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The map label for this gene is trpC [H]

Identifier: 197118340

GI number: 197118340

Start: 2261373

End: 2262173

Strand: Direct

Name: trpC [H]

Synonym: Gbem_1957

Alternate gene names: 197118340

Gene position: 2261373-2262173 (Clockwise)

Preceding gene: 197118339

Following gene: 197118341

Centisome position: 49.0

GC content: 63.42

Gene sequence:

>801_bases
ATGACGCAGCTCCCCGATGTGCTGAAAAAAATAGTCGATTACAAGCAGGGCGAAGTCGCGGCCATGAAGGCGGAAGTGCC
GCTGAACGAAATCATGGACCGGCTCGCCGAACTGGAAGACCACCCCCGGGGGTTCCAGGCAGCGCTCATCAACTCGCTCT
CCTCGGGATGGACCCCCATCATCGCGGAGGTGAAGAAGGGGTCCCCGTCCAAGGGGCTGATCAGGCCCGACTTCGACCCG
CTGCAGATAGCCCGGACCTACCAGGAAAACGGCGCCACCTGCCTCTCCATCCTCACCGACGAGCATTTCTTCATGGGGCA
CCTGAGCTACTTGGCCGCCATCCGCGAAGAGGTTTCGCTCCCGCTTCTGCGCAAGGACTTCATCTTCGACCCCTATCAGA
TCTACCAGGCCCGCGCCGCCGGGGCCGACGCCATCCTCCTCATCGCCGCCATGCTGGATCTCCCCCAGTTGCGGGACTTC
GCCGCGCTGGCCCAGGAGCTCTCCATGGACGTGCTCCTGGAGGTGCATGACGAGAAGGAGCTGGAGACGGCCCTGCAGAC
CGACTGCAGCATGATCGGCATCAACAACCGCGATCTAAGGAGCTTCGTGGTCGACATCCGCACCTCGGAGCGTCTGGCCG
CGCTGGTGCCGCAGGGGCGCCTGGTGGTAGCGGAAAGCGGCATCAACAGGCGCGAGGAGATCGTGCACCTCATGTCGATG
GGGCTGCACGCCTTTCTCATCGGCGAGTCGCTGATGCGCGAGGACGACTTCGGCGCGAAGCTGCGCGAACTGGTGGGTTA
A

Upstream 100 bases:

>100_bases
CGACCCTCCCCCGCAAGGGGGGAGGGAGGTTTAGATCAGGACCGGGACCATTGTGATAAGAGCAGATCAAGGGTCGCAGG
ATACGGAAGGATTTACATTT

Downstream 100 bases:

>100_bases
CTGCGACAATCCGTCCCAAAGGAGTGGCTATGAATACCAAGTTTATGCTCGATGAATCCCGCATCCCTAAACAGTGGTAC
AACATCATCCCCGACATGCC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MTQLPDVLKKIVDYKQGEVAAMKAEVPLNEIMDRLAELEDHPRGFQAALINSLSSGWTPIIAEVKKGSPSKGLIRPDFDP
LQIARTYQENGATCLSILTDEHFFMGHLSYLAAIREEVSLPLLRKDFIFDPYQIYQARAAGADAILLIAAMLDLPQLRDF
AALAQELSMDVLLEVHDEKELETALQTDCSMIGINNRDLRSFVVDIRTSERLAALVPQGRLVVAESGINRREEIVHLMSM
GLHAFLIGESLMREDDFGAKLRELVG

Sequences:

>Translated_266_residues
MTQLPDVLKKIVDYKQGEVAAMKAEVPLNEIMDRLAELEDHPRGFQAALINSLSSGWTPIIAEVKKGSPSKGLIRPDFDP
LQIARTYQENGATCLSILTDEHFFMGHLSYLAAIREEVSLPLLRKDFIFDPYQIYQARAAGADAILLIAAMLDLPQLRDF
AALAQELSMDVLLEVHDEKELETALQTDCSMIGINNRDLRSFVVDIRTSERLAALVPQGRLVVAESGINRREEIVHLMSM
GLHAFLIGESLMREDDFGAKLRELVG
>Mature_265_residues
TQLPDVLKKIVDYKQGEVAAMKAEVPLNEIMDRLAELEDHPRGFQAALINSLSSGWTPIIAEVKKGSPSKGLIRPDFDPL
QIARTYQENGATCLSILTDEHFFMGHLSYLAAIREEVSLPLLRKDFIFDPYQIYQARAAGADAILLIAAMLDLPQLRDFA
ALAQELSMDVLLEVHDEKELETALQTDCSMIGINNRDLRSFVVDIRTSERLAALVPQGRLVVAESGINRREEIVHLMSMG
LHAFLIGESLMREDDFGAKLRELVG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=259, Percent_Identity=41.3127413127413, Blast_Score=177, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322638, Length=214, Percent_Identity=40.1869158878505, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 29674; Mature: 29542

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLPDVLKKIVDYKQGEVAAMKAEVPLNEIMDRLAELEDHPRGFQAALINSLSSGWTPI
CCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
IAEVKKGSPSKGLIRPDFDPLQIARTYQENGATCLSILTDEHFFMGHLSYLAAIREEVSL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHCC
PLLRKDFIFDPYQIYQARAAGADAILLIAAMLDLPQLRDFAALAQELSMDVLLEVHDEKE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCHHH
LETALQTDCSMIGINNRDLRSFVVDIRTSERLAALVPQGRLVVAESGINRREEIVHLMSM
HHHHHHCCCCEECCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
GLHAFLIGESLMREDDFGAKLRELVG
HHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TQLPDVLKKIVDYKQGEVAAMKAEVPLNEIMDRLAELEDHPRGFQAALINSLSSGWTPI
CCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHH
IAEVKKGSPSKGLIRPDFDPLQIARTYQENGATCLSILTDEHFFMGHLSYLAAIREEVSL
HHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHCC
PLLRKDFIFDPYQIYQARAAGADAILLIAAMLDLPQLRDFAALAQELSMDVLLEVHDEKE
CHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHCCHHH
LETALQTDCSMIGINNRDLRSFVVDIRTSERLAALVPQGRLVVAESGINRREEIVHLMSM
HHHHHHCCCCEECCCCHHHHHHHHHHCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
GLHAFLIGESLMREDDFGAKLRELVG
HHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]