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The map label for this gene is mco [H]

Identifier: 209548706

GI number: 209548706

Start: 1125760

End: 1127151

Strand: Reverse

Name: mco [H]

Synonym: Rleg2_1103

Alternate gene names: 209548706

Gene position: 1127151-1125760 (Counterclockwise)

Preceding gene: 209548708

Following gene: 209548705

Centisome position: 24.84

GC content: 64.44

Gene sequence:

>1392_bases
ATGCCCCTCCTGACCCGTCGCAATCTTCTCAAGGCATCCGCCGTGGCGGGCGCCTATGGCGTCGGCCTCGGCATTGCCGG
CAAATTCGGGCCTGCCGAGGCGGCTCCCGAGCCGCAGTTGCTGACGGCTGTCAAGACCGAGGCGATGCTGACCGAGATCG
GACCGACCCGGGAGATCATGAGCTGGGGCCATGACGGCATGCCGCCGGTTCTCAGGATGACGAAGGGACGCCCCTATGCG
GCGCGGCTGAAAAACGGGCTCGACGAGCCGACGACGATCCACTGGCATGGGCTTCGCATCGATAACCGCATGGACGGCGT
GCCCTTCATGACGCAGCCCTATGTCTATACCGGCGACAGCTTCGACTATGCCTTCACGCCGCCGGATGCCGGCACCTTCT
GGTATCATCCGCATTGCAATACGCTGACGCAGATGGGGCACGGCATGACCGGGGTCCTCGTCGTCGAAGATCCGGCCGAC
CCTGAATTCGATGCTGAGGTTGTCCTGAACCTGCGCGACTGGCGGCTCGGCGGCGACGGACAGTTCATCGCCCCTTTCCG
GCCGCGTGACGCCGCGAAGTCGGGCACCTACGGCACGGTGCGCACCGCCAACTGGCATCGGGAGCCGCAATATGACGCGC
CGGCCGGCGGGTTGGTCCGGCTGCGCATCGCGGTCACCGACGTGACGCGGATCTTCTCGCTGAAGGTTGAAGGCGCCGAT
ACGACCGTCATCGCCATCGACGGCAATCCGGTGCCGAAGCGTTTTCCCCTCGACCTGCTGCAGATCGGTCCGGGCCAGCG
GCTCGATCTTGCCGTGCGCATGCCGGATAGAGAAGGCGCTGTCGCGACGCTCGAGGATATCCGCGGCACGACACCGAAGA
CGATCGCCAGCCTGCGTGCCACCGGATCGTCGCTGAAGCGTGAGATCGGCGATCTCGCGCCGCTTGCCGAAAATCCGGTG
GCGAAGGCCGATCTTTCCGCCGCCGAAGAGATCCCGCTGGTGCTGAGCGCCACGGCCGAAAATACCGCCACTGACAGCAT
CTGCGGCACACTCGGCTACAGCTTCTGGGCCATCAACAAGGTGCCGTGGCCGGGCGACACGCCCGATCCGACGGCGCCGC
TGGCGGAACTGAAGCTCGGCAAGAGCTATGTCTTCAATCTGGAGAATACGACGCCGCACGCGCATCCGATCCATCTGCAC
GGGATGAGCTTTACGGTGATCTCCTCTTCGACGCGGCAGGTGATGCCGCTCGTCTCCGATACCTATCTCATCCAGCCGGA
CGAGAAGGTGCAGCTCGCCTTCGTCGCCGACAATCCCGGCGACTGGCTGCTGCATTGCCATATCATCGAGCACCAGAAGA
CCGGAATGACCAGCTACCTCAGAGTGAGCTGA

Upstream 100 bases:

>100_bases
CAGCGGCCCGTATGCTGCGGCAGTTTGGCCGCGCTTCCCGTATTGATGAAGAAGCTGGTCAACTTTAAAAGGATCGGCAT
TCTCACTGTGGAGCGCCCGC

Downstream 100 bases:

>100_bases
GGCGGCCTGTGCCGCAGTTTGGACGTAATTCTTCGCCAGCAATGCGCGAAGCTTATGCTGTTGTATTGACATATCGAAGC
GAAAGGAGAAGGAAGGTTCA

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MPLLTRRNLLKASAVAGAYGVGLGIAGKFGPAEAAPEPQLLTAVKTEAMLTEIGPTREIMSWGHDGMPPVLRMTKGRPYA
ARLKNGLDEPTTIHWHGLRIDNRMDGVPFMTQPYVYTGDSFDYAFTPPDAGTFWYHPHCNTLTQMGHGMTGVLVVEDPAD
PEFDAEVVLNLRDWRLGGDGQFIAPFRPRDAAKSGTYGTVRTANWHREPQYDAPAGGLVRLRIAVTDVTRIFSLKVEGAD
TTVIAIDGNPVPKRFPLDLLQIGPGQRLDLAVRMPDREGAVATLEDIRGTTPKTIASLRATGSSLKREIGDLAPLAENPV
AKADLSAAEEIPLVLSATAENTATDSICGTLGYSFWAINKVPWPGDTPDPTAPLAELKLGKSYVFNLENTTPHAHPIHLH
GMSFTVISSSTRQVMPLVSDTYLIQPDEKVQLAFVADNPGDWLLHCHIIEHQKTGMTSYLRVS

Sequences:

>Translated_463_residues
MPLLTRRNLLKASAVAGAYGVGLGIAGKFGPAEAAPEPQLLTAVKTEAMLTEIGPTREIMSWGHDGMPPVLRMTKGRPYA
ARLKNGLDEPTTIHWHGLRIDNRMDGVPFMTQPYVYTGDSFDYAFTPPDAGTFWYHPHCNTLTQMGHGMTGVLVVEDPAD
PEFDAEVVLNLRDWRLGGDGQFIAPFRPRDAAKSGTYGTVRTANWHREPQYDAPAGGLVRLRIAVTDVTRIFSLKVEGAD
TTVIAIDGNPVPKRFPLDLLQIGPGQRLDLAVRMPDREGAVATLEDIRGTTPKTIASLRATGSSLKREIGDLAPLAENPV
AKADLSAAEEIPLVLSATAENTATDSICGTLGYSFWAINKVPWPGDTPDPTAPLAELKLGKSYVFNLENTTPHAHPIHLH
GMSFTVISSSTRQVMPLVSDTYLIQPDEKVQLAFVADNPGDWLLHCHIIEHQKTGMTSYLRVS
>Mature_462_residues
PLLTRRNLLKASAVAGAYGVGLGIAGKFGPAEAAPEPQLLTAVKTEAMLTEIGPTREIMSWGHDGMPPVLRMTKGRPYAA
RLKNGLDEPTTIHWHGLRIDNRMDGVPFMTQPYVYTGDSFDYAFTPPDAGTFWYHPHCNTLTQMGHGMTGVLVVEDPADP
EFDAEVVLNLRDWRLGGDGQFIAPFRPRDAAKSGTYGTVRTANWHREPQYDAPAGGLVRLRIAVTDVTRIFSLKVEGADT
TVIAIDGNPVPKRFPLDLLQIGPGQRLDLAVRMPDREGAVATLEDIRGTTPKTIASLRATGSSLKREIGDLAPLAENPVA
KADLSAAEEIPLVLSATAENTATDSICGTLGYSFWAINKVPWPGDTPDPTAPLAELKLGKSYVFNLENTTPHAHPIHLHG
MSFTVISSSTRQVMPLVSDTYLIQPDEKVQLAFVADNPGDWLLHCHIIEHQKTGMTSYLRVS

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=531, Percent_Identity=25.0470809792844, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321067, Length=468, Percent_Identity=23.9316239316239, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6323703, Length=450, Percent_Identity=26, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6320714, Length=460, Percent_Identity=21.7391304347826, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI18859919, Length=490, Percent_Identity=24.0816326530612, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 50369; Mature: 50238

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLTRRNLLKASAVAGAYGVGLGIAGKFGPAEAAPEPQLLTAVKTEAMLTEIGPTREIM
CCCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
SWGHDGMPPVLRMTKGRPYAARLKNGLDEPTTIHWHGLRIDNRMDGVPFMTQPYVYTGDS
HCCCCCCCHHHEECCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEECCEEEECCC
FDYAFTPPDAGTFWYHPHCNTLTQMGHGMTGVLVVEDPADPEFDAEVVLNLRDWRLGGDG
CCEEECCCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCC
QFIAPFRPRDAAKSGTYGTVRTANWHREPQYDAPAGGLVRLRIAVTDVTRIFSLKVEGAD
CEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEECCCC
TTVIAIDGNPVPKRFPLDLLQIGPGQRLDLAVRMPDREGAVATLEDIRGTTPKTIASLRA
EEEEEECCCCCCCCCCCHHEECCCCCCEEEEEECCCCCCCEEEHHHHCCCCHHHHHHHHH
TGSSLKREIGDLAPLAENPVAKADLSAAEEIPLVLSATAENTATDSICGTLGYSFWAINK
HHHHHHHHHHHHCCCCCCCCCHHCCCHHCCCCEEEEECCCCCCHHHHHHHHCCEEEEECC
VPWPGDTPDPTAPLAELKLGKSYVFNLENTTPHAHPIHLHGMSFTVISSSTRQVMPLVSD
CCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCEEEECCEEEEEEECCCCEEEEEECC
TYLIQPDEKVQLAFVADNPGDWLLHCHIIEHQKTGMTSYLRVS
EEEECCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEC
>Mature Secondary Structure 
PLLTRRNLLKASAVAGAYGVGLGIAGKFGPAEAAPEPQLLTAVKTEAMLTEIGPTREIM
CCCCHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHH
SWGHDGMPPVLRMTKGRPYAARLKNGLDEPTTIHWHGLRIDNRMDGVPFMTQPYVYTGDS
HCCCCCCCHHHEECCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCEECCEEEECCC
FDYAFTPPDAGTFWYHPHCNTLTQMGHGMTGVLVVEDPADPEFDAEVVLNLRDWRLGGDG
CCEEECCCCCCEEEECCCCHHHHHHCCCCEEEEEEECCCCCCCCCEEEEEEEEEEECCCC
QFIAPFRPRDAAKSGTYGTVRTANWHREPQYDAPAGGLVRLRIAVTDVTRIFSLKVEGAD
CEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEEEEEEEEEEEECCCC
TTVIAIDGNPVPKRFPLDLLQIGPGQRLDLAVRMPDREGAVATLEDIRGTTPKTIASLRA
EEEEEECCCCCCCCCCCHHEECCCCCCEEEEEECCCCCCCEEEHHHHCCCCHHHHHHHHH
TGSSLKREIGDLAPLAENPVAKADLSAAEEIPLVLSATAENTATDSICGTLGYSFWAINK
HHHHHHHHHHHHCCCCCCCCCHHCCCHHCCCCEEEEECCCCCCHHHHHHHHCCEEEEECC
VPWPGDTPDPTAPLAELKLGKSYVFNLENTTPHAHPIHLHGMSFTVISSSTRQVMPLVSD
CCCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCEEEECCEEEEEEECCCCEEEEEECC
TYLIQPDEKVQLAFVADNPGDWLLHCHIIEHQKTGMTSYLRVS
EEEECCCCCEEEEEEECCCCCEEEEEEEEECCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]