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The map label for this gene is rmlD [C]

Identifier: 209696412

GI number: 209696412

Start: 3271747

End: 3272628

Strand: Direct

Name: rmlD [C]

Synonym: VSAL_I3020

Alternate gene names: 209696412

Gene position: 3271747-3272628 (Clockwise)

Preceding gene: 209696411

Following gene: 209696413

Centisome position: 98.39

GC content: 43.65

Gene sequence:

>882_bases
ATGCGGGTATTAATTACAGGATGTTATGGTCAAGTTGGTCATTGCCTTACTGCTCAATTAGTGAATAAAGCAAGCACAAG
CGTGCTTGCTTTAGACCGAGATCAGTTAGACATCACTAATCAAGATGCTGTGAATGCAATTGCTGATGATTTTCAACCCA
CGATTATTATCAATGCGGCGGCGCATACTGCCGTGGATAAAGCGGAAGACGAAGTGGATTTGTCATACGCGATTAATCGT
GATGGACCTAACTATTTAGCGCAAGCCGCACAGCGAGTTGGTGCGGCTATGTTGCATATCTCAACCGATTATGTCTTTGA
AGGTAATAAGGTTGGTGAGTATGACGAGCGTGATGTTACGCATCCACAAGGCGTTTACGGTGAAAGTAAATTAGCCGGTG
AAAGCGCCGTAGCAAACGCGTGCGATAAACACATTATCCTTCGTACTGCTTGGGTGTTTGGTGAGCATGGTAATAATTTT
GTCAAAACCATGCTCCGTTTAGGCGTAACTCGAGATGAATTAAGCATTGTTGGAGACCAGTTTGGTGGACCAACGTACGC
GGGTGATATTGCCAACGCATTGATTACTATCGCAGAGCGCATTACCCAAGGTAATATGGTTGATTATGGTGTCTATCACT
ATTCTGGTTTGCCTCATGTGAGTTGGTACGAGTTTGCTGATGCTATTTTTGATACAGCAAAAGAGCAAGGTGTAATTAAG
ACAAAGCCAAGCTTAACGGGCATCACAACAGTGCAATACCCAACCCCAGCGAAACGTCCAAGTAACTCTTGCCTAAATAC
CAATAAAATCACAACCGCATTTTCAATAGAAGCGAGTGATTGGCAAACGGCCCTAAAGAACATACAAGCGTATACAGGAT
AA

Upstream 100 bases:

>100_bases
ATGAGCAAGTGTTAACACTTGCGAAACCGATGATGAAGAATGAGTATGGCCAATATTTGACTCGCTTAGTAAATGAAAGT
CAAAAAAAGGCCATGAATTG

Downstream 100 bases:

>100_bases
GTGCATGAAAGTGATTGATACTCGCATTCCCGATGTGAAAATTATTGAGCCATCGGTTTTTGGTGATGAACGCGGCTTCT
TTATGGAAACCTGGAATCAA

Product: dTDP-6-deoxy-l-mannose-dehydrogenase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRVLITGCYGQVGHCLTAQLVNKASTSVLALDRDQLDITNQDAVNAIADDFQPTIIINAAAHTAVDKAEDEVDLSYAINR
DGPNYLAQAAQRVGAAMLHISTDYVFEGNKVGEYDERDVTHPQGVYGESKLAGESAVANACDKHIILRTAWVFGEHGNNF
VKTMLRLGVTRDELSIVGDQFGGPTYAGDIANALITIAERITQGNMVDYGVYHYSGLPHVSWYEFADAIFDTAKEQGVIK
TKPSLTGITTVQYPTPAKRPSNSCLNTNKITTAFSIEASDWQTALKNIQAYTG

Sequences:

>Translated_293_residues
MRVLITGCYGQVGHCLTAQLVNKASTSVLALDRDQLDITNQDAVNAIADDFQPTIIINAAAHTAVDKAEDEVDLSYAINR
DGPNYLAQAAQRVGAAMLHISTDYVFEGNKVGEYDERDVTHPQGVYGESKLAGESAVANACDKHIILRTAWVFGEHGNNF
VKTMLRLGVTRDELSIVGDQFGGPTYAGDIANALITIAERITQGNMVDYGVYHYSGLPHVSWYEFADAIFDTAKEQGVIK
TKPSLTGITTVQYPTPAKRPSNSCLNTNKITTAFSIEASDWQTALKNIQAYTG
>Mature_293_residues
MRVLITGCYGQVGHCLTAQLVNKASTSVLALDRDQLDITNQDAVNAIADDFQPTIIINAAAHTAVDKAEDEVDLSYAINR
DGPNYLAQAAQRVGAAMLHISTDYVFEGNKVGEYDERDVTHPQGVYGESKLAGESAVANACDKHIILRTAWVFGEHGNNF
VKTMLRLGVTRDELSIVGDQFGGPTYAGDIANALITIAERITQGNMVDYGVYHYSGLPHVSWYEFADAIFDTAKEQGVIK
TKPSLTGITTVQYPTPAKRPSNSCLNTNKITTAFSIEASDWQTALKNIQAYTG

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. RmlD uses NADH and NADPH nearly equally well [H]

COG id: COG1091

COG function: function code M; dTDP-4-dehydrorhamnose reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Homo sapiens, GI33519455, Length=288, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI11034825, Length=288, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1788352, Length=292, Percent_Identity=41.4383561643836, Blast_Score=219, Evalue=2e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 31782; Mature: 31782

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLITGCYGQVGHCLTAQLVNKASTSVLALDRDQLDITNQDAVNAIADDFQPTIIINAA
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECH
AHTAVDKAEDEVDLSYAINRDGPNYLAQAAQRVGAAMLHISTDYVFEGNKVGEYDERDVT
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEEEECEEEECCCCCCCCCCCCC
HPQGVYGESKLAGESAVANACDKHIILRTAWVFGEHGNNFVKTMLRLGVTRDELSIVGDQ
CCCCCCCCHHHCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHC
FGGPTYAGDIANALITIAERITQGNMVDYGVYHYSGLPHVSWYEFADAIFDTAKEQGVIK
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEE
TKPSLTGITTVQYPTPAKRPSNSCLNTNKITTAFSIEASDWQTALKNIQAYTG
ECCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRVLITGCYGQVGHCLTAQLVNKASTSVLALDRDQLDITNQDAVNAIADDFQPTIIINAA
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEECH
AHTAVDKAEDEVDLSYAINRDGPNYLAQAAQRVGAAMLHISTDYVFEGNKVGEYDERDVT
HHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCEEEEEEECEEEECCCCCCCCCCCCC
HPQGVYGESKLAGESAVANACDKHIILRTAWVFGEHGNNFVKTMLRLGVTRDELSIVGDQ
CCCCCCCCHHHCCHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHC
FGGPTYAGDIANALITIAERITQGNMVDYGVYHYSGLPHVSWYEFADAIFDTAKEQGVIK
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEE
TKPSLTGITTVQYPTPAKRPSNSCLNTNKITTAFSIEASDWQTALKNIQAYTG
ECCCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]