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The map label for this gene is hbd [H]

Identifier: 197117805

GI number: 197117805

Start: 1634036

End: 1634902

Strand: Direct

Name: hbd [H]

Synonym: Gbem_1417

Alternate gene names: 197117805

Gene position: 1634036-1634902 (Clockwise)

Preceding gene: 197117804

Following gene: 197117806

Centisome position: 35.41

GC content: 62.86

Gene sequence:

>867_bases
ATGAACGTCGAGGATATCACCACAATGGGAATGGCAGGCGCCGGCAGCATGGGGGCGGGAATCGCCCAGGTGGCGGCGAT
GGCGGGGCTCAAGGTGCAGGTGGTGGACACGGGCGCAGGGGCGTGCGACCGCGCCAGGAAGACCATCGTGAAAAGCCTGG
AGCGGATCGTCAAGAAGGGGACCATGACGGAAGCCCAGATGGAGGAGACCCTGGGGCGGATCAGCTTCTCCACGGACGTG
GCGAGCTTCAAAGGGATTCCCTTCATCTTCGAGGCGGTGTTCGAGGACATCGCGGTGAAGAAGGAACTCTTCGCCAAACT
CGACGCGGTCTGCGGCGAGGACACCATCTACGCCACCAACACCTCTTCCATCTCCATCACCGAGATGGCGGCCCTGGTGA
AAAACCCCGCTAACTTCGTCGGGATGCACTTCTTCAACCCGGTGCCGGTGATGAAGCTGGTCGAGGTGATCCCCGCGCTG
CAGACGGCAGAGGCGACCAAGAACCTCGCGCTCGCCATGTCCCAAAAGCTCGGCAAGACCTCCATCACCTGCAAGGACAC
CCCCGGTTTCGTCGTGAACCGCCTCTTCGTCCCCTACATCATCGACGCGGTCCGGCTGCTCGAGGAAGGGGTGGCGTCGG
CCGAGGACATCGACATTGCCATGAAGCTCGGCTGCAACATGCCCATGGGGCCGCTCGAATTCCAGGACTTCGCCGGGGTC
GACATCGGCTACCACGTCACCAACATCTTCCACGAGTACCTGAAGCAGGAGCGCTTCGCCCCCCCGGGGCTCTTGCGCAA
CATGATCAAGGCGGGCTACCTGGGACGCAAGGCGGGACGAGGGTTCTACGAGTACCCGGCCAGCTGA

Upstream 100 bases:

>100_bases
CGCCTTCGGCGAGAAGAGAAAACCGAACTTTTTAAGCAGATAACCTCAACGATTTCGATAACGAGACCAACTCACTACGA
TTGCAAAAAGGAGGATACGC

Downstream 100 bases:

>100_bases
AAAAACGTCGATAAATCGATCCAACCGAAATAGGAGGCCTACCATGGCTGCAACGATCTGGAAGGAAATCAAGAACTGGC
GCGAGATCTACAACTCGCGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNVEDITTMGMAGAGSMGAGIAQVAAMAGLKVQVVDTGAGACDRARKTIVKSLERIVKKGTMTEAQMEETLGRISFSTDV
ASFKGIPFIFEAVFEDIAVKKELFAKLDAVCGEDTIYATNTSSISITEMAALVKNPANFVGMHFFNPVPVMKLVEVIPAL
QTAEATKNLALAMSQKLGKTSITCKDTPGFVVNRLFVPYIIDAVRLLEEGVASAEDIDIAMKLGCNMPMGPLEFQDFAGV
DIGYHVTNIFHEYLKQERFAPPGLLRNMIKAGYLGRKAGRGFYEYPAS

Sequences:

>Translated_288_residues
MNVEDITTMGMAGAGSMGAGIAQVAAMAGLKVQVVDTGAGACDRARKTIVKSLERIVKKGTMTEAQMEETLGRISFSTDV
ASFKGIPFIFEAVFEDIAVKKELFAKLDAVCGEDTIYATNTSSISITEMAALVKNPANFVGMHFFNPVPVMKLVEVIPAL
QTAEATKNLALAMSQKLGKTSITCKDTPGFVVNRLFVPYIIDAVRLLEEGVASAEDIDIAMKLGCNMPMGPLEFQDFAGV
DIGYHVTNIFHEYLKQERFAPPGLLRNMIKAGYLGRKAGRGFYEYPAS
>Mature_288_residues
MNVEDITTMGMAGAGSMGAGIAQVAAMAGLKVQVVDTGAGACDRARKTIVKSLERIVKKGTMTEAQMEETLGRISFSTDV
ASFKGIPFIFEAVFEDIAVKKELFAKLDAVCGEDTIYATNTSSISITEMAALVKNPANFVGMHFFNPVPVMKLVEVIPAL
QTAEATKNLALAMSQKLGKTSITCKDTPGFVVNRLFVPYIIDAVRLLEEGVASAEDIDIAMKLGCNMPMGPLEFQDFAGV
DIGYHVTNIFHEYLKQERFAPPGLLRNMIKAGYLGRKAGRGFYEYPAS

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=280, Percent_Identity=44.2857142857143, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI296179427, Length=297, Percent_Identity=41.7508417508418, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=36.2676056338028, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=31.3993174061433, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=31.3993174061433, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI115430219, Length=229, Percent_Identity=30.5676855895196, Blast_Score=102, Evalue=3e-22,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=42.6056338028169, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788682, Length=263, Percent_Identity=36.5019011406844, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790281, Length=266, Percent_Identity=32.3308270676692, Blast_Score=142, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=43.205574912892, Blast_Score=247, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17563036, Length=283, Percent_Identity=40.6360424028269, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=39.1003460207612, Blast_Score=217, Evalue=5e-57,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=32.9787234042553, Blast_Score=162, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=281, Percent_Identity=32.7402135231317, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=32.9787234042553, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17558304, Length=281, Percent_Identity=31.6725978647687, Blast_Score=157, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=30.1418439716312, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=28.9752650176678, Blast_Score=138, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI193203623, Length=193, Percent_Identity=25.9067357512953, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=25.9067357512953, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=37.2340425531915, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=37.2340425531915, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=37.2340425531915, Blast_Score=175, Evalue=4e-44,
Organism=Drosophila melanogaster, GI45549573, Length=235, Percent_Identity=30.2127659574468, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129993, Length=235, Percent_Identity=26.8085106382979, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31071; Mature: 31071

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVEDITTMGMAGAGSMGAGIAQVAAMAGLKVQVVDTGAGACDRARKTIVKSLERIVKKG
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
TMTEAQMEETLGRISFSTDVASFKGIPFIFEAVFEDIAVKKELFAKLDAVCGEDTIYATN
CCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TSSISITEMAALVKNPANFVGMHFFNPVPVMKLVEVIPALQTAEATKNLALAMSQKLGKT
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SITCKDTPGFVVNRLFVPYIIDAVRLLEEGVASAEDIDIAMKLGCNMPMGPLEFQDFAGV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC
DIGYHVTNIFHEYLKQERFAPPGLLRNMIKAGYLGRKAGRGFYEYPAS
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCC
>Mature Secondary Structure
MNVEDITTMGMAGAGSMGAGIAQVAAMAGLKVQVVDTGAGACDRARKTIVKSLERIVKKG
CCCCHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHC
TMTEAQMEETLGRISFSTDVASFKGIPFIFEAVFEDIAVKKELFAKLDAVCGEDTIYATN
CCCHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
TSSISITEMAALVKNPANFVGMHFFNPVPVMKLVEVIPALQTAEATKNLALAMSQKLGKT
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
SITCKDTPGFVVNRLFVPYIIDAVRLLEEGVASAEDIDIAMKLGCNMPMGPLEFQDFAGV
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCHHHHCCC
DIGYHVTNIFHEYLKQERFAPPGLLRNMIKAGYLGRKAGRGFYEYPAS
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA