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The map label for this gene is ttcA [H]

Identifier: 209549539

GI number: 209549539

Start: 1988669

End: 1989541

Strand: Reverse

Name: ttcA [H]

Synonym: Rleg2_1945

Alternate gene names: 209549539

Gene position: 1989541-1988669 (Counterclockwise)

Preceding gene: 209549540

Following gene: 209549538

Centisome position: 43.84

GC content: 59.91

Gene sequence:

>873_bases
ATGAATATCGCAGCCAATATTGCGGATGATCTGGAAAGCGGCGACGCCAACGGCAGCGTCGGCCATGCGCTTTTTGCGGA
TGCTCCGCGTTCGGTCTCCTTCAACAAGCTGCGCAAACGGCTGCTCAGGCAGGTGCGCCAGGCCTTCGACGATTTCGATA
TGCTGAAGGGGCAGAAGCGCTGGCTGGTCGGCCTTTCCGGCGGCAAGGATTCCTACGGGCTGCTGGCGCTGCTGCTCGAT
CTGCAATGGCGCGGGCTGCTACCGGTCGAGCTGATTGCCTGCAATCTCGACCAGGGGCAGCCGAACTTTCCAAAACATGT
ATTGCCGGATTATCTGACCAAAATCGGCGTGCAGCATCGGATCGAATACCGGGATACCTATTCGATCGTGAAGGAGAAGG
TGCCGGAGGGGGCGACCTATTGCTCGCTCTGTTCGCGGCTGCGGCGTGGCAATCTTTACCGCGTCGCCCGGGAAGAGGGC
TGCGATGCTCTGGTGCTCGGCCACCACCGCGAGGACATTCTCGAAACCTTCTTCATGAATTTCTTCCACGGCGGGCGGCT
TGCCTCCATGCCGGCGAAGCTTCTGAACGACGAGGGTGACCTGATGGTGCTGCGGCCGCTTGCCTATGCCGCCGAGGACG
ACCTCGCAAAGTTTGCCGCCGCCATGCTGTTTCCGATCATCCCCTGCGATCTTTGCGGCTCGCAGGACGGGCTGCAGCGC
AATGCGATGAAGGATATGCTTGCCGATATCGAGCGGCGCATGCCGGGACGCAAGGATACGATGCTGCGGGCGCTTTCGCA
TGTGAACCCATCGCATCTGCTCGATCCGAAACTCTTCGACTTTTCCACCCTTGGTGTCACCGATCCTTCATGA

Upstream 100 bases:

>100_bases
AATGCTGGCGGCGCGCACCGGCTGGTCGGTTTTCGGCGATTGACGCTGTGTTGGCGAACTCGTTTCTGCTAAGGCAGACA
GACCTCGATAGGACGACGCA

Downstream 100 bases:

>100_bases
AAGTCCGGCTAAGCAGCTGGCTATTGCATGAAGCGCAGGAATTCGCATGACCATTTCAGATCAGGATATTCTCTTTCTCG
GCGATTGCGTGAAGGAGGCG

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MNIAANIADDLESGDANGSVGHALFADAPRSVSFNKLRKRLLRQVRQAFDDFDMLKGQKRWLVGLSGGKDSYGLLALLLD
LQWRGLLPVELIACNLDQGQPNFPKHVLPDYLTKIGVQHRIEYRDTYSIVKEKVPEGATYCSLCSRLRRGNLYRVAREEG
CDALVLGHHREDILETFFMNFFHGGRLASMPAKLLNDEGDLMVLRPLAYAAEDDLAKFAAAMLFPIIPCDLCGSQDGLQR
NAMKDMLADIERRMPGRKDTMLRALSHVNPSHLLDPKLFDFSTLGVTDPS

Sequences:

>Translated_290_residues
MNIAANIADDLESGDANGSVGHALFADAPRSVSFNKLRKRLLRQVRQAFDDFDMLKGQKRWLVGLSGGKDSYGLLALLLD
LQWRGLLPVELIACNLDQGQPNFPKHVLPDYLTKIGVQHRIEYRDTYSIVKEKVPEGATYCSLCSRLRRGNLYRVAREEG
CDALVLGHHREDILETFFMNFFHGGRLASMPAKLLNDEGDLMVLRPLAYAAEDDLAKFAAAMLFPIIPCDLCGSQDGLQR
NAMKDMLADIERRMPGRKDTMLRALSHVNPSHLLDPKLFDFSTLGVTDPS
>Mature_290_residues
MNIAANIADDLESGDANGSVGHALFADAPRSVSFNKLRKRLLRQVRQAFDDFDMLKGQKRWLVGLSGGKDSYGLLALLLD
LQWRGLLPVELIACNLDQGQPNFPKHVLPDYLTKIGVQHRIEYRDTYSIVKEKVPEGATYCSLCSRLRRGNLYRVAREEG
CDALVLGHHREDILETFFMNFFHGGRLASMPAKLLNDEGDLMVLRPLAYAAEDDLAKFAAAMLFPIIPCDLCGSQDGLQR
NAMKDMLADIERRMPGRKDTMLRALSHVNPSHLLDPKLFDFSTLGVTDPS

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) [H]

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family [H]

Homologues:

Organism=Escherichia coli, GI1787606, Length=258, Percent_Identity=55.0387596899225, Blast_Score=295, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI193211090, Length=231, Percent_Identity=30.3030303030303, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17540090, Length=185, Percent_Identity=29.1891891891892, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063 [H]

Pfam domain/function: PF01171 ATP_bind_3 [H]

EC number: NA

Molecular weight: Translated: 32446; Mature: 32446

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIAANIADDLESGDANGSVGHALFADAPRSVSFNKLRKRLLRQVRQAFDDFDMLKGQKR
CCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
WLVGLSGGKDSYGLLALLLDLQWRGLLPVELIACNLDQGQPNFPKHVLPDYLTKIGVQHR
EEEEECCCCCHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHH
IEYRDTYSIVKEKVPEGATYCSLCSRLRRGNLYRVAREEGCDALVLGHHREDILETFFMN
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHHCCCCEEEECCCHHHHHHHHHHH
FFHGGRLASMPAKLLNDEGDLMVLRPLAYAAEDDLAKFAAAMLFPIIPCDLCGSQDGLQR
HHCCCCHHHCCHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHH
NAMKDMLADIERRMPGRKDTMLRALSHVNPSHLLDPKLFDFSTLGVTDPS
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCEECCCCCCC
>Mature Secondary Structure
MNIAANIADDLESGDANGSVGHALFADAPRSVSFNKLRKRLLRQVRQAFDDFDMLKGQKR
CCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
WLVGLSGGKDSYGLLALLLDLQWRGLLPVELIACNLDQGQPNFPKHVLPDYLTKIGVQHR
EEEEECCCCCHHHHHHHHHHHHCCCCCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHH
IEYRDTYSIVKEKVPEGATYCSLCSRLRRGNLYRVAREEGCDALVLGHHREDILETFFMN
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEHHHCCCCEEEECCCHHHHHHHHHHH
FFHGGRLASMPAKLLNDEGDLMVLRPLAYAAEDDLAKFAAAMLFPIIPCDLCGSQDGLQR
HHCCCCHHHCCHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHH
NAMKDMLADIERRMPGRKDTMLRALSHVNPSHLLDPKLFDFSTLGVTDPS
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA