGATCCATCTCGTGTCTATCCCGGTGACAAATACCTCGGTCAATCCGGCGCG
TTCCACCGGCCAGGCGCTTTTCGTCGGCGGCTGGGCATTGCAGCAGCTCCGGCTGTTCTGGATTGCACCGCTTGCGGGCG
GGGCGCTCGGCGGTCTGGTGTGGAAGGTTCTCGACGACGCCGACTGA

Upstream 100 bases:

>100_bases
CCTTGCGCGAAGCTTGCCGCAGCATTTCTCGCCAGCTTGACCGGACTCAAATTGTGGCAGATTCACTATGAACTCTCTGG
TTGAGATATAGGAGGTGCGC

Downstream 100 bases:

>100_bases
CTGCAAGACCTGAGGCTATCCCGTTGAGCCCGCGTGGTTTTTCCATGCGGGCTTTTCCGTTTTGACAGATCGGCTGGGAG
GTTCGCCTCGGCACTTCGAA

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQKSLVAEFLGTFWLVFGGCGSAVLAAAYPELGIGFVGVAFAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRFPAAR
LLPYIGVQLVGAVAAAALLYLIASGKAGFELGGFAANGYGDHSPGGYSLLSALLIEVLLTMFFLIIILGSTSSRVPAGFA
PLAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGGWALQQLRLFWIAPLAGGALGGLVWKVLDDAD

Sequences:

>Translated_228_residues
MQKSLVAEFLGTFWLVFGGCGSAVLAAAYPELGIGFVGVAFAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRFPAAR
LLPYIGVQLVGAVAAAALLYLIASGKAGFELGGFAANGYGDHSPGGYSLLSALLIEVLLTMFFLIIILGSTSSRVPAGFA
PLAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGGWALQQLRLFWIAPLAGGALGGLVWKVLDDAD
>Mature_228_residues
MQKSLVAEFLGTFWLVFGGCGSAVLAAAYPELGIGFVGVAFAFGLTVLTMAYAVGGISGGHFNPAVSLGLTVAGRFPAAR
LLPYIGVQLVGAVAAAALLYLIASGKAGFELGGFAANGYGDHSPGGYSLLSALLIEVLLTMFFLIIILGSTSSRVPAGFA
PLAIGLGLTLIHLVSIPVTNTSVNPARSTGQALFVGGWALQQLRLFWIAPLAGGALGGLVWKVLDDAD

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=227, Percent_Identity=39.2070484581498, Blast_Score=117, Evalue=8e-27,
Organism=Homo sapiens, GI4502183, Length=221, Percent_Identity=38.0090497737557, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=36.036036036036, Blast_Score=107, Evalue=8e-24,
Organism=Homo sapiens, GI4755125, Length=219, Percent_Identity=31.5068493150685, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4502181, Length=219, Percent_Identity=31.5068493150685, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI6912506, Length=224, Percent_Identity=33.9285714285714, Blast_Score=98, Evalue=5e-21,
Organism=Homo sapiens, GI157266307, Length=241, Percent_Identity=32.7800829875519, Blast_Score=94, Evalue=8e-20,
Organism=Homo sapiens, GI86792455, Length=222, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI22538420, Length=249, Percent_Identity=30.9236947791165, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI45446752, Length=208, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=69.8564593301435, Blast_Score=283, Evalue=5e-78,
Organism=Escherichia coli, GI1790362, Length=214, Percent_Identity=31.3084112149533, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993722, Length=232, Percent_Identity=32.3275862068966, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71992966, Length=234, Percent_Identity=26.0683760683761, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558372, Length=239, Percent_Identity=28.0334728033473, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=94, Percent_Identity=38.2978723404255, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6325450, Length=234, Percent_Identity=28.2051282051282, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24652747, Length=225, Percent_Identity=36.8888888888889, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI45551084, Length=225, Percent_Identity=36.8888888888889, Blast_Score=120, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24652751, Length=227, Percent_Identity=33.4801762114537, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922038, Length=229, Percent_Identity=33.6244541484716, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136672, Length=229, Percent_Identity=29.6943231441048, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45550503, Length=230, Percent_Identity=25.6521739130435, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23169; Mature: 23169

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKSLVAEFLGTFWLVFGGCGSAVLAAAYPELGIGFVGVAFAFGLTVLTMAYAVGGISGG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLTVAGRFPAARLLPYIGVQLVGAVAAAALLYLIASGKAGFELGGFAANGYG
CCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEECCCC
DHSPGGYSLLSALLIEVLLTMFFLIIILGSTSSRVPAGFAPLAIGLGLTLIHLVSIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGGWALQQLRLFWIAPLAGGALGGLVWKVLDDAD
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MQKSLVAEFLGTFWLVFGGCGSAVLAAAYPELGIGFVGVAFAFGLTVLTMAYAVGGISGG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHCCCCCC
HFNPAVSLGLTVAGRFPAARLLPYIGVQLVGAVAAAALLYLIASGKAGFELGGFAANGYG
CCCHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEECCCC
DHSPGGYSLLSALLIEVLLTMFFLIIILGSTSSRVPAGFAPLAIGLGLTLIHLVSIPVTN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTGQALFVGGWALQQLRLFWIAPLAGGALGGLVWKVLDDAD
CCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]