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The map label for this gene is rnd [H]

Identifier: 209548705

GI number: 209548705

Start: 1124485

End: 1125630

Strand: Reverse

Name: rnd [H]

Synonym: Rleg2_1102

Alternate gene names: 209548705

Gene position: 1125630-1124485 (Counterclockwise)

Preceding gene: 209548706

Following gene: 209548704

Centisome position: 24.8

GC content: 64.22

Gene sequence:

>1146_bases
ATGATCGAAACCACCGCCGATTTGGCGGCCGCCTGCAAAGAGCTGGCCAAGTCCGACTTCATCACCATCGACACCGAATT
CCTGCGCGAGACGACCTTCTGGCCGGAGCTTTGCCTGATCCAGATGGCAAGCCCGACGACCGAAGTGCTCGTCGATCCGC
TGGCCAAGGGCATCGATCTCGCCCCCTTCTTCGAGCTGATGGCCGATCCGAAGGTGCTGAAGGTCTTTCACGCGGCCCGT
CAGGATATCGAAATCATCTTCAATCGCGGCAATCTCATTCCGCATCCGATCTTCGACACACAGGTCGCCGCCATGGTCTG
CGGCTTCGGCGACAGCGTCTCCTATGACCAGCTGGTCAGCCGCATCAAGAACGTCCACATCGACAAGTCGTCGCGCTTCA
CCGACTGGAGCCGCCGGCCGCTCTCCGACAAGCAGCTGGAATATGCGCTGGCCGACGTCACCCACCTGCGCGACGTCTAT
CTGTCGCTGAAGGCGGAACTCGATCGTGAAGGCCGCACCTCCTGGCTCTCCGAGGAGATGGACATTCTCGAGGCGCGCGA
AACCTACGACCTGCATCCCGACGATGCCTGGCAGCGGCTGAAGATGCGCCTGCGCAAGCCGCAGGAGCTGGCGATCCTGA
AATTTGTCGCCGCCTGGCGCGAACGCGAGGCGCGGTCGCGCAACGTGCCGCGTTCACGGGTGCTGAAGGACGATGCGATC
TACGAGATCGCCCAGCAGCAGCCCAAGGATACCGAGGCGCTCGGCCGGTTGCGCACCATTCCGAAAGGCTGGGAGCGCTC
GACCTCCGGCGGCGCCGTCATCGAGGCCGTCAACGCCGCGCTCGCTCTTCCGAAAGCCGATATGCCACATGTGCCGCGCC
AGGCGCAGGCGCCCGAAGGGGCCGCCGCCGCCGTCGAATTGCTGAAGGTGCTCTTGAAGCTGATTTCGGAGAAACACGGC
GTGGCGCCGAAGGTGATCGCCAACAGCGAGGATCTCGACCGGATCGCCGCCGAGGGCGAGAAGGCCGAAGTCGCCGCCCT
GAACGGCTGGCGGCGCGACCTTTTCGGCGAGCCGGCGCTGCAGCTGATCCAGGGTCAGATCGCTCTGCGCTTCGTCGGCC
GCAAGGTCGAAACCGTCAGCCTCTAG

Upstream 100 bases:

>100_bases
TCTTCGCCAGCAATGCGCGAAGCTTATGCTGTTGTATTGACATATCGAAGCGAAAGGAGAAGGAAGGTTCAACCGACCTT
TTCCTTGCGAATGAAATGAT

Downstream 100 bases:

>100_bases
GTTCAAGTGTTGCAGCGCCTTTGCGCGTGCGCGCGGCGTTGTAAGACGACAATCGAATTCGCTTGACGCTTTTTTCCCAG
CTGAAACAATGGCTGACGGC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIETTADLAAACKELAKSDFITIDTEFLRETTFWPELCLIQMASPTTEVLVDPLAKGIDLAPFFELMADPKVLKVFHAAR
QDIEIIFNRGNLIPHPIFDTQVAAMVCGFGDSVSYDQLVSRIKNVHIDKSSRFTDWSRRPLSDKQLEYALADVTHLRDVY
LSLKAELDREGRTSWLSEEMDILEARETYDLHPDDAWQRLKMRLRKPQELAILKFVAAWREREARSRNVPRSRVLKDDAI
YEIAQQQPKDTEALGRLRTIPKGWERSTSGGAVIEAVNAALALPKADMPHVPRQAQAPEGAAAAVELLKVLLKLISEKHG
VAPKVIANSEDLDRIAAEGEKAEVAALNGWRRDLFGEPALQLIQGQIALRFVGRKVETVSL

Sequences:

>Translated_381_residues
MIETTADLAAACKELAKSDFITIDTEFLRETTFWPELCLIQMASPTTEVLVDPLAKGIDLAPFFELMADPKVLKVFHAAR
QDIEIIFNRGNLIPHPIFDTQVAAMVCGFGDSVSYDQLVSRIKNVHIDKSSRFTDWSRRPLSDKQLEYALADVTHLRDVY
LSLKAELDREGRTSWLSEEMDILEARETYDLHPDDAWQRLKMRLRKPQELAILKFVAAWREREARSRNVPRSRVLKDDAI
YEIAQQQPKDTEALGRLRTIPKGWERSTSGGAVIEAVNAALALPKADMPHVPRQAQAPEGAAAAVELLKVLLKLISEKHG
VAPKVIANSEDLDRIAAEGEKAEVAALNGWRRDLFGEPALQLIQGQIALRFVGRKVETVSL
>Mature_381_residues
MIETTADLAAACKELAKSDFITIDTEFLRETTFWPELCLIQMASPTTEVLVDPLAKGIDLAPFFELMADPKVLKVFHAAR
QDIEIIFNRGNLIPHPIFDTQVAAMVCGFGDSVSYDQLVSRIKNVHIDKSSRFTDWSRRPLSDKQLEYALADVTHLRDVY
LSLKAELDREGRTSWLSEEMDILEARETYDLHPDDAWQRLKMRLRKPQELAILKFVAAWREREARSRNVPRSRVLKDDAI
YEIAQQQPKDTEALGRLRTIPKGWERSTSGGAVIEAVNAALALPKADMPHVPRQAQAPEGAAAAVELLKVLLKLISEKHG
VAPKVIANSEDLDRIAAEGEKAEVAALNGWRRDLFGEPALQLIQGQIALRFVGRKVETVSL

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=252, Percent_Identity=26.984126984127, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI50301240, Length=252, Percent_Identity=26.984126984127, Blast_Score=92, Evalue=7e-19,
Organism=Escherichia coli, GI1788105, Length=375, Percent_Identity=30.1333333333333, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17531757, Length=257, Percent_Identity=26.0700389105058, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=167, Percent_Identity=28.7425149700599, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078302, Length=263, Percent_Identity=26.2357414448669, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 42767; Mature: 42767

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETTADLAAACKELAKSDFITIDTEFLRETTFWPELCLIQMASPTTEVLVDPLAKGIDL
CCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCH
APFFELMADPKVLKVFHAARQDIEIIFNRGNLIPHPIFDTQVAAMVCGFGDSVSYDQLVS
HHHHHHHCCHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
RIKNVHIDKSSRFTDWSRRPLSDKQLEYALADVTHLRDVYLSLKAELDREGRTSWLSEEM
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DILEARETYDLHPDDAWQRLKMRLRKPQELAILKFVAAWREREARSRNVPRSRVLKDDAI
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YEIAQQQPKDTEALGRLRTIPKGWERSTSGGAVIEAVNAALALPKADMPHVPRQAQAPEG
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
AAAAVELLKVLLKLISEKHGVAPKVIANSEDLDRIAAEGEKAEVAALNGWRRDLFGEPAL
HHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHCCHHHHHCCCHHH
QLIQGQIALRFVGRKVETVSL
HHHHHHHHHHHHCCCHHEECC
>Mature Secondary Structure
MIETTADLAAACKELAKSDFITIDTEFLRETTFWPELCLIQMASPTTEVLVDPLAKGIDL
CCCCHHHHHHHHHHHHHCCEEEEEHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCCH
APFFELMADPKVLKVFHAARQDIEIIFNRGNLIPHPIFDTQVAAMVCGFGDSVSYDQLVS
HHHHHHHCCHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
RIKNVHIDKSSRFTDWSRRPLSDKQLEYALADVTHLRDVYLSLKAELDREGRTSWLSEEM
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
DILEARETYDLHPDDAWQRLKMRLRKPQELAILKFVAAWREREARSRNVPRSRVLKDDAI
HHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
YEIAQQQPKDTEALGRLRTIPKGWERSTSGGAVIEAVNAALALPKADMPHVPRQAQAPEG
HHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
AAAAVELLKVLLKLISEKHGVAPKVIANSEDLDRIAAEGEKAEVAALNGWRRDLFGEPAL
HHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHCCCCCHHHHHCCHHHHHCCCHHH
QLIQGQIALRFVGRKVETVSL
HHHHHHHHHHHHCCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]