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The map label for this gene is ubiB [H]

Identifier: 209696392

GI number: 209696392

Start: 3247883

End: 3249514

Strand: Direct

Name: ubiB [H]

Synonym: VSAL_I2998

Alternate gene names: 209696392

Gene position: 3247883-3249514 (Clockwise)

Preceding gene: 209696391

Following gene: 209696393

Centisome position: 97.68

GC content: 42.16

Gene sequence:

>1632_bases
ATGACCCCATCAGAGCTAAAACGCTTATATCAAATCACCAAGGTTCAACTTGAGTATGGATTGGATGAGCTATTGCCTGA
TCATGCATTAACTCAATTACCAAAACGTTTACGCAAAGGGTTATTTTGGATTAAGAATCGCTATCCAGAAAAACCATTGG
GTGAGCGTTTACGGTTAGCATTGCAAGAATTGGGTCCGGTTTGGATTAAATTCGGTCAAATGATGTCTACGCGTCGTGAT
CTTTTTCCTCCTCATTTAGCTGATCAATTAGCTTTACTGCAAGACCAGGTCGCCCCCTTTGATGGCCAGCTAGCAAAAGA
TCAAATGGAGTTATCATTGGGTGGACCATTAGAAAATTGGTTTACGGATTTTGATATTGTCCCATTAGCATCCGCCTCGA
TTGCTCAAGTACACACCGCAAAATTGAAAGAGTCTGGTCGTGAGATTGTCCTTAAGGTTATTCGTCCGGATATTCGCCCA
GTGATTGAAGCGGATATTCGCCTGATGTATCGCATGGCTACCTTGGTAGAGAAACACATACCAGAAGCGCGCCGCCTTAA
ACCGGTCGAGGTCATCGAAGAATATGAGAAAACCTTAATCGATGAGCTAGACTTAAGAAGAGAGGCGAGCAATGCAATGC
AATTGCGTCGCAACTTTGAAGGCAGTGAAGAGCTGTATGTCCCTGAAGTTATTTTGGATGTCAGTTCTGAACACTTGATG
GTGTCTGAGCGTATTTATGGTATTCAAGTTTCTGACATCGAGCAACTAGAGAAAAATGGCACCAACATGAAGCTGTTGGC
TGAACGTGGTGTGTCGGTTTTCTTTACTCAAGTATTTCGTGACAGCTTTTTCCATGCGGATATGCACCCGGGTAACGTAT
TTGTAAATCCGGATAATCCAGAGAATCCGCAGTGGATTGGATTAGATTGTGGTATTGTTGGAACACTCAATAAAGAAGAC
AAGCGCTATTTAGCGGAGAACTTACTTGGCTTTTTTAATAGCGATTATCGTAAAGTCGCACAGTTACATATTGATTCAGG
TTGGGTTCCGGCAGAGACTAATGTCGAAGAATTCGAATTTGCTATCCGTATTGTCTGTGAGCCGATTTTTGCTAAACCAT
TAGGTGAGATATCTTTTGGTCATGTGTTATTGAATTTATTTAACACAGCACGTCGCTTTAATATGGAAGTGCAGCCGCAA
TTAGTCTTATTGCAAAAGACGTTATTATACGTGGAAGGATTAGGCAGACAGCTATATCCTCAATTGGATTTGTGGGCAAC
CGCCAAACCGTTTCTAGAAACGTGGATGGCAAAACAAATTGGACCGGCAGCCTTTTTGACTGCTTTGACTGAGAAAGCGC
CATTTTGGGCTGAGAAACTGCCAGAACTACCTGATTTAGTTTATGACAGTTTGCGCCAAGGCAAAGTTCTTAATCAACGA
ATGGATAAACTTTACGCAGGTTATCGTCAAAGTAAGCGTCAACAGGCAAAAGGACAATTCCTATTTAATGTTGGAGCAAC
TCTGCTGATTTGTTCTGCGGTGTTATTAACCAGTAACATTACTGCGTTAGCATCAATTAGTGCTGCTACAGGTGTCACGT
TTTGGCTATTAAGCTGGCGAGCATATCGTTAA

