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The map label for this gene is folK [H]

Identifier: 209696099

GI number: 209696099

Start: 2913582

End: 2914070

Strand: Reverse

Name: folK [H]

Synonym: VSAL_I2691

Alternate gene names: 209696099

Gene position: 2914070-2913582 (Counterclockwise)

Preceding gene: 209696100

Following gene: 209696098

Centisome position: 87.64

GC content: 34.97

Gene sequence:

>489_bases
ATGAGCACTGTGTATATCGGTGTAGGTTCCAATATTGATCCTGAAAAACACGCAAAAATAGCAATAACAGAGCTAAAGCA
ATTGGGTAAGTTAAAAAAAGTATCAACAATTTATGAAGCGGAACCGGTTGGTTTTTCGGGGGATAATTTCTTTAATTTTG
TTGTTGAGCTTGAAACAAAGCACAGTTTATCTTTGTTAGGCGATTATTTGCGTGCTATCGAGATTAAGTGGGGTCGCAAG
CCCCAAGCACAAAAAAATCAAGATAGAACCTTAGATCTTGATATTTTACTTTATGATAATGTCGTATCTAAATTAGCTCC
AACATTACCAAGAAGCGATCTTTTTAAGTTCGCTTTTGTGATTTTGCCTATGGTTGAATTAAATCCTGAATTGGTTATTC
CAAGTACAGATAAAACCATTAGTGAAATATGGGCGGGTTTCCCTAGAACTCAATCATTAACACCTGTCACTTTGACATTG
ATTATTTAA

Upstream 100 bases:

>100_bases
TGACTCGTTTTTCTGTTCCTTGGGTTCGCATTCATTTATCAAAACCTGGTGCGGTAGTTAACGCGCACAGTGTTGGTGTG
GTGATTGAACGAGGATCAAA

Downstream 100 bases:

>100_bases
GAGATGTAATGACGTATTTTGAAGCATTTTTTCTTGCTTTATTGCAAGGATTTACTGAATTTTTACCAATATCTAGTTCG
GCTCATTTAATTTTACCGTC

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MSTVYIGVGSNIDPEKHAKIAITELKQLGKLKKVSTIYEAEPVGFSGDNFFNFVVELETKHSLSLLGDYLRAIEIKWGRK
PQAQKNQDRTLDLDILLYDNVVSKLAPTLPRSDLFKFAFVILPMVELNPELVIPSTDKTISEIWAGFPRTQSLTPVTLTL
II

Sequences:

>Translated_162_residues
MSTVYIGVGSNIDPEKHAKIAITELKQLGKLKKVSTIYEAEPVGFSGDNFFNFVVELETKHSLSLLGDYLRAIEIKWGRK
PQAQKNQDRTLDLDILLYDNVVSKLAPTLPRSDLFKFAFVILPMVELNPELVIPSTDKTISEIWAGFPRTQSLTPVTLTL
II
>Mature_161_residues
STVYIGVGSNIDPEKHAKIAITELKQLGKLKKVSTIYEAEPVGFSGDNFFNFVVELETKHSLSLLGDYLRAIEIKWGRKP
QAQKNQDRTLDLDILLYDNVVSKLAPTLPRSDLFKFAFVILPMVELNPELVIPSTDKTISEIWAGFPRTQSLTPVTLTLI
I

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=145, Percent_Identity=33.7931034482759, Blast_Score=71, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 18174; Mature: 18043

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVYIGVGSNIDPEKHAKIAITELKQLGKLKKVSTIYEAEPVGFSGDNFFNFVVELETK
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
HSLSLLGDYLRAIEIKWGRKPQAQKNQDRTLDLDILLYDNVVSKLAPTLPRSDLFKFAFV
CCHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCHHHHHHHHHH
ILPMVELNPELVIPSTDKTISEIWAGFPRTQSLTPVTLTLII
HHHHHHCCCCEEECCCCCHHHHHHCCCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
STVYIGVGSNIDPEKHAKIAITELKQLGKLKKVSTIYEAEPVGFSGDNFFNFVVELETK
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCC
HSLSLLGDYLRAIEIKWGRKPQAQKNQDRTLDLDILLYDNVVSKLAPTLPRSDLFKFAFV
CCHHHHHHHHHHEEEECCCCCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCHHHHHHHHHH
ILPMVELNPELVIPSTDKTISEIWAGFPRTQSLTPVTLTLII
HHHHHHCCCCEEECCCCCHHHHHHCCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10080886 [H]