| Definition | Geobacter bemidjiensis Bem chromosome, complete genome. |
|---|---|
| Accession | NC_011146 |
| Length | 4,615,150 |
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The map label for this gene is topA [H]
Identifier: 197119084
GI number: 197119084
Start: 3127358
End: 3129697
Strand: Reverse
Name: topA [H]
Synonym: Gbem_2711
Alternate gene names: 197119084
Gene position: 3129697-3127358 (Counterclockwise)
Preceding gene: 197119085
Following gene: 197119083
Centisome position: 67.81
GC content: 61.54
Gene sequence:
>2340_bases ATGTCTCAGAATCTCGTCATCGTTGAGTCTCCCGCCAAGGCGAAGACCATTGAAAAATTCCTCGGCCACGACTACAAGGT CCTGGCCTCGTTCGGTCACGTGCGCGCCCTCCCCAGCAAGCAGGGGTCGGTGGACACGGAGCACGACTTCGAGCCGAAGT ACGCCGTCCTCCCCGAGAGCAAAAAGCACATCGACGCCATCAAGAAGGAGATGAAGGGGATCTCCTCGCTCCTCCTGGCG ACAGACCCCGACCGCGAAGGGGAGGCGATCTCCTGGCACCTTTTGGCCGCGCTCGGCCTGGACGGGAAGAAGAAGCTCCC GTTCGAGATCAAGCGGGTGGTCTTCCACGAGATCACCAAGGACGCCATCGTGCATGCGGTGGAGAATCCCCGCGACATCG CCCTTGACTTGGTCGACGCCCAGCAGGCCCGCTCCATCCTCGATTACCTGGTCGGCTTCACCCTCTCCCCGTTTCTTTGG AAGAAGATCCGCTACGGCCTTTCCGCGGGGCGCGTGCAGTCCGTCGCCCTGAGGCTCATCTGCGAGCGCGAGAAGGAGAT CCAGGCCTTCAAGGAGCAGGAATACTGGACCATCGCCGCGAAGCTTGAGACCGCCAAGAAGCAGGGGCTCACGGCGACGC TGGTGGAGGCCGAGGGGAAGAAGCTCGGCAAGTTCGACATCCCGGACCAGGAAACCGCCTTCCGGCACTTCGCCAAGCTC GGGGGAAAGGAATTCCCGACGCAGGAAGGGGACGAGAAGGGAACGCCGCTGGTGGTCGATAAACCCGCGCACCCGGAGTA CCGGGTCGACAAGGTCACCAAGAGCGAGAGAAAGCGCCAGCCTTCTCCACCTTTCACCACCTCCACCTTGCAGCAGGAGG CGGCGCGCAAATTGGGCTTCTCCGCCAAGAAGACCATGTCCACGGCGCAAAAACTCTATGAGGGTATCGACGTCGGCGAA GGGGCCGTCGGTCTCATCACCTACATGCGTACCGACTCCGTCGCCCTTTCCAACGTGGCGCTGGAAGAGGCCAAGTCGGT GATTACCTCGCTCTACGGCAAGGAATACGCGCTGGAGAAGCCGCGCTTCTTCAAGAACAAGTCCAAAAACGCCCAGGAAG CGCACGAGGCGGTCCGCCCGACCTACATCGCCAAGACCCCGATCGAGCTGAAGAAGTTCTTAAGCTCCGACCAGTTCAAG CTCTACGACCTGATCTGGAAGAGGACCGTCGCCTGCCAGATGGCCGAGGCGCTCCTGGACCAGACCTCGGTCGACATCGG CGCGGGAGAGGGTTTCCGCTTCCGGGTCGCCGGCACCGTGATCCGCTTCGCCGGCTTCATGAAGCTCTACATCGAGGGGG TCGACGACGAGACGGAGGACAAGGAGAAGGAAGGCCTGCTTCCGCCGCTGGCCGAGGGGGACATCCTCAAGCTGCAGCAG CTCCTCCCCGAGCGGCACTTCACCCAGCCCCCGCCGCGCTACACCGAGGCGAGCCTGGTGAAGACCCTGGAGGAGTACGG CATCGGGCGCCCGTCCACCTACGCCTCCATCATGAACACCCTTACCGAGAGGAAGTACGCGCGTCTCGACAAGAAGCGCT TCTTCCCCGAGGACGTGGGGATGGTGGTCTCCGACCTTTTGACCAACCACTTCACCCAGTACGTCGACTACAACTTCACC GCGAACCTGGAAGAAGAACTCGACATGGTCTCGCGCGGCGAGAAGCAGTGGCGCCCGCTCCTGCACGAGTTCTGGGGTCC CTTCATCAACCTTCTGAAGTTGAAGGAAGGTGAGGTGAACAAGTCCGACCTCACCACCGAGGCGACCAACGAGGTCTGCC CCGAGTGCGGCAAGCCCCTGGTGGTGAAGCTCGGCAAGTTCGGCAAGTTCTACGCCTGCACCGGCTATCCCGAATGCCGT TACATCCGTCCCTTGGACAAGGAGACGGGCGAGGTGGTCGAACCGGTGGTTTCCGAGGAAATCTGCGACAAGTGCGGTAG CCACATGCTGATCAAAGACGGGCGTTTCGGCAAGTACTTGGCCTGCTCCGCCTACCCCAACTGCAAGAACATCCAGCCCT TGGTGAAGCCCAAGGGGACCGGGATCACCTGCGCCGAATGCGGCAAGGGTGAGCTGATCGAGAAGAAGTCCCGTTTCGGC AAGCTCTTCTACTCCTGCAACCGCTATCCCGAGTGCAAGTTCGCCCTGTGGGATCTCCCGGTGCAGCAGCCCTGCCCCAA GTGCGGCTTCCCGCTTTTGATCAAGAAGGTCTACAAGCGCGAAGGCGAGTTCCTCAAGTGCCCGAAAGAAGGGTGCGACT ACAAGAGCAACCAGTCCTAG
Upstream 100 bases:
>100_bases CTTGGAAATGAAGGGAGCCATAGTCCAACTCCCGGGCAAGCGCTTCGCAGTTGCGTGAGGCGTTGCCCCCAAAGGCGTAA AATCCATACTAGGTGGACAC
Downstream 100 bases:
>100_bases AGCGGGCTGGGCAGGTTTATAGGTGCTACCATGATGCGGGGTCTTAGGACCCCGCTTTGGTTTTTAAGGGATATTCCGGG GAGCCAGAGACGTGTCCCTC
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 779; Mature: 778
Protein sequence:
>779_residues MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLA TDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLW KKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKL GGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGE GAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFK LYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQ LLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFT ANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECR YIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFG KLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
Sequences:
>Translated_779_residues MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLA TDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLW KKIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKL GGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGE GAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFK LYDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQ LLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFT ANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECR YIRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFG KLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS >Mature_778_residues SQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPESKKHIDAIKKEMKGISSLLLAT DPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITKDAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWK KIRYGLSAGRVQSVALRLICEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKLG GKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGFSAKKTMSTAQKLYEGIDVGEG AVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEKPRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKL YDLIWKRTVACQMAEALLDQTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQL LPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVGMVVSDLLTNHFTQYVDYNFTA NLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVNKSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRY IRPLDKETGEVVEPVVSEEICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFGK LFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=638, Percent_Identity=25.3918495297806, Blast_Score=134, Evalue=2e-31, Organism=Homo sapiens, GI4507635, Length=810, Percent_Identity=22.3456790123457, Blast_Score=109, Evalue=1e-23, Organism=Escherichia coli, GI1787529, Length=789, Percent_Identity=37.5158428390368, Blast_Score=473, Evalue=1e-134, Organism=Escherichia coli, GI48994931, Length=156, Percent_Identity=43.5897435897436, Blast_Score=156, Evalue=4e-39, Organism=Escherichia coli, GI1788061, Length=568, Percent_Identity=23.943661971831, Blast_Score=107, Evalue=3e-24, Organism=Caenorhabditis elegans, GI17555378, Length=559, Percent_Identity=25.9391771019678, Blast_Score=118, Evalue=2e-26, Organism=Drosophila melanogaster, GI24585251, Length=647, Percent_Identity=24.4204018547141, Blast_Score=127, Evalue=3e-29,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 87855; Mature: 87724
Theoretical pI: Translated: 8.32; Mature: 8.32
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.3 %Cys (Translated Protein) 1.3 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 2.3 %Cys (Mature Protein) 1.2 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MSQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPES CCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCC KKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITK HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHH DAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLI HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH CEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKL HHHHHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH GGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGF CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC SAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEK HHHHHHHHHHHHHHCCCCCCCCEEHHEEHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCC PRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLD CHHHHCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH QTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQ HCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHH LLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVG HCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH MVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVN HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC KSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEE HHHCCHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCEECCCCCCHHHHHHHHHHHH ICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFG HHHHCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHH KLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS HHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHCCCCCCCCC >Mature Secondary Structure SQNLVIVESPAKAKTIEKFLGHDYKVLASFGHVRALPSKQGSVDTEHDFEPKYAVLPES CCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCC KKHIDAIKKEMKGISSLLLATDPDREGEAISWHLLAALGLDGKKKLPFEIKRVVFHEITK HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHCCCCCCCCCHHHHHHHHHHHHH DAIVHAVENPRDIALDLVDAQQARSILDYLVGFTLSPFLWKKIRYGLSAGRVQSVALRLI HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH CEREKEIQAFKEQEYWTIAAKLETAKKQGLTATLVEAEGKKLGKFDIPDQETAFRHFAKL HHHHHHHHHHHHCCCEEEHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHH GGKEFPTQEGDEKGTPLVVDKPAHPEYRVDKVTKSERKRQPSPPFTTSTLQQEAARKLGF CCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCC SAKKTMSTAQKLYEGIDVGEGAVGLITYMRTDSVALSNVALEEAKSVITSLYGKEYALEK HHHHHHHHHHHHHHCCCCCCCCEEHHEEHCCCCHHHHHHHHHHHHHHHHHHHCCHHHCCC PRFFKNKSKNAQEAHEAVRPTYIAKTPIELKKFLSSDQFKLYDLIWKRTVACQMAEALLD CHHHHCCCCCHHHHHHHHCCCEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH QTSVDIGAGEGFRFRVAGTVIRFAGFMKLYIEGVDDETEDKEKEGLLPPLAEGDILKLQQ HCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCHHHHHHH LLPERHFTQPPPRYTEASLVKTLEEYGIGRPSTYASIMNTLTERKYARLDKKRFFPEDVG HCCHHCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHH MVVSDLLTNHFTQYVDYNFTANLEEELDMVSRGEKQWRPLLHEFWGPFINLLKLKEGEVN HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCC KSDLTTEATNEVCPECGKPLVVKLGKFGKFYACTGYPECRYIRPLDKETGEVVEPVVSEE HHHCCHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCEECCCCCCHHHHHHHHHHHH ICDKCGSHMLIKDGRFGKYLACSAYPNCKNIQPLVKPKGTGITCAECGKGELIEKKSRFG HHHHCCCCEEEECCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHH KLFYSCNRYPECKFALWDLPVQQPCPKCGFPLLIKKVYKREGEFLKCPKEGCDYKSNQS HHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 9384377 [H]