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The map label for this gene is dxs

Identifier: 209694501

GI number: 209694501

Start: 1030373

End: 1032256

Strand: Reverse

Name: dxs

Synonym: VSAL_I0933

Alternate gene names: 209694501

Gene position: 1032256-1030373 (Counterclockwise)

Preceding gene: 209694502

Following gene: 209694499

Centisome position: 31.04

GC content: 41.19

Gene sequence:

>1884_bases
ATGTCACTTGATATTTCAAAATACCCAATTCTGGCTTTGGCAAACACACCAGATGAACTACGTTCTTTGCCAAAAGAAAG
CCTACCTGCTTTATGTGATGAGCTTCGTGCTTATCTTTTAAAGTCTGTCAGTAAATCGAGTGGCCATTTAGCTTCTGGGC
TTGGTGTTGTTGAACTGACTGTCGCTTTACATTACGTCTACAATACCCCATTTGATCAACTTATTTGGGATGTAGGCCAT
CAAGCTTACCCTCATAAGATCTTAACGGGTCGTCGTGAAAAACTGTCTACCATTCGTCAAAAAGATGGATTACACCCTTT
CCCATGGCGCGATGAAAGCGAATATGATGTGCTTTCTGTTGGTCACTCTTCAACTTCGATAAGCGCCGCTCTGGGTTTAG
CTATCTGTGCTGAAAAAGAGCAAGCCAATAGAAAAGTCATTAGTGTTATTGGTGATGGTGCTATTACGGCAGGCATGGCG
TTTGAAGCATTAAACCACGCCGGTGATATACATCCAGATATGTTAGTTGTCTTAAATGACAATGAGATGTCAATTTCAGA
AAATGTTGGCGCACTTAATAATCAATTAGCTCGCGTATTATCAGGCAGTTTATACACCTCCATTCGTGAAGGTGGTAAAA
AAGTACTCTCTGGTACCCCTACGATTAAAGAATTACTTAAGCGTACTGAAGAACATATCAAAGGGATGGTCATTCCTGGA
ACGATGTTCGAAGAACTAGGCTTTAACTATATTGGCCCTGTCGATGGTCATGATGTAAACGAATTAGTTCGTACTCTTAA
GAATATGCGCAACCTAAAAGGTCCGCAGTTCTTACACATTATGACGAAAAAAGGCAAAGGCTATGAGCCTGCAGAAAAAG
ATCCTATTAGCTACCATGGTGTACCTAAATTTGATCCAAGCAATCACTCATTACCGAAGTCATCAGGTGGAAAACCAACG
TTCTCAAATATTTTTGGTGATTTTCTTTGTGATATGGCAAAGGACGATGACAAATTAATGGCCATCACGCCTGCAATGCG
TGAAGGATCTGGCATGGTTCGTTTTTCAAAAGAATTCCCAGGTCAATATTTTGATACCGCAATTGCAGAGCAACACGCAG
TAACGCTAGCCAGTGGTATGGCTATCGCAGGTTATAATCCTATTGTCGCCATTTATTCAACGTTCTTACAACGTGGTTAT
GACCAACTGATTCATGATGTTGCCATCATGAATTTACCTGTAATGTTTGCTATCGACCGTGCTGGTCTGGTTGGTGCCGA
TGGTCAAACCCATCAAGGTGCTTTTGACATCAGCTTTATGCGCTGTATTCCAAACATGGTAATTATGACCCCAAGCGATG
AAAACGAATGTCGCCAGATGCTTTATACGGGACATAAACATACTGGACCAAGTGCTGTTCGCTATCCTCGAGGAAGTGCG
ACCGGTATTGAGGTTAATAAAGAGATGCAAGCGTTAGAAATAGGTAAAGGTCGATTAATCCGTGAAACTAAAATCACAGA
AAAAGGCGAACGTGTTGCTATCTTAAACTTCGGCACCTTTTTATCGAACAGTGTAGAAGCAGCAGAAAAACTAGACGCAA
CGGTTGCCGATATGCGCTTTGCTAAACCGTTAGATGAAACCTTACTTTGTGAGTTAGTCACAAGCCATGATGTATTAGTG
ACCATCGAAGAAAATGCAATTTCAGGTGGTGCCGGCTCAGGCGTTATTGAGTTCCTAATGAAAAACCGTCTAATCAAACC
AGTACTTCAACTTGGCTTACCTGACCAATTTATTGCTCAAGGAACACAAGAAGAAATGCATGCTGAGTTAATGTTAGATG
CAACAGGTATTGAAAAACAAATCCGAGATTATCTGGATTTATAA

Upstream 100 bases:

>100_bases
ACTGCATTAGATGATATTCCATATAACACGGATGCAATGCAAGCGTTCGCTCAATACGTCATCGAGCGTAAAAACTAAAA
CAGATAAGCGCTGAATAATT

Downstream 100 bases:

>100_bases
TTCATATCATTTCATAAAAAAATGCCACAACGTTGTGGCATTTTTTATCACTGTAATAAGTACGATTATCTAATTTAATT
TCGGTGCATCAAAATCATTC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MSLDISKYPILALANTPDELRSLPKESLPALCDELRAYLLKSVSKSSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRREKLSTIRQKDGLHPFPWRDESEYDVLSVGHSSTSISAALGLAICAEKEQANRKVISVIGDGAITAGMA
FEALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHIKGMVIPG
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNHSLPKSSGGKPT
FSNIFGDFLCDMAKDDDKLMAITPAMREGSGMVRFSKEFPGQYFDTAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGY
DQLIHDVAIMNLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
TGIEVNKEMQALEIGKGRLIRETKITEKGERVAILNFGTFLSNSVEAAEKLDATVADMRFAKPLDETLLCELVTSHDVLV
TIEENAISGGAGSGVIEFLMKNRLIKPVLQLGLPDQFIAQGTQEEMHAELMLDATGIEKQIRDYLDL

Sequences:

>Translated_627_residues
MSLDISKYPILALANTPDELRSLPKESLPALCDELRAYLLKSVSKSSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGH
QAYPHKILTGRREKLSTIRQKDGLHPFPWRDESEYDVLSVGHSSTSISAALGLAICAEKEQANRKVISVIGDGAITAGMA
FEALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHIKGMVIPG
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNHSLPKSSGGKPT
FSNIFGDFLCDMAKDDDKLMAITPAMREGSGMVRFSKEFPGQYFDTAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGY
DQLIHDVAIMNLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
TGIEVNKEMQALEIGKGRLIRETKITEKGERVAILNFGTFLSNSVEAAEKLDATVADMRFAKPLDETLLCELVTSHDVLV
TIEENAISGGAGSGVIEFLMKNRLIKPVLQLGLPDQFIAQGTQEEMHAELMLDATGIEKQIRDYLDL
>Mature_626_residues
SLDISKYPILALANTPDELRSLPKESLPALCDELRAYLLKSVSKSSGHLASGLGVVELTVALHYVYNTPFDQLIWDVGHQ
AYPHKILTGRREKLSTIRQKDGLHPFPWRDESEYDVLSVGHSSTSISAALGLAICAEKEQANRKVISVIGDGAITAGMAF
EALNHAGDIHPDMLVVLNDNEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHIKGMVIPGT
MFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHGVPKFDPSNHSLPKSSGGKPTF
SNIFGDFLCDMAKDDDKLMAITPAMREGSGMVRFSKEFPGQYFDTAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYD
QLIHDVAIMNLPVMFAIDRAGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSAT
GIEVNKEMQALEIGKGRLIRETKITEKGERVAILNFGTFLSNSVEAAEKLDATVADMRFAKPLDETLLCELVTSHDVLVT
IEENAISGGAGSGVIEFLMKNRLIKPVLQLGLPDQFIAQGTQEEMHAELMLDATGIEKQIRDYLDL

