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The map label for this gene is arlS [H]

Identifier: 197119050

GI number: 197119050

Start: 3096485

End: 3097843

Strand: Direct

Name: arlS [H]

Synonym: Gbem_2673

Alternate gene names: 197119050

Gene position: 3096485-3097843 (Clockwise)

Preceding gene: 197119049

Following gene: 197119051

Centisome position: 67.09

GC content: 60.34

Gene sequence:

>1359_bases
ATGAGCCTGAAGCTAAGCATACGCCTGCGACTGACCCTTTGGTACTCCGCAGCCCTTGCGGCAATCATCCTCTGCTTTAC
CCTCGGGGTCTACTGGTCGGTGCGCTCCAGTTTGCTGAGCAGCATGGATGCCCAGTTGGATCGTGACTTGGCTACGGTTA
CCCGGGTTGCCCGGGACCAGCCCAATGAAATAAACGAACTGGCCCAGCACGGTTCGGTCGATCTGTTCCAGGTGCGAGAT
GGAAATGTCGTGCTGGCGGAAACGGGGGATTGGAGCAGGGCAGCAATGGAAAAGGCTCCGCCCTCCCCGACTCACCAAAG
GCCATGGTCATGGGTTGCGTCAAGCGGCCTCGGATTTCGTCTGAAGGCGTTAACGATTACGGCACCGGGGCACGCATACC
TGATTACGGTCGCTGAGGACGAGGCGAACCTTCGTGCCAGTCTGAAAAGCCTCAGCACCGTCCTTTCCCTTGGAGTGCCG
TTGGCGCTGGTTCTGGCGCTGATAGGCGGCTACCTCTTAGCCGGTCGCGTCTTGGCGCCCATCGAGACCATGGCGGGGAA
GGCCCGAGAGATCACGGCGGATCGGCTTTCAGAGCGGCTGCCGGTCGAGCAAGATGACGAATTCGGCAAGCTTGCCCAGG
TCTTCAACCAAACCTTCGCCCGTCTGGAGGAGTCGTTCGACAGGTTGCGCCGGTTCACCTCGGACGCGTCCCATGAACTG
AGGACGCCACTCACTGCGATTCGGAGTGTGGGAGAGGTAGGGCTGCGCAAGGGTCTGGATGCCGACGCGCTGCGCGAGGT
GATATCCAGCATGCTTGAAGAGGCGGACCGGCTGACCAAGCTGGTGGACAGTCTGCTGACCTTGAGCCGGGCGGAATCAG
GGACGTTAAAACTGAGGCCAGAGCCGACCAACCTGGTCGCCTTGGTGTCGGAGGTCATCGAATGCCTGGAGGTGTTAGCG
GAAGAGAAAGAGCAGAACATAGCACTGATGGCCAGCCAAGAAGCGGTTGCAGACATCGACCGCGGGACGATACGCCAGGC
GCTGATGAACGTCCTGGACAACGCGATTAAGTACTCACCGCAGGGAAGCCGGATAAGTGTCTGTGTCGAGGTATCTGCCG
GCGAGGCTACCGTCGAGGTCAGTGACGGTGGCCCCGGTATCGCCCCCGAACACGCCAAGAAGGTATTCGACCGTTTTTAC
CGCATCGATAGCGGGCGCTCCCGGGAGGTGGGCGGAACTGGCTTGGGACTGGCCATCGCGAGATGGGCGGTGGAGGTAAA
CGGAGGGCGCATAGAATTGGAGAGCGAGCCTGGCAAGGGGAGCATCTTCAGAATCGTACTCCCGGTCCGGGAATCTTAA

Upstream 100 bases:

>100_bases
TCCATATTGCACGCCTTCGGCGCAAGATCGACGGTCCCTTCAAGCTGAAGCTCCTTAAGACGGTGCGGGGTCTGGGCTTC
ACCGTGAACGGTGAGGTGAT

Downstream 100 bases:

>100_bases
CCATTGGTGCAGCATGATCAACAGCAATACGACAAAAGGAGGAATTTGATGAGAAAAACTGTCGCAGCAAGCATCAAAAC
CGGAATGGCGCTCTTACTGG

Product: HAMP domain-containing sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSLKLSIRLRLTLWYSAALAAIILCFTLGVYWSVRSSLLSSMDAQLDRDLATVTRVARDQPNEINELAQHGSVDLFQVRD
GNVVLAETGDWSRAAMEKAPPSPTHQRPWSWVASSGLGFRLKALTITAPGHAYLITVAEDEANLRASLKSLSTVLSLGVP
LALVLALIGGYLLAGRVLAPIETMAGKAREITADRLSERLPVEQDDEFGKLAQVFNQTFARLEESFDRLRRFTSDASHEL
RTPLTAIRSVGEVGLRKGLDADALREVISSMLEEADRLTKLVDSLLTLSRAESGTLKLRPEPTNLVALVSEVIECLEVLA
EEKEQNIALMASQEAVADIDRGTIRQALMNVLDNAIKYSPQGSRISVCVEVSAGEATVEVSDGGPGIAPEHAKKVFDRFY
RIDSGRSREVGGTGLGLAIARWAVEVNGGRIELESEPGKGSIFRIVLPVRES

Sequences:

>Translated_452_residues
MSLKLSIRLRLTLWYSAALAAIILCFTLGVYWSVRSSLLSSMDAQLDRDLATVTRVARDQPNEINELAQHGSVDLFQVRD
GNVVLAETGDWSRAAMEKAPPSPTHQRPWSWVASSGLGFRLKALTITAPGHAYLITVAEDEANLRASLKSLSTVLSLGVP
LALVLALIGGYLLAGRVLAPIETMAGKAREITADRLSERLPVEQDDEFGKLAQVFNQTFARLEESFDRLRRFTSDASHEL
RTPLTAIRSVGEVGLRKGLDADALREVISSMLEEADRLTKLVDSLLTLSRAESGTLKLRPEPTNLVALVSEVIECLEVLA
EEKEQNIALMASQEAVADIDRGTIRQALMNVLDNAIKYSPQGSRISVCVEVSAGEATVEVSDGGPGIAPEHAKKVFDRFY
RIDSGRSREVGGTGLGLAIARWAVEVNGGRIELESEPGKGSIFRIVLPVRES
>Mature_451_residues
SLKLSIRLRLTLWYSAALAAIILCFTLGVYWSVRSSLLSSMDAQLDRDLATVTRVARDQPNEINELAQHGSVDLFQVRDG
NVVLAETGDWSRAAMEKAPPSPTHQRPWSWVASSGLGFRLKALTITAPGHAYLITVAEDEANLRASLKSLSTVLSLGVPL
ALVLALIGGYLLAGRVLAPIETMAGKAREITADRLSERLPVEQDDEFGKLAQVFNQTFARLEESFDRLRRFTSDASHELR
TPLTAIRSVGEVGLRKGLDADALREVISSMLEEADRLTKLVDSLLTLSRAESGTLKLRPEPTNLVALVSEVIECLEVLAE
EKEQNIALMASQEAVADIDRGTIRQALMNVLDNAIKYSPQGSRISVCVEVSAGEATVEVSDGGPGIAPEHAKKVFDRFYR
IDSGRSREVGGTGLGLAIARWAVEVNGGRIELESEPGKGSIFRIVLPVRES

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=307, Percent_Identity=32.8990228013029, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=36.6812227074236, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=31.1594202898551, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789403, Length=463, Percent_Identity=30.6695464362851, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788279, Length=294, Percent_Identity=29.2517006802721, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790346, Length=283, Percent_Identity=32.1554770318021, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=29.5652173913043, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786912, Length=213, Percent_Identity=31.4553990610329, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787894, Length=256, Percent_Identity=28.515625, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=29.2035398230088, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=30.5936073059361, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=30, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1788549, Length=277, Percent_Identity=26.7148014440433, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=30.0675675675676, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=28.2700421940928, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790861, Length=248, Percent_Identity=29.4354838709677, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=32.7731092436975, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=291, Percent_Identity=30.2405498281787, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787374, Length=282, Percent_Identity=29.0780141843972, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=223, Percent_Identity=26.9058295964126, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI87082128, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790567, Length=214, Percent_Identity=28.5046728971963, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=76, Percent_Identity=43.421052631579, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49152; Mature: 49021

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKLSIRLRLTLWYSAALAAIILCFTLGVYWSVRSSLLSSMDAQLDRDLATVTRVARDQ
CCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PNEINELAQHGSVDLFQVRDGNVVLAETGDWSRAAMEKAPPSPTHQRPWSWVASSGLGFR
CHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCEE
LKALTITAPGHAYLITVAEDEANLRASLKSLSTVLSLGVPLALVLALIGGYLLAGRVLAP
EEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
IETMAGKAREITADRLSERLPVEQDDEFGKLAQVFNQTFARLEESFDRLRRFTSDASHEL
HHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RTPLTAIRSVGEVGLRKGLDADALREVISSMLEEADRLTKLVDSLLTLSRAESGTLKLRP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
EPTNLVALVSEVIECLEVLAEEKEQNIALMASQEAVADIDRGTIRQALMNVLDNAIKYSP
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGSRISVCVEVSAGEATVEVSDGGPGIAPEHAKKVFDRFYRIDSGRSREVGGTGLGLAIA
CCCEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RWAVEVNGGRIELESEPGKGSIFRIVLPVRES
HHEEEECCCEEEEECCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SLKLSIRLRLTLWYSAALAAIILCFTLGVYWSVRSSLLSSMDAQLDRDLATVTRVARDQ
CEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PNEINELAQHGSVDLFQVRDGNVVLAETGDWSRAAMEKAPPSPTHQRPWSWVASSGLGFR
CHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCEE
LKALTITAPGHAYLITVAEDEANLRASLKSLSTVLSLGVPLALVLALIGGYLLAGRVLAP
EEEEEEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
IETMAGKAREITADRLSERLPVEQDDEFGKLAQVFNQTFARLEESFDRLRRFTSDASHEL
HHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
RTPLTAIRSVGEVGLRKGLDADALREVISSMLEEADRLTKLVDSLLTLSRAESGTLKLRP
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
EPTNLVALVSEVIECLEVLAEEKEQNIALMASQEAVADIDRGTIRQALMNVLDNAIKYSP
CCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGSRISVCVEVSAGEATVEVSDGGPGIAPEHAKKVFDRFYRIDSGRSREVGGTGLGLAIA
CCCEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
RWAVEVNGGRIELESEPGKGSIFRIVLPVRES
HHEEEECCCEEEEECCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA