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The map label for this gene is rmlA [H]

Identifier: 209696411

GI number: 209696411

Start: 3270860

End: 3271747

Strand: Direct

Name: rmlA [H]

Synonym: VSAL_I3019

Alternate gene names: 209696411

Gene position: 3270860-3271747 (Clockwise)

Preceding gene: 209696410

Following gene: 209696412

Centisome position: 98.37

GC content: 40.2

Gene sequence:

>888_bases
ATGAAAGGGATTGTTCTCGCTGGTGGTTCAGGTACACGTCTGTACCCATTAACTCGTGGTGTATCTAAACAACTATTGCC
TATCTACGATAAGCCAATGGTGTTTTATCCTATTTCTACCTTAATGCTGGCGGGCATTAAAGACATTTTAATTATTACTA
CGCCTGAAGATAACGCGGGTTTTAAACGTTTATTGGGTGATGGCTCTTACTTTGGTATTAATATCGAGTATGCCATTCAA
CCTAGTCCAGATGGTTTAGCGCAAGCCTTTATTATCGGTGAAGAGTTCATTGGTAATGACAGTGTGTGTTTGGTGTTGGG
AGACAATATTTTCTATGGCCAATTTTTCTCTCAAACGTTAAAAAATGCGGCGTCTCGTGAATCTGGAGCGACAGTATTTG
GTTATCAAGTAAAGGACCCTGAGCGTTTTGGTGTGGTTGAGTTTGATGACAACATGAAGGCGATTTCGATTGAAGAAAAA
CCTGAAGCACCAAAATCAAATTATGCGGTAACCGGGCTTTATTTCTACGATAACGATGTGATTGAGATGGCGAAGAAAGT
AACTCCTTCACATCGAGGTGAGCTTGAAATTACCACGTTGAATGAGATGTACCTTAATAATGGCTCGTTAAATGTTGAGT
TATTAGGTCGTGGTTTTGCGTGGCTTGATACTGGAACGCATGAAAGTCTTCATGAAGCGTCTTCATTTGTACAAACCATT
GAGAATGTTCAAGGGTTAAAGGTGGCGTGTTTGGAAGAAATATCGTGGCGTAATGGTTGGTTGAGTGATGAGCAAGTGTT
AACACTTGCGAAACCGATGATGAAGAATGAGTATGGCCAATATTTGACTCGCTTAGTAAATGAAAGTCAAAAAAAGGCCA
TGAATTGA

Upstream 100 bases:

>100_bases
GGTATTTAAATAACCAAGAATGGTGTCAACATGTACAAGATGGCAGCTATCAACGTGAGCGCCTAGGTGTAGAGTCAGTA
GAATCAAAGGAAAGTAAATA

Downstream 100 bases:

>100_bases
TGCGGGTATTAATTACAGGATGTTATGGTCAAGTTGGTCATTGCCTTACTGCTCAATTAGTGAATAAAGCAAGCACAAGC
GTGCTTGCTTTAGACCGAGA

Product: glucose-1-phosphate thymidyl transferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKGIVLAGGSGTRLYPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSYFGINIEYAIQ
PSPDGLAQAFIIGEEFIGNDSVCLVLGDNIFYGQFFSQTLKNAASRESGATVFGYQVKDPERFGVVEFDDNMKAISIEEK
PEAPKSNYAVTGLYFYDNDVIEMAKKVTPSHRGELEITTLNEMYLNNGSLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEISWRNGWLSDEQVLTLAKPMMKNEYGQYLTRLVNESQKKAMN

Sequences:

>Translated_295_residues
MKGIVLAGGSGTRLYPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSYFGINIEYAIQ
PSPDGLAQAFIIGEEFIGNDSVCLVLGDNIFYGQFFSQTLKNAASRESGATVFGYQVKDPERFGVVEFDDNMKAISIEEK
PEAPKSNYAVTGLYFYDNDVIEMAKKVTPSHRGELEITTLNEMYLNNGSLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEISWRNGWLSDEQVLTLAKPMMKNEYGQYLTRLVNESQKKAMN
>Mature_295_residues
MKGIVLAGGSGTRLYPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAGFKRLLGDGSYFGINIEYAIQ
PSPDGLAQAFIIGEEFIGNDSVCLVLGDNIFYGQFFSQTLKNAASRESGATVFGYQVKDPERFGVVEFDDNMKAISIEEK
PEAPKSNYAVTGLYFYDNDVIEMAKKVTPSHRGELEITTLNEMYLNNGSLNVELLGRGFAWLDTGTHESLHEASSFVQTI
ENVQGLKVACLEEISWRNGWLSDEQVLTLAKPMMKNEYGQYLTRLVNESQKKAMN

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=292, Percent_Identity=71.2328767123288, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1788351, Length=288, Percent_Identity=67.3611111111111, Blast_Score=416, Evalue=1e-118,
Organism=Escherichia coli, GI1787488, Length=245, Percent_Identity=24.8979591836735, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI133931050, Length=226, Percent_Identity=25.2212389380531, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=228, Percent_Identity=27.1929824561404, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=24.2290748898678, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=24.2290748898678, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32772; Mature: 32772

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIVLAGGSGTRLYPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAG
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
FKRLLGDGSYFGINIEYAIQPSPDGLAQAFIIGEEFIGNDSVCLVLGDNIFYGQFFSQTL
HHHHHCCCCEEEEEEEEEECCCCCHHHEEEEECHHHCCCCCEEEEECCCEEEHHHHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDDNMKAISIEEKPEAPKSNYAVTGLYFYDNDV
HHHHCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
IEMAKKVTPSHRGELEITTLNEMYLNNGSLNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHEEEECCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
ENVQGLKVACLEEISWRNGWLSDEQVLTLAKPMMKNEYGQYLTRLVNESQKKAMN
HHCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIVLAGGSGTRLYPLTRGVSKQLLPIYDKPMVFYPISTLMLAGIKDILIITTPEDNAG
CCCEEEECCCCCEEEEECCCCCCCCCCCCCCCEEEECHHHHHHCCCCEEEEEECCCCCCC
FKRLLGDGSYFGINIEYAIQPSPDGLAQAFIIGEEFIGNDSVCLVLGDNIFYGQFFSQTL
HHHHHCCCCEEEEEEEEEECCCCCHHHEEEEECHHHCCCCCEEEEECCCEEEHHHHHHHH
KNAASRESGATVFGYQVKDPERFGVVEFDDNMKAISIEEKPEAPKSNYAVTGLYFYDNDV
HHHHCCCCCCEEEEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEEEEEEEEECCHH
IEMAKKVTPSHRGELEITTLNEMYLNNGSLNVELLGRGFAWLDTGTHESLHEASSFVQTI
HHHHHHCCCCCCCEEEEEEEHEEEECCCCEEEEEEECCEEEEECCCHHHHHHHHHHHHHH
ENVQGLKVACLEEISWRNGWLSDEQVLTLAKPMMKNEYGQYLTRLVNESQKKAMN
HHCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]