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The map label for this gene is rmlC [H]

Identifier: 209696413

GI number: 209696413

Start: 3272633

End: 3273187

Strand: Direct

Name: rmlC [H]

Synonym: VSAL_I3021

Alternate gene names: 209696413

Gene position: 3272633-3273187 (Clockwise)

Preceding gene: 209696412

Following gene: 209696414

Centisome position: 98.42

GC content: 40.0

Gene sequence:

>555_bases
ATGAAAGTGATTGATACTCGCATTCCCGATGTGAAAATTATTGAGCCATCGGTTTTTGGTGATGAACGCGGCTTCTTTAT
GGAAACCTGGAATCAAGCGAAATTTGAAGAGTTAGTGACTGGTAAGCCTACCCGATTCGTACAAGATAACCATTCAAAAT
CTAAGAAAGGGATTTTGCGTGGCTTGCATTATCAAACTGAAAACACCCAAGGGAAATTAGTTCGTGTGGTTTCAGGAGAG
GTGTTTGACGTGGCGGTCGATATACGTAAAGGCTCTCCAACGTTTGGTCAGTGGGTTGGCGAGTATTTATCCGCAGAAAA
CAAGCGGCAGTTGTGGGTGCCGAAAGGGTTTGCACATGGTTTTTATGTAACGAGTGATGAAGCTGAATTTGTATATAAGT
GTACGGATTATTATAATCCGAAAGTTGAAATATCACTTTTTTGGGCCGATGAGAGCTTAGCTATAAATTGGCCTCTTTCC
GGAATTCCCATGCTTTCTGAAAAAGATATAAATGGAATAAAATTTGAAAAGATAATTAGTAATGATTGGGCATGA

Upstream 100 bases:

>100_bases
TCTTGCCTAAATACCAATAAAATCACAACCGCATTTTCAATAGAAGCGAGTGATTGGCAAACGGCCCTAAAGAACATACA
AGCGTATACAGGATAAGTGC

Downstream 100 bases:

>100_bases
CTGAAGAAACAACTAAGCAAGACGGAAATAAAATAATAGCGAAAAATGCTATTTTCTTGTATTTAAGAATGTTTTTTACT
TTAGGTGTATCTTTATATAC

Product: dTDP-6-deoxy-D-xylo-4-hexulose-3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MKVIDTRIPDVKIIEPSVFGDERGFFMETWNQAKFEELVTGKPTRFVQDNHSKSKKGILRGLHYQTENTQGKLVRVVSGE
VFDVAVDIRKGSPTFGQWVGEYLSAENKRQLWVPKGFAHGFYVTSDEAEFVYKCTDYYNPKVEISLFWADESLAINWPLS
GIPMLSEKDINGIKFEKIISNDWA

Sequences:

>Translated_184_residues
MKVIDTRIPDVKIIEPSVFGDERGFFMETWNQAKFEELVTGKPTRFVQDNHSKSKKGILRGLHYQTENTQGKLVRVVSGE
VFDVAVDIRKGSPTFGQWVGEYLSAENKRQLWVPKGFAHGFYVTSDEAEFVYKCTDYYNPKVEISLFWADESLAINWPLS
GIPMLSEKDINGIKFEKIISNDWA
>Mature_184_residues
MKVIDTRIPDVKIIEPSVFGDERGFFMETWNQAKFEELVTGKPTRFVQDNHSKSKKGILRGLHYQTENTQGKLVRVVSGE
VFDVAVDIRKGSPTFGQWVGEYLSAENKRQLWVPKGFAHGFYVTSDEAEFVYKCTDYYNPKVEISLFWADESLAINWPLS
GIPMLSEKDINGIKFEKIISNDWA

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=180, Percent_Identity=56.6666666666667, Blast_Score=206, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI17550412, Length=174, Percent_Identity=47.7011494252874, Blast_Score=160, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 21105; Mature: 21105

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVIDTRIPDVKIIEPSVFGDERGFFMETWNQAKFEELVTGKPTRFVQDNHSKSKKGILR
CCCCCCCCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHCCCCCEEECCCCCCCHHHHHH
GLHYQTENTQGKLVRVVSGEVFDVAVDIRKGSPTFGQWVGEYLSAENKRQLWVPKGFAHG
HCEECCCCCCCEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCCC
FYVTSDEAEFVYKCTDYYNPKVEISLFWADESLAINWPLSGIPMLSEKDINGIKFEKIIS
EEEECCCCEEEEEECCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEECC
NDWA
CCCC
>Mature Secondary Structure
MKVIDTRIPDVKIIEPSVFGDERGFFMETWNQAKFEELVTGKPTRFVQDNHSKSKKGILR
CCCCCCCCCCEEEECCCCCCCCCCCEEECCCCHHHHHHHCCCCCEEECCCCCCCHHHHHH
GLHYQTENTQGKLVRVVSGEVFDVAVDIRKGSPTFGQWVGEYLSAENKRQLWVPKGFAHG
HCEECCCCCCCEEEEEECCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCCCCC
FYVTSDEAEFVYKCTDYYNPKVEISLFWADESLAINWPLSGIPMLSEKDINGIKFEKIIS
EEEECCCCEEEEEECCCCCCEEEEEEEECCCCEEEECCCCCCCCCCCCCCCCEEEEEECC
NDWA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170390; 8157605; 12384590; 12704152 [H]