Click here to switch to the map view.

The map label for this gene is folB [H]

Identifier: 209696100

GI number: 209696100

Start: 2914067

End: 2914420

Strand: Reverse

Name: folB [H]

Synonym: VSAL_I2692

Alternate gene names: 209696100

Gene position: 2914420-2914067 (Counterclockwise)

Preceding gene: 209696102

Following gene: 209696099

Centisome position: 87.65

GC content: 40.11

Gene sequence:

>354_bases
ATGGATTTAGTATTTATAAAACAACTTGAAGTTATTACAACCATTGGTGTTTATGAGTGGGAACAGGGCATTAAACAGAA
GCTAGTATTAGATATTGATATGGCTCACGATAATAAACCAGCCGCGGATTCTGATAATGTAGAGCAATGCTTAAATTATG
CAGAAGTCAGCGACGCGGTTACTGCGCATATTCAACAAGGGCGTTTTTTACTTGTTGAGCGAGTGGCAGAAGAAATTGCC
GAGCTAATAATGACTCGTTTTTCTGTTCCTTGGGTTCGCATTCATTTATCAAAACCTGGTGCGGTAGTTAACGCGCACAG
TGTTGGTGTGGTGATTGAACGAGGATCAAAATGA

Upstream 100 bases:

>100_bases
TTATAGTATATTGCTCTACACATTGAGCAAGGTAATAACAATATTACGTTGTTTTTCTTTTGATGGGTATCCGACCTCTT
AATAAAAAGTGTGATCAAAG

Downstream 100 bases:

>100_bases
GCACTGTGTATATCGGTGTAGGTTCCAATATTGATCCTGAAAAACACGCAAAAATAGCAATAACAGAGCTAAAGCAATTG
GGTAAGTTAAAAAAAGTATC

Product: dihydroneopterin aldolase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 117; Mature: 117

Protein sequence:

>117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAADSDNVEQCLNYAEVSDAVTAHIQQGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK

Sequences:

>Translated_117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAADSDNVEQCLNYAEVSDAVTAHIQQGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
>Mature_117_residues
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAADSDNVEQCLNYAEVSDAVTAHIQQGRFLLVERVAEEIA
ELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=117, Percent_Identity=64.1025641025641, Blast_Score=164, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13083; Mature: 13083

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAADSDNVEQCLNYAEVSDAV
CCEEEHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TAHIQQGRFLLVERVAEEIAELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECEEEEEEECCCC
>Mature Secondary Structure
MDLVFIKQLEVITTIGVYEWEQGIKQKLVLDIDMAHDNKPAADSDNVEQCLNYAEVSDAV
CCEEEHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
TAHIQQGRFLLVERVAEEIAELIMTRFSVPWVRIHLSKPGAVVNAHSVGVVIERGSK
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEECEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]