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The map label for this gene is atoC [H]

Identifier: 197117909

GI number: 197117909

Start: 1760735

End: 1762120

Strand: Reverse

Name: atoC [H]

Synonym: Gbem_1522

Alternate gene names: 197117909

Gene position: 1762120-1760735 (Counterclockwise)

Preceding gene: 197117910

Following gene: 197117908

Centisome position: 38.18

GC content: 61.62

Gene sequence:

>1386_bases
GTGACAGGAAAGAAAAGGATCATGGTGGTGGACAACGAGGAGGGGCTATGCCGCATGATGGAGGCGGTCCTCTCCGACAA
TGGCTATGCGGTCACCGCGCACACCAGGAGCTTCGAGGCGGCCGAAAGCTTCCAGGCGGGCCAATGGGACCTCTTGGTGA
CCGACATCAAGATGCCGGGGATGGACGGGCTGGAGCTTTTGCAGAAGGTAAAGCAGAAGGACCCGGCACTCCCGGTCATC
ATGGTCACCGCCTACGCCACCGTGGAGATGTCGATACAGGCGCTCAGGAAGGGAGCTTACGACATGCTCACCAAGCCCTT
CGAGCCCGAGGAGCTCCTGTACCGGGTGAAGAACGCCCTGCAGCACACCCGCCTCATGGAGGAGAACCGCGAACTCCGGG
AGGAGCTTGTGGGGAGGTTCAACTTCGGCAACATCATCGGCGCCTCCACCGCGCTCAAGGAGGTCCTGGAGCGCGTGGAG
AAGCTCGCCGTGCGCGATACCTCGGTGCTGATCACCGGCGAATCCGGCACCGGAAAGGAGCTGATAGCGCAGGCGATCCA
CTACAACTCCCCCAGAAAGGAGAAGAAGTTCGTCGCCATCAACTGCGGCGCCCTCCCCGCCTCCCTTTTGGAAAGCGAAC
TCTTCGGCTACCGCAAGGGGGCCTTCACCGGGGCGGCGGAGAACCGCCGCGGGCTTTTGGAGACCGCCGACGGCGGCACC
CTCTTTCTCGACGAGGTGGGAAACCTCCCCATGACGGTGCAAAAGACGCTTTTGCGCTTTCTGCAGGAACAGGAGTTCAA
CCGGCTGGGGGACCCCACCCCCACCAAGGTGGACGTCCGGGTCCTTTCCGCCACCAACTCCGACATGAAGCAGGCGGTCA
AGGCGGGTGATTTCCGCGAGGATCTCTATTACCGCCTGAACGTGGTCAACATCCACCTCCCCCCCCTAAGGGAGAGAAAG
GACGACATAGCGCTTTTGGCGGCGCATTTCATCTCGCTTCAGAACTCCAAGTTCGGGACCCAGATCAAGGGGCTCGACCG
CGAGGCGCTGGAGGCGGCGGCGGAGTTTCCCTGGCCCGGCAACATCCGGCAGCTTAGAAACGTGATGGAGGCGTGCCTCG
CTATGGAGAACAACGACTACATCACCTTCCCGGTCTTGTCCCAGTTCATCGAGGTGGCCCCGCTGGAGACGGGGGGCGAG
GCGCCGGCCGAAGAAGGGGAATACGCCAAGGCACTGATGCGCTTCGAGACGGAGTACCTGCGGGGGCTTTTGCGCAAAAA
CCAGGGGAACGTCGAGGCAGCAGCGAAAGAGGCCGGCACCAACATGGCGACCATCTACCGCAAGATCAAGAAGTACGGCA
TCAGGAAGGAAGAGTACAACTTGTAA

Upstream 100 bases:

>100_bases
GCGCCGGGACCACGGTCGAGGTGCGGCTGCCGATCAACCGGGACGACTACTGTTAAGATAAGTGCCGCCCCGCTGCGGGG
AGAGGTACGGAGGGCTAAGC

Downstream 100 bases:

>100_bases
ACCGCAGCTTTCCCCGCAAGGCAGCGGAACTATTTGCAGCATTGCAAAAACGACGTTTCTCGCTGTTGCAAGGCTGCAAA
TGTCCCCTCTCCGCGCCGTC

Product: sigma-54-dependent transcriptional response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTGKKRIMVVDNEEGLCRMMEAVLSDNGYAVTAHTRSFEAAESFQAGQWDLLVTDIKMPGMDGLELLQKVKQKDPALPVI
MVTAYATVEMSIQALRKGAYDMLTKPFEPEELLYRVKNALQHTRLMEENRELREELVGRFNFGNIIGASTALKEVLERVE
KLAVRDTSVLITGESGTGKELIAQAIHYNSPRKEKKFVAINCGALPASLLESELFGYRKGAFTGAAENRRGLLETADGGT
LFLDEVGNLPMTVQKTLLRFLQEQEFNRLGDPTPTKVDVRVLSATNSDMKQAVKAGDFREDLYYRLNVVNIHLPPLRERK
DDIALLAAHFISLQNSKFGTQIKGLDREALEAAAEFPWPGNIRQLRNVMEACLAMENNDYITFPVLSQFIEVAPLETGGE
APAEEGEYAKALMRFETEYLRGLLRKNQGNVEAAAKEAGTNMATIYRKIKKYGIRKEEYNL

Sequences:

>Translated_461_residues
MTGKKRIMVVDNEEGLCRMMEAVLSDNGYAVTAHTRSFEAAESFQAGQWDLLVTDIKMPGMDGLELLQKVKQKDPALPVI
MVTAYATVEMSIQALRKGAYDMLTKPFEPEELLYRVKNALQHTRLMEENRELREELVGRFNFGNIIGASTALKEVLERVE
KLAVRDTSVLITGESGTGKELIAQAIHYNSPRKEKKFVAINCGALPASLLESELFGYRKGAFTGAAENRRGLLETADGGT
LFLDEVGNLPMTVQKTLLRFLQEQEFNRLGDPTPTKVDVRVLSATNSDMKQAVKAGDFREDLYYRLNVVNIHLPPLRERK
DDIALLAAHFISLQNSKFGTQIKGLDREALEAAAEFPWPGNIRQLRNVMEACLAMENNDYITFPVLSQFIEVAPLETGGE
APAEEGEYAKALMRFETEYLRGLLRKNQGNVEAAAKEAGTNMATIYRKIKKYGIRKEEYNL
>Mature_460_residues
TGKKRIMVVDNEEGLCRMMEAVLSDNGYAVTAHTRSFEAAESFQAGQWDLLVTDIKMPGMDGLELLQKVKQKDPALPVIM
VTAYATVEMSIQALRKGAYDMLTKPFEPEELLYRVKNALQHTRLMEENRELREELVGRFNFGNIIGASTALKEVLERVEK
LAVRDTSVLITGESGTGKELIAQAIHYNSPRKEKKFVAINCGALPASLLESELFGYRKGAFTGAAENRRGLLETADGGTL
FLDEVGNLPMTVQKTLLRFLQEQEFNRLGDPTPTKVDVRVLSATNSDMKQAVKAGDFREDLYYRLNVVNIHLPPLRERKD
DIALLAAHFISLQNSKFGTQIKGLDREALEAAAEFPWPGNIRQLRNVMEACLAMENNDYITFPVLSQFIEVAPLETGGEA
PAEEGEYAKALMRFETEYLRGLLRKNQGNVEAAAKEAGTNMATIYRKIKKYGIRKEEYNL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=42.0131291028446, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790299, Length=475, Percent_Identity=38.9473684210526, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1788905, Length=453, Percent_Identity=38.6313465783664, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=39.5505617977528, Blast_Score=325, Evalue=3e-90,
Organism=Escherichia coli, GI87082117, Length=355, Percent_Identity=42.2535211267606, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1789087, Length=337, Percent_Identity=43.3234421364985, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI1789233, Length=320, Percent_Identity=40, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082152, Length=323, Percent_Identity=40.5572755417957, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1786524, Length=351, Percent_Identity=39.6011396011396, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI87081872, Length=228, Percent_Identity=47.8070175438597, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1787583, Length=323, Percent_Identity=36.5325077399381, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1789828, Length=242, Percent_Identity=34.7107438016529, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=29.6928327645051, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=35.3448275862069, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789809, Length=122, Percent_Identity=31.1475409836066, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=26.7241379310345, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1786599, Length=125, Percent_Identity=31.2, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789402, Length=129, Percent_Identity=28.6821705426357, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1790860, Length=121, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=29.1338582677165, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787375, Length=112, Percent_Identity=28.5714285714286, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51654; Mature: 51523

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGKKRIMVVDNEEGLCRMMEAVLSDNGYAVTAHTRSFEAAESFQAGQWDLLVTDIKMPG
CCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCC
MDGLELLQKVKQKDPALPVIMVTAYATVEMSIQALRKGAYDMLTKPFEPEELLYRVKNAL
CCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHH
QHTRLMEENRELREELVGRFNFGNIIGASTALKEVLERVEKLAVRDTSVLITGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
LIAQAIHYNSPRKEKKFVAINCGALPASLLESELFGYRKGAFTGAAENRRGLLETADGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCE
LFLDEVGNLPMTVQKTLLRFLQEQEFNRLGDPTPTKVDVRVLSATNSDMKQAVKAGDFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCHHH
DLYYRLNVVNIHLPPLRERKDDIALLAAHFISLQNSKFGTQIKGLDREALEAAAEFPWPG
HHEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHCCCCCC
NIRQLRNVMEACLAMENNDYITFPVLSQFIEVAPLETGGEAPAEEGEYAKALMRFETEYL
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RGLLRKNQGNVEAAAKEAGTNMATIYRKIKKYGIRKEEYNL
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure 
TGKKRIMVVDNEEGLCRMMEAVLSDNGYAVTAHTRSFEAAESFQAGQWDLLVTDIKMPG
CCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCC
MDGLELLQKVKQKDPALPVIMVTAYATVEMSIQALRKGAYDMLTKPFEPEELLYRVKNAL
CCHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHH
QHTRLMEENRELREELVGRFNFGNIIGASTALKEVLERVEKLAVRDTSVLITGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHH
LIAQAIHYNSPRKEKKFVAINCGALPASLLESELFGYRKGAFTGAAENRRGLLETADGGT
HHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCE
LFLDEVGNLPMTVQKTLLRFLQEQEFNRLGDPTPTKVDVRVLSATNSDMKQAVKAGDFRE
EEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHCCHHH
DLYYRLNVVNIHLPPLRERKDDIALLAAHFISLQNSKFGTQIKGLDREALEAAAEFPWPG
HHEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHCCCCCC
NIRQLRNVMEACLAMENNDYITFPVLSQFIEVAPLETGGEAPAEEGEYAKALMRFETEYL
CHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RGLLRKNQGNVEAAAKEAGTNMATIYRKIKKYGIRKEEYNL
HHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]