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The map label for this gene is era [H]

Identifier: 209548602

GI number: 209548602

Start: 1021405

End: 1022346

Strand: Direct

Name: era [H]

Synonym: Rleg2_0999

Alternate gene names: 209548602

Gene position: 1021405-1022346 (Clockwise)

Preceding gene: 209548601

Following gene: 209548603

Centisome position: 22.51

GC content: 61.57

Gene sequence:

>942_bases
ATGACACAAGAAGAAGATATCGCGGCCGAAGCTGCCGCAGAAACCAGTGGTCCGACGCATTCGGGCTTCGTCGCGCTGAT
CGGGCCGACCAATGCCGGCAAGTCGACGCTGGTGAACCGCCTGGTTGGCGCCAAGGTCTCGATCGTCAGCCATAAGGTCC
AGACGACACGTGCCATCGTCCGCGGCATCGCGATCCACGACAACGCCCAGATCGTCTTCATGGATACACCCGGTATCTTC
AAGCCGCGCCGCCGGCTCGACCGCGCCATGGTGACCTCGGCCTGGGGCGGCGCGAGGGATGCCGATCTGATCGTGCTGCT
GATCGACAGCGAGCGCGGCCTGCGCGGCGATGCCGAAGCCATCCTCGAAGGCCTCAAGGAAGTCCGGCAGCCGAAGATCC
TGCTGCTCAACAAGATCGACCGCGTCAACCGCGAGGATCTGCTGGCCCTCGCGGCCGCTGCCAATGAGAAGATCGCCTTC
GATCGCACCTTCATGATATCGGCCGAAAACGGCTCCGGCTGCGACGATGTCATGGATTATCTGGCCGCGACGCTGCCGGA
GGGGCCGTGGTATTATCCCGAAAACCAGATCTCCGATCTGCCGATGCGCCAGCTCGCCGCCGAGATCACCCGCGAGAAGC
TGTTCCTGCGGCTGCACCAGGAGCTTCCCTACGCCTCGCATGTCGAAACCGAGAAGTGGGAAGAGCGCAAGGATGGCTCG
GTGCGTATCGAGCAGGTGATCTATCTCGAGCGCGACAGCCAGAAGAAAATCGCGCTCGGCAAGGGTGGTGAAACCATCAA
GGCGATCTCGACGGCTTCCCGCAAGGAATTGTCGGAGATCCTCGAGCAGCCGGTCCACCTCTTCCTGTTCGTCAAAGTTC
GCGAGAACTGGGGTGATGATCCCGAACGGTTCCGCGAAATGGGTCTCGATTTCCCGAAATAA

Upstream 100 bases:

>100_bases
GTAGAGCGGTCGAAGCGTGCCGCCGAACAGGTTGCGGCGACGAAGATGCTTGAGCGCGAAGGCATTTGGCAGCAATCGCC
TGCCGGAAACTGACGGGACA

Downstream 100 bases:

>100_bases
GGGATGGCAAGAATTTGCTCATTCGGCTGCCAGCCCCTTGTTTCCGAATAAAAAAACCGCATCGCTCACGGAACAATTCG
GTAACTTGTGCATTCCTTGA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTQEEDIAAEAAAETSGPTHSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIF
KPRRRLDRAMVTSAWGGARDADLIVLLIDSERGLRGDAEAILEGLKEVRQPKILLLNKIDRVNREDLLALAAAANEKIAF
DRTFMISAENGSGCDDVMDYLAATLPEGPWYYPENQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGS
VRIEQVIYLERDSQKKIALGKGGETIKAISTASRKELSEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK

Sequences:

>Translated_313_residues
MTQEEDIAAEAAAETSGPTHSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIF
KPRRRLDRAMVTSAWGGARDADLIVLLIDSERGLRGDAEAILEGLKEVRQPKILLLNKIDRVNREDLLALAAAANEKIAF
DRTFMISAENGSGCDDVMDYLAATLPEGPWYYPENQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGS
VRIEQVIYLERDSQKKIALGKGGETIKAISTASRKELSEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK
>Mature_312_residues
TQEEDIAAEAAAETSGPTHSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAIVRGIAIHDNAQIVFMDTPGIFK
PRRRLDRAMVTSAWGGARDADLIVLLIDSERGLRGDAEAILEGLKEVRQPKILLLNKIDRVNREDLLALAAAANEKIAFD
RTFMISAENGSGCDDVMDYLAATLPEGPWYYPENQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGSV
RIEQVIYLERDSQKKIALGKGGETIKAISTASRKELSEILEQPVHLFLFVKVRENWGDDPERFREMGLDFPK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=29.0625, Blast_Score=118, Evalue=6e-27,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=38.013698630137, Blast_Score=199, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24646434, Length=311, Percent_Identity=27.6527331189711, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34944; Mature: 34813

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50823 KH_TYPE_2 ; PS00284 SERPIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQEEDIAAEAAAETSGPTHSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAIV
CCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RGIAIHDNAQIVFMDTPGIFKPRRRLDRAMVTSAWGGARDADLIVLLIDSERGLRGDAEA
HHEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
ILEGLKEVRQPKILLLNKIDRVNREDLLALAAAANEKIAFDRTFMISAENGSGCDDVMDY
HHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHH
LAATLPEGPWYYPENQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGS
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
VRIEQVIYLERDSQKKIALGKGGETIKAISTASRKELSEILEQPVHLFLFVKVRENWGDD
EEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
PERFREMGLDFPK
HHHHHHCCCCCCC
>Mature Secondary Structure 
TQEEDIAAEAAAETSGPTHSGFVALIGPTNAGKSTLVNRLVGAKVSIVSHKVQTTRAIV
CCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RGIAIHDNAQIVFMDTPGIFKPRRRLDRAMVTSAWGGARDADLIVLLIDSERGLRGDAEA
HHEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHH
ILEGLKEVRQPKILLLNKIDRVNREDLLALAAAANEKIAFDRTFMISAENGSGCDDVMDY
HHHHHHHHCCCCEEEEHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEEECCCCCHHHHHHH
LAATLPEGPWYYPENQISDLPMRQLAAEITREKLFLRLHQELPYASHVETEKWEERKDGS
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
VRIEQVIYLERDSQKKIALGKGGETIKAISTASRKELSEILEQPVHLFLFVKVRENWGDD
EEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCC
PERFREMGLDFPK
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]