Upstream 100 bases:

>100_bases
TTGCGTACTTCTGCGATCAAGTGTCTGATGTTGAAAAACACCTCGCACAATTAGACGCTCGCTTGACGCAATTATTACAG
ACAGCATCAATGGAGCGCGC

Downstream 100 bases:

>100_bases
TAAGCGTTACTCTATTTAGCAATTTTTTAACCCCTAACACGCTGAGGAAATAAGCATGGGTGGTATTAGTATTTGGCAAC
TTCTTATAATTGCAGTAATT

Product: ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MTPSELKRLYQITKVQLEYGLDELLPDHALTQLPKRLRKGLFWIKNRYPEKPLGERLRLALQELGPVWIKFGQMMSTRRD
LFPPHLADQLALLQDQVAPFDGQLAKDQMELSLGGPLENWFTDFDIVPLASASIAQVHTAKLKESGREIVLKVIRPDIRP
VIEADIRLMYRMATLVEKHIPEARRLKPVEVIEEYEKTLIDELDLRREASNAMQLRRNFEGSEELYVPEVILDVSSEHLM
VSERIYGIQVSDIEQLEKNGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPDNPENPQWIGLDCGIVGTLNKED
KRYLAENLLGFFNSDYRKVAQLHIDSGWVPAETNVEEFEFAIRIVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMAKQIGPAAFLTALTEKAPFWAEKLPELPDLVYDSLRQGKVLNQR
MDKLYAGYRQSKRQQAKGQFLFNVGATLLICSAVLLTSNITALASISAATGVTFWLLSWRAYR

Sequences:

>Translated_543_residues
MTPSELKRLYQITKVQLEYGLDELLPDHALTQLPKRLRKGLFWIKNRYPEKPLGERLRLALQELGPVWIKFGQMMSTRRD
LFPPHLADQLALLQDQVAPFDGQLAKDQMELSLGGPLENWFTDFDIVPLASASIAQVHTAKLKESGREIVLKVIRPDIRP
VIEADIRLMYRMATLVEKHIPEARRLKPVEVIEEYEKTLIDELDLRREASNAMQLRRNFEGSEELYVPEVILDVSSEHLM
VSERIYGIQVSDIEQLEKNGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPDNPENPQWIGLDCGIVGTLNKED
KRYLAENLLGFFNSDYRKVAQLHIDSGWVPAETNVEEFEFAIRIVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQ
LVLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMAKQIGPAAFLTALTEKAPFWAEKLPELPDLVYDSLRQGKVLNQR
MDKLYAGYRQSKRQQAKGQFLFNVGATLLICSAVLLTSNITALASISAATGVTFWLLSWRAYR
>Mature_542_residues
TPSELKRLYQITKVQLEYGLDELLPDHALTQLPKRLRKGLFWIKNRYPEKPLGERLRLALQELGPVWIKFGQMMSTRRDL
FPPHLADQLALLQDQVAPFDGQLAKDQMELSLGGPLENWFTDFDIVPLASASIAQVHTAKLKESGREIVLKVIRPDIRPV
IEADIRLMYRMATLVEKHIPEARRLKPVEVIEEYEKTLIDELDLRREASNAMQLRRNFEGSEELYVPEVILDVSSEHLMV
SERIYGIQVSDIEQLEKNGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPDNPENPQWIGLDCGIVGTLNKEDK
RYLAENLLGFFNSDYRKVAQLHIDSGWVPAETNVEEFEFAIRIVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQL
VLLQKTLLYVEGLGRQLYPQLDLWATAKPFLETWMAKQIGPAAFLTALTEKAPFWAEKLPELPDLVYDSLRQGKVLNQRM
DKLYAGYRQSKRQQAKGQFLFNVGATLLICSAVLLTSNITALASISAATGVTFWLLSWRAYR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=262, Percent_Identity=29.3893129770992, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI40254938, Length=254, Percent_Identity=29.5275590551181, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI217035081, Length=210, Percent_Identity=30.952380952381, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI32261307, Length=315, Percent_Identity=23.4920634920635, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI34147522, Length=249, Percent_Identity=30.1204819277108, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI2367309, Length=547, Percent_Identity=68.0073126142596, Blast_Score=765, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559152, Length=280, Percent_Identity=27.8571428571429, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17555620, Length=477, Percent_Identity=22.4318658280922, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32565180, Length=317, Percent_Identity=25.5520504731861, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6325148, Length=440, Percent_Identity=25, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323282, Length=302, Percent_Identity=25.4966887417219, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321319, Length=243, Percent_Identity=21.8106995884774, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI22024280, Length=280, Percent_Identity=29.6428571428571, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24662575, Length=249, Percent_Identity=27.710843373494, Blast_Score=102, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 62186; Mature: 62055

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSELKRLYQITKVQLEYGLDELLPDHALTQLPKRLRKGLFWIKNRYPEKPLGERLRLA
CCHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPHLADQLALLQDQVAPFDGQLAKDQMELSLGGPLENW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHH
FTDFDIVPLASASIAQVHTAKLKESGREIVLKVIRPDIRPVIEADIRLMYRMATLVEKHI
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPVEVIEEYEKTLIDELDLRREASNAMQLRRNFEGSEELYVPEVILDVSSEHLM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHCCCCCEE
VSERIYGIQVSDIEQLEKNGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPDNP
EEHHEECCCHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
ENPQWIGLDCGIVGTLNKEDKRYLAENLLGFFNSDYRKVAQLHIDSGWVPAETNVEEFEF
CCCCEEEECCCEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCHHHHHH
AIRIVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWATAKPFLETWMAKQIGPAAFLTALTEKAPFWAEKLPELPDLVYDSLRQGKVLNQR
CCHHHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHCCHHHHHH
MDKLYAGYRQSKRQQAKGQFLFNVGATLLICSAVLLTSNITALASISAATGVTFWLLSWR
HHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AYR
CCC
>Mature Secondary Structure 
TPSELKRLYQITKVQLEYGLDELLPDHALTQLPKRLRKGLFWIKNRYPEKPLGERLRLA
CHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LQELGPVWIKFGQMMSTRRDLFPPHLADQLALLQDQVAPFDGQLAKDQMELSLGGPLENW
HHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHH
FTDFDIVPLASASIAQVHTAKLKESGREIVLKVIRPDIRPVIEADIRLMYRMATLVEKHI
CCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
PEARRLKPVEVIEEYEKTLIDELDLRREASNAMQLRRNFEGSEELYVPEVILDVSSEHLM
CHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCHHHHHCCCCCEE
VSERIYGIQVSDIEQLEKNGTNMKLLAERGVSVFFTQVFRDSFFHADMHPGNVFVNPDNP
EEHHEECCCHHHHHHHHHCCCCEEEHHHCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
ENPQWIGLDCGIVGTLNKEDKRYLAENLLGFFNSDYRKVAQLHIDSGWVPAETNVEEFEF
CCCCEEEECCCEEECCCCHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCCCCCCHHHHHH
AIRIVCEPIFAKPLGEISFGHVLLNLFNTARRFNMEVQPQLVLLQKTLLYVEGLGRQLYP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHCC
QLDLWATAKPFLETWMAKQIGPAAFLTALTEKAPFWAEKLPELPDLVYDSLRQGKVLNQR
CCHHHHCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHCCHHHHHH
MDKLYAGYRQSKRQQAKGQFLFNVGATLLICSAVLLTSNITALASISAATGVTFWLLSWR
HHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AYR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA