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The map label for this gene is argHA [H]

Identifier: 209696117

GI number: 209696117

Start: 2934250

End: 2936124

Strand: Direct

Name: argHA [H]

Synonym: VSAL_I2710

Alternate gene names: 209696117

Gene position: 2934250-2936124 (Clockwise)

Preceding gene: 209696109

Following gene: 209696121

Centisome position: 88.24

GC content: 41.6

Gene sequence:

>1875_bases
ATGGCATTATGGGGCGGACGTTTTAGTCAAGCAGCAGACACAAGATTTAAACAGTTTAACGATTCACTTCGTATTGATTA
TCGCCTTGCAGAACAAGACATTGTCGGCTCTATCGCATGGTCTAAAGCACTACTTTCTGTCAATGTTATTACAGAAATAG
AACAACAAAAACTTGAATTAGCATTGAATGAATTGAAATTAGAAGTGATGGAAGATCCTGAACAGATCTTATTGTCAGAC
GCTGAAGATATTCATAGCTGGGTTGAGACACAGCTTATCGGTAAAGTGGGTGATTTAGGTAAAAAACTCCACACTGGTCG
TTCTCGTAATGATCAAGTGGCGACAGATTTAAAATTGTGGTGTCGTCAACAAGGCCATCAACTGCTTCGCACATTAGATT
TATTATTGAACCAACTCGTGAATGTAGCGAGTGAGCATCAGGCGACGGTGCTTCCTGGTTATACTCACCTACAACGTGCA
CAACCTGTGACATTTGCGCATTGGTGTTTGGCGTATGTTGAAATGATTGAGCGTGATTACTCTCGCCTTGAAGATGCGAT
TAAGCGTTTAGATACGTGTCCATTAGGATCAGGGGCTTTGGCTGGAACGGCTTATCCAATGGATCGTGAGAAATTGGCTC
GTAATCTTGGTTTTCAAAGAGCAACACGTAATAGCTTAGACTCTGTATCGGATCGTGATCATGTGATGGAGTTAATGTCG
ATTGCTTCAATCTCTATGGTTCACCTTTCTCGTCTTGCCGAAGACATGATTTTTTATAACTCAGGTGAATCTAATTTCAT
TGAGTTAGCGGATACCGTGACGTCTGGTTCATCATTGATGCCACAGAAAAAGAACCCGGATGCCTTAGAGCTTATCCGTG
GTAAATGTGGCCGTGTATATGGCGCATTGGCTGGTATGATGATGACAGTAAAAGCGTTGCCCTTAGCCTATAATAAAGAC
ATGCAAGAAGACAAAGAAGGTTTGTTTGATGCATTAGACAGCTGGTCTGATTGTATTGAAATGGCTGCACTTTGCTTTGA
AGGCATTAAAATAAATAAAGAACGTACTTTAGAAGCGGCGAAACAAGGGTATGCAAACTCAACCGAATTAGCCGATTATT
TGGTAGCGAAAGGCATTCCATTCCGCGAAGCTCATCATATCGTTGGTGTTGCTGTGGTTAGTGCAATAGAAAAAGGCTGT
GCATTAGAAGAGTTATCTATTGCAGAATTAAAAGTATTCTCTGATGTGATTGAAGACGATGTGTATGCAATTTTAACTAT
CGAATCTTGTCTTGCGAAACGTAATGCCCTAGGTGGTGTTGCTCCTGAACAGGTAGCTTATGCTGTTGAGCAAGCAGGTA
AACGTTTAGAAGAGCGTGATTCGACAGGGGTTAAAGTTCGTCCTGCACGATTAACGGATTTAGATGCATTAGAAGGAATG
GTCGCTTACTGGGCTGGTCTTGGAGAGAATTTACCACGTAGTCGTAATGAGTTGGTGCGTGATATTGGATCGTTTGCAGT
ATCAGAACATCATGGGGAAGTGACTGGGTGTGCCTCTTTGTATGTGTACGATTCTGGTTTAGCTGAAATTCGCTCATTAG
GTGTTGAAGCGGGATGGCAGAGTCAAGGTCAAGGGAAAGCGATTGTTCAACACTTGGTAGAAAAAGCGCGTGAAATGGCG
ATTAATAAAGTGTTTGTATTAACTCGTGTGCCTGAATTCTTTATGAAACAAGATTTTATTCCAACATCTCGTTCGTTGTT
ACCAGAGAAAGTATTGAAAGATTGCGATCAGTGTCCTCGTCAACATGCGTGTGATGAAGTGGCATTAGAGGTGAATCTGC
AAGAGCAAATTATTATCAAAACGAATGTGGCTTAA

Upstream 100 bases:

>100_bases
TGGAATTGCCGTAAGTTTGAATCATCAAGAAAAATACTGAATTAAATCAGACTTAATAGTTTCAAAAAGCAGTGAGCACT
GTGCATTTAGGAGAAACACC

Downstream 100 bases:

>100_bases
CTGGCGTTGAATGGTAATGATCGGCACTGAGCTAAAAATACAGAATAAAGAGAAAAAGTGGTGAACTTTTTAATTAAAGA
CTAGTCTTATTAATACTGCT

Product: bifunctional argininosuccinate lyase/N-acetylglutamate synthase

Products: NA

Alternate protein names: Argininosuccinate lyase; ASAL; Arginosuccinase; Probable acetyltransferase [H]

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MALWGGRFSQAADTRFKQFNDSLRIDYRLAEQDIVGSIAWSKALLSVNVITEIEQQKLELALNELKLEVMEDPEQILLSD
AEDIHSWVETQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGHQLLRTLDLLLNQLVNVASEHQATVLPGYTHLQRA
QPVTFAHWCLAYVEMIERDYSRLEDAIKRLDTCPLGSGALAGTAYPMDREKLARNLGFQRATRNSLDSVSDRDHVMELMS
IASISMVHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKCGRVYGALAGMMMTVKALPLAYNKD
MQEDKEGLFDALDSWSDCIEMAALCFEGIKINKERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVAVVSAIEKGC
ALEELSIAELKVFSDVIEDDVYAILTIESCLAKRNALGGVAPEQVAYAVEQAGKRLEERDSTGVKVRPARLTDLDALEGM
VAYWAGLGENLPRSRNELVRDIGSFAVSEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQSQGQGKAIVQHLVEKAREMA
INKVFVLTRVPEFFMKQDFIPTSRSLLPEKVLKDCDQCPRQHACDEVALEVNLQEQIIIKTNVA

Sequences:

>Translated_624_residues
MALWGGRFSQAADTRFKQFNDSLRIDYRLAEQDIVGSIAWSKALLSVNVITEIEQQKLELALNELKLEVMEDPEQILLSD
AEDIHSWVETQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGHQLLRTLDLLLNQLVNVASEHQATVLPGYTHLQRA
QPVTFAHWCLAYVEMIERDYSRLEDAIKRLDTCPLGSGALAGTAYPMDREKLARNLGFQRATRNSLDSVSDRDHVMELMS
IASISMVHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKCGRVYGALAGMMMTVKALPLAYNKD
MQEDKEGLFDALDSWSDCIEMAALCFEGIKINKERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVAVVSAIEKGC
ALEELSIAELKVFSDVIEDDVYAILTIESCLAKRNALGGVAPEQVAYAVEQAGKRLEERDSTGVKVRPARLTDLDALEGM
VAYWAGLGENLPRSRNELVRDIGSFAVSEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQSQGQGKAIVQHLVEKAREMA
INKVFVLTRVPEFFMKQDFIPTSRSLLPEKVLKDCDQCPRQHACDEVALEVNLQEQIIIKTNVA
>Mature_623_residues
ALWGGRFSQAADTRFKQFNDSLRIDYRLAEQDIVGSIAWSKALLSVNVITEIEQQKLELALNELKLEVMEDPEQILLSDA
EDIHSWVETQLIGKVGDLGKKLHTGRSRNDQVATDLKLWCRQQGHQLLRTLDLLLNQLVNVASEHQATVLPGYTHLQRAQ
PVTFAHWCLAYVEMIERDYSRLEDAIKRLDTCPLGSGALAGTAYPMDREKLARNLGFQRATRNSLDSVSDRDHVMELMSI
ASISMVHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKCGRVYGALAGMMMTVKALPLAYNKDM
QEDKEGLFDALDSWSDCIEMAALCFEGIKINKERTLEAAKQGYANSTELADYLVAKGIPFREAHHIVGVAVVSAIEKGCA
LEELSIAELKVFSDVIEDDVYAILTIESCLAKRNALGGVAPEQVAYAVEQAGKRLEERDSTGVKVRPARLTDLDALEGMV
AYWAGLGENLPRSRNELVRDIGSFAVSEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQSQGQGKAIVQHLVEKAREMAI
NKVFVLTRVPEFFMKQDFIPTSRSLLPEKVLKDCDQCPRQHACDEVALEVNLQEQIIIKTNVA

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 N-acetyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=449, Percent_Identity=43.652561247216, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303542, Length=449, Percent_Identity=43.652561247216, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI68303549, Length=449, Percent_Identity=41.6481069042316, Blast_Score=331, Evalue=2e-90,
Organism=Homo sapiens, GI68303547, Length=449, Percent_Identity=40.9799554565702, Blast_Score=324, Evalue=1e-88,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=71.9298245614035, Blast_Score=675, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321806, Length=446, Percent_Identity=42.6008968609865, Blast_Score=354, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6324993, Length=330, Percent_Identity=25.7575757575758, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221473854, Length=449, Percent_Identity=42.0935412026726, Blast_Score=352, Evalue=6e-97,
Organism=Drosophila melanogaster, GI78706858, Length=449, Percent_Identity=42.0935412026726, Blast_Score=352, Evalue=6e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR009049
- InterPro:   IPR011244
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 69303; Mature: 69172

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALWGGRFSQAADTRFKQFNDSLRIDYRLAEQDIVGSIAWSKALLSVNVITEIEQQKLEL
CCCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNELKLEVMEDPEQILLSDAEDIHSWVETQLIGKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRQQGHQLLRTLDLLLNQLVNVASEHQATVLPGYTHLQRAQPVTFAHWCLAYVEMIERDY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLEDAIKRLDTCPLGSGALAGTAYPMDREKLARNLGFQRATRNSLDSVSDRDHVMELMS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHH
IASISMVHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKCGRVY
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALAGMMMTVKALPLAYNKDMQEDKEGLFDALDSWSDCIEMAALCFEGIKINKERTLEAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KQGYANSTELADYLVAKGIPFREAHHIVGVAVVSAIEKGCALEELSIAELKVFSDVIEDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
VYAILTIESCLAKRNALGGVAPEQVAYAVEQAGKRLEERDSTGVKVRPARLTDLDALEGM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
VAYWAGLGENLPRSRNELVRDIGSFAVSEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCHHHHHHCCCCCCCC
SQGQGKAIVQHLVEKAREMAINKVFVLTRVPEFFMKQDFIPTSRSLLPEKVLKDCDQCPR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHCHHHHHHHHHHCHH
QHACDEVALEVNLQEQIIIKTNVA
HHCCCHHEEEECCCCEEEEEECCC
>Mature Secondary Structure 
ALWGGRFSQAADTRFKQFNDSLRIDYRLAEQDIVGSIAWSKALLSVNVITEIEQQKLEL
CCCCCCCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNELKLEVMEDPEQILLSDAEDIHSWVETQLIGKVGDLGKKLHTGRSRNDQVATDLKLW
HHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
CRQQGHQLLRTLDLLLNQLVNVASEHQATVLPGYTHLQRAQPVTFAHWCLAYVEMIERDY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
SRLEDAIKRLDTCPLGSGALAGTAYPMDREKLARNLGFQRATRNSLDSVSDRDHVMELMS
HHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHH
IASISMVHLSRLAEDMIFYNSGESNFIELADTVTSGSSLMPQKKNPDALELIRGKCGRVY
HHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHH
GALAGMMMTVKALPLAYNKDMQEDKEGLFDALDSWSDCIEMAALCFEGIKINKERTLEAA
HHHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KQGYANSTELADYLVAKGIPFREAHHIVGVAVVSAIEKGCALEELSIAELKVFSDVIEDD
HCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
VYAILTIESCLAKRNALGGVAPEQVAYAVEQAGKRLEERDSTGVKVRPARLTDLDALEGM
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHH
VAYWAGLGENLPRSRNELVRDIGSFAVSEHHGEVTGCASLYVYDSGLAEIRSLGVEAGWQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHEEEEEECCCHHHHHHCCCCCCCC
SQGQGKAIVQHLVEKAREMAINKVFVLTRVPEFFMKQDFIPTSRSLLPEKVLKDCDQCPR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHCHHHHHHHHHHCHH
QHACDEVALEVNLQEQIIIKTNVA
HHCCCHHEEEECCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA