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The map label for this gene is czcR [H]

Identifier: 197119049

GI number: 197119049

Start: 3095799

End: 3096488

Strand: Direct

Name: czcR [H]

Synonym: Gbem_2672

Alternate gene names: 197119049

Gene position: 3095799-3096488 (Clockwise)

Preceding gene: 197119048

Following gene: 197119050

Centisome position: 67.08

GC content: 56.67

Gene sequence:

>690_bases
ATGCACATTCTGGTGATCGAGGATGAGCCTAAGGTCGCGGGAGCGCTGAAGAAGGGGCTGGAGGCGGAAAACTATATGGT
TTCAGTCGCCGGCAGTGGTGAGGACGGGTTCTTTCGGCTTAATACGGAGGTCTTCGACCTTGTCCTTCTTGACCTGATGC
TACCGGGGCGCGATGGAATAGAGGTTCTCACCGCACTTAGAAAGCAGGGGTTCGACACGCCAGTTCTGATTCTCACTGCG
CGAGATTCTGTCGATGACCGAGTCCTGGGGCTTGACAGCGGCGCCGATGACTATCTGGTGAAACCGTTCGCCTTTCCGGA
ACTGCTGGCCCGGATACGCCTCGTCCTGCGCAGGGAGAAGAAAGAGAAAGAGCAGGTGTTGAAGCTCTTCCTCGCCGACC
TCGACCTGGATTTGGTGACACGAAAGGTGGTGCGCCACGACCAGGAGATCGAATTGACTGCGCGGGAATTCGAACTGTTG
GAGTACCTGCTGCGCTACAAGGGCAACATAGTGTCGCGTGAAATGCTGTCGAGGGACGTATGGCAGGTTAAGGATCGCTC
CACGCCGCTGGATAACGTCATCGACGTCCATATTGCACGCCTTCGGCGCAAGATCGACGGTCCCTTCAAGCTGAAGCTCC
TTAAGACGGTGCGGGGTCTGGGCTTCACCGTGAACGGTGAGGTGATATGA

Upstream 100 bases:

>100_bases
GCTTCCTCTAGCCACCAAGGCAATCCTGAATTTTTCGTCAGAATAACTTCAGTTGTGAAACTGGAAACTTTCTATAACAT
TAAAGACAAGGAGGGAGCTG

Downstream 100 bases:

>100_bases
GCCTGAAGCTAAGCATACGCCTGCGACTGACCCTTTGGTACTCCGCAGCCCTTGCGGCAATCATCCTCTGCTTTACCCTC
GGGGTCTACTGGTCGGTGCG

Product: winged-helix transcriptional response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MHILVIEDEPKVAGALKKGLEAENYMVSVAGSGEDGFFRLNTEVFDLVLLDLMLPGRDGIEVLTALRKQGFDTPVLILTA
RDSVDDRVLGLDSGADDYLVKPFAFPELLARIRLVLRREKKEKEQVLKLFLADLDLDLVTRKVVRHDQEIELTAREFELL
EYLLRYKGNIVSREMLSRDVWQVKDRSTPLDNVIDVHIARLRRKIDGPFKLKLLKTVRGLGFTVNGEVI

Sequences:

>Translated_229_residues
MHILVIEDEPKVAGALKKGLEAENYMVSVAGSGEDGFFRLNTEVFDLVLLDLMLPGRDGIEVLTALRKQGFDTPVLILTA
RDSVDDRVLGLDSGADDYLVKPFAFPELLARIRLVLRREKKEKEQVLKLFLADLDLDLVTRKVVRHDQEIELTAREFELL
EYLLRYKGNIVSREMLSRDVWQVKDRSTPLDNVIDVHIARLRRKIDGPFKLKLLKTVRGLGFTVNGEVI
>Mature_229_residues
MHILVIEDEPKVAGALKKGLEAENYMVSVAGSGEDGFFRLNTEVFDLVLLDLMLPGRDGIEVLTALRKQGFDTPVLILTA
RDSVDDRVLGLDSGADDYLVKPFAFPELLARIRLVLRREKKEKEQVLKLFLADLDLDLVTRKVVRHDQEIELTAREFELL
EYLLRYKGNIVSREMLSRDVWQVKDRSTPLDNVIDVHIARLRRKIDGPFKLKLLKTVRGLGFTVNGEVI

Specific function: Member of the two-component regulatory system CzcS/CzcR involved in the control of cobalt, zinc and cadmium homeostasis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=44.3946188340807, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=43.3035714285714, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=38.7387387387387, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=36.8888888888889, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=36.5638766519824, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=42.8571428571429, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=37.3913043478261, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=33.7837837837838, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.7837837837838, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=34.3891402714932, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=34.9557522123894, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=32.1888412017167, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=31.4893617021277, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=31.7596566523605, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=37.719298245614, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788905, Length=101, Percent_Identity=36.6336633663366, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26096; Mature: 26096

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHILVIEDEPKVAGALKKGLEAENYMVSVAGSGEDGFFRLNTEVFDLVLLDLMLPGRDGI
CEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCHH
EVLTALRKQGFDTPVLILTARDSVDDRVLGLDSGADDYLVKPFAFPELLARIRLVLRREK
HHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHH
KEKEQVLKLFLADLDLDLVTRKVVRHDQEIELTAREFELLEYLLRYKGNIVSREMLSRDV
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
WQVKDRSTPLDNVIDVHIARLRRKIDGPFKLKLLKTVRGLGFTVNGEVI
HHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCC
>Mature Secondary Structure
MHILVIEDEPKVAGALKKGLEAENYMVSVAGSGEDGFFRLNTEVFDLVLLDLMLPGRDGI
CEEEEECCCCHHHHHHHHCCCCCCEEEEEECCCCCCEEEECHHHHHHHHHHHHCCCCCHH
EVLTALRKQGFDTPVLILTARDSVDDRVLGLDSGADDYLVKPFAFPELLARIRLVLRREK
HHHHHHHHCCCCCCEEEEEECCCCCCEEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHH
KEKEQVLKLFLADLDLDLVTRKVVRHDQEIELTAREFELLEYLLRYKGNIVSREMLSRDV
HHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
WQVKDRSTPLDNVIDVHIARLRRKIDGPFKLKLLKTVRGLGFTVNGEVI
HHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9044283 [H]