Click here to switch to the map view.

The map label for this gene is sthA [H]

Identifier: 209696289

GI number: 209696289

Start: 3135177

End: 3136592

Strand: Direct

Name: sthA [H]

Synonym: VSAL_I2890

Alternate gene names: 209696289

Gene position: 3135177-3136592 (Clockwise)

Preceding gene: 209696286

Following gene: 209696293

Centisome position: 94.29

GC content: 40.47

Gene sequence:

>1416_bases
ATGACAAACTCGACCACTACACGCTCAACCCATTTTGATGCCATCGTAATTGGTAGTGGCCCAGGAGGAGAAGGTGCTGC
AATGGGCCTAACCAAAGCCAACCTTAATGTCGCAATTATTGAGAGAGAGCCAAGTGTCGGTGGAGGTTGTACACACTGGG
GGACTATCCCATCGAAAGCACTTCGTCATGCAGTAAGTCGTATTCTAGAATTTAATTCAAATCCGCTTTATTGTAAGAAT
AATACCAGTCTTCATTCTACTTTTTCTGATATTTTAGGCCATGCAAAAAGTGTCATCGATAAACAAACAAGAATGAGACA
AGGCTTTTACGACCGTAATCAATGCTCTCTTATCTTTGGTGAAGCCAGTTTTGTAGAAAAAAATACGATTGCAGTGACAG
CAAAAGATGGCTCAATTGAAACGTATACCGCTGATAAGTTTATTATTGCCACAGGATCTCGCCCTTACCGCCCCGCCGGT
GTTAATTTCAATCATAGCCGTGTTTATGATAGTGACTCCATTCTTTCACTAAAACACGACCCTCGCCATATCATTATTTA
TGGTGCTGGTGTCATTGGCAGTGAATACGCGTCTATATTTAGAGGATTAGGCGTTAAGGTTGATTTAATAAACACTCGAG
ATCGTTTACTGTCATTTTTAGATAATGAAATGTCCGACGCTCTCTCTTATCATTTTTGGAATAGCGGTATTGTCATACGC
AATGATGAAACCTTTAAAAAAATCGAAGCCACTGATGACGGCATTATTATGCATTTAGAATCTGGCAAAAAAATGAAAGC
GGATTGTGTTTTACTTGCCAATGGTCGAACAGGAAATACAGACAAACTCAACCTCTCTTCTGTTGGACTTGAAGCCGATT
CTCGAGGACAGTTAACAGTAAACGGTAATTACCAAACAGATGTCGATCATATTTATGCAGTTGGTGATGTCATCGGTTAC
CCAAGCCTTGCTAGTGCTGCTTATGACCAAGGCCGATTTACCGCTCAAGCCATCGTAAAAGGTAAATCAGAAGCCAAATT
GATTGATCATATTCCTACTGGTATTTACACCATACCTGAGATTAGTTCAGTAGGAAAAACAGAACAAGAGCTAACAGCAG
AGAAAGTGCCTTACGAAGTAGGGCGAGCTTCTTTCAAACACTTAGCAAGAGCCCAGATTGCAGGAATGGATATTGGTAGT
TTGAAAATTCTATTCCATCGAGAAACAAAAGAAATTTTAGGTATCCACTGCTTTGGAGAGCGAGCGGCTGAAATCATTCA
TATCGGGCAAGCCATTATGGAACAAAAAGGCAACGCTAATACTATTGAGTATTTTGTCAATACTACATTTAACTACCCAA
CTATGGCTGAGGCCTATCGCGTAGCAGCTCTTAACGGCTTAAATCGACTTTTTTAA

Upstream 100 bases:

>100_bases
GTCTCCACTCTATCTCACTCATTTGATTTACCAAATGAATGAAAAGGTTAAAATACTTTGCTAGCAATGTTGCGAGATTG
ATAATAATAAGGCGCTACTG

Downstream 100 bases:

>100_bases
ACACTCAAATATAATAAATACTAAAAAGGGTTAAGTGTTTACTTAACCCTTTTTTATTATTTTTAATCAATATGATAGAG
TATTTGGCCTATGATAGGAA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MTNSTTTRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSKALRHAVSRILEFNSNPLYCKN
NTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTIAVTAKDGSIETYTADKFIIATGSRPYRPAG
VNFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRDRLLSFLDNEMSDALSYHFWNSGIVIR
NDETFKKIEATDDGIIMHLESGKKMKADCVLLANGRTGNTDKLNLSSVGLEADSRGQLTVNGNYQTDVDHIYAVGDVIGY
PSLASAAYDQGRFTAQAIVKGKSEAKLIDHIPTGIYTIPEISSVGKTEQELTAEKVPYEVGRASFKHLARAQIAGMDIGS
LKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGNANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_471_residues
MTNSTTTRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSKALRHAVSRILEFNSNPLYCKN
NTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTIAVTAKDGSIETYTADKFIIATGSRPYRPAG
VNFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRDRLLSFLDNEMSDALSYHFWNSGIVIR
NDETFKKIEATDDGIIMHLESGKKMKADCVLLANGRTGNTDKLNLSSVGLEADSRGQLTVNGNYQTDVDHIYAVGDVIGY
PSLASAAYDQGRFTAQAIVKGKSEAKLIDHIPTGIYTIPEISSVGKTEQELTAEKVPYEVGRASFKHLARAQIAGMDIGS
LKILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGNANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_470_residues
TNSTTTRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSKALRHAVSRILEFNSNPLYCKNN
TSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFGEASFVEKNTIAVTAKDGSIETYTADKFIIATGSRPYRPAGV
NFNHSRVYDSDSILSLKHDPRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRDRLLSFLDNEMSDALSYHFWNSGIVIRN
DETFKKIEATDDGIIMHLESGKKMKADCVLLANGRTGNTDKLNLSSVGLEADSRGQLTVNGNYQTDVDHIYAVGDVIGYP
SLASAAYDQGRFTAQAIVKGKSEAKLIDHIPTGIYTIPEISSVGKTEQELTAEKVPYEVGRASFKHLARAQIAGMDIGSL
KILFHRETKEILGIHCFGERAAEIIHIGQAIMEQKGNANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=466, Percent_Identity=29.1845493562232, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=26.9978401727862, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI22035672, Length=415, Percent_Identity=28.9156626506024, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI291045266, Length=443, Percent_Identity=25.0564334085779, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI33519430, Length=400, Percent_Identity=25.75, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519428, Length=400, Percent_Identity=25.75, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI33519426, Length=400, Percent_Identity=25.75, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148277065, Length=402, Percent_Identity=25.6218905472637, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148277071, Length=402, Percent_Identity=25.6218905472637, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI291045268, Length=317, Percent_Identity=26.4984227129338, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI87082354, Length=463, Percent_Identity=76.0259179265659, Blast_Score=752, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=455, Percent_Identity=29.4505494505495, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789915, Length=429, Percent_Identity=28.4382284382284, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=25.8620689655172, Blast_Score=141, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI32565766, Length=468, Percent_Identity=31.6239316239316, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=474, Percent_Identity=25.5274261603376, Blast_Score=111, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71983419, Length=360, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71983429, Length=360, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982272, Length=268, Percent_Identity=26.4925373134328, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17559934, Length=257, Percent_Identity=25.2918287937743, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=492, Percent_Identity=27.0325203252033, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6325240, Length=470, Percent_Identity=26.5957446808511, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=25.7928118393235, Blast_Score=135, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21358499, Length=474, Percent_Identity=30.8016877637131, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24640553, Length=495, Percent_Identity=27.6767676767677, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24640551, Length=493, Percent_Identity=27.789046653144, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24640549, Length=488, Percent_Identity=27.6639344262295, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=24.8459958932238, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51498; Mature: 51367

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSTTTRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSKA
CCCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHH
LRHAVSRILEFNSNPLYCKNNTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFG
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
EASFVEKNTIAVTAKDGSIETYTADKFIIATGSRPYRPAGVNFNHSRVYDSDSILSLKHD
CCCEEECCEEEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECC
PRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRDRLLSFLDNEMSDALSYHFWNSGIVIR
CCEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEECCCEEEE
NDETFKKIEATDDGIIMHLESGKKMKADCVLLANGRTGNTDKLNLSSVGLEADSRGQLTV
CCCHHHEEECCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEEHEECCCCCCCCEEEE
NGNYQTDVDHIYAVGDVIGYPSLASAAYDQGRFTAQAIVKGKSEAKLIDHIPTGIYTIPE
CCCCCCCHHHEEEHHHHHCCCCHHHHHHHCCCEEEEHHHCCCCCHHHHHHCCCCEEECCC
ISSVGKTEQELTAEKVPYEVGRASFKHLARAQIAGMDIGSLKILFHRETKEILGIHCFGE
CHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHEEEEEECH
RAAEIIHIGQAIMEQKGNANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNSTTTRSTHFDAIVIGSGPGGEGAAMGLTKANLNVAIIEREPSVGGGCTHWGTIPSKA
CCCCCCCCEEEEEEEEECCCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCCCCCHHHH
LRHAVSRILEFNSNPLYCKNNTSLHSTFSDILGHAKSVIDKQTRMRQGFYDRNQCSLIFG
HHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEC
EASFVEKNTIAVTAKDGSIETYTADKFIIATGSRPYRPAGVNFNHSRVYDSDSILSLKHD
CCCEEECCEEEEEECCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEEECC
PRHIIIYGAGVIGSEYASIFRGLGVKVDLINTRDRLLSFLDNEMSDALSYHFWNSGIVIR
CCEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHEEEEECCCEEEE
NDETFKKIEATDDGIIMHLESGKKMKADCVLLANGRTGNTDKLNLSSVGLEADSRGQLTV
CCCHHHEEECCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEEHEECCCCCCCCEEEE
NGNYQTDVDHIYAVGDVIGYPSLASAAYDQGRFTAQAIVKGKSEAKLIDHIPTGIYTIPE
CCCCCCCHHHEEEHHHHHCCCCHHHHHHHCCCEEEEHHHCCCCCHHHHHHCCCCEEECCC
ISSVGKTEQELTAEKVPYEVGRASFKHLARAQIAGMDIGSLKILFHRETKEILGIHCFGE
CHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHEEEEEECH
RAAEIIHIGQAIMEQKGNANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA