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The map label for this gene is glyA [H]

Identifier: 209694441

GI number: 209694441

Start: 965183

End: 966433

Strand: Reverse

Name: glyA [H]

Synonym: VSAL_I0864

Alternate gene names: 209694441

Gene position: 966433-965183 (Counterclockwise)

Preceding gene: 209694443

Following gene: 209694439

Centisome position: 29.06

GC content: 44.36

Gene sequence:

>1251_bases
ATGCTTAAGCGTGATATGAACATTGCAGATTACGATGCAGACTTGTTTGCAGCAATCCAGGAAGAGACAGTACGTCAAGA
AGAGCATATCGAGCTGATTGCTTCTGAAAACTACACTAGCCCACGAGTGATGGAAGCTCAAGGTTCACAACTAACAAACA
AGTATGCTGAAGGTTACCCTGGTAAGCGTTACTACGGTGGCTGTGAGTTCGTTGATAAAGTGGAAACACTGGCTATCAAC
CGTGCATGTGAATTGTTTGGCGCAGAGTACGCAAACGTACAACCGCATTCAGGTTCTCAAGCGAACAATGCCGTTTACAT
GGCACTACTAAACGCTGGCGATACCGTGTTAGGTATGAGCCTTGCTCACGGTGGTCACTTAACTCACGGTTCTCCAGTAA
ACTTCTCTGGTAAGCTTTACAACATCATTCCTTACGGTATTGATGAAGCGGGTCAAATTGACTACGAAGAAATGGAAGCG
CTAGCAATAGAACATAAACCTAAGATGATCATCGGTGGTTTCTCTGCTTACTCTCAAATTTGTGATTGGGCGCGTATGCG
TGAAATCGCAGACAAAGTTGGTGCTTACTTTTTCGTTGATATGGCTCACGTAGCGGGTCTTATTGCTGCTGGTGTTTACC
CTAACCCTGTCCCACACGCTCACGTAGTAACAACAACAACGCATAAAACATTGGCTGGTCCTCGTGGTGGTCTTATTCTT
TCTAACGAAGGCGAAGATCTTTACAAGAAACTGAACTCAGCAGTATTCCCTGGTGGTCAAGGTGGCCCTCTAATGCACGT
TATCGCTGGTAAAGCGGTGGCATTTAAAGAAGCACTAGAACCAGAATTTAAAGAATACCAAGTTCGTGTTGTTGCTAATG
CAAAAGCAATGGTTGCAGAGTTTCTTGCTCGTGGTTACAACATCGTTTCAGGCTCTACTGAAAACCACTTGTTCTTGGTT
GATTTAATCGACAAAGACATCACTGGTAAAGAAGCCGATGCGGCTCTGGGTTCAGCTAACATTACCGTGAATAAAAACTC
AGTACCAAACGATCCACGTAGCCCGTTTGTTACTTCTGGTATCCGTGTTGGTTCTCCTTCAATTACTCGTCGTGGTTTCT
CTGAAGAAGACGCGAAGAACCTTGCTGGCTGGATGTGTGACATTCTAGACAACATGGGTGATGAGTCTGTTATCGAAGCA
ACTAAAGCGAAAGTATTAGAAATCTGTAAGCGTTTACCTGTATACGCTTAA

Upstream 100 bases:

>100_bases
CAAATTATGTAGAATAACGACCAGTTAAGGCTAGTGACGTAATCGTTTGCGTCATTGGGCTATTTTTGGGTTTTATATTT
ATCTGAGTCAGGAGATACAG

Downstream 100 bases:

>100_bases
TTTTTAATTCAGTTTTAAAAATTGAAAAGGTCAGCCTGTTATAGGTTGGCCTTTTTTATTGCCTAAAATTTAATGAACTG
TTGAGGGTTGTATTTCTTTA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLKRDMNIADYDADLFAAIQEETVRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDKVETLAIN
RACELFGAEYANVQPHSGSQANNAVYMALLNAGDTVLGMSLAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGQIDYEEMEA
LAIEHKPKMIIGGFSAYSQICDWARMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
SNEGEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKEYQVRVVANAKAMVAEFLARGYNIVSGSTENHLFLV
DLIDKDITGKEADAALGSANITVNKNSVPNDPRSPFVTSGIRVGSPSITRRGFSEEDAKNLAGWMCDILDNMGDESVIEA
TKAKVLEICKRLPVYA

Sequences:

>Translated_416_residues
MLKRDMNIADYDADLFAAIQEETVRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDKVETLAIN
RACELFGAEYANVQPHSGSQANNAVYMALLNAGDTVLGMSLAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGQIDYEEMEA
LAIEHKPKMIIGGFSAYSQICDWARMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
SNEGEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKEYQVRVVANAKAMVAEFLARGYNIVSGSTENHLFLV
DLIDKDITGKEADAALGSANITVNKNSVPNDPRSPFVTSGIRVGSPSITRRGFSEEDAKNLAGWMCDILDNMGDESVIEA
TKAKVLEICKRLPVYA
>Mature_416_residues
MLKRDMNIADYDADLFAAIQEETVRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYPGKRYYGGCEFVDKVETLAIN
RACELFGAEYANVQPHSGSQANNAVYMALLNAGDTVLGMSLAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGQIDYEEMEA
LAIEHKPKMIIGGFSAYSQICDWARMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
SNEGEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKEYQVRVVANAKAMVAEFLARGYNIVSGSTENHLFLV
DLIDKDITGKEADAALGSANITVNKNSVPNDPRSPFVTSGIRVGSPSITRRGFSEEDAKNLAGWMCDILDNMGDESVIEA
TKAKVLEICKRLPVYA

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=405, Percent_Identity=45.4320987654321, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI261862352, Length=402, Percent_Identity=45.273631840796, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI261862350, Length=402, Percent_Identity=45.273631840796, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI261862348, Length=402, Percent_Identity=45.273631840796, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI261862346, Length=404, Percent_Identity=44.5544554455446, Blast_Score=334, Evalue=8e-92,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=46.1346633416459, Blast_Score=318, Evalue=6e-87,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=43.5567010309278, Blast_Score=286, Evalue=3e-77,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=81.0551558752998, Blast_Score=688, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=401, Percent_Identity=44.6384039900249, Blast_Score=337, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=44.6384039900249, Blast_Score=337, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=428, Percent_Identity=43.6915887850467, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=44.2786069651741, Blast_Score=338, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=45.25, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=45.25, Blast_Score=348, Evalue=5e-96,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45131; Mature: 45131

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRDMNIADYDADLFAAIQEETVRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECCCCHHHHHHHHCCCC
GKRYYGGCEFVDKVETLAINRACELFGAEYANVQPHSGSQANNAVYMALLNAGDTVLGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGQIDYEEMEALAIEHKPKMIIGGFSAYSQI
ECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
CDWARMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
SNEGEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKEYQVRVVANAKAMVAE
ECCCHHHHHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHHCCCCHHEEEEEEECHHHHHHH
FLARGYNIVSGSTENHLFLVDLIDKDITGKEADAALGSANITVNKNSVPNDPRSPFVTSG
HHHCCCEEECCCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCEECC
IRVGSPSITRRGFSEEDAKNLAGWMCDILDNMGDESVIEATKAKVLEICKRLPVYA
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKRDMNIADYDADLFAAIQEETVRQEEHIELIASENYTSPRVMEAQGSQLTNKYAEGYP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCEEECCCCHHHHHHHHCCCC
GKRYYGGCEFVDKVETLAINRACELFGAEYANVQPHSGSQANNAVYMALLNAGDTVLGMS
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEE
LAHGGHLTHGSPVNFSGKLYNIIPYGIDEAGQIDYEEMEALAIEHKPKMIIGGFSAYSQI
ECCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHCCCCCEEEECHHHHHHH
CDWARMREIADKVGAYFFVDMAHVAGLIAAGVYPNPVPHAHVVTTTTHKTLAGPRGGLIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHCCCCCCEEE
SNEGEDLYKKLNSAVFPGGQGGPLMHVIAGKAVAFKEALEPEFKEYQVRVVANAKAMVAE
ECCCHHHHHHHHHCCCCCCCCCCEEEEHHCCHHHHHHHHCCCCHHEEEEEEECHHHHHHH
FLARGYNIVSGSTENHLFLVDLIDKDITGKEADAALGSANITVNKNSVPNDPRSPFVTSG
HHHCCCEEECCCCCCCEEEEEECCCCCCCCCHHHHCCCCEEEECCCCCCCCCCCCCEECC
IRVGSPSITRRGFSEEDAKNLAGWMCDILDNMGDESVIEATKAKVLEICKRLPVYA
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA