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The map label for this gene is rnc [H]

Identifier: 209548601

GI number: 209548601

Start: 1020678

End: 1021397

Strand: Direct

Name: rnc [H]

Synonym: Rleg2_0998

Alternate gene names: 209548601

Gene position: 1020678-1021397 (Clockwise)

Preceding gene: 209548600

Following gene: 209548602

Centisome position: 22.49

GC content: 62.64

Gene sequence:

>720_bases
ATGAGCAAGGCGCAGACGCTTTCTGCGGCAGACCGCGCAAAGCTTGAAGGCCTGATCGGTCACGACTTCGCCGAAAAGGA
ACGCCTGGACCGGGCGCTGACCCACGCTAGCGCCCGCACCGAGAAGGGCGGCAATTACGAACGGCTGGAATTCCTCGGCG
ACAGGGTTCTCGGGCTCTGCATCGCCGAGCTTCTGTTCCGCACCTTCGGCACGGCGGGGGAAGGCGAACTCTCGGTTCGC
CTCAACCAGCTGGTCAGCGCCGAAACCTGCGCTGCGGTCGCCGACGAACTCAATCTTCATCTTTATATCCGCACCGGCGC
CGACGTGAAGAAATTGACCGGCAAACGGATGATGAACGTGCGCGCCGACGTGGTCGAAAGCCTGATCGCCGCGATCTATC
TCGACGGCGGCCTCGAAGTTGCTCGCCGCTTCATCCTGCGCTACTGGCAGGGCAGGGCGGTCAGGGCCGATGGCGCCAAG
CGCGACGCCAAGACCGAGCTGCAGGAGTGGTCGCACGCGAAATTCGGCGTCACACCAAACTACCGGGTTGATGAACGCAG
CGGACCGGATCATGATCCGCGCTTCAAGGTGACGGTGGAAGTTGCTGGCATAAAGCCGGAAACCGGCGTAGAGCGGTCGA
AGCGTGCCGCCGAACAGGTTGCGGCGACGAAGATGCTTGAGCGCGAAGGCATTTGGCAGCAATCGCCTGCCGGAAACTGA

Upstream 100 bases:

>100_bases
CCAGCGTCATCTTCTTCTCGCTCGGCAACGACACCTCCTTCCGCGAAATCTGGAAGTGGCCGACGAACATGCGCTGGGAT
CGCCTCTTCAAGGTTGTTGA

Downstream 100 bases:

>100_bases
CGGGACAATGACACAAGAAGAAGATATCGCGGCCGAAGCTGCCGCAGAAACCAGTGGTCCGACGCATTCGGGCTTCGTCG
CGCTGATCGGGCCGACCAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MSKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLCIAELLFRTFGTAGEGELSVR
LNQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNVRADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAK
RDAKTELQEWSHAKFGVTPNYRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN

Sequences:

>Translated_239_residues
MSKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLCIAELLFRTFGTAGEGELSVR
LNQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNVRADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAK
RDAKTELQEWSHAKFGVTPNYRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN
>Mature_238_residues
SKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLCIAELLFRTFGTAGEGELSVRL
NQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNVRADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAKR
DAKTELQEWSHAKFGVTPNYRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=192, Percent_Identity=31.25, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI155030236, Length=192, Percent_Identity=31.25, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788920, Length=205, Percent_Identity=34.1463414634146, Blast_Score=110, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=214, Percent_Identity=31.7757009345794, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202651, Length=214, Percent_Identity=31.7757009345794, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17137682, Length=228, Percent_Identity=32.0175438596491, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 26452; Mature: 26321

Theoretical pI: Translated: 8.68; Mature: 8.68

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLC
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
IAELLFRTFGTAGEGELSVRLNQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHH
RADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAKRDAKTELQEWSHAKFGVTPN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCCCC
YRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN
CCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKAQTLSAADRAKLEGLIGHDFAEKERLDRALTHASARTEKGGNYERLEFLGDRVLGLC
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
IAELLFRTFGTAGEGELSVRLNQLVSAETCAAVADELNLHLYIRTGADVKKLTGKRMMNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHH
RADVVESLIAAIYLDGGLEVARRFILRYWQGRAVRADGAKRDAKTELQEWSHAKFGVTPN
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCCCC
YRVDERSGPDHDPRFKVTVEVAGIKPETGVERSKRAAEQVAATKMLEREGIWQQSPAGN
CCCCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA