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The map label for this gene is aceE [H]

Identifier: 209696034

GI number: 209696034

Start: 2839473

End: 2842136

Strand: Reverse

Name: aceE [H]

Synonym: VSAL_I2625

Alternate gene names: 209696034

Gene position: 2842136-2839473 (Counterclockwise)

Preceding gene: 209696035

Following gene: 209696033

Centisome position: 85.47

GC content: 43.13

Gene sequence:

>2664_bases
ATGTCTGACATGAAGCATGACGTTGATGCACTAGAAACTCAAGATTGGTTAGAAGCTCTTGAGTCAGTTGTACGTGAAGA
GGGTGTTGAACGCGCCCAGTATCTATTAGAGCAAGTTCTTGATAAAGCTCGTTTAGATGGTGTTGATATGGCTACAGGTA
TCAATACAAACTACATCAATACCATCCCAGCAACGCAAGAACCTGCGTACCCTGGTGATGTTACTCTTGAGCGTCGTATC
CGTTCAATTATTCGTTGGAACGCAATCATGATCGTTCTACGTGCTTCTAAGAAAGATTTGGATCTAGGCGGCCACATGGC
GTCTTACCAATCTGCAGCAGCATTTTACGAAGTCTGTTTTAACCATTTCTTCCGTGCTCCGAATGAGACGGATGGTGGTG
ATTTAGTTTATTACCAAGGTCATATCTCTCCAGGTATCTATTCTCGTGCATTCGTTGAAGGTCGTTTAACGGAAGAGCAA
CTAGATAACTTCCGTCAAGAAGTTGATGGTAAAGGTATTCCTTCTTACCCGCACCCTAAACTGATGCCTGAATTCTGGCA
GTTCCCTACCGTATCTATGGGTCTTGGTCCTATTTCTGCAATCTATCAAGCGCGTTTCCTTAAGTACCTTGATGGCCGTG
GCATGAAAGAAACATCAGCACAACGTGTTTACGCGTTCCTAGGTGATGGTGAGATGGATGAGCCAGAATCACGCGGTGCG
ATCTCTTTCGCTGCTCGTGAAAAACTGGACAACCTATGTTTCTTAATTAACTGTAACCTACAGCGTCTAGATGGCCCTGT
TATGGGTAACGGTAGCATCATTCAAGAACTAGAAGGCCTATTTAAAGGCGCTGGCTGGAATGTTGTTAAAGTTATTTGGG
GCAGCAACTGGGATTCACTACTTGCTAAAGACACGACTGGTAAGCTTCTTCAGTTAATGAACGAAACTATCGATGGTGAT
TACCAAACATTCAAATCTAAAGATGGTGCTTACGTACGTGAGAACTTCTTTGGTAAATACCCAGAAACAGCAGCACTTGT
TGCTGACATGACTGATGACGAAATCTTCGCTCTTAAGCGTGGTGGTCATGACTCATCTAAACTGTTTGCTGCATTCAACA
ATGCAAAAGAAACAAACGGTAAGCCAACAGTAATCCTAGCTAAAACAGTTAAAGGTTACGGCATGGGTGATGCAGCTGAA
GGTAAGAACATTGCACACGGTGTTAAGAAAATGGACATGACTCATGTTCAACACTTACGTGATCGTTTAGGCCTACAAGA
CATTCTTTCTGATGAGAAGATTAAAGAACTGCCTTATCTAACACTAGAAGAAGGTTCTGCAGAGTACAAATACCTACACG
CTCGTCGTGATGCGCTACATGGTTATACGCCTAAGCGTCTGCCTAAGTTCACTCAAGAATTCATTGTTCCTGAAGTTAAC
GCGTTTGATGCTCTTCTTGGTGAACAAAAGCGTGATATCTCTACGACAATGGCATTTGTTCGTGCGCTTAACGTTCTTCT
TAAAGACAAAAATATTGGTAAGAACATTGTTCCTATCATTGCCGATGAAGCTCGTACTTTTGGTATGGAAGGTTTATTCC
GTCAGGTTGGTATCTATAACCCACACGGCCAAACATATACTCCTGAGGATAAAGGCATTGTTTCTTACTACAAAGAAGCA
ACGTCTGGTCAAGTACTTCAAGAAGGCATCAATGAGTTAGGTGCTATGTCTTCATGGGTTGCCGCAGCAACGTCATACAG
CACTAACGATCTTCCTATGATCCCATTCTACATTTACTACTCTATGTTCGGTTTCCAACGTGTTGGTGATATGGCATGGA
TGGCGGGTGACCAACAAGCACGTGGTTTCCTATTAGGCGCTACTGCAGGTCGTACTACGCTAAATGGTGAAGGTCTACAA
CACGAAGATGGTCACTCACACATTCAAGCGAACACCGTGCCTAACTGTATCTCTTACGATCCAACATTCGCTTACGAATT
AGCGATCATCATGCAAGACGGTATTCGTCGCATGTACGGTGAAAACCAAGAGAACATTTATTACTACCTAACGCTAATGA
ATGAAAACTACGCAATGCCAGCAATGCCACAAGGCGCTGAAGAAGGCATTCGTAAAGGTATTTATAAGCTTGAGTCTTAC
GTTGGTGATAAAGCTAAAGTTCAATTAATGAGCTCTGGTACTATCATGAACGAAGCACGTAAAGCGGCTCAAATTTTGAG
TGAAGAGTACGGTGTTGCTTCTGATGTTTACTCTGTGACATCGTTCAATGAATTGACTCGTGACGGCCAAGCGGTAGAGC
GTGACAACATGCTTCACCCTGAAGCTGCAACGAAAGTACCTTACATTACTCAAGTTCTTGGTAACGAACCTGCAATCGCA
GTAACGGATTACATGAAGAACTACGCTGAGCAAGTACGTGCATTCGTTCCTGCTGAGTCTTACAAAGTACTTGGTACTGA
TGGTTTTGGTCGTTCAGACAGCCGTGAGAACTTACGTCGTCACTTCGAAGTTAACGCAGGCTACGTTGTAGTTGCTGCTC
TAGCTGAACTTGTGAAACGTGGTGATATTGATAAATCTGTAGTTGCAGAAGCAATTGCTAAATTCAATATCGATACTGAA
AAAACTAACCCGCTATACGCATAA

Upstream 100 bases:

>100_bases
GAGTGCTCACTTCGTCGAATTCAACAAAGTAATGACATGAATTAATCTGATTCATTTCATTGTCACCCTATTTGAACCAA
CAAATAAAAGGATAGCTCGC

Downstream 100 bases:

>100_bases
GGTAGAAAACAATGACAATCGAAATTAATGTACCTGACATCGGTGCAGATGAGGTTGAAGTAACTGAGATTCTAGTTAAG
GTCGGTGACCGAGTTGAAGA

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 887; Mature: 886

Protein sequence:

>887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMATGINTNYINTIPATQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLDGRGMKETSAQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVRENFFGKYPETAALVADMTDDEIFALKRGGHDSSKLFAAFNNAKETNGKPTVILAKTVKGYGMGDAAE
GKNIAHGVKKMDMTHVQHLRDRLGLQDILSDEKIKELPYLTLEEGSAEYKYLHARRDALHGYTPKRLPKFTQEFIVPEVN
AFDALLGEQKRDISTTMAFVRALNVLLKDKNIGKNIVPIIADEARTFGMEGLFRQVGIYNPHGQTYTPEDKGIVSYYKEA
TSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIQANTVPNCISYDPTFAYELAIIMQDGIRRMYGENQENIYYYLTLMNENYAMPAMPQGAEEGIRKGIYKLESY
VGDKAKVQLMSSGTIMNEARKAAQILSEEYGVASDVYSVTSFNELTRDGQAVERDNMLHPEAATKVPYITQVLGNEPAIA
VTDYMKNYAEQVRAFVPAESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALAELVKRGDIDKSVVAEAIAKFNIDTE
KTNPLYA

Sequences:

>Translated_887_residues
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMATGINTNYINTIPATQEPAYPGDVTLERRI
RSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQ
LDNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLDGRGMKETSAQRVYAFLGDGEMDEPESRGA
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGD
YQTFKSKDGAYVRENFFGKYPETAALVADMTDDEIFALKRGGHDSSKLFAAFNNAKETNGKPTVILAKTVKGYGMGDAAE
GKNIAHGVKKMDMTHVQHLRDRLGLQDILSDEKIKELPYLTLEEGSAEYKYLHARRDALHGYTPKRLPKFTQEFIVPEVN
AFDALLGEQKRDISTTMAFVRALNVLLKDKNIGKNIVPIIADEARTFGMEGLFRQVGIYNPHGQTYTPEDKGIVSYYKEA
TSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQ
HEDGHSHIQANTVPNCISYDPTFAYELAIIMQDGIRRMYGENQENIYYYLTLMNENYAMPAMPQGAEEGIRKGIYKLESY
VGDKAKVQLMSSGTIMNEARKAAQILSEEYGVASDVYSVTSFNELTRDGQAVERDNMLHPEAATKVPYITQVLGNEPAIA
VTDYMKNYAEQVRAFVPAESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALAELVKRGDIDKSVVAEAIAKFNIDTE
KTNPLYA
>Mature_886_residues
SDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMATGINTNYINTIPATQEPAYPGDVTLERRIR
SIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCFNHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQL
DNFRQEVDGKGIPSYPHPKLMPEFWQFPTVSMGLGPISAIYQARFLKYLDGRGMKETSAQRVYAFLGDGEMDEPESRGAI
SFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSLLAKDTTGKLLQLMNETIDGDY
QTFKSKDGAYVRENFFGKYPETAALVADMTDDEIFALKRGGHDSSKLFAAFNNAKETNGKPTVILAKTVKGYGMGDAAEG
KNIAHGVKKMDMTHVQHLRDRLGLQDILSDEKIKELPYLTLEEGSAEYKYLHARRDALHGYTPKRLPKFTQEFIVPEVNA
FDALLGEQKRDISTTMAFVRALNVLLKDKNIGKNIVPIIADEARTFGMEGLFRQVGIYNPHGQTYTPEDKGIVSYYKEAT
SGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYYSMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQH
EDGHSHIQANTVPNCISYDPTFAYELAIIMQDGIRRMYGENQENIYYYLTLMNENYAMPAMPQGAEEGIRKGIYKLESYV
GDKAKVQLMSSGTIMNEARKAAQILSEEYGVASDVYSVTSFNELTRDGQAVERDNMLHPEAATKVPYITQVLGNEPAIAV
TDYMKNYAEQVRAFVPAESYKVLGTDGFGRSDSRENLRRHFEVNAGYVVVAALAELVKRGDIDKSVVAEAIAKFNIDTEK
TNPLYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786304, Length=883, Percent_Identity=72.8199320498301, Blast_Score=1382, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=250, Percent_Identity=29.2, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99018; Mature: 98887

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMATGINTNYIN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEE
TIPATQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLDGRGMKETSAQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHH
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVRENFFGKYPETAALVADMTDDEIFALKR
HHCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCCEEEEEC
GGHDSSKLFAAFNNAKETNGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVQHLR
CCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKIKELPYLTLEEGSAEYKYLHARRDALHGYTPKRLPKFTQEFIVPEVN
HHCCHHHHHCCHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
AFDALLGEQKRDISTTMAFVRALNVLLKDKNIGKNIVPIIADEARTFGMEGLFRQVGIYN
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHCHHHHHHHHCCCC
PHGQTYTPEDKGIVSYYKEATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIQANTVPNCISYD
HHHHHHHHCCHHHHCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PTFAYELAIIMQDGIRRMYGENQENIYYYLTLMNENYAMPAMPQGAEEGIRKGIYKLESY
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
VGDKAKVQLMSSGTIMNEARKAAQILSEEYGVASDVYSVTSFNELTRDGQAVERDNMLHP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC
EAATKVPYITQVLGNEPAIAVTDYMKNYAEQVRAFVPAESYKVLGTDGFGRSDSRENLRR
HHHCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALAELVKRGDIDKSVVAEAIAKFNIDTEKTNPLYA
HCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDMKHDVDALETQDWLEALESVVREEGVERAQYLLEQVLDKARLDGVDMATGINTNYIN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEE
TIPATQEPAYPGDVTLERRIRSIIRWNAIMIVLRASKKDLDLGGHMASYQSAAAFYEVCF
CCCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHH
NHFFRAPNETDGGDLVYYQGHISPGIYSRAFVEGRLTEEQLDNFRQEVDGKGIPSYPHPK
HHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCC
LMPEFWQFPTVSMGLGPISAIYQARFLKYLDGRGMKETSAQRVYAFLGDGEMDEPESRGA
CCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHEEEEEECCCCCCCCCCCCC
ISFAAREKLDNLCFLINCNLQRLDGPVMGNGSIIQELEGLFKGAGWNVVKVIWGSNWDSL
CHHHHHHHHCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHH
LAKDTTGKLLQLMNETIDGDYQTFKSKDGAYVRENFFGKYPETAALVADMTDDEIFALKR
HHCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHCCCCCCCCEEEEECCCCCEEEEEC
GGHDSSKLFAAFNNAKETNGKPTVILAKTVKGYGMGDAAEGKNIAHGVKKMDMTHVQHLR
CCCCCHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
DRLGLQDILSDEKIKELPYLTLEEGSAEYKYLHARRDALHGYTPKRLPKFTQEFIVPEVN
HHCCHHHHHCCHHHHHCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCH
AFDALLGEQKRDISTTMAFVRALNVLLKDKNIGKNIVPIIADEARTFGMEGLFRQVGIYN
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHCHHHHHHHHCCCC
PHGQTYTPEDKGIVSYYKEATSGQVLQEGINELGAMSSWVAAATSYSTNDLPMIPFYIYY
CCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
SMFGFQRVGDMAWMAGDQQARGFLLGATAGRTTLNGEGLQHEDGHSHIQANTVPNCISYD
HHHHHHHHCCHHHHCCCHHHCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCC
PTFAYELAIIMQDGIRRMYGENQENIYYYLTLMNENYAMPAMPQGAEEGIRKGIYKLESY
CCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
VGDKAKVQLMSSGTIMNEARKAAQILSEEYGVASDVYSVTSFNELTRDGQAVERDNMLHP
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC
EAATKVPYITQVLGNEPAIAVTDYMKNYAEQVRAFVPAESYKVLGTDGFGRSDSRENLRR
HHHCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHH
HFEVNAGYVVVAALAELVKRGDIDKSVVAEAIAKFNIDTEKTNPLYA
HCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]