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=489, Percent_Identity=22.6993865030675, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI4507521, Length=489, Percent_Identity=22.6993865030675, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI133778974, Length=656, Percent_Identity=21.6463414634146, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI225637461, Length=425, Percent_Identity=22.3529411764706, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI225637459, Length=425, Percent_Identity=22.5882352941176, Blast_Score=74, Evalue=6e-13,
Organism=Homo sapiens, GI225637463, Length=425, Percent_Identity=22.3529411764706, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=74.6006389776358, Blast_Score=979, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=409, Percent_Identity=23.4718826405868, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666278, Length=651, Percent_Identity=23.963133640553, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI45551847, Length=652, Percent_Identity=22.8527607361963, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45550715, Length=652, Percent_Identity=22.8527607361963, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24645119, Length=551, Percent_Identity=23.2304900181488, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_ALISL (B6EIA7)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262429.1
- GeneID:   6986736
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0933
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68704; Mature: 68572

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDISKYPILALANTPDELRSLPKESLPALCDELRAYLLKSVSKSSGHLASGLGVVELT
CCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHH
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRREKLSTIRQKDGLHPFPWRDESEYDVLSV
HHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAALGLAICAEKEQANRKVISVIGDGAITAGMAFEALNHAGDIHPDMLVVLND
CCCCCHHHHHHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHIKGMVIPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSNHSLPKSSGGKPTFSNIFGDFLCDMAKDDDKLMAITPAMREGSGMVRFSKEFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHCCCCCEEEHHHCC
GQYFDTAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYDQLIHDVAIMNLPVMFAIDR
CHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
TGIEVNKEMQALEIGKGRLIRETKITEKGERVAILNFGTFLSNSVEAAEKLDATVADMRF
CCEEECCHHHHHHCCCCCEEEHHHCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHH
AKPLDETLLCELVTSHDVLVTIEENAISGGAGSGVIEFLMKNRLIKPVLQLGLPDQFIAQ
HCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GTQEEMHAELMLDATGIEKQIRDYLDL
CCHHHHHHHHHEECCCHHHHHHHHHCC
>Mature Secondary Structure 
SLDISKYPILALANTPDELRSLPKESLPALCDELRAYLLKSVSKSSGHLASGLGVVELT
CCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHH
VALHYVYNTPFDQLIWDVGHQAYPHKILTGRREKLSTIRQKDGLHPFPWRDESEYDVLSV
HHHHHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEE
GHSSTSISAALGLAICAEKEQANRKVISVIGDGAITAGMAFEALNHAGDIHPDMLVVLND
CCCCCHHHHHHHHHHHCCHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNQLARVLSGSLYTSIREGGKKVLSGTPTIKELLKRTEEHIKGMVIPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHHHHCCEECCC
TMFEELGFNYIGPVDGHDVNELVRTLKNMRNLKGPQFLHIMTKKGKGYEPAEKDPISYHG
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSNHSLPKSSGGKPTFSNIFGDFLCDMAKDDDKLMAITPAMREGSGMVRFSKEFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCHHCCCCCEEEHHHCC
GQYFDTAIAEQHAVTLASGMAIAGYNPIVAIYSTFLQRGYDQLIHDVAIMNLPVMFAIDR
CHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
AGLVGADGQTHQGAFDISFMRCIPNMVIMTPSDENECRQMLYTGHKHTGPSAVRYPRGSA
CCEECCCCCCCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCCCEECCCCCC
TGIEVNKEMQALEIGKGRLIRETKITEKGERVAILNFGTFLSNSVEAAEKLDATVADMRF
CCEEECCHHHHHHCCCCCEEEHHHCCCCCCEEEEEECCHHHCCHHHHHHHHHHHHHHHHH
AKPLDETLLCELVTSHDVLVTIEENAISGGAGSGVIEFLMKNRLIKPVLQLGLPDQFIAQ
HCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHC
GTQEEMHAELMLDATGIEKQIRDYLDL
CCHHHHHHHHHEECCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA