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The map label for this gene is fhs

Identifier: 209695622

GI number: 209695622

Start: 2345262

End: 2346926

Strand: Reverse

Name: fhs

Synonym: VSAL_I2184

Alternate gene names: 209695622

Gene position: 2346926-2345262 (Counterclockwise)

Preceding gene: 209695626

Following gene: 209695621

Centisome position: 70.58

GC content: 42.88

Gene sequence:

>1665_bases
ATGAAAAGCGATATTGAGATCTGCCAAACTGCGACACTTATAAGAATGAAAACGATTGCGTCTAACTTAGGGCTGCATGA
TGATGACATTACGCCACAAGGTCGCTATAAAGCGAAAGTCAATATTGATGCCTTAAAACACCTTGAAGATAAACCAAGTG
GAAAACTTATTTTGGTTACCGCAATCACTCCAACGCCTTTAGGGGAAGGAAAAACGGTAACAACCATAGGATTAGCACAA
GGCTTAGCTAAATTAGGGGAATCCGTCAGTGCTTGTATTCGTCAACCCTCAATGGGTCCCGTTTTTGGGGTAAAAGGCGG
TGCCGCGGGTGGTGGTTATAGCCAAGTCGCTCCTATGGAAGAATTAAACCTACATTTAACAGGTGATATCCATGCAATAA
CGGCCGCACATAACCTCGCTTCCGCCGCTATTGACGCACGTATTTATCACGAACAACGTTTGGGTTATAACATTTTTTCA
GAAAAGAATGATCTCCCCGCATTACGTATTGATCCAACCCAAGTGGTTTGGAAACGAGTGATGGACCATAATGACCGTGC
TCTACGCATGGTGACCATCGGAAAGAATGAAGACAATAAAACCATTAATGGTTATGAACGCGAAGATGGTTTCGATATAA
CTGCCGCTTCAGAATTAATGGCCATTCTCGCTTTAGCCACTGACCTTCAAGATCTTCGTCAACGTATCGGTCGCATTGTT
GTTGCTTACAACCTTGATGGACTGCCTATCACCACAGAAGACTTGCAAGTGGCTGGCGCAATGACAGTCACAATGAAATT
CGCAATCAATCCAACGTTAATGCAAACACTTGAAGGCGTTCCAACGTTCGTTCATTCTGGGCCATTCGCAAACATCGCTC
ATGGTAACTCGTCGATTATTGCTGATAACATCGCCTTAAAATTGACCGATTATACCGTGTTAGTGGCCACATTACGTGGA
ATAAAAGCAAATTCGGGATTGTTTCCTCTATCATCAGGTCAATCCTTACCTAAAGCACTCTTTGTACCAAATCAAGAGGC
ATTAATTGCAGGATTAGATAATTTACATTGGCACATCAAAAACTGTGCTAAATATGGGTTGCCTGTTGTTGTTGCCATAA
ATCGATTCCCTGAAGACACTCAAGAAGAGCTCGATTTTTTAGCTGATTGGGTTACGAGTCAGTCTTCTGAACTAAACCTT
GATGTTGCCATTAGTGAAGCATTTGGAAAAGGAGGCGAAGGCACTCGCGAACTCGCCCAAAAAGTGCTAATCGCATGCGC
ACAAGAAACAGAGTTTACGCCACTTTATACTCCAGACATGAGTTTACTAGACAAATTAACCGCTGTAGCCATAAAAGGAT
ATGGCGCTGAACGCCTTGAACTTTCAGAAAAAGCACAGCAACAACTCGCTATGTTTGAACAGTTAGGCTATCAACACTTA
TCAGTATGCATGGCAAAAACACCGGCATCGATATCGACTGATGGCAACATTAAAGGCGCTCCAACTGACTTTATTGTACC
GATTCGTGAATTACGATTGTGTGCTGGTGCAGGCTTTGTGTATGCCTTATGTGGCAACGTAATGACAATGCCTGGCTTGC
CTGAAAAACCCGCATTCATGAATTTAGATATTGATAGTAATGGAAACATCACAGGGCTAAGCTAA

Upstream 100 bases:

>100_bases
ATTATTTTTAGGTAATTCATTCTGTCTCCCCCTATTTATGTGGTATAAAACAGGCGCTTCTTTTCTGGTGTTTAACTCTT
TCCTAAAGGTTCCCGTTATT

Downstream 100 bases:

>100_bases
GATCACATTACTTAATGTAGATCATGTTCTATGTGTTACATTTACTGTTAATCTAGCTTCAACTTTTTATATAAATTTAA
ATAATAATTTTGAGGTTATC

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS

Number of amino acids: Translated: 554; Mature: 554

Protein sequence:

>554_residues
MKSDIEICQTATLIRMKTIASNLGLHDDDITPQGRYKAKVNIDALKHLEDKPSGKLILVTAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYNIFS
EKNDLPALRIDPTQVVWKRVMDHNDRALRMVTIGKNEDNKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGLPITTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVLVATLRG
IKANSGLFPLSSGQSLPKALFVPNQEALIAGLDNLHWHIKNCAKYGLPVVVAINRFPEDTQEELDFLADWVTSQSSELNL
DVAISEAFGKGGEGTRELAQKVLIACAQETEFTPLYTPDMSLLDKLTAVAIKGYGAERLELSEKAQQQLAMFEQLGYQHL
SVCMAKTPASISTDGNIKGAPTDFIVPIRELRLCAGAGFVYALCGNVMTMPGLPEKPAFMNLDIDSNGNITGLS

Sequences:

>Translated_554_residues
MKSDIEICQTATLIRMKTIASNLGLHDDDITPQGRYKAKVNIDALKHLEDKPSGKLILVTAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYNIFS
EKNDLPALRIDPTQVVWKRVMDHNDRALRMVTIGKNEDNKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGLPITTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVLVATLRG
IKANSGLFPLSSGQSLPKALFVPNQEALIAGLDNLHWHIKNCAKYGLPVVVAINRFPEDTQEELDFLADWVTSQSSELNL
DVAISEAFGKGGEGTRELAQKVLIACAQETEFTPLYTPDMSLLDKLTAVAIKGYGAERLELSEKAQQQLAMFEQLGYQHL
SVCMAKTPASISTDGNIKGAPTDFIVPIRELRLCAGAGFVYALCGNVMTMPGLPEKPAFMNLDIDSNGNITGLS
>Mature_554_residues
MKSDIEICQTATLIRMKTIASNLGLHDDDITPQGRYKAKVNIDALKHLEDKPSGKLILVTAITPTPLGEGKTVTTIGLAQ
GLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPMEELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYNIFS
EKNDLPALRIDPTQVVWKRVMDHNDRALRMVTIGKNEDNKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
VAYNLDGLPITTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSIIADNIALKLTDYTVLVATLRG
IKANSGLFPLSSGQSLPKALFVPNQEALIAGLDNLHWHIKNCAKYGLPVVVAINRFPEDTQEELDFLADWVTSQSSELNL
DVAISEAFGKGGEGTRELAQKVLIACAQETEFTPLYTPDMSLLDKLTAVAIKGYGAERLELSEKAQQQLAMFEQLGYQHL
SVCMAKTPASISTDGNIKGAPTDFIVPIRELRLCAGAGFVYALCGNVMTMPGLPEKPAFMNLDIDSNGNITGLS

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family

Homologues:

Organism=Homo sapiens, GI222136639, Length=614, Percent_Identity=44.9511400651466, Blast_Score=462, Evalue=1e-130,
Organism=Homo sapiens, GI36796743, Length=615, Percent_Identity=42.9268292682927, Blast_Score=435, Evalue=1e-122,
Organism=Homo sapiens, GI310124614, Length=90, Percent_Identity=40, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17568737, Length=619, Percent_Identity=43.4571890145396, Blast_Score=436, Evalue=1e-122,
Organism=Caenorhabditis elegans, GI17568739, Length=619, Percent_Identity=43.4571890145396, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319558, Length=635, Percent_Identity=40.4724409448819, Blast_Score=424, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6321643, Length=630, Percent_Identity=40.9523809523809, Blast_Score=420, Evalue=1e-118,
Organism=Drosophila melanogaster, GI62472483, Length=624, Percent_Identity=39.2628205128205, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45551871, Length=624, Percent_Identity=39.2628205128205, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24645718, Length=624, Percent_Identity=39.2628205128205, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI17137370, Length=624, Percent_Identity=39.2628205128205, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FTHS_ALISL (B6EIJ9)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263551.1
- GeneID:   6987644
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I2184
- HOGENOM:   HBG677721
- OMA:   DTERELS
- ProtClustDB:   PRK13506
- HAMAP:   MF_01543
- InterPro:   IPR000559
- InterPro:   IPR020628

Pfam domain/function: PF01268 FTHFS

EC number: =6.3.4.3

Molecular weight: Translated: 59637; Mature: 59637

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00721 FTHFS_1; PS00722 FTHFS_2; PS00173 XYLOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSDIEICQTATLIRMKTIASNLGLHDDDITPQGRYKAKVNIDALKHLEDKPSGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCCCEEEEE
AITPTPLGEGKTVTTIGLAQGLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPME
EECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
ELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYNIFSEKNDLPALRIDPTQVVWKRV
HCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEECHHHHHHHHH
MDHNDRALRMVTIGKNEDNKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEE
VAYNLDGLPITTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSII
EEEECCCCCCCHHHHHEEEEEEEEEEEECCHHHHHHHCCCCHHHCCCCCCEECCCCCCEE
ADNIALKLTDYTVLVATLRGIKANSGLFPLSSGQSLPKALFVPNQEALIAGLDNLHWHIK
ECCEEEEEECCEEEEHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHHHEECCCHHHHHHH
NCAKYGLPVVVAINRFPEDTQEELDFLADWVTSQSSELNLDVAISEAFGKGGEGTRELAQ
HHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCHHHHHH
KVLIACAQETEFTPLYTPDMSLLDKLTAVAIKGYGAERLELSEKAQQQLAMFEQLGYQHL
HHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHH
SVCMAKTPASISTDGNIKGAPTDFIVPIRELRLCAGAGFVYALCGNVMTMPGLPEKPAFM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCEEECCCCCCCCCEE
NLDIDSNGNITGLS
EEEECCCCCEECCC
>Mature Secondary Structure
MKSDIEICQTATLIRMKTIASNLGLHDDDITPQGRYKAKVNIDALKHLEDKPSGKLILVT
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHCCCCCCCCEEEEE
AITPTPLGEGKTVTTIGLAQGLAKLGESVSACIRQPSMGPVFGVKGGAAGGGYSQVAPME
EECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCHH
ELNLHLTGDIHAITAAHNLASAAIDARIYHEQRLGYNIFSEKNDLPALRIDPTQVVWKRV
HCCEEEECCEEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEECHHHHHHHHH
MDHNDRALRMVTIGKNEDNKTINGYEREDGFDITAASELMAILALATDLQDLRQRIGRIV
HCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCEEE
VAYNLDGLPITTEDLQVAGAMTVTMKFAINPTLMQTLEGVPTFVHSGPFANIAHGNSSII
EEEECCCCCCCHHHHHEEEEEEEEEEEECCHHHHHHHCCCCHHHCCCCCCEECCCCCCEE
ADNIALKLTDYTVLVATLRGIKANSGLFPLSSGQSLPKALFVPNQEALIAGLDNLHWHIK
ECCEEEEEECCEEEEHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHHHEECCCHHHHHHH
NCAKYGLPVVVAINRFPEDTQEELDFLADWVTSQSSELNLDVAISEAFGKGGEGTRELAQ
HHHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCCCCHHHHHH
KVLIACAQETEFTPLYTPDMSLLDKLTAVAIKGYGAERLELSEKAQQQLAMFEQLGYQHL
HHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHH
SVCMAKTPASISTDGNIKGAPTDFIVPIRELRLCAGAGFVYALCGNVMTMPGLPEKPAFM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHCCEEECCCCCCCCCEE
NLDIDSNGNITGLS
EEEECCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA