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The map label for this gene is moeA [H]

Identifier: 209549418

GI number: 209549418

Start: 1870425

End: 1871648

Strand: Direct

Name: moeA [H]

Synonym: Rleg2_1824

Alternate gene names: 209549418

Gene position: 1870425-1871648 (Clockwise)

Preceding gene: 209549417

Following gene: 209549424

Centisome position: 41.22

GC content: 67.08

Gene sequence:

>1224_bases
ATGAACCTTCTCCCGGTCGCAGAGGCCTTAAGCCGGCTGCTCTCCCGCGCAACGCCCGTCGCGGCATCCGAGACATTGCC
GCTCGCCGAGGCTGAAGGCCGCGTCCTGGCCGTCGATCTCAAGTCCGGGATAACCCAGCCTCCCTTCGATGCCTCGGCCA
TGGATGGCTATGCGCTGCGCCGCGACGATGCGCCGGAGCCGGGCGCCGTGCTGAAGGTCATCGGCACGTCTGCCGCCGGC
CACGGCTTCGAAGGAAGCGTCGGCAAGGGTGAGGCCGTCCGCATCTTCACCGGCGCGCCCGTTCCGGCAGGCGCCGACAG
CGTGCTGCTGCAGGAGGATGCAGAGAAGATCGAAGACGGCGTCCGCACCAATTTCCCCGTGCGGCAGGGCCAGCATGTAC
GTCCCCGCGGCCAGGATTTTACCGAAGGCGAAGCCGTGCTCGCGGCCGGCACCGTGCTCGATTTCTCGCGCCTGACGGTC
GCTGCCGGCATGAACCGGCCCGATGTCGAGGTCCTCAAACGCCCGCTGATTGCCATTCTCGCAACCGGCGACGAACTGCT
GCCGCCCGGAAGCACGCCCGGCCCTTCGCAGATCATCGCTTCCAATACCTTCGGCATCGCAGCCCTTGCCCGCAAAGCCG
GCGCCGACGTTCTCGATCTCGGCATCGTCCCGGACGATAAGGTGAGGATTACCGCGGCGATCGATACGGCGCGGGCCGCT
GAGGCCGATGTCATCGTCACGCTCGGCGGCGCTTCGGTCGGCGACCATGATCTGGTGCAGGCGACGTTGATCGAGGCCGG
CATGCAGCTGGATTTCTGGCGCATCGCCATGCGGCCCGGCAAACCGCTGATGGTGGGCAGCTTCGGCGAGACCCATGTGC
TCGGCCTGCCCGGCAATCCGGTCTCGAGCCTCGTCTGCTCGCTGCTCTTCCTGGAACCGCTGATCCGCAAGCTCGCTTCC
CTGCCGCCGGTGCGGCGCGAGGCAATGGTGGGGGCAGCCACCCCACTGCGCGCCAACGACCACCGCCAGGACTATATCAG
GGCGAAACTGTCGAAGTCCGCCGCCGGAACCTGGCTCGCCGAGGCCTTCGGCAAGCAGGATTCCTCGATGATGAAAGTGT
TTGCCCAGGCCGATTGCCTCATCATCCGCCCGCCACATGCGCCGGAACTGCCGGCCGGAGCGCCCTGCCCGGTCATGCTG
TTGCGGCCGGATCTTTTGGCATAG

Upstream 100 bases:

>100_bases
ACATGGCCAAGGCCGCCGATAAGGCAATGGAGATCGGCGGCGTCAGGCTGCTCGAAAAATCCGGCGGCAAGTCGGGCGAT
TTCCGTCATCCGGAGGCGAG

Downstream 100 bases:

>100_bases
TTCCGACTTTCCAACTGCTTCAGGAAAGCGAAAACACGCCCGCCTGCACCATTCCGCCGCTGGACCCCGCGCCAAATTCC
GCAACCGCATGCGTCGCGAT

Product: molybdenum cofactor synthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNLLPVAEALSRLLSRATPVAASETLPLAEAEGRVLAVDLKSGITQPPFDASAMDGYALRRDDAPEPGAVLKVIGTSAAG
HGFEGSVGKGEAVRIFTGAPVPAGADSVLLQEDAEKIEDGVRTNFPVRQGQHVRPRGQDFTEGEAVLAAGTVLDFSRLTV
AAGMNRPDVEVLKRPLIAILATGDELLPPGSTPGPSQIIASNTFGIAALARKAGADVLDLGIVPDDKVRITAAIDTARAA
EADVIVTLGGASVGDHDLVQATLIEAGMQLDFWRIAMRPGKPLMVGSFGETHVLGLPGNPVSSLVCSLLFLEPLIRKLAS
LPPVRREAMVGAATPLRANDHRQDYIRAKLSKSAAGTWLAEAFGKQDSSMMKVFAQADCLIIRPPHAPELPAGAPCPVML
LRPDLLA

Sequences:

>Translated_407_residues
MNLLPVAEALSRLLSRATPVAASETLPLAEAEGRVLAVDLKSGITQPPFDASAMDGYALRRDDAPEPGAVLKVIGTSAAG
HGFEGSVGKGEAVRIFTGAPVPAGADSVLLQEDAEKIEDGVRTNFPVRQGQHVRPRGQDFTEGEAVLAAGTVLDFSRLTV
AAGMNRPDVEVLKRPLIAILATGDELLPPGSTPGPSQIIASNTFGIAALARKAGADVLDLGIVPDDKVRITAAIDTARAA
EADVIVTLGGASVGDHDLVQATLIEAGMQLDFWRIAMRPGKPLMVGSFGETHVLGLPGNPVSSLVCSLLFLEPLIRKLAS
LPPVRREAMVGAATPLRANDHRQDYIRAKLSKSAAGTWLAEAFGKQDSSMMKVFAQADCLIIRPPHAPELPAGAPCPVML
LRPDLLA
>Mature_407_residues
MNLLPVAEALSRLLSRATPVAASETLPLAEAEGRVLAVDLKSGITQPPFDASAMDGYALRRDDAPEPGAVLKVIGTSAAG
HGFEGSVGKGEAVRIFTGAPVPAGADSVLLQEDAEKIEDGVRTNFPVRQGQHVRPRGQDFTEGEAVLAAGTVLDFSRLTV
AAGMNRPDVEVLKRPLIAILATGDELLPPGSTPGPSQIIASNTFGIAALARKAGADVLDLGIVPDDKVRITAAIDTARAA
EADVIVTLGGASVGDHDLVQATLIEAGMQLDFWRIAMRPGKPLMVGSFGETHVLGLPGNPVSSLVCSLLFLEPLIRKLAS
LPPVRREAMVGAATPLRANDHRQDYIRAKLSKSAAGTWLAEAFGKQDSSMMKVFAQADCLIIRPPHAPELPAGAPCPVML
LRPDLLA

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=407, Percent_Identity=34.6437346437346, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI10880983, Length=407, Percent_Identity=34.6437346437346, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=38.8020833333333, Blast_Score=254, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI25147659, Length=364, Percent_Identity=30.2197802197802, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=341, Percent_Identity=25.5131964809384, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17136978, Length=422, Percent_Identity=29.3838862559242, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24638841, Length=422, Percent_Identity=29.3838862559242, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42539; Mature: 42539

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLPVAEALSRLLSRATPVAASETLPLAEAEGRVLAVDLKSGITQPPFDASAMDGYALR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEC
RDDAPEPGAVLKVIGTSAAGHGFEGSVGKGEAVRIFTGAPVPAGADSVLLQEDAEKIEDG
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
VRTNFPVRQGQHVRPRGQDFTEGEAVLAAGTVLDFSRLTVAAGMNRPDVEVLKRPLIAIL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCCEEEE
ATGDELLPPGSTPGPSQIIASNTFGIAALARKAGADVLDLGIVPDDKVRITAAIDTARAA
ECCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCC
EADVIVTLGGASVGDHDLVQATLIEAGMQLDFWRIAMRPGKPLMVGSFGETHVLGLPGNP
CCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VSSLVCSLLFLEPLIRKLASLPPVRREAMVGAATPLRANDHRQDYIRAKLSKSAAGTWLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHH
EAFGKQDSSMMKVFAQADCLIIRPPHAPELPAGAPCPVMLLRPDLLA
HHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECCHHCC
>Mature Secondary Structure
MNLLPVAEALSRLLSRATPVAASETLPLAEAEGRVLAVDLKSGITQPPFDASAMDGYALR
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEHHCCCCCCCCCCCCCCCEEEC
RDDAPEPGAVLKVIGTSAAGHGFEGSVGKGEAVRIFTGAPVPAGADSVLLQEDAEKIEDG
CCCCCCCCCEEEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHC
VRTNFPVRQGQHVRPRGQDFTEGEAVLAAGTVLDFSRLTVAAGMNRPDVEVLKRPLIAIL
CCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHCCCEEEE
ATGDELLPPGSTPGPSQIIASNTFGIAALARKAGADVLDLGIVPDDKVRITAAIDTARAA
ECCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCEEEECCCCCCCEEEEEEECCCCCC
EADVIVTLGGASVGDHDLVQATLIEAGMQLDFWRIAMRPGKPLMVGSFGETHVLGLPGNP
CCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCEEEEECCCCH
VSSLVCSLLFLEPLIRKLASLPPVRREAMVGAATPLRANDHRQDYIRAKLSKSAAGTWLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHH
EAFGKQDSSMMKVFAQADCLIIRPPHAPELPAGAPCPVMLLRPDLLA
HHHCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEEECCHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]