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The map label for this gene is gmk [H]

Identifier: 209693823

GI number: 209693823

Start: 250943

End: 251566

Strand: Direct

Name: gmk [H]

Synonym: VSAL_I0210

Alternate gene names: 209693823

Gene position: 250943-251566 (Clockwise)

Preceding gene: 209693821

Following gene: 209693824

Centisome position: 7.55

GC content: 38.3

Gene sequence:

>624_bases
ATGAGCAAAGGTACACTTTATATTGTTTCAGCCCCAAGTGGCGCTGGTAAATCAAGCTTGATCTCTGCATTAATAGAGAG
CAACCCTACTTATGCAATGAAAGTCTCTGTCTCTCATACCACTCGTGGCATGCGTCCTGGCGAACAAGATGGTGTTCATT
ACCATTTTATGCAGAAAGAGCATTTTGAAGATCTGATCGAAAAAGAAGAGTTTTTGGAATATGCCGAAGTATTTGGTAAT
TATTACGGAACTTCTCGCGTTTGGATCGAAGAAACGTTAGATAAAGGCATTGATGTATTTTTGGATATTGATTGGCAAGG
TGCTCGTCAAATTCGCATACAAATGCCTTTAGCAAAAAGCCTTTTCATCTTACCACCTTCAAATGGTGAACTTGAGCGTC
GACTAAATGTTCGCGGGCAAGACAGTGAAGCGGTCATTGCGAAACGAATGAGCGAAGCAAAATCAGAAATTTCTCACTAT
AATGAATATGATTATGTGATTATTAATGACGATTTTGATACTGCACAAATGGATTTTAAAGCTATTATCCGTGCAGAGCG
CTTAAAACAAGATAAACAAACATCAAAATATAAAGGCATGTTGTCAGCTCTTTTAGCCGATTAA

Upstream 100 bases:

>100_bases
ATTCTTTCAAATTATTCGTTAATTTACGTATTTCATTGATTCATTTTCATTCAATATCGTGCTATTCTTCGCCACCCAAT
TTTCTACGCTGGAAACGCTA

Downstream 100 bases:

>100_bases
TCGACCTTTACTTGACTATTTTATCTATCAAGAGTATTCGTATCTAGAAAGTTAGCACTGATACTTGTATAATTTCTCGT
CATATAATATTTTTAACATT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 207; Mature: 206

Protein sequence:

>207_residues
MSKGTLYIVSAPSGAGKSSLISALIESNPTYAMKVSVSHTTRGMRPGEQDGVHYHFMQKEHFEDLIEKEEFLEYAEVFGN
YYGTSRVWIEETLDKGIDVFLDIDWQGARQIRIQMPLAKSLFILPPSNGELERRLNVRGQDSEAVIAKRMSEAKSEISHY
NEYDYVIINDDFDTAQMDFKAIIRAERLKQDKQTSKYKGMLSALLAD

Sequences:

>Translated_207_residues
MSKGTLYIVSAPSGAGKSSLISALIESNPTYAMKVSVSHTTRGMRPGEQDGVHYHFMQKEHFEDLIEKEEFLEYAEVFGN
YYGTSRVWIEETLDKGIDVFLDIDWQGARQIRIQMPLAKSLFILPPSNGELERRLNVRGQDSEAVIAKRMSEAKSEISHY
NEYDYVIINDDFDTAQMDFKAIIRAERLKQDKQTSKYKGMLSALLAD
>Mature_206_residues
SKGTLYIVSAPSGAGKSSLISALIESNPTYAMKVSVSHTTRGMRPGEQDGVHYHFMQKEHFEDLIEKEEFLEYAEVFGNY
YGTSRVWIEETLDKGIDVFLDIDWQGARQIRIQMPLAKSLFILPPSNGELERRLNVRGQDSEAVIAKRMSEAKSEISHYN
EYDYVIINDDFDTAQMDFKAIIRAERLKQDKQTSKYKGMLSALLAD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=197, Percent_Identity=36.0406091370558, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI226874833, Length=197, Percent_Identity=36.0406091370558, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI4504221, Length=197, Percent_Identity=36.0406091370558, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI14780902, Length=200, Percent_Identity=30.5, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI4505237, Length=171, Percent_Identity=30.4093567251462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118263, Length=171, Percent_Identity=30.4093567251462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=171, Percent_Identity=30.4093567251462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118255, Length=171, Percent_Identity=30.4093567251462, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI111154074, Length=160, Percent_Identity=33.125, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI21361598, Length=202, Percent_Identity=30.1980198019802, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=27.5280898876405, Blast_Score=67, Evalue=9e-12,
Organism=Homo sapiens, GI21536464, Length=195, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=207, Percent_Identity=64.2512077294686, Blast_Score=283, Evalue=8e-78,
Organism=Caenorhabditis elegans, GI193203132, Length=190, Percent_Identity=36.8421052631579, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=190, Percent_Identity=36.8421052631579, Blast_Score=127, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17557440, Length=181, Percent_Identity=26.5193370165746, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17556244, Length=160, Percent_Identity=31.875, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=39.344262295082, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI21356141, Length=189, Percent_Identity=37.5661375661376, Blast_Score=124, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23600; Mature: 23469

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGTLYIVSAPSGAGKSSLISALIESNPTYAMKVSVSHTTRGMRPGEQDGVHYHFMQKE
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHH
HFEDLIEKEEFLEYAEVFGNYYGTSRVWIEETLDKGIDVFLDIDWQGARQIRIQMPLAKS
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCE
LFILPPSNGELERRLNVRGQDSEAVIAKRMSEAKSEISHYNEYDYVIINDDFDTAQMDFK
EEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
AIIRAERLKQDKQTSKYKGMLSALLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKGTLYIVSAPSGAGKSSLISALIESNPTYAMKVSVSHTTRGMRPGEQDGVHYHFMQKE
CCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCEEEEEHHHH
HFEDLIEKEEFLEYAEVFGNYYGTSRVWIEETLDKGIDVFLDIDWQGARQIRIQMPLAKS
HHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCE
LFILPPSNGELERRLNVRGQDSEAVIAKRMSEAKSEISHYNEYDYVIINDDFDTAQMDFK
EEEECCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
AIIRAERLKQDKQTSKYKGMLSALLAD
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA