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The map label for this gene is livH [H]

Identifier: 197118326

GI number: 197118326

Start: 2247213

End: 2248088

Strand: Direct

Name: livH [H]

Synonym: Gbem_1943

Alternate gene names: 197118326

Gene position: 2247213-2248088 (Clockwise)

Preceding gene: 197118325

Following gene: 197118327

Centisome position: 48.69

GC content: 59.59

Gene sequence:

>876_bases
ATGTTCTTACAACAGCTAGTCAACGGAGTCGCCCTTGGAAGCGTATATGCGCTGATCGCACTGGGTTACACCATGGTCTA
CGGCATCATCACCCTGATCAACTTCGCCCACGGCGAGATTTTCATGGTGGGGGCCTTCATCGGATTGCTTCTGGTCTCCT
TTTTCAAGGTCAACGTCTTCGTCGCCATCATCGGCGCCATGATCTTCTGCATGATCATGGGGGTGCTGATCGAGCTGATC
GCCTACCGTCCGCTTAGGAAGTCCTCCAGGCTTTCCGCTCTCATCTCCGCGATCGGCGTCTCCATCTTCCTCTCCTCGCT
GGCCCTCATGGTCTTCGGGGCCGACGCCAAAGGGTTCCCCGACGGCGCCTTCCCGGTGCACCAGATCCAGGTCGGCAGCG
CCGACATCTCAACCTTGCAGCTCCTGATCATCGGCGTTTCTGCAGCCCTCATGATGGCGCTTGAGTTCATCGTCCAAAAG
ACCAAGATCGGCAAGGCAATGCGCGCCACCTCCGAGGACTACAACACCTCGGCCCTGATGGGGATCAACGTGAACCGGGT
CATCTCCTTCACCTTCGCCCTCGGCTCCGCACTCGCCGCGGCGGGCGGGGTGCTGGTCGGGGTCCTCTTCAACGCCGTCT
CCTTCAACATGGGTCTCATGGCCGGCCTCAAGGCCTTCGCCGCCGCAGTCCTCGGTGGGATCGGCTCGATTCCCGGCGCC
ATGCTGGGGGGGCTTCTGCTGGGCGTCTCCGAGGTCTTCGGTGTCGCCATCGGGTACTCGTCCTACCGTGATGCGATCGC
CTTTACCATTCTCGTGCTCGTTCTCCTTGTAAAGCCGACAGGCCTTTTGGGACAAAAAATTACAAAGAAGGTGTAG

Upstream 100 bases:

>100_bases
GTGAAGTAACAATCATTCGCGCAGGTTCACTGTTTTTGGTAATACCACACAGCAACATGCATCTGTCGCCGGATTACAAT
CTCAGTCGAAGGAAGTCGAC

Downstream 100 bases:

>100_bases
ATTCGATGGCAGATTTCCTTAATAGCTTGGTCGGCGCCGTCGACCCGTACATGATGCAGATCCTGGTCAACATCGGCATC
GCTATCGTGCTGGCGCTGGG

Product: branched-chain amino acid ABC transporter membrane protein

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFLQQLVNGVALGSVYALIALGYTMVYGIITLINFAHGEIFMVGAFIGLLLVSFFKVNVFVAIIGAMIFCMIMGVLIELI
AYRPLRKSSRLSALISAIGVSIFLSSLALMVFGADAKGFPDGAFPVHQIQVGSADISTLQLLIIGVSAALMMALEFIVQK
TKIGKAMRATSEDYNTSALMGINVNRVISFTFALGSALAAAGGVLVGVLFNAVSFNMGLMAGLKAFAAAVLGGIGSIPGA
MLGGLLLGVSEVFGVAIGYSSYRDAIAFTILVLVLLVKPTGLLGQKITKKV

Sequences:

>Translated_291_residues
MFLQQLVNGVALGSVYALIALGYTMVYGIITLINFAHGEIFMVGAFIGLLLVSFFKVNVFVAIIGAMIFCMIMGVLIELI
AYRPLRKSSRLSALISAIGVSIFLSSLALMVFGADAKGFPDGAFPVHQIQVGSADISTLQLLIIGVSAALMMALEFIVQK
TKIGKAMRATSEDYNTSALMGINVNRVISFTFALGSALAAAGGVLVGVLFNAVSFNMGLMAGLKAFAAAVLGGIGSIPGA
MLGGLLLGVSEVFGVAIGYSSYRDAIAFTILVLVLLVKPTGLLGQKITKKV
>Mature_291_residues
MFLQQLVNGVALGSVYALIALGYTMVYGIITLINFAHGEIFMVGAFIGLLLVSFFKVNVFVAIIGAMIFCMIMGVLIELI
AYRPLRKSSRLSALISAIGVSIFLSSLALMVFGADAKGFPDGAFPVHQIQVGSADISTLQLLIIGVSAALMMALEFIVQK
TKIGKAMRATSEDYNTSALMGINVNRVISFTFALGSALAAAGGVLVGVLFNAVSFNMGLMAGLKAFAAAVLGGIGSIPGA
MLGGLLLGVSEVFGVAIGYSSYRDAIAFTILVLVLLVKPTGLLGQKITKKV

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=301, Percent_Identity=46.1794019933555, Blast_Score=244, Evalue=7e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30302; Mature: 30302

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLQQLVNGVALGSVYALIALGYTMVYGIITLINFAHGEIFMVGAFIGLLLVSFFKVNVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VAIIGAMIFCMIMGVLIELIAYRPLRKSSRLSALISAIGVSIFLSSLALMVFGADAKGFP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DGAFPVHQIQVGSADISTLQLLIIGVSAALMMALEFIVQKTKIGKAMRATSEDYNTSALM
CCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
GINVNRVISFTFALGSALAAAGGVLVGVLFNAVSFNMGLMAGLKAFAAAVLGGIGSIPGA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MLGGLLLGVSEVFGVAIGYSSYRDAIAFTILVLVLLVKPTGLLGQKITKKV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure
MFLQQLVNGVALGSVYALIALGYTMVYGIITLINFAHGEIFMVGAFIGLLLVSFFKVNVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
VAIIGAMIFCMIMGVLIELIAYRPLRKSSRLSALISAIGVSIFLSSLALMVFGADAKGFP
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DGAFPVHQIQVGSADISTLQLLIIGVSAALMMALEFIVQKTKIGKAMRATSEDYNTSALM
CCCCCHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEE
GINVNRVISFTFALGSALAAAGGVLVGVLFNAVSFNMGLMAGLKAFAAAVLGGIGSIPGA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
MLGGLLLGVSEVFGVAIGYSSYRDAIAFTILVLVLLVKPTGLLGQKITKKV
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]