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The map label for this gene is zraS [H]

Identifier: 197117910

GI number: 197117910

Start: 1762165

End: 1764135

Strand: Reverse

Name: zraS [H]

Synonym: Gbem_1523

Alternate gene names: 197117910

Gene position: 1764135-1762165 (Counterclockwise)

Preceding gene: 197117912

Following gene: 197117909

Centisome position: 38.22

GC content: 60.32

Gene sequence:

>1971_bases
GTGCAGAAGTACCTCTTCGCCTTCATAAACAAACTGAAACTGCGCTGGAAGATGGTGGTGCTGGTGTTGCCGCTGGCGAT
CATACCGATCTTCCTCGTGGGCGGGGTCATCGGCTACATCTCCACCAAGCAGGCCTATCTGGGGATCACCCAGACCAGCA
AGGACGACCTGCAGCACATGGCCGGCTTCACCGTCGACCTTTTGAACTCCCACTACCAACAGTTCCAGGTCTACAAGCAG
GACAAGGAGAAGACCTTCCACGAAGAGTTGAGGACGGTGAGCGAGCTTGCCTTCAACGTGGTGAAGTCGCAGCAGAGCCT
GCAGCAAAAAGGGCGCATGGACATGGCGGCGGCGCAGCGCGAGGCGCGTAACGCCCTGGCCAAGGTAAACGTGGGGAAGA
CCGGCTACATCTACGCCATGAACAGCCGCGGAGAGCTGAAGGTCCACGTGGCGCAGGAAGGGGTCAACGTCTTTGACAGC
CGGGACGAGACCGGGCGCTACTTCATCCGCGAGATGATAGAGAAGGCCCGCCGCTCGAAGCCCGGCGAGGTGCTCTACAT
CGTCTACCCCTGGCGCAACGCGGCACTGGGCGACAAGTCGCTCAGGAAGAAGGTGGTGGCCTACCGCTACTTCAAGGAGT
GGGACTGGATCATCGCGGCAGGGGGTTACCTGGAGGAGACCTACGAGGACGTGGCCTTCGAGCGCCGCTCCTTCCAGGAG
TTGAAGGAAAAGATCAAGGGTAAGAAGGTGGGCAAGACCGGCTACATCTTCGCCATGGATACCTCGGGTAACTTCATGAT
CCACCCGACCGGGGAGGGAAAGAACTTCCTGAACGCGGTCGATTTCAGCGGGCAGCATTTCATCAAGGAGATGTGCGAGA
GGAAAACCGGCTGGATCCGCTACCCCTGGAAGAACAAGGGGGACAGCGGCCCCAGGATGAAGATCGTCCGCTACGAGTAC
TTCCAGCCCTGGAACTGGATCGTCGCGGTAGGCTCCTACGAAGAGGAGTTCTACCAGGAGGCGAACGTGATCAAGGGGCG
CATCATGGAGAGCATGGTGGTGCTCACCATCCTGGTAAGCGTGATGGCCGTGTTCCTGGTGCTTCTTGCCTCCAGGGTGA
TGACCGAGCCGATTTCCAGGATGATCGAGGTGATCAGGAGGGTGAAGCAGGGGCGCCTGGACGAGACCATGAAGGTGGAG
ACCCAGGACGAATTGGGGGAACTCGCCACCGCCTTCAACCGGATGACCAAGATCATCAAGCACAACAAGGAGCTGGAGGC
GAACCTGGCCCAGCAGGGGAAGATGGCGTCCTTAGGCGTCCTCTCCTCGGGCGTCGCCCATGAGATCAACAACCCGCTCG
GGGTGATACTGGGGTACGCCGCGTATATAGAGAAGAAGCTCTCCCCGGACGACCCCAACTACCGGTTCATCCACGAGATC
AAGCGCGAGAGCAAGCGCTGCAAGAAGATCGTGCAGGACCTCCTCTCCTACGCCCGCACCCCGCAGCCGGTGCTGGAGCC
GACCGACCTGAACGCGCTTTTGGAGCAGATCGTGGACTTCGCCGCGAACCACACCGACATGCACCACGTCTCGGTGGAAA
AAAGCTTCGACCCCTCGCTTCCGGAGATCATGGTGGACGGCGACCAGTTGCGCCAGGTGGCGATCAACCTGATCCTGAAC
GCCGGCGCCGCCATGCAAAAGGGGGGAAAGCTCGTGGTCAGCACCCAAAACGGGGAAGACAACTGCGTGAGCCTCAAGTT
CTCCGACAACGGCGCGGGAATCGCGGCCGAGCACATGGAGCGGATCTTCGAGCCGTTTTTCACCACCAAGGTCAAGGGAA
CAGGGCTCGGGCTTGCCATCACCAGGCAGATCGTCGAGCAGCACCACGGCAAGATCGGCATCGAGAGCGAGATCGGCGCC
GGGACCACGGTCGAGGTGCGGCTGCCGATCAACCGGGACGACTACTGTTAA

Upstream 100 bases:

>100_bases
TATACGATAGTATTGCGAACGTTGTTTTACACTGGCCGAAAAGTACCTATCCGGCCACAGCGACAGGGCCTACGCCTAAA
CCGATTCAGCCGGGGGAGCC

Downstream 100 bases:

>100_bases
GATAAGTGCCGCCCCGCTGCGGGGAGAGGTACGGAGGGCTAAGCGTGACAGGAAAGAAAAGGATCATGGTGGTGGACAAC
GAGGAGGGGCTATGCCGCAT

Product: HAMP domain-containing sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 656; Mature: 656

Protein sequence:

>656_residues
MQKYLFAFINKLKLRWKMVVLVLPLAIIPIFLVGGVIGYISTKQAYLGITQTSKDDLQHMAGFTVDLLNSHYQQFQVYKQ
DKEKTFHEELRTVSELAFNVVKSQQSLQQKGRMDMAAAQREARNALAKVNVGKTGYIYAMNSRGELKVHVAQEGVNVFDS
RDETGRYFIREMIEKARRSKPGEVLYIVYPWRNAALGDKSLRKKVVAYRYFKEWDWIIAAGGYLEETYEDVAFERRSFQE
LKEKIKGKKVGKTGYIFAMDTSGNFMIHPTGEGKNFLNAVDFSGQHFIKEMCERKTGWIRYPWKNKGDSGPRMKIVRYEY
FQPWNWIVAVGSYEEEFYQEANVIKGRIMESMVVLTILVSVMAVFLVLLASRVMTEPISRMIEVIRRVKQGRLDETMKVE
TQDELGELATAFNRMTKIIKHNKELEANLAQQGKMASLGVLSSGVAHEINNPLGVILGYAAYIEKKLSPDDPNYRFIHEI
KRESKRCKKIVQDLLSYARTPQPVLEPTDLNALLEQIVDFAANHTDMHHVSVEKSFDPSLPEIMVDGDQLRQVAINLILN
AGAAMQKGGKLVVSTQNGEDNCVSLKFSDNGAGIAAEHMERIFEPFFTTKVKGTGLGLAITRQIVEQHHGKIGIESEIGA
GTTVEVRLPINRDDYC

Sequences:

>Translated_656_residues
MQKYLFAFINKLKLRWKMVVLVLPLAIIPIFLVGGVIGYISTKQAYLGITQTSKDDLQHMAGFTVDLLNSHYQQFQVYKQ
DKEKTFHEELRTVSELAFNVVKSQQSLQQKGRMDMAAAQREARNALAKVNVGKTGYIYAMNSRGELKVHVAQEGVNVFDS
RDETGRYFIREMIEKARRSKPGEVLYIVYPWRNAALGDKSLRKKVVAYRYFKEWDWIIAAGGYLEETYEDVAFERRSFQE
LKEKIKGKKVGKTGYIFAMDTSGNFMIHPTGEGKNFLNAVDFSGQHFIKEMCERKTGWIRYPWKNKGDSGPRMKIVRYEY
FQPWNWIVAVGSYEEEFYQEANVIKGRIMESMVVLTILVSVMAVFLVLLASRVMTEPISRMIEVIRRVKQGRLDETMKVE
TQDELGELATAFNRMTKIIKHNKELEANLAQQGKMASLGVLSSGVAHEINNPLGVILGYAAYIEKKLSPDDPNYRFIHEI
KRESKRCKKIVQDLLSYARTPQPVLEPTDLNALLEQIVDFAANHTDMHHVSVEKSFDPSLPEIMVDGDQLRQVAINLILN
AGAAMQKGGKLVVSTQNGEDNCVSLKFSDNGAGIAAEHMERIFEPFFTTKVKGTGLGLAITRQIVEQHHGKIGIESEIGA
GTTVEVRLPINRDDYC
>Mature_656_residues
MQKYLFAFINKLKLRWKMVVLVLPLAIIPIFLVGGVIGYISTKQAYLGITQTSKDDLQHMAGFTVDLLNSHYQQFQVYKQ
DKEKTFHEELRTVSELAFNVVKSQQSLQQKGRMDMAAAQREARNALAKVNVGKTGYIYAMNSRGELKVHVAQEGVNVFDS
RDETGRYFIREMIEKARRSKPGEVLYIVYPWRNAALGDKSLRKKVVAYRYFKEWDWIIAAGGYLEETYEDVAFERRSFQE
LKEKIKGKKVGKTGYIFAMDTSGNFMIHPTGEGKNFLNAVDFSGQHFIKEMCERKTGWIRYPWKNKGDSGPRMKIVRYEY
FQPWNWIVAVGSYEEEFYQEANVIKGRIMESMVVLTILVSVMAVFLVLLASRVMTEPISRMIEVIRRVKQGRLDETMKVE
TQDELGELATAFNRMTKIIKHNKELEANLAQQGKMASLGVLSSGVAHEINNPLGVILGYAAYIEKKLSPDDPNYRFIHEI
KRESKRCKKIVQDLLSYARTPQPVLEPTDLNALLEQIVDFAANHTDMHHVSVEKSFDPSLPEIMVDGDQLRQVAINLILN
AGAAMQKGGKLVVSTQNGEDNCVSLKFSDNGAGIAAEHMERIFEPFFTTKVKGTGLGLAITRQIVEQHHGKIGIESEIGA
GTTVEVRLPINRDDYC

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=34.7457627118644, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788549, Length=230, Percent_Identity=35.2173913043478, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI1788393, Length=298, Percent_Identity=27.5167785234899, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1790300, Length=225, Percent_Identity=32.4444444444444, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789808, Length=300, Percent_Identity=23, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=271, Percent_Identity=26.9372693726937, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87081816, Length=341, Percent_Identity=26.6862170087977, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=27.6497695852535, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=220, Percent_Identity=25.9090909090909, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1789149, Length=334, Percent_Identity=23.0538922155689, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786912, Length=279, Percent_Identity=29.7491039426523, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786783, Length=317, Percent_Identity=26.4984227129338, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790346, Length=295, Percent_Identity=23.728813559322, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790861, Length=212, Percent_Identity=26.4150943396226, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=23.2, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=24.7619047619048, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74544; Mature: 74544

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKYLFAFINKLKLRWKMVVLVLPLAIIPIFLVGGVIGYISTKQAYLGITQTSKDDLQHM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHH
AGFTVDLLNSHYQQFQVYKQDKEKTFHEELRTVSELAFNVVKSQQSLQQKGRMDMAAAQR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EARNALAKVNVGKTGYIYAMNSRGELKVHVAQEGVNVFDSRDETGRYFIREMIEKARRSK
HHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHCCC
PGEVLYIVYPWRNAALGDKSLRKKVVAYRYFKEWDWIIAAGGYLEETYEDVAFERRSFQE
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHH
LKEKIKGKKVGKTGYIFAMDTSGNFMIHPTGEGKNFLNAVDFSGQHFIKEMCERKTGWIR
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCEE
YPWKNKGDSGPRMKIVRYEYFQPWNWIVAVGSYEEEFYQEANVIKGRIMESMVVLTILVS
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMAVFLVLLASRVMTEPISRMIEVIRRVKQGRLDETMKVETQDELGELATAFNRMTKIIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
HNKELEANLAQQGKMASLGVLSSGVAHEINNPLGVILGYAAYIEKKLSPDDPNYRFIHEI
CCCHHHHHHHHCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KRESKRCKKIVQDLLSYARTPQPVLEPTDLNALLEQIVDFAANHTDMHHVSVEKSFDPSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
PEIMVDGDQLRQVAINLILNAGAAMQKGGKLVVSTQNGEDNCVSLKFSDNGAGIAAEHME
CCEEECHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
RIFEPFFTTKVKGTGLGLAITRQIVEQHHGKIGIESEIGAGTTVEVRLPINRDDYC
HHHHHHHHCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MQKYLFAFINKLKLRWKMVVLVLPLAIIPIFLVGGVIGYISTKQAYLGITQTSKDDLQHM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCHHHHHHH
AGFTVDLLNSHYQQFQVYKQDKEKTFHEELRTVSELAFNVVKSQQSLQQKGRMDMAAAQR
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
EARNALAKVNVGKTGYIYAMNSRGELKVHVAQEGVNVFDSRDETGRYFIREMIEKARRSK
HHHHHHHEECCCCCEEEEEECCCCCEEEEEECCCCHHHCCCCCHHHHHHHHHHHHHHCCC
PGEVLYIVYPWRNAALGDKSLRKKVVAYRYFKEWDWIIAAGGYLEETYEDVAFERRSFQE
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHH
LKEKIKGKKVGKTGYIFAMDTSGNFMIHPTGEGKNFLNAVDFSGQHFIKEMCERKTGWIR
HHHHHCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHHHHCCCCCEE
YPWKNKGDSGPRMKIVRYEYFQPWNWIVAVGSYEEEFYQEANVIKGRIMESMVVLTILVS
CCCCCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VMAVFLVLLASRVMTEPISRMIEVIRRVKQGRLDETMKVETQDELGELATAFNRMTKIIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
HNKELEANLAQQGKMASLGVLSSGVAHEINNPLGVILGYAAYIEKKLSPDDPNYRFIHEI
CCCHHHHHHHHCCCCHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHH
KRESKRCKKIVQDLLSYARTPQPVLEPTDLNALLEQIVDFAANHTDMHHVSVEKSFDPSL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCC
PEIMVDGDQLRQVAINLILNAGAAMQKGGKLVVSTQNGEDNCVSLKFSDNGAGIAAEHME
CCEEECHHHHHHHHHHHHHCCCHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHH
RIFEPFFTTKVKGTGLGLAITRQIVEQHHGKIGIESEIGAGTTVEVRLPINRDDYC
HHHHHHHHCEